One-week acid suppression trial in uninvestigated dyspepsia patients with epigastric pain or burning to predict response to 8 weeks' treatment with esomeprazole: a randomized, placebo-controlled study.

abstract：BACKGROUND:The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and coeliac disease-associated genetics. It remains unclear whether this approach is also applicable for adults with various clinical presentations. AIM:To evaluate the ...

journal_title：Alimentary pharmacology & therapeutics

authors： Fuchs V,Kurppa K,Huhtala H,Laurila K,Mäki M,Collin P,Salmi T,Luostarinen L,Saavalainen P,Kaukinen K

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan. AIM:To estimate the preventive effect by normal dose, not high-dose histamine-H2 receptor antagonists (H2RA) for NSAID-induced ulce...

journal_title：Alimentary pharmacology & therapeutics

authors： Miyake K,Ueki N,Suzuki K,Shinji Y,Kusunoki M,Hiratsuka T,Nishigaki H,Tatsuguchi A,Futagami S,Wada K,Tsukui T,Nakajima A,Yoshino S,Sakamoto C

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Controversy exists on how to measure patient-reported outcomes in irritable bowel syndrome (IBS) clinical trials effectively. Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS. AIM:To test the psychometrics of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spiegel B,Bolus R,Harris LA,Lucak S,Naliboff B,Esrailian E,Chey WD,Lembo A,Karsan H,Tillisch K,Talley J,Mayer E,Chang L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. Aim To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Castaño G,Burgueño A,Fernández Gianotti T,Pirola CJ,Sookoian S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:Practitioners routinely misuse acid suppression medications on general medical floors and inappropriately continue the drug at discharge. AIMS:To: (i) retrospectively study the appropriateness of acid suppression use on the general medical floors; (ii) characterize the patient population discharged on unnec...

journal_title：Alimentary pharmacology & therapeutics

authors： Zink DA,Pohlman M,Barnes M,Cannon ME

更新日期：2005-05-15 00:00:00

abstract：BACKGROUND:ONO-2952 is a novel and selective inhibitor of translocator protein 18 kDa that reduces stress-induced defecation and visceral hyperalgesia in rat models. AIM:To evaluate the efficacy and safety of ONO-2952 in females with irritable bowel syndrome with diarrhoea in an exploratory proof-of-concept study. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Whitehead WE,Duffy K,Sharpe J,Nabata T,Bruce M

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Recent genome-wide association studies based on adult and paediatric populations have implicated >30 genes/loci as susceptibility loci for Crohn's disease (CD). AIMS:To investigate whether reported genes/loci were also associated with CD in Canadian children. DESIGN AND METHODS:A case-control design was im...

journal_title：Alimentary pharmacology & therapeutics

authors： Amre DK,Mack DR,Morgan K,Israel D,Deslandres C,Seidman EG,Lambrette P,Costea I,Krupoves A,Fegury H,Dong J,Grimard G,Levy E

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Adalimumab, at an induction dose of 160/80 mg followed by 40 mg every other week is approved for treatment of refractory Crohn's disease (CD) and for patients with loss of response to infliximab. AIM:To evaluate the indications for adalimumab, the proportion of inflammatory bowel disease patients who requir...

journal_title：Alimentary pharmacology & therapeutics

authors： Swaminath A,Ullman T,Rosen M,Mayer L,Lichtiger S,Abreu MT

更新日期：2009-02-01 00:00:00

abstract：:Twenty-four-hour intragastric acidity was measured in 10 patients with a past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order of the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. dec...

journal_title：Alimentary pharmacology & therapeutics

authors： Howden CW,Tsai HH,Reid JL

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Pancreatic exocrine insufficiency (PEI) results in maldigestion, leading to abdominal pain, steatorrhoea, malnutrition and weight loss. AIM:To assess the efficacy and safety of pancreatin (Creon 40000 MMS) in treating PEI due to chronic pancreatitis (CP). METHODS:This was a 1-week, double-blind, randomised...

journal_title：Alimentary pharmacology & therapeutics

authors： Thorat V,Reddy N,Bhatia S,Bapaye A,Rajkumar JS,Kini DD,Kalla MM,Ramesh H

