Drug interactions with antisecretory agents.

abstract：BACKGROUND:None of the proposed materials tested for the management of perianal fistulae has proven to be a definitive treatment. AIM:To assess a new repair scaffold and drug delivery device conceived to target perianal fistula repair. METHODS:Poly(D,L-lactide-co-glycolide) porous microspheres containing either antib...

journal_title：Alimentary pharmacology & therapeutics

authors： Blaker JJ,Pratten J,Ready D,Knowles JC,Forbes A,Day RM

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease generally has a benign course; however, patients with non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma. Currently, there is a lack of consensus about optimal NASH treatment. AIM:To assess the efficacy of insulin-sensitizing agents ...

journal_title：Alimentary pharmacology & therapeutics

authors： Rakoski MO,Singal AG,Rogers MA,Conjeevaram H

更新日期：2010-11-01 00:00:00

abstract：:Visceral hypersensitivity is highly prevalent in all functional bowel disorders. Most also demonstrate wider patterns of somatic referral of intestinal pain or discomfort. This hypersensitivity may explain the symptoms as the sensitive gut can be more easily provoked by normal or abnormal motor events in the gut. Visc...

journal_title：Alimentary pharmacology & therapeutics

authors： Mertz H

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Gastric cancer can be divided into cardia and noncardia gastric adenocarcinoma (NCGA). Non cardia gastric cancer is a disease that has declined in global incidence but has remained as an extremely lethal cancer. AIM:To review recent advances in epidemiology and strategies in prevention of non cardia gastric...

journal_title：Alimentary pharmacology & therapeutics

authors： Fock KM

更新日期：2014-08-01 00:00:00

abstract：:Ranitidine hydrochloride, a histamine H2-receptor antagonist, was intravenously administered to 61 pregnant women at a dose of 50 mg as premedication for caesarean section; its effects on gastric secretion were studied in the mother and the newborn. The volume of the maternal gastric juice collected immediately after ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ikenoue T,Iito J,Matsuda Y,Hokanishi H

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:Fistulae will develop in approximately one-third of patients with Crohn's disease. With an expected spontaneous healing rate of only 10%, fistulizing Crohn's disease requires a comprehensive strategy with a medical and possible surgical approach. AIM:To summarize the current literature evaluating various me...

journal_title：Alimentary pharmacology & therapeutics

authors： Bressler B,Sands BE

更新日期：2006-11-01 00:00:00

abstract：AIM:To evaluate (i) the diagnostic usefulness of a delayed test in initially negative patients; and (ii) the reliability of the rapid urease test, histology or a combination of the two to diagnose Helicobacter pylori during emergency endoscopy in a large clinical practice series. PATIENTS AND METHODS:Records of patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Güell M,Artigau E,Esteve V,Sánchez-Delgado J,Junquera F,Calvet X

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Common risk factors exist in colorectal neoplasia (cancer or adenoma) and coronary artery disease. AIM:To investigate in a retrospective study if there is coexistence of the two events in patients > OR =50 years. METHODS:Computer data on colonoscopies performed on symptomatic patients, the corresponding me...

journal_title：Alimentary pharmacology & therapeutics

authors： Chan AO,Lam KF,Tong T,Siu DC,Jim MH,Hui WM,Lai KC,Yuen MF,Lam SK,Wong BC

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of proton pump inhibitor vs. ranitidine bismuth citrate (RBC) with two antibiotics for 1 week in Helicobacter pylori eradication. METHODS:Randomized trials comparing 1-week regimens with (i) proton pump inhibitor plus two antibiotics [clarithromycin (C) and amoxycillin (A) or a nitroi...

journal_title：Alimentary pharmacology & therapeutics

authors： Gisbert JP,González L,Calvet X,Roqué M,Gabriel R,Pajares JM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Some patients requiring acid suppression may be unable to take oral medications. AIM:To compare the gastric acid inhibition effects of lansoprazole 30 mg administered either intravenous or orally in erosive oesophagitis patients. METHODS:The study included 87 Helicobacter pylori-negative patients with eros...

