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Omeprazole, clarithromycin and furazolidone for the eradication of Helicobacter pylori in patients with duodenal ulcer.

Abstract：

AIM:To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. METHODS:Forty H. pylori-positive patients with duodenal ulcer were randomized to receive 20 mg omeprazole o.m. or b.d. for 1 month plus 500 mg clarithromycin (b.d. ) and 200 mg furazolidone (b.d.) for 1 week. RESULTS:Three months after the end of the treatment the eradication rates were 90% by intention-to-treat analysis, and 97% by per protocol analysis. Mild side-effects were observed in 25 patients, none of whom abandoned the protocol. No difference was observed between the 20 mg and 40 mg omeprazole daily doses. Cure or significant improvement of the symptoms and of the histological alterations were observed after H. pylori eradication. CONCLUSION:Our results demonstrate that clarithromycin and furazolidone in combination with omeprazole are a good alternative for H. pylori eradication in Brazilian patients with duodenal ulcer.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Dani R,Queiroz DM,Dias MG,Franco JM,Magalhães LC,Mendes GS,Moreira LS,De Castro LP,Toppa NH,Rocha GA,Cabral MM,Salles PG

doi

10.1046/j.1365-2036.1999.00653.x

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1647-52

issue

12

eissn

0269-2813

issn

1365-2036

pii

apt653

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验

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