Symptom relief and duodenal ulcer healing with omeprazole or cimetidine. Opus (Omeprazole Peptic Ulcer Study) Research Group.

abstract：BACKGROUND:Optimal management approach is not well defined for subjects who fail initial first- and second-line Helicobacter pylori eradication attempts and are dealt on a case-by-case basis by the specialists. AIM:To evaluate the efficacy and safety of standard and 'rescue' eradication therapies at primary and second...

journal_title：Alimentary pharmacology & therapeutics

authors： Qasim A,Sebastian S,Thornton O,Dobson M,McLoughlin R,Buckley M,O'Connor H,O'Morain C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors effectively suppress intragastric acid. Nocturnal acid breakthrough occurs on any dosing regimen of oral proton pump inhibitors. Histamine(2)-receptor antagonists (H(2)RA) suppress intragastric acidity independently of meals and help to control nocturnal acid breakthrough. Because prot...

journal_title：Alimentary pharmacology & therapeutics

authors： Tutuian R,Katz PO,Ahmed F,Korn S,Castell DO

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The use of healthcare resources for the management of constipation is not well-known. AIM:To analyse healthcare seeking for constipation, defined by three different criteria, and its related factors and to assess the frequency of use of laxatives, suppositories and enemas for the treatment of constipation. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gálvez C,Garrigues V,Ortiz V,Ponce M,Nos P,Ponce J

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Tumour necrosis factor (TNF)-antagonists have an established role in the treatment of inflammatory bowel diseases (IBDs), however, subtherapeutic drug levels and the formation of anti-drug antibodies (ADAs) may decrease their efficacy. AIM:The evidence supporting the use of therapeutic drug monitoring (TDM)...

journal_title：Alimentary pharmacology & therapeutics

authors： Khanna R,Sattin BD,Afif W,Benchimol EI,Bernard EJ,Bitton A,Bressler B,Fedorak RN,Ghosh S,Greenberg GR,Marshall JK,Panaccione R,Seidman EG,Silverberg MS,Steinhart AH,Sy R,Van Assche G,Walters TD,Sandborn WJ,Feagan BG

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

journal_title：Alimentary pharmacology & therapeutics

authors： Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The effect of anti-viral treatment on downstream costs for hepatitis C virus (HCV)-infected patients is unknown. AIM:To evaluate follow-up costs in patients with chronic HCV, stratified by liver disease severity. METHODS:Using a US private insurance database, mean all-cause per-patient-per-month (PPPM) US ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gordon SC,Hamzeh FM,Pockros PJ,Hoop RS,Buikema AR,Korner EJ,Terrault NA

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Metoclopramide is a dopamine receptor antagonist which has been used for treatment of a variety of gastrointestinal symptoms over the last thirty years. In 2009, the FDA issued a black box warning regarding long-term or high-dose use of this medication because of the risk of developing tardive dyskinesia. A...

journal_title：Alimentary pharmacology & therapeutics

authors： Rao AS,Camilleri M

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The mechanism of hypergastrinaemia during omeprazole therapy is unclear, but is generally assumed to be entirely a consequence of acid suppression. However, direct stimulation of G cells by omeprazole could also be a factor. In order to further investigate the mechanism of omeprazole-induced hypergastrinaemi...

journal_title：Alimentary pharmacology & therapeutics

authors： Banerjee S,Ardill JE,Beattie AD,McColl KE

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:We have observed an increase in hepatotoxicity (DILI) reporting related to the use of anabolic androgenic steroids (AAS) for bodybuilding. AIM:To characterise phenotype presentation, outcome and severity of AAS DILI. METHODS:Data on 25 cases of AAS DILI reported to the Spanish (20) and Latin-American (5) D...

journal_title：Alimentary pharmacology & therapeutics

authors： Robles-Diaz M,Gonzalez-Jimenez A,Medina-Caliz I,Stephens C,García-Cortes M,García-Muñoz B,Ortega-Alonso A,Blanco-Reina E,Gonzalez-Grande R,Jimenez-Perez M,Rendón P,Navarro JM,Gines P,Prieto M,Garcia-Eliz M,Bessone F,Brahm

