The role of hepatitis E virus testing in drug-induced liver injury.

abstract：BACKGROUND:Few studies have evaluated the effects of rabeprazole on low-dose aspirin (LDA)-induced gastroduodenal injuries. AIM:To conduct a randomised, double-blind, triple-dummy, active-controlled, multicentre trial, named the PLANETARIUM study, to assess the efficacy, dose-response relationship and safety of rabepr...

journal_title：Alimentary pharmacology & therapeutics

authors： Iwakiri R,Higuchi K,Kato M,Fujishiro M,Kinoshita Y,Watanabe T,Takeuchi T,Yamauchi M,Sanomura M,Nakagawa H,Sugisaki N,Okada Y,Ogawa H,Arakawa T,Fujimoto K

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:The herbal treatment with myrrh, dry extract of chamomile flowers and coffee charcoal has anti-inflammatory and antidiarrhoeal potential and might benefit patients with UC. Aminosalicylates are used as standard treatment for maintaining remission in ulcerative colitis (UC). AIM:To compare the efficacy of th...

journal_title：Alimentary pharmacology & therapeutics

authors： Langhorst J,Varnhagen I,Schneider SB,Albrecht U,Rueffer A,Stange R,Michalsen A,Dobos GJ

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Pregabalin has a broad spectrum of analgesic and antihyperalgesic activity in both basic and clinical studies. However, its mechanisms and sites of action have yet to be determined in humans. AIMS:To assess the antinociceptive effect of pregabalin on experimental gut pain in patients with visceral hyperalge...

journal_title：Alimentary pharmacology & therapeutics

authors： Olesen SS,Graversen C,Olesen AE,Frøkjaer JB,Wilder-Smith O,van Goor H,Valeriani M,Drewes AM

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Colorectal cancer is the second commonest cause of cancer mortality. Some countries are implementing colorectal cancer screening to detect lesions at an early stage using non-invasive tools like the faecal immunochemical test. Despite affordability, this test shows a low sensitivity for precancerous lesions ...

journal_title：Alimentary pharmacology & therapeutics

authors： Malagón M,Ramió-Pujol S,Serrano M,Serra-Pagès M,Amoedo J,Oliver L,Bahí A,Mas-de-Xaxars T,Torrealba L,Gilabert P,Miquel-Cusachs JO,García-Nimo L,Saló J,Guardiola J,Piñol V,Cubiella J,Castells A,Aldeguer X,Garcia-Gil J

更新日期：2019-06-01 00:00:00

abstract：:Gastric acid suppression is the most effective medical therapy to control acidic gastro-oesophageal reflux: individuals in whom therapy fails usually have inadequate acid suppression. Twenty-four-hour intragastric pH-metry measures the percentage of time that gastric pH is above 4 or 3, the critical thresholds for tis...

journal_title：Alimentary pharmacology & therapeutics

authors： Hatlebakk JG

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Triple therapy based upon omeprazole, amoxycillin and clarithromycin for 7 days is the reference treatment used in France for the eradication of Helicobacter pylori. However, optimal dosages of omeprazole and clarithromycin have not been determined. AIMS:To compare four eradication regimens using this treat...

journal_title：Alimentary pharmacology & therapeutics

authors： Bigard MA,Delchier JC,Riachi G,Thibault P,Barthelemy P

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. AIMS:To determine whether circulating microRNAs are reliable biomarkers for IBD monitoring. METHODS:Serum levels of 17 candidate microRNAs were measured by quantitative real-t...

journal_title：Alimentary pharmacology & therapeutics

authors： Chen P,Li Y,Li L,Yu Q,Chao K,Zhou G,Qiu Y,Feng R,Huang S,He Y,Chen B,Chen M,Zeng Z,Zhang S

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Direct antiviral therapies for chronic hepatitis C virus (HCV) infection have expanded treatment options for neglected patient populations, including elderly patients who are ineligible/intolerant to receive interferon (IFN)-based therapy. AIM:To investigate the efficacy, tolerability and potential for drug...

journal_title：Alimentary pharmacology & therapeutics

authors： Vermehren J,Peiffer KH,Welsch C,Grammatikos G,Welker MW,Weiler N,Zeuzem S,Welzel TM,Sarrazin C

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Small bowel bacterial overgrowth is common in Crohn's disease but its treatment is not clearly defined. Metronidazole and ciprofloxacin are effective antibiotics in active Crohn's disease. AIM:To investigate the efficacy of metronidazole and ciprofloxacin in the treatment of bacterial overgrowth in patients...

journal_title：Alimentary pharmacology & therapeutics

authors： Castiglione F,