Effects of lactulose and polyethylene glycol on colonic transit.

abstract：BACKGROUND:The efficacy of cyclosporin in the management of ulcerative colitis is recognized. Not all patients respond to this treatment. Existing clinical and laboratory parameters are of little use in identifying those most likely to respond. AIMS:To determine whether in-vitro sensitivity to cyclosporin as measured ...

journal_title：Alimentary pharmacology & therapeutics

authors： McCormack G,O'Donoghue D,Baird A

更新日期：2001-05-01 00:00:00

abstract：:The purpose of this study was to determine whether portal hypertension potentiates intestinal ulceration induced by indomethacin. Portal hypertension was produced in male Sprague-Dawley rats by two-staged ligation of the portal vein. Sham-operated rats were used as controls. The rats were given 20 mg/kg of indomethaci...

journal_title：Alimentary pharmacology & therapeutics

authors： Jonas GM,Erickson RA,Chung K

更新日期：1991-02-01 00:00:00

abstract：:Colorectal cancer is a common cancer and common cause of death. The mortality rate from colorectal cancer can be reduced by identification and removal of cancer precursors, adenomas, or by detection of cancer at an earlier stage. Pilot screening programmes have demonstrated decreased colorectal cancer mortality; as a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Nicholson FB,Barro JL,Atkin W,Lilford R,Patnick J,Williams CB,Pignone M,Steele R,Kamm MA

更新日期：2005-12-01 00:00:00

abstract：:In a double-blind, placebo-controlled study of SK&F 94482 (BMY-25368) (400-mg, post-evening meal, for 7 days in 11 healthy subjects), there was a significant 75% decrease in median integrated 24-h intragastric acidity during dosing with the drug (218 mmol h/L) compared with placebo (883 mmol h/L; P = 0.003). The singl...

journal_title：Alimentary pharmacology & therapeutics

authors： Gavey CJ,Smith JT,Nwokolo CU,Pounder RE

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Historically, the beneficial effects of the nonsystemic oral agent rifaximin on various gastrointestinal (GI) disorders have been attributed to direct antibiotic activity on gut microbiota. However, data are accumulating to suggest that other nonantibacterial effects may be involved in rifaximin efficacy. A...

journal_title：Alimentary pharmacology & therapeutics

authors： DuPont HL

更新日期：2016-01-01 00:00:00

abstract：AIM:: To quantify through systematic review the pharmacokinetic profiles of the oral delayed release and sustained release mesalazine (5-aminosalicylate, 5ASA) formulations (Asacol, Salofalk, Mesasal, Claversal, Pentasa) and pro-drugs (sulfasalazine, olsalazine, balsalazide) used in the management of ulcerative colitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Sandborn WJ,Hanauer SB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The diagnostic value of ascitic cholesterol in the differential diagnosis of ascites is controversial. AIM:To investigate the diagnostic performance of ascitic cholesterol in the differential diagnosis of ascites. METHODS:Consecutive patients with new-onset ascites were enrolled prospectively. The pertinen...

journal_title：Alimentary pharmacology & therapeutics

authors： Du L,Zhu S,Lu Z,Xu T,Bai T,Xu D,Wei X,Li J,Xu K,Ye J,Hou X,Song Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. AIMS:To determine whether circulating microRNAs are reliable biomarkers for IBD monitoring. METHODS:Serum levels of 17 candidate microRNAs were measured by quantitative real-t...

journal_title：Alimentary pharmacology & therapeutics

authors： Chen P,Li Y,Li L,Yu Q,Chao K,Zhou G,Qiu Y,Feng R,Huang S,He Y,Chen B,Chen M,Zeng Z,Zhang S

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Local delivery of therapeutic agents to the stomach may be a useful strategy in the treatment of Helicobacter pylori infection. We aimed to see whether the intragastric distribution and gastric retention of a therapeutic agent could be improved, either by giving omeprazole or by dosing after a meal. METHODS...

journal_title：Alimentary pharmacology & therapeutics

authors： Atherton JC,Washington N,Bracewell MA,Sutton LJ,Greaves JL,Perkins AC,Hawkey CJ,Spiller RC

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Patients on maintenance dialysis typically show a suboptimal immune response to hepatitis B virus vaccine compared with the non-uraemic population. Some authors have claimed that dialysis mode has an impact on the immune response to hepatitis B virus vaccine but consistent information is lacking on this issu...

