The effect of SK&F 94482 (BMY-25368) on 24-hour intragastric acidity and plasma gastrin concentration in healthy subjects.


:In a double-blind, placebo-controlled study of SK&F 94482 (BMY-25368) (400-mg, post-evening meal, for 7 days in 11 healthy subjects), there was a significant 75% decrease in median integrated 24-h intragastric acidity during dosing with the drug (218 mmol h/L) compared with placebo (883 mmol h/L; P = 0.003). The single daily dose of 400 mg SK&F 94482 decreased median hourly intragastric acidity until the time of the next dose 24 h later. There was also a sustained and significant 80% rise in median 24-h integrated plasma-gastrin concentration during dosing with SK&F 94482 (364 pmol h/L) when compared with placebo (202 pmol h/L; P = 0.003). The study demonstrates a significant inverse correlation between 24-h integrated intragastric acidity and 24-h plasma gastrin concentration (rs = -0.484; P less than 0.001). The study shows that a single oral daily dose of an H2-antagonist can provide control of intragastric acidity throughout the day and night, decreased acidity being associated with statistically significantly, but modestly elevated plasma-gastrin levels.


Aliment Pharmacol Ther


Gavey CJ,Smith JT,Nwokolo CU,Pounder RE




Has Abstract


1989-12-01 00:00:00












  • Increasing comorbidities in a South Korea insured population-based cohort of patients with chronic hepatitis B.

    abstract:BACKGROUND:It is controversial whether chronic hepatitis B (CHB) patients have more non-liver comorbidities than non-CHB subjects. AIM:To characterise the demographics, comorbidity and health utilisation of CHB patients in South Korea and compare them to matched controls. METHODS:Using the Health Insurance Review & A...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Oh H,Jun DW,Lee IH,Ahn HJ,Kim BO,Jung S,Nguyen MH

    更新日期:2020-07-01 00:00:00

  • Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis.

    abstract:BACKGROUND:Several clinical trials evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol can reduce the incidence of post-ERCP pancreatitis. AIM:To compare proph...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Bai Y,Gao J,Zhang W,Zou D,Li Z

    更新日期:2008-09-01 00:00:00

  • Comparison of two 3-day Helicobacter pylori eradication regimens with a standard 1-week regimen.

    abstract:BACKGROUND:The duration of Helicobacter pylori eradication regimens has decreased to 1 week with cure rates of over 90%. This can be attributed to the use of triple drug regimens including potent inhibitors of gastric acid secretion and clarithromycin. There is no theoretical reason why shorter regimens should not be p...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Grimley CE,Penny A,O'sullivan M,Shebani M,Lismore JR,Cross R,Illing RC,Loft DE,Nwokolo CU

    更新日期:1999-07-01 00:00:00

  • Accuracy of the stool antigen test in the diagnosis of Helicobacter pylori infection before treatment and in patients on omeprazole therapy.

    abstract:AIM:To evaluate the Helicobacter pylori stool antigen (HpSA) test in the assessment of H. pylori infection and the effect of omeprazole treatment on its accuracy. METHODS:Study 1: 140 dyspeptic patients were enrolled in the study and defined as H. pylori positive if histology and rapid urease test, or culture alone we...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Manes G,Balzano A,Iaquinto G,Ricci C,Piccirillo MM,Giardullo N,Todisco A,Lioniello M,Vaira D

    更新日期:2001-01-01 00:00:00

  • Prevention of post-operative recurrence of Crohn's disease requires adequate mucosal concentration of mesalazine. Gruppo Italiano per lo Studio del Colon e del Retto.

    abstract:BACKGROUND:Surgical resection of Crohn's disease is followed by early recurrence in a high percentage of patients. Mesalazine has been shown to be effective in the prevention of post-operative recurrence, but some 50% of patients under treatment recur at 3 years of follow-up. AIM:To establish whether the mucosal conce...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Frieri G,Pimpo MT,Andreoli A,Annese V,Comberlato M,Corrao G,Palumbo G,Sturniolo GC,Tonelli F,Caprilli R