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:There is a need for a simple, therapeutic test that is of diagnostic value and can also provide rapid symptom relief in patients who present with classic, mild symptoms suggestive of gastro-oesophageal reflux disease (GERD), when the diagnosis is based on symptom assessment alone. AIM:To assess the diagnost...

journal_title：Alimentary pharmacology & therapeutics

authors： Bate CM,Riley SA,Chapman RW,Durnin AT,Taylor MD

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Clearance of hepatitis B surface antigen (HBsAg) indicates clinical control of hepatitis B virus (HBV) infection. However, little is known about the impact of viral genomic variations on HBsAg loss. METHODS:We explored the association between viral genomic factors and HBsAg loss in 2121HBeAg-negative patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Tseng TC,Liu CJ,Chen CL,Yang WT,Yang HC,Su TH,Wang CC,Kuo SF,Liu CH,Chen PJ,Chen DS,Kao JH

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Coeliac disease (CD), originally thought to be largely confined to Northern Europe and Australasia and uncommon in North America and the Middle East, is now recognised to be equally common in all these countries. It is still thought to be rare in the Orient and Sub-Saharan Africa. AIM:To assess geographical...

journal_title：Alimentary pharmacology & therapeutics

authors： Kang JY,Kang AH,Green A,Gwee KA,Ho KY

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Twice-daily dosing is increasingly used to improve gastric acid control, although not all proton-pump inhibitors are more effective when doses are split. Standard dose esomeprazole provides better gastric acid control than other standard dose proton-pump inhibitors. AIMS:To compare the effect of standard do...

journal_title：Alimentary pharmacology & therapeutics

authors： Hammer J,Schmidt B

更新日期：2004-05-15 00:00:00

abstract：BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

journal_title：Alimentary pharmacology & therapeutics

authors： Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...

journal_title：Alimentary pharmacology & therapeutics

authors： Niro GA,Ciancio A,Tillman HL,Lagget M,Olivero A,Perri F,Fontana R,Little N,Campbell F,Smedile A,Manns MP,Andriulli A,Rizzetto M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:The disease severity of non-alcoholic fatty liver disease (NAFLD) and the distinction between simple steatosis and non-alcoholic steatohepatitis (NASH) are based on the pathohistological presence of steatosis, inflammation, ballooning and fibrosis. However, little is known about the relation between such str...

journal_title：Alimentary pharmacology & therapeutics

authors： Eriksen PL,Thomsen KL,Larsen LP,Grønbaek H,Vilstrup H,Sørensen M

更新日期：2019-07-01 00:00:00

abstract：AIM:To determine whether misoprostol promotes the healing of non-steroidal anti-inflammatory drug-induced gastroduodenal lesions in a human experimental model. METHODS:Mucosal damage and healing of mucosal biopsy sites were assessed endoscopically in 10 healthy, Helicobacter pylori-negative volunteers with a normal in...

journal_title：Alimentary pharmacology & therapeutics

authors： Dorta G,Nicolet M,Vouillamoz D,Margalith D,Blum AL,Armstrong D,Saraga E

更新日期：1996-08-01 00:00:00

abstract：:The effects of identical morning (08.05 hours) and evening (20.05 hours) meals on intragastric pH were compared in 12 healthy volunteers receiving gastric antisecretory medication. Dosing included continuous intravenous infusion ranitidine (50 mg bolus followed by 12.5 mg/h) or a matching placebo which were randomly a...

journal_title：Alimentary pharmacology & therapeutics

authors： Sanders SW,Moore JG,Day GM,Tolman KG

更新日期：1992-04-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is associated with metabolic manifestations including insulin resistance and diabetes through various mechanisms. Whether HCV infection is associated with an increased risk of post-transplant diabetes in liver transplant recipients is unclear. AIM:To assess the association of HCV inf...

journal_title：Alimentary pharmacology & therapeutics

authors： Younossi Z,Stepanova M,Saab S,Trimble G,Mishra A,Henry L

更新日期：2015-01-01 00:00:00

abstract：:Both duodenal and gastric ulcer disease are closely associated with Helicobacter pylori infection. An infected individual has an estimated lifetime risk of 10-20% for the development of peptic ulcer disease, which is at least 3-4 fold higher than in non-infected subjects. H. pylori infection can be diagnosed in 90-100...