journal_title：Alimentary pharmacology & therapeutics

authors： Kovacs TO,Lee CQ,Chiu YL,Pilmer BL,Metz DC

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:The detrimental effect of smoking on development and progression of Crohn's disease (CD) is generally accepted. AIM:To evaluate the awareness of smoking risks in a Belgian inflammatory bowel disease (IBD) population. METHODS:In the out-patient clinic of a tertiary referral centre, 625 consecutive patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： De Bie C,Ballet V,Hendriks N,Coenen S,Weyts E,Van Assche G,Vermeire S,Ferrante M

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Helicobacter has been identified in isolated cases of hepato-biliary diseases, but its role in the pathogenesis of these conditions remains unclear. AIM:To determine whether Helicobacter could be detected in bile obtained at endoscopic retrograde cholangiopancreatography, and to evaluate the prevalence of t...

journal_title：Alimentary pharmacology & therapeutics

authors： Fallone CA,Tran S,Semret M,Discepola F,Behr M,Barkun AN

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Treatment with interferon-alpha has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events. AIM:To investigate the safety of pegylated interferon alpha-2b in 300 hepatitis B e antigen-positive patients...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zonneveld M,Flink HJ,Verhey E,Senturk H,Zeuzem S,Akarca US,Cakaloglu Y,Simon C,So TM,Gerken G,de Man RA,Hansen BE,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Hepatitis B (HBV)-infected patients have a higher morbidity and mortality when super-infected by hepatitis A (HAV). AIM:To evaluate the immunogenicity and safety of a commercial inactivated HAV vaccine in Chinese patients with chronic HBV infection. METHODS:Sixty-five HBV-infected patients (30 carriers, 22...

journal_title：Alimentary pharmacology & therapeutics

authors： Tsang SW,Sung JJ

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Adalimumab, at an induction dose of 160/80 mg followed by 40 mg every other week is approved for treatment of refractory Crohn's disease (CD) and for patients with loss of response to infliximab. AIM:To evaluate the indications for adalimumab, the proportion of inflammatory bowel disease patients who requir...

journal_title：Alimentary pharmacology & therapeutics

authors： Swaminath A,Ullman T,Rosen M,Mayer L,Lichtiger S,Abreu MT

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Data on whether long-acting somatostatin analogue octreotide causes or prevents pancreatic injury following endoscopic retrograde cholangiopancreatography (ERCP) are controversial. AIM:This multicentre, prospective trial studied the effect of octreotide on pancreatic injury in a large unselected group of pa...

journal_title：Alimentary pharmacology & therapeutics

authors： Tulassay Z,Döbrönte Z,Prónai L,Zágoni T,Juhász L

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Therapeutic drug monitoring is a powerful strategy known to improve the clinical outcomes and to optimise the healthcare resources in the treatment of autoimmune diseases. Currently, most of the methods commercially available for the quantification of infliximab (IFX) are ELISA-based, with a turnaround time ...

journal_title：Alimentary pharmacology & therapeutics

authors： Afonso J,Lopes S,Gonçalves R,Caldeira P,Lago P,Tavares de Sousa H,Ramos J,Gonçalves AR,Ministro P,Rosa I,Vieira AI,Dias CC,Magro F,Portuguese IBD Study Group (GEDII).

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:The threshold plasma paracetamol concentration at which N-acetylcysteine (NAC) treatment is recommended to treat paracetamol poisoning in a patient with induced liver enzymes (for example, with chronic liver disease or taking anticonvulsant drugs) is 50% lower than in a patient without induced liver enzymes....

journal_title：Alimentary pharmacology & therapeutics

authors： Jones AL,Jarvie DR,Simpson D,Hayes PC,Prescott LF

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown that pH is an important determinant of mucus structure and function, but the relationship in vivo is unclear. Omeprazole increases intragastric pH and also allows bacterial overgrowth. In this study we have assessed the effect of omeprazole on gastric juice viscosity and examined ...

journal_title：Alimentary pharmacology & therapeutics

authors： Goddard AF,Spiller RC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Haemorrhage from ruptured oesophageal varices is a common cause of death in people with cirrhosis. Guidelines recommend screening for varices at time of cirrhosis diagnosis and throughout the course of the disease. Conventional gastroscopy is the criterion standard for variceal screening; however, is invasiv...

journal_title：Alimentary pharmacology & therapeutics

authors： Wickremeratne T,Turner S,O'Beirne J

更新日期：2019-06-01 00:00:00

abstract：:The common response to infection is infiltration of the affected tissue by inflammatory cells. It is now recognized that the epithelium plays a crucial role in this immunological process by producing an array of proinflammatory cytokines including interleukin-8, tumour necrosis factor-alpha, monocyte chemotactic prote...