    更新日期:1999-05-01 00:00:00

  • A novel diagnostic tool for detecting oesophageal pathology: the PillCam oesophageal video capsule.

    abstract:BACKGROUND:Gastro-oesophageal reflux disease is a common entity. Erosive oesophagitis, ulcers and Barrett's oesophagus, which is found in up to 10% of gastro-oesophageal reflux disease patients, characterize severe gastro-oesophageal reflux disease. Patients with Barrett's oesophagus have 0.5% per patient-year risk of ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Eliakim R,Yassin K,Shlomi I,Suissa A,Eisen GM

    更新日期:2004-11-15 00:00:00

  • Increased risk of developing Crohn's disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease.

    abstract:BACKGROUND:Anti-TNFα agents have revolutionised management of chronic inflammatory diseases. Paradoxically, these agents might provoke development of de novo autoimmune diseases. AIM:To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Korzenik J,Larsen MD,Nielsen J,Kjeldsen J,Nørgård BM

    更新日期:2019-08-01 00:00:00

  • Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?

    abstract:BACKGROUND:A direct role for neutrophils in the pathophysiology of indomethacin-induced gastric damage is controversial. Therefore, such damage was evaluated in hamsters. METHODS:Gastric antral damage was evaluated 4 h after the oro-gastric administration of indomethacin (30 mg/kg). Prior to indomethacin, hamsters wer...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Fitzpatrick LR,Sakurai K,Le T

    更新日期:1999-02-01 00:00:00

  • Effects of vedolizumab on health-related quality of life in patients with ulcerative colitis: results from the randomised GEMINI 1 trial.

    abstract:BACKGROUND:Health-related quality of life (HRQL) is often diminished in patients with ulcerative colitis. AIM:To evaluate the effects of vedolizumab on HRQL in patients with ulcerative colitis. METHODS:Using maintenance phase data from the GEMINI 1 study, an analysis of covariance model was used to calculate mean dif...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Feagan BG,Patel H,Colombel JF,Rubin DT,James A,Mody R,Lasch K

    更新日期:2017-01-01 00:00:00

  • Steroid dependency and trends in prescribing for inflammatory bowel disease - a 20-year national population-based study.

    abstract:BACKGROUND:It is unclear whether adherence to prescribing standards has been achieved in inflammatory bowel disease (IBD). AIM:To determine how prescribing of 5-aminosalicylates (5-ASAs), steroids and thiopurines has changed in response to emerging evidence. METHODS:We examined trends in oral and topical therapies in...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Chhaya V,Saxena S,Cecil E,Subramanian V,Curcin V,Majeed A,Pollok RC

    更新日期:2016-09-01 00:00:00

  • Characterisation of the gastrointestinal mucosa-associated microbiota: a novel technique to prevent cross-contamination during endoscopic procedures.

    abstract:BACKGROUND:The mucosa-associated microbiota appears to be highly relevant to host-microbe interactions in the gastrointestinal (GI) tract. Thus, precise characterisation of the mucosa-associated microbiota may provide important insights for diagnostic and therapeutic development. However, for technical reasons, mucosal...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Shanahan ER,Zhong L,Talley NJ,Morrison M,Holtmann G

    更新日期:2016-06-01 00:00:00

  • The effects of low doses of ranitidine on intragastric acidity in healthy men.

    abstract:BACKGROUND:H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. AIM:To determine the effects of single low doses of ranitidine on intragastric acidity. METHODS:Intragastric pH was measured for 9 h after lunch in five studies i...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wyeth JW,Pounder RE,Sercombe JC,Snell CC

    更新日期:1998-03-01 00:00:00

  • A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg. Dutch Multicentre PBC Study Group.

    abstract:BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

    更新日期:1998-10-01 00:00:00

  • Cytokines in the cotton top tamarin model of human ulcerative colitis.

