Meta-analysis: combination therapy with interferon-alpha 2a/2b and ribavirin for patients with chronic hepatitis C previously non-responsive to interferon.

abstract：BACKGROUND:Early differentiation of malignant from benign bile duct obstruction is of utmost importance. AIM:To identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based applicatio...

journal_title：Alimentary pharmacology & therapeutics

authors： Meister T,Uphoff MA,Heinecke A,Domagk D,Kunsch S,Lindhorst A,Ellenrieder V,Heinzow HS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans. AIMS:To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalge...

journal_title：Alimentary pharmacology & therapeutics

authors： Olesen SS,Graversen C,Olesen AE,Frøkjaer JB,Wilder-Smith O,van Goor H,Valeriani M,Drewes AM

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori eradication has become the standard treatment for duodenal ulcer. However, there is no relevant evidence for antibacterial treatment of the white scar stage of duodenal ulcer (duodenal ulcer scar) in patients with no past history of duodenal ulcer. AIM:To investigate whether H. pylori er...

journal_title：Alimentary pharmacology & therapeutics

authors： Kim JS,Kim SG,Choi IJ,Park MJ,Kim BG,Jung HC,Song IS

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...

journal_title：Alimentary pharmacology & therapeutics

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Ockenga J,Kreutz R,Garbe E

更新日期：2013-10-01 00:00:00

abstract：AIM:To measure 24-h ambulatory oesophageal pH data in patients with gastro-oesophageal reflux disease prior to, during and after acute treatment with comparable doses of omeprazole and ranitidine. METHODS:The subjects were 20 adults with at least 8% acid contact time. Ten subjects were treated for 1 week with omeprazo...

journal_title：Alimentary pharmacology & therapeutics

authors： Orr WC,Mellow MH,Grossman MR

更新日期：1995-10-01 00:00:00

abstract：:Upper gastrointestinal symptoms are highly prevalent; usually those consulting have multiple symptoms, confounding management. Here, common clinically relevant management issues are considered based on the best available evidence. Regardless of the presenting symptoms, determine if there are any alarm features; these ...

journal_title：Alimentary pharmacology & therapeutics

authors： Talley NJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Misoprostol is known to be effective in stimulating intestinal transit both in healthy individuals and in patients with chronic constipation when evaluated in short-term trials. The aim of this study was to determine the utility of misoprostol in the long-term management of patients with chronic refractory c...

journal_title：Alimentary pharmacology & therapeutics

authors： Roarty TP,Weber F,Soykan I,McCallum RW

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM:To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS:Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean dif...

journal_title：Alimentary pharmacology & therapeutics

authors： Feagan BG,Patel H,Colombel JF,Rubin DT,James A,Mody R,Lasch K

更新日期：2017-01-01 00:00:00

abstract：:Candidiasis of the oropharynx and oesophagus is one of the most common problems encountered in patients with HIV disease. Fluconazole is a bis-triazole antifungal agent with a long serum half-life. Sixteen anti-HIV positive patients (15 haemophiliacs and one blood transfusion recipient) with a clinical diagnosis of or...

journal_title：Alimentary pharmacology & therapeutics

authors： Lim SG,Lee CA,Hales M,O'Doherty M,Winter M,Kernoff PB

更新日期：1991-04-01 00:00:00

abstract：BACKGROUND:Cross-sectional imaging techniques, including ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI), are increasingly used for evaluation of Crohn's disease (CD). Aim  To perform an assessment of the diagnostic accuracy of cross-sectional imaging techniques for diagnosis of CD, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Panés J,Bouzas R,Chaparro M,García-Sánchez V,Gisbert JP,Martínez de Guereñu B,Mendoza JL,Paredes JM,Quiroga S,Ripollés T,Rimola J