journal_title：Alimentary pharmacology & therapeutics

authors： Hecht G,Savkovic SD

更新日期：1997-12-01 00:00:00

abstract：:Variceal haemorrhage is a common medical emergency with a high mortality (30-50%). Adequate resuscitation is vital, and once stabilised the patient should be moved to a high-dependency area. Antibiotics reduce mortality, and the vasoactive drug terlipressin should be administered if early endoscopy is unavailable. Ear...

journal_title：Alimentary pharmacology & therapeutics

authors： Ferguson JW,Tripathi D,Hayes PC

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Collagenous and lymphocytic colitis are fairly common causes of chronic non-bloody diarrhoea, especially in elderly female. AIM:To present a systematic review of microscopic colitis. METHODS:A PubMed search using the MeSH terms microscopic colitis, collagenous colitis, lymphocytic colitis and chronic diarr...

journal_title：Alimentary pharmacology & therapeutics

authors： Nyhlin N,Bohr J,Eriksson S,Tysk C

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Guidelines recommend withholding sofosbuvir (SOF) in patients with an estimated glomerular filtration rate (eGFR) of less than 30 mL/min. AIM:To assess the risk of acute kidney injury (AKI) in patients with no renal contraindications for SOF-based treatment. METHODS:This multicenter retrospective observati...

journal_title：Alimentary pharmacology & therapeutics

authors： Maan R,Al Marzooqi SH,Klair JS,Karkada J,Cerocchi O,Kowgier M,Harrell SM,Rhodes KD,Janssen HLA,Feld JJ,Duarte-Rojo A

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:The Th2 allergic pathway in eosinophilic oesophagitis (EoE) responds to food antigen exposure. AIM:To compare the presence and temporal pattern of food antigen penetration in oesophageal mucosa in active and inactive EoE and controls METHODS: Thirty-two patients with EoE (20 active) and 10 controls were ask...

journal_title：Alimentary pharmacology & therapeutics

authors： Ravi A,Marietta EV,Alexander JA,Peterson K,Lavey C,Geno DM,Murray JA,Katzka DA

更新日期：2021-02-01 00:00:00

abstract：:The treatment of severe and active Crohn's disease is currently based on immunosuppression, but also involves the management of nutrition, appropriate selection of patients for surgery, and maintenance of remission in the long term. Corticosteroids remain the drug of the first choice, particularly in the acute setting...

journal_title：Alimentary pharmacology & therapeutics

authors： Parkes M,Jewell DP

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Treatment with a continuous i.v. proton pump inhibitor is presumed to promote clot formation and stability by sustaining intragastric pH > or = 6. AIM:We postulated that very frequent oral dosing of proton pump inhibitors should simulate i.v. infusion and achieve similar pH control. METHODS:Twenty healthy ...

journal_title：Alimentary pharmacology & therapeutics

authors： Pais SA,Nathwani RA,Dhar V,Nowain A,Laine L

更新日期：2006-06-01 00:00:00

abstract：:The present study examined whether histamine could affect the growth of the enterochromaffin-like (ECL) cell and the parietal cell. The effects of the unsurmountable histamine H2-receptor antagonist loxtidine (80 mg/kg) and the H+, K(+)-ATPase inhibitor omeprazole (100 mumol/kg) were compared in female Sprague-Dawley ...

journal_title：Alimentary pharmacology & therapeutics

authors： Brenna E,Waldum HL,Sandvik AK,Schulze Søgnen B,Kristensen A

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The effect of direct-acting anti-virals (DAAs) in children and adolescents with chronic hepatitis C virus (HCV) infection is difficult to determine, since few, aged between 3 and 18 years, have been enrolled in clinical trials, and some data come from observational studies. AIM:To summarise the evidence on ...

journal_title：Alimentary pharmacology & therapeutics

authors： Indolfi G,Giometto S,Serranti D,Bettiol A,Bigagli E,De Masi S,Lucenteforte E

更新日期：2020-10-01 00:00:00

abstract：:Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twe...

journal_title：Alimentary pharmacology & therapeutics

authors： Prewett EJ,Luk YW,Fraser AG,Lam WM,Pounder RE

更新日期：1992-02-01 00:00:00