更新日期：2012-09-01 00:00:00

abstract：:The study investigated the oral absorption of two antifungal agents, fluconazole and itraconazole, under conditions of low intragastric acidity. Twelve healthy male volunteers received each of 4 dosing regimens: 200 mg itraconazole alone, 200 mg itraconazole and famotidine, 100 mg fluconazole alone, and 100 mg flucona...

journal_title：Alimentary pharmacology & therapeutics

authors： Lim SG,Sawyerr AM,Hudson M,Sercombe J,Pounder RE

更新日期：1993-06-01 00:00:00

abstract：:There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-o...

journal_title：Alimentary pharmacology & therapeutics

authors： Fraser AG

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Combination treatment with azathioprine for 6-12 months is the preferred strategy for starting infliximab due to improved pharmacokinetics. However, optimised infliximab monotherapy with proactive dose escalations in case of low trough levels is a safer but under-studied alternative. AIM:To compare the clin...

journal_title：Alimentary pharmacology & therapeutics

authors： Drobne D,Kurent T,Golob S,Švegl P,Rajar P,Hanžel J,Koželj M,Novak G,Smrekar N,Ferkolj I,Štabuc B

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Erythromycin is a potent stimulator of gastrointestinal motility. Recent studies have examined the use of intravenous erythromycin to clear the stomach of blood before oesophago-gastroduodenoscopy (EGD) for acute upper gastrointestinal haemorrhage (UGIH). These studies have shown clinical effectiveness. AIM...

journal_title：Alimentary pharmacology & therapeutics

authors： Winstead NS,Wilcox CM

更新日期：2007-11-15 00:00:00

abstract：BACKGROUND:Patients with reflux disease often complain of heartburn after ingestion of coffee. Induction of gastro-oesophageal reflux has been demonstrated by pH-metry following the intake of coffee in healthy volunteers. The reflux was reduced when the coffee had undergone a decaffeination process. The aim of this stu...

journal_title：Alimentary pharmacology & therapeutics

authors： Pehl C,Pfeiffer A,Wendl B,Kaess H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Risk benefit strategies in managing inflammatory bowel diseases (IBD) are dependent upon understanding the risks of uncontrolled inflammation vs those of treatments. Malignancy and mortality in IBD have been associated with disease-related inflammation and immune suppression, but data are limited due to thei...

journal_title：Alimentary pharmacology & therapeutics

authors： Joosse ME,Aardoom MA,Kemos P,Turner D,Wilson DC,Koletzko S,Martin-de-Carpi J,Fagerberg UL,Spray C,Tzivinikos C,Sladek M,Shaoul R,Roma-Giannikou E,Bronsky J,Serban DE,Ruemmele FM,Garnier-Lengline H,Veres G,Hojsak I,K

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of proton pump inhibitor vs. ranitidine bismuth citrate (RBC) with two antibiotics for 1 week in Helicobacter pylori eradication. METHODS:Randomized trials comparing 1-week regimens with (i) proton pump inhibitor plus two antibiotics [clarithromycin (C) and amoxycillin (A) or a nitroi...

journal_title：Alimentary pharmacology & therapeutics

authors： Gisbert JP,González L,Calvet X,Roqué M,Gabriel R,Pajares JM

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:A-gliadin residues 31-49 (peptide A) binds to HLA-DQ2 and is toxic to coeliac small bowel. Analogues of this peptide, which bind to DQ2 molecules but are non-toxic, may be a potential route to inducing tolerance to gliadin in patients with coeliac disease. METHODS:Toxicity was investigated with small bowel ...

journal_title：Alimentary pharmacology & therapeutics

authors： Biagi F,Ellis HJ,Parnell ND,Shidrawi RG,Thomas PD,O'Reilly N,Corazza GR,Ciclitira PJ

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

journal_title：Alimentary pharmacology & therapeutics

authors： Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In developed countries, hepatitis E is a porcine zoonosis caused by hepatitis E virus (HEV) genotype 3. In developing countries, hepatitis E is mainly caused by genotype 1, and causes increased mortality in patients with pre-existing chronic liver disease (CLD). AIM:To determine the role of HEV in patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： Blasco-Perrin H,Madden RG,Stanley A,Crossan C,Hunter JG,Vine L,Lane K,Devooght-Johnson N,Mclaughlin C,Petrik J,Stableforth B,Hussaini H,Phillips M,Mansuy JM,Forrest E,Izopet J,Blatchford O,Scobie L,Peron JM,Dalton H