journal_title：Alimentary pharmacology & therapeutics

authors： Fabrizi F,Dixit V,Bunnapradist S,Martin P

更新日期：2006-04-15 00:00:00

abstract：:Faecal impaction with or without encopresis is a very common problem. We performed a randomized, open-label, prospective study to compare the efficacy and acceptability of the treatment of faecal impaction using either mineral oil or pineapple-flavoured isotonic intestinal lavage solution containing polyethylene glyco...

journal_title：Alimentary pharmacology & therapeutics

authors： Tolia V,Lin CH,Elitsur Y

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Butyrate, propionate and acetate are short chain fatty acids (SCFA), important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis. However, they may also regulate immune responses and the composition of the intestinal microbiota. Consequently, their importance in a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gill PA,van Zelm MC,Muir JG,Gibson PR

更新日期：2018-07-01 00:00:00

abstract：:Coeliac disease is a chronic inflammatory condition associated with small intestinal injury that results in the malabsorption of different nutrients. The damaging factor is gluten present in wheat, barley and rye. The diagnosis relies on the clinical picture of the patient, serological markers for coeliac disease, cha...

journal_title：Alimentary pharmacology & therapeutics

authors： Abdulkarim AS,Murray JA

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:It has been shown that azathioprine prolongs the response to ciclosporin of steroid-refractory ulcerative colitis, but no specific data are available concerning its toxicity in this indication. AIM AND METHODS:The charts of 21 patients with steroid-refractory ulcerative colitis who received azathioprine ove...

journal_title：Alimentary pharmacology & therapeutics

authors： Actis GC,Bresso F,Astegiano M,Demarchi B,Sapone N,Boscaglia C,Rizzetto M

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Small bowel bacterial overgrowth is common in Crohn's disease but its treatment is not clearly defined. Metronidazole and ciprofloxacin are effective antibiotics in active Crohn's disease. AIM:To investigate the efficacy of metronidazole and ciprofloxacin in the treatment of bacterial overgrowth in patients...

journal_title：Alimentary pharmacology & therapeutics

authors： Castiglione F,Rispo A,Di Girolamo E,Cozzolino A,Manguso F,Grassia R,Mazzacca G

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL). AIM:A randomized, double-blind, placebo-controlled, phase III trial to evaluate the efficacy and safety of a selective, high-affinity 5-HT(4) receptor agonist, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Quigley EM,Vandeplassche L,Kerstens R,Ausma J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Patients with thalassaemia major depend on blood transfusions. In Italy, up to 80% of thalassaemia patients bear HCV antibodies due to HCV contaminated transfusions before 1990. Thalassaemia patients with HCV infection have high risk of developing HCC. Treatment based on Pegylated-IFN (Peg-IFN) and Ribavirin...

journal_title：Alimentary pharmacology & therapeutics

authors： Mangia A,Sarli R,Gamberini R,Piga A,Cenderello G,Piazzolla V,Santoro R,Caruso V,Quarta A,Ganga R,Copetti M,Forni G

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:In 1997-1998, 6127 asymptomatic children aged 2-4 years were screened for coeliac disease (CD) by anti-endomysium (EmA) testing in the Netherlands. After 6 (+/-2) months, biopsies were performed in 57 seropositive children; 31(54%) had villous atrophy, but 26 (46%), all HLA-DQ2/DQ8 positive, had normal histo...

journal_title：Alimentary pharmacology & therapeutics

authors： Hogen Esch CE,Csizmadia GD,van Hoogstraten IM,Schreurs MW,Mearin ML,von Blomberg BM

更新日期：2010-04-01 00:00:00

abstract：:Acid suppression therapy with proton pump inhibitors is associated with well-established benefits in the management of gastro-oesophageal reflux (GERD) and other acid-related disorders. However, a number of issues still remain unsettled. Despite their clinical efficacy, when given once daily, currently available proto...

journal_title：Alimentary pharmacology & therapeutics

authors： Scarpignato C,Pelosini I

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Small intestinal bacterial overgrowth and sugar malabsorption (lactose, fructose, sorbitol) may play a role in irritable bowel syndrome. The lactulose breath test is a reliable and non-invasive test for the diagnosis of small intestinal bacterial overgrowth. The lactose, fructose and sorbitol hydrogen breath...

journal_title：Alimentary pharmacology & therapeutics

authors： Nucera G,Gabrielli M,Lupascu A,Lauritano EC,Santoliquido A,Cremonini F,Cammarota G,Tondi P,Pola P,Gasbarrini G,Gasbarrini A