    abstract::The cotton top tamarin is a unique model of human ulcerative colitis. This disease is clinically and histologically similar. It is also complicated in some cases by colon cancer. The cotton top tamarin provides an appropriate animal model for assessing new treatments in inflammatory bowel disease. ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Warren BF

    更新日期:1996-01-01 00:00:00

  • Comparison of two low-dose one-week triple therapy regimens with and without metronidazole for cure of H. pylori infection.

    abstract:BACKGROUND:One-week triple therapy consisting of omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. is an effective therapy for H. pylori infection with a cure rate of 93%. We therefore compared two similar 1-week regimens consisting of a lansoprazole, clarithromycin and either metronidazole o...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jaup BH,Norrby A

    更新日期:1996-06-01 00:00:00

  • Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long-term follow-up study of 1317 patients.

    abstract:BACKGROUND:Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy. AIM:To compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based co...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

    更新日期:2019-06-01 00:00:00

  • Randomised clinical trial: a placebo-controlled study of subcutaneous or intradermal NEXVAX2, an investigational immunomodulatory peptide therapy for coeliac disease.

    abstract:BACKGROUND:Nexvax2 contains three gluten-derived peptides, intended to tolerize coeliac disease patients to gluten. Sequences cover six epitopes that trigger immune activation in human leucocyte antigen-DQ2.5-positive patients, most notably after an initial dose. Patients experience gastrointestinal symptoms with incre...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Truitt KE,Daveson AJM,Ee HC,Goel G,MacDougall J,Neff K,Anderson RP

    更新日期:2019-09-01 00:00:00

  • Renal function and cardiovascular risk profile after conversion from ciclosporin to tacrolimus: prospective study in 80 liver transplant recipients.

    abstract:BACKGROUND:Increased risk of cardiovascular and cerebrovascular disease in liver transplant recipients results in particular from the side effects of calcineurin inhibitor-based immunosuppressive therapy. Several studies have demonstrated a more favourable outcome for patients receiving tacrolimus (TAC) as compared wit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Beckebaum S,Klein C,Varghese J,Sotiropoulos GC,Saner F,Schmitz K,Gerken G,Paul A,Cicinnati VR

    更新日期:2009-10-15 00:00:00

  • What is the role of serology in assessing Helicobacter pylori eradication?

    abstract:AIM:To assess the decline in Helicobacter pylori antibodies after eradication of infection. METHODS:The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bergey B,Marchildon P,Peacock J,Mégraud F

    更新日期:2003-09-15 00:00:00

  • One-week acid suppression trial in uninvestigated dyspepsia patients with epigastric pain or burning to predict response to 8 weeks' treatment with esomeprazole: a randomized, placebo-controlled study.

    abstract:BACKGROUND:While empiric acid-suppressive therapy for uninvestigated dyspepsia patients with symptoms of epigastric pain or burning is standard practice, it is unknown whether an early response to therapy predicts outcome. AIM:To evaluate whether a 1-w acid suppression trial is effective for predicting 8-w response in...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: van Zanten SV,Flook N,Talley NJ,Vakil N,Lauritsen K,Bolling-Sternevald E,Persson T,Björck E,Svedberg LE,STARS II Study Group.

    更新日期:2007-09-01 00:00:00

  • The risk of later surgery at the anastomotic site following right hemicolectomy for Crohn's disease in a national cohort of 12 230 patients.

    abstract:BACKGROUND:Crohn's disease (CD) has a high-risk of bowel resection and later surgery for recurrent disease. Recent guidelines recommend colonoscopy 6-12 months following surgery to reduce further surgical intervention through medical therapy intensification. AIMS:To investigate the risk of further surgery at the anast...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: King D,Coupland B,Dosanjh A,Cole A,Adderley NJ,Reulen RC,Patel P,Trudgill NJ

    更新日期:2021-01-01 00:00:00

  • Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis?

    abstract:BACKGROUND:Despite similar clinical symptoms, collagenous colitis (CC) and lymphocytic colitis (LC) are considered two distinct disease entities. AIM:To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in CC and LC to establish whether they could be s...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Rasmussen MA,Munck LK