更新日期：2015-09-01 00:00:00

abstract：AIM:To develop a scale to assess the severity of hepatic encephalopathy using simple dichotomic items. METHODS:A list of 48 items was created by selecting items that are simple to recognize and categorize; it was applied to thirty-six cirrhotic in-patients with episodic encephalopathy, in addition to the adapted-West-...

journal_title：Alimentary pharmacology & therapeutics

authors： Ortiz M,Córdoba J,Doval E,Jacas C,Pujadas F,Esteban R,Guardia J

更新日期：2007-09-15 00:00:00

abstract：AIM:To develop general rules on how to pursue a therapeutic goal of interventional endoscopy without getting lost in abundant details. METHODS:The influences of various medical interventions on the survival of a patient with gastrointestinal haemorrhage are modelled by an influence diagram. Survival is the focal point...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A,Gavin MW

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Endocytoscopy (EC) enables in vivo microscopic imaging at 1400-fold magnification, thereby allowing the analysis of mucosal structures at the cellular level. In contrast to fluorescence imaging with confocal laser endomicroscopy which allows analysis of mucosal structures up to 250 μm in depth, EC is based o...

journal_title：Alimentary pharmacology & therapeutics

authors： Neumann H,Fuchs FS,Vieth M,Atreya R,Siebler J,Kiesslich R,Neurath MF

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Patients with chronic pancreatitis or pancreatic cancer commonly develop exocrine pancreatic insufficiency, and may not be adequately treated with pancreatic enzyme replacement therapy (PERT). AIMS:To estimate the frequency of diagnostic testing for exocrine insufficiency, and appropriate use of PERT, in a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Forsmark CE,Tang G,Xu H,Tuft M,Hughes SJ,Yadav D

更新日期：2020-05-01 00:00:00

abstract：:There is general agreement that Helicobacter pylori eradication is indicated in all infected patients with duodenal ulcer disease and is probably indicated in all infected patients with gastric ulcer disease. However, translation of treatment recommendations into practice leads to some difficult clinical decisions. Th...

journal_title：Alimentary pharmacology & therapeutics

authors： Walsh JH

更新日期：1995-01-01 00:00:00

abstract：:Irritable bowel syndrome is a disease that can be diagnosed positively on the basis of an established series of criteria and limited exclusion of organic disease. It is the most common disease diagnosed by gastroenterologists and affects about 20% of all people at any one time. Symptoms fluctuate, and the overall prev...

journal_title：Alimentary pharmacology & therapeutics

authors： Camilleri M,Choi MG

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong CR,Njei B,Nguyen MH,Nguyen A,Lim JK

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Direct-acting antiviral (DAA) regimens have shown high efficacy and tolerability for patients with HCV genotype 1/1b (GT1/1b) in clinical trials. However, robust real-world evidence of interferon (IFN)-free DAA treatment for HCV GT1-infected patients in Asia is still lacking. AIM:To systematically review an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ji F,Wei B,Yeo YH,Ogawa E,Zou B,Stave CD,Li Z,Dang S,Furusyo N,Cheung RC,Nguyen MH

更新日期：2018-03-01 00:00:00

abstract：:Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30-60 mg daily. In 40 patients (95.2%) the ulcers healed within 2-12 weeks. In the remaining 2 p...

journal_title：Alimentary pharmacology & therapeutics

authors： Brunner G,Arnold R,Hennig U,Fuchs W

更新日期：1993-01-01 00:00:00

abstract：:Colorectal cancer is a common cancer and common cause of death. The mortality rate from colorectal cancer can be reduced by identification and removal of cancer precursors, adenomas, or by detection of cancer at an earlier stage. Pilot screening programmes have demonstrated decreased colorectal cancer mortality; as a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Nicholson FB,Barro JL,Atkin W,Lilford R,Patnick J,Williams CB,Pignone M,Steele R,Kamm MA

更新日期：2005-12-01 00:00:00