更新日期：2005-06-01 00:00:00

abstract：AIM:To compare cheaper and simpler once-daily regimens, with and without a proton pump inhibitor, with standard, twice-daily, triple therapy. METHODS:A randomized, placebo-controlled, treatment trial in Vietnam allocated 296 Helicobacter pylori-infected patients with peptic ulcer of >or= 5 mm to one of three regimens:...

journal_title：Alimentary pharmacology & therapeutics

authors： Wheeldon TU,Hoang TT,Phung DC,Björkman A,Granström M,Sörberg M

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglob...

journal_title：Alimentary pharmacology & therapeutics

authors： Zipprich A,Meiss F,Steudel N,Sziegoleit U,Fleig WE,Kleber G

更新日期：2003-06-15 00:00:00

abstract：INTRODUCTION:With the rising incidence of oesophageal cancer, palliative treatment has an increasingly important role. With median survival unlikely to exceed 6 months, in advanced disease the palliative therapy chosen must not hasten patient's demise. AIM:To establish the outcome of both modern and historical palliat...

journal_title：Alimentary pharmacology & therapeutics

authors： Jethwa P,Lala A,Powell J,McConkey CC,Gillison EW,Spychal RT

更新日期：2005-02-15 00:00:00

abstract：BACKGROUND:None of the proposed materials tested for the management of perianal fistulae has proven to be a definitive treatment. AIM:To assess a new repair scaffold and drug delivery device conceived to target perianal fistula repair. METHODS:Poly(D,L-lactide-co-glycolide) porous microspheres containing either antib...

journal_title：Alimentary pharmacology & therapeutics

authors： Blaker JJ,Pratten J,Ready D,Knowles JC,Forbes A,Day RM

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo-terminal ileum. AIM:To identify predictors of early post-operative endoscopic recurrence. METHODS:From September 2010 to September 2017, the REMIND group conducted a prospective n...

journal_title：Alimentary pharmacology & therapeutics

authors： Auzolle C,Nancey S,Tran-Minh ML,Buisson A,Pariente B,Stefanescu C,Fumery M,Marteau P,Treton X,Hammoudi N,REMIND Study Group Investigators.,Jouven X,Seksik P,Allez M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Guidelines recommend withholding sofosbuvir (SOF) in patients with an estimated glomerular filtration rate (eGFR) of less than 30 mL/min. AIM:To assess the risk of acute kidney injury (AKI) in patients with no renal contraindications for SOF-based treatment. METHODS:This multicenter retrospective observati...

journal_title：Alimentary pharmacology & therapeutics

authors： Maan R,Al Marzooqi SH,Klair JS,Karkada J,Cerocchi O,Kowgier M,Harrell SM,Rhodes KD,Janssen HLA,Feld JJ,Duarte-Rojo A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Recently, the therapeutic landscape with regard to anti-HCV therapy has changed dramatically. The new directly acting anti-virals (DAAs) have demonstrated improved sustained virological response (SVR) compared with pegylated-interferon and ribavirin. AIM:To examine and present the latest data with regard to...

journal_title：Alimentary pharmacology & therapeutics

authors： Joshi D,Carey I,Agarwal K

更新日期：2013-04-01 00:00:00

abstract：:Suppositories containing 300 mg 5-aminosalicylic acid (1.96 mmol) or 425 mg acetyl-5-aminosalicylic acid (1.96 mmol) were used in 40 patients with idiopathic proctitis to determine the efficacy of acetyl-5-aminosalicylic acid in treating this bowel inflammation. Each patient was treated with 5-aminosalicylic acid or a...

journal_title：Alimentary pharmacology & therapeutics

authors： van Hogezand RA,van Hees PA,van Gorp JP,van Lier HJ,Bakker JH,Wesseling P,van Haelst UJ,van Tongeren JH

更新日期：1988-02-01 00:00:00

abstract：:The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

更新日期：2003-06-01 00:00:00

abstract：:Antisecretory agents may affect the absorption, metabolism, and renal excretion of other drugs. Inhibition of gastric acid secretion may decrease the gastrointestinal absorption of drugs such as ketoconazole that dissolve poorly in the absence of adequate acid. With anti-secretory agents, the drug interaction mechanis...

journal_title：Alimentary pharmacology & therapeutics

authors： Hansten PD

更新日期：1991-01-01 00:00:00