    更新日期:2012-07-01 00:00:00

  • Evaluation of Helicobacter species in inflammatory bowel disease.

    abstract:BACKGROUND:Bacteria have been implicated in the pathogenesis of inflammatory bowel disease. Helicobacter species have been shown to cause colitis in animal models and have been identified in human diarrhoeal illness and Crohn's disease. AIM:To determine whether Helicobacter species are present in human inflammatory bo...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Bell SJ,Chisholm SA,Owen RJ,Borriello SP,Kamm MA

    更新日期:2003-09-01 00:00:00

  • Review article: gastro-oesophageal reflux and laryngeal symptoms.

    abstract::There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-o...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Fraser AG

    更新日期:1994-06-01 00:00:00

  • Effects of midazolam on small bowel motility in humans.

    abstract:BACKGROUND:Benzodiazepines are used as sedatives for some intestinal procedures and as hypnotics, and this is the reason for studying their effects on duodenojejunal motility. METHODS:Antroduodenojejunal manometry was performed in 13 healthy volunteers on two different occasions, when placebo or midazolam were given i...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Castedal M,Björnsson E,Abrahamsson H

    更新日期:2000-05-01 00:00:00

  • Influence of the timing of administration of 300 mg ranitidine on 24-hour gastric pH in patients acute duodenal ulcer.

    abstract::The 24-hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of administration of 300 mg ranitidine: post evening meal, or bedtime. This double-blind crossover trial involved 3 centres. Twenty-four-hour gastric pH was measured under s...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cortot A,Guillemot F,Moreau J,Soule JC,Veyrac M,Alberola B,Pappo M

    更新日期:1992-08-01 00:00:00

  • Hepatitis B virus RNA decline without concomitant viral antigen decrease is associated with a low probability of sustained response and hepatitis B surface antigen loss.

    abstract:BACKGROUND:Serum hepatitis B virus (HBV) RNA may reflect intrahepatic HBV replication. Novel anti-viral drugs have shown potent HBV RNA decline without concomitant hepatitis B surface antigen (HBsAg) decrease. How this relates to off-treatment response is yet unclear. AIM:To study the degree of on-treatment viral anti...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Brakenhoff SM,de Man RA,Boonstra A,van Campenhout MJH,de Knegt RJ,van Bömmel F,van der Eijk AA,Berg T,Hansen BE,Janssen HLA,Sonneveld MJ

    更新日期:2021-01-01 00:00:00

  • Colonoscopy-controlled intra-individual comparisons to screen relevant neoplasia: faecal immunochemical test vs. guaiac-based faecal occult blood test.

    abstract:BACKGROUND:Guaiac-based faecal occult blood tests (g-FOBTs) are most commonly used in colorectal cancer (CRC) screening programmes. Faecal immunochemical tests (FITs) are thought to be superior. AIM:To compare performance of a g-FOBT and a quantitative FIT for detection of CRCs and advanced adenomas in a colonoscopy-c...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究


    authors: Oort FA,Terhaar Sive Droste JS,Van Der Hulst RW,Van Heukelem HA,Loffeld RJ,Wesdorp IC,Van Wanrooij RL,De Baaij L,Mutsaers ER,van der Reijt S,Coupe VM,Berkhof J,Bouman AA,Meijer GA,Mulder CJ

    更新日期:2010-02-01 00:00:00

  • Coeliac disease: a biopsy is not always necessary for diagnosis.

    abstract:BACKGROUND:In view of the high diagnostic accuracy of immunoglobulin-A-tissue transglutaminase antibodies for detecting coeliac disease, we have explored whether a small bowel biopsy is always required to establish the diagnosis. AIM:To define the transglutaminase antibody level giving a positive predictive value for ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Hill PG,Holmes GK

    更新日期:2008-04-01 00:00:00

  • Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire.

    abstract:BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

    更新日期:2007-05-01 00:00:00