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:The therapeutic effect of enteral nutrition in Crohn's disease (CD) and the epidemiological associations between diet and inflammatory bowel disease (IBD) implicate diet in IBD causation. There is little evidence, however, to support specific dietary changes and patients often receive contradictory advice. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Richman E,Rhodes JM

更新日期：2013-11-01 00:00:00

abstract：:Proton pump inhibitors have dramatically influenced the management of acid-peptic disorders in recent years. They all have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochromes P450 2C19 and 3A4. There is some variation in their potential for drug interactions due to differ...

journal_title：Alimentary pharmacology & therapeutics

authors： Stedman CA,Barclay ML

更新日期：2000-08-01 00:00:00

abstract：BACKGROUND:Locally acquired hepatitis E is an emerging infection in developed countries and can be misdiagnosed as drug-induced liver injury. AIM:To study the role of hepatitis E virus (HEV) testing in drug-induced liver injury. METHODS:Retrospective review of a cohort of patients with suspected drug-induced liver in...

journal_title：Alimentary pharmacology & therapeutics

authors： Dalton HR,Fellows HJ,Stableforth W,Joseph M,Thurairajah PH,Warshow U,Hazeldine S,Remnarace R,Ijaz S,Hussaini SH,Bendall RP

更新日期：2007-11-15 00:00:00

abstract：BACKGROUND:Intravenous octreotide is an established treatment of oesophageal variceal haemorrhage in the cirrhotic patient. AIM:To examine the organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients with portal hypertension. METHODS:Thirteen patients with cirrhosis had hepatic venous ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ottesen LH,Flyvbjerg A,Møller S,Bendtsen F

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma is the leading cause of death in cirrhosis. A majority of patients present at an advanced stage with poor prognosis. AIM:To review the current screening, diagnosis and management strategies involved in hepatocellular carcinoma. METHODS:A literature search was performed using PubMed...

journal_title：Alimentary pharmacology & therapeutics

authors： Cabrera R,Nelson DR

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:Globally, the incidence rates of inflammatory bowel disease (IBD) are increasing; however, data from high-incidence areas are conflicting. Previous studies in Denmark have assessed incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) using short observation periods. AIM:To investigate trends ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lophaven SN,Lynge E,Burisch J

更新日期：2017-04-01 00:00:00

abstract：AIM:To determine whether a 5-day regimen with rabeprazole, clarithromycin and amoxicillin (RCA) was as effective as a 7-day regimen. METHODS:A total of 139 H. pylori-infected patients were randomized to receive either a 5-day or 7-day course of rabeprazole 10 mg b.d., clarithromycin 400 mg b.d. and amoxicillin 750 mg ...

journal_title：Alimentary pharmacology & therapeutics

authors： Isomoto H,Furusu H,Morikawa T,Mizuta Y,Nishiyama T,Omagari K,Murase K,Inoue K,Murata I,Kohno S

更新日期：2000-12-01 00:00:00

abstract：AIM:To update previous overviews of placebo-controlled double-blind trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome. METHODS AND TRIALS: A total of 23 randomized clinical trials were selected for meta-analyses of their efficacy and tolerance. Six drugs were analysed: c...

journal_title：Alimentary pharmacology & therapeutics

authors： Poynard T,Regimbeau C,Benhamou Y

更新日期：2001-03-01 00:00:00

abstract：:Proton pump inhibitor-based triple therapy is the most commonly used treatment for eradication of Helicobacter pylori, with pooled eradication rates of approximately 90%. In the USA, per protocol eradication rates with 10-day proton pump inhibitor-based triple therapy are approximately 85%. Esomeprazole, a new proton ...

journal_title：Alimentary pharmacology & therapeutics

authors： Laine L

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Optimal management approach is not well defined for subjects who fail initial first- and second-line Helicobacter pylori eradication attempts and are dealt on a case-by-case basis by the specialists. AIM:To evaluate the efficacy and safety of standard and 'rescue' eradication therapies at primary and second...