journal_title：Alimentary pharmacology & therapeutics

authors： Kuipers EJ,Thijs JC,Festen HP

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Intravenous octreotide is an established treatment of oesophageal variceal haemorrhage in the cirrhotic patient. AIM:To examine the organ extraction and splanchnic haemodynamic effects of octreotide in cirrhotic patients with portal hypertension. METHODS:Thirteen patients with cirrhosis had hepatic venous ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ottesen LH,Flyvbjerg A,Møller S,Bendtsen F

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:The prevalence of coeliac disease (CD) may be increased in individuals with dyspepsia, but evidence is conflicting. AIMS:To conduct a systematic review and meta-analysis of studies reporting prevalence of CD in dyspepsia. METHODS:MEDLINE, EMBASE, and CINAHL were searched up to February 2009. Case series an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ford AC,Ching E,Moayyedi P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Bacteria have been implicated in the pathogenesis of inflammatory bowel disease. Helicobacter species have been shown to cause colitis in animal models and have been identified in human diarrhoeal illness and Crohn's disease. AIM:To determine whether Helicobacter species are present in human inflammatory bo...

journal_title：Alimentary pharmacology & therapeutics

authors： Bell SJ,Chisholm SA,Owen RJ,Borriello SP,Kamm MA

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Previous epidemiological studies suggest that patients diagnosed with nonalcoholic fatty liver disease (NAFLD) who drink light to moderate amounts of alcohol (up to ~30 g per day) have less severe histological lesions compared with nondrinkers. However, while the cross-sectional nature of current evidence pr...

journal_title：Alimentary pharmacology & therapeutics

authors： Sookoian S,Flichman D,Castaño GO,Pirola CJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In Sweden, the most common causes of liver cirrhosis are alcohol overconsumption and hepatitis C. However, recent data on the clinical characteristics of Swedish patients with cirrhosis are scarce. AIMS:To determine the incidence, clinical presentation, aetiological spectrum and survival rates of liver cirr...

journal_title：Alimentary pharmacology & therapeutics

authors： Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and are associated with poor outcomes. AIM:To provide an overview of data on the importance, assessment and management of malnutrition/sarcopenia and frailty in cirrhosis. METHODS:A literature search was conducted in PubMed and other...

journal_title：Alimentary pharmacology & therapeutics

authors： Bunchorntavakul C,Reddy KR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglob...

journal_title：Alimentary pharmacology & therapeutics

authors： Zipprich A,Meiss F,Steudel N,Sziegoleit U,Fleig WE,Kleber G

更新日期：2003-06-15 00:00:00

abstract：:Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30-60 mg daily. In 40 patients (95.2%) the ulcers healed within 2-12 weeks. In the remaining 2 p...

journal_title：Alimentary pharmacology & therapeutics

authors： Brunner G,Arnold R,Hennig U,Fuchs W

更新日期：1993-01-01 00:00:00

abstract：AIM:To assess the pathophysiology and treatment of neurogenic dysphagia. METHODS:46 patients with brain damage, 46 with neurodegenerative diseases and eight healthy volunteers were studied by videofluoroscopy while swallowing 3-20 mL liquid (20.4 mPa s), nectar (274.4 mPa s) and pudding (3931.2 mPa s) boluses. RESULT...

journal_title：Alimentary pharmacology & therapeutics

authors： Clavé P,de Kraa M,Arreola V,Girvent M,Farré R,Palomera E,Serra-Prat M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Third-generation cephalosporins (TGC) constitute the empirical first-line therapy for spontaneous bacterial peritonitis (SBP). Hospitalisation, invasive procedures and use of antibiotics may challenge this concept due to an increase in enterococci and other TGC-resistant microorganisms. AIM:To determine pre...

journal_title：Alimentary pharmacology & therapeutics

authors： Reuken PA,Pletz MW,Baier M,Pfister W,Stallmach A,Bruns T

更新日期：2012-05-01 00:00:00