journal_title：Alimentary pharmacology & therapeutics

authors： Qasim A,Sebastian S,Thornton O,Dobson M,McLoughlin R,Buckley M,O'Connor H,O'Morain C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates. METHODS:A comprehensive search of a...

journal_title：Alimentary pharmacology & therapeutics

authors： Houben MH,van de Beek D,Hensen EF,de Craen AJ,Rauws EA,Tytgat GN

更新日期：1999-08-01 00:00:00

abstract：:In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o.m. and 91 cimetidine 800 mg nocte for 2 or, if then not healed, 4 weeks. After 2 weeks the healing rates on an intention-to-treat basis were: for omeprazole 62% and for cimetidine 33% (P less than 0.001), an...

journal_title：Alimentary pharmacology & therapeutics

authors： Crowe JP,Wilkinson SP,Bate CM,Willoughby CP,Peers EM,Richardson PD

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Recently a new 'all in one' single capsule with the three components of bismuth-based triple therapy became available in trials for treating Helicobacter pylori. AIM:To investigate the efficacy and tolerability of this new capsule when combined with lansoprazole. METHODS:A total of 66 consecutive infected ...

journal_title：Alimentary pharmacology & therapeutics

authors： De Boer WA,Van Etten RJ,Van De Wouw BA,Schneeberger PM,Van Oijen AH,Jansen JB

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong CR,Njei B,Nguyen MH,Nguyen A,Lim JK

更新日期：2017-12-01 00:00:00

abstract：:The decision regarding prophylactic treatment after surgery in Crohn's disease (CD) requires a good estimation of the risk of recurrence. It is also important to consider the consequences of recurrence for the patient, and the risks and benefits of treatment, bearing in mind that it will be given over a long period. S...

journal_title：Alimentary pharmacology & therapeutics

authors： Lémann M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Oral aloe vera gel is widely used by patients with inflammatory bowel disease and is under therapeutic evaluation for this condition. AIM:To assess the effects of aloe vera in vitro on the production of reactive oxygen metabolites, eicosanoids and interleukin-8, all of which may be pathogenic in inflammator...

journal_title：Alimentary pharmacology & therapeutics

authors： Langmead L,Makins RJ,Rampton DS

更新日期：2004-03-01 00:00:00

abstract：AIM:To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. METHODS:Forty H. pylori-positive patients with duodenal ulcer were randomized to receive 20 mg omeprazole o.m. or b.d. for 1 month plus 500 mg clarithromy...

journal_title：Alimentary pharmacology & therapeutics

authors： Dani R,Queiroz DM,Dias MG,Franco JM,Magalhães LC,Mendes GS,Moreira LS,De Castro LP,Toppa NH,Rocha GA,Cabral MM,Salles PG

更新日期：1999-12-01 00:00:00

abstract：AIM:To determine factors affecting compliance of a follow-up colonoscopy in patients with previously diagnosed adenomatous colon polyps. METHODS:A retrospective review was performed on patients with adenomatous polyps excised between January and December 1998. Twenty-nine clinical factors were assessed in patients gro...

journal_title：Alimentary pharmacology & therapeutics

authors： Siddiqui AA,Patel A,Huerta S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Both high-fibre dietary advice and the prescription of fibre as a bulking agent are very common in primary and secondary care management of irritable bowel syndrome. Irritable bowel syndrome patients with constipation may have delayed intestinal transit. Therefore, fibres that accelerate intestinal transit m...

journal_title：Alimentary pharmacology & therapeutics

authors： Bijkerk CJ,Muris JW,Knottnerus JA,Hoes AW,de Wit NJ

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Drug toxicity is the leading cause of acute liver failure in the United States. Further understanding of hepatotoxicity is becoming increasingly important as more drugs come to market. AIMS:(i) To provide an update on recent advances in our understanding of hepatotoxicity of select commonly used drug classe...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang CY,Schiano TD

更新日期：2007-05-15 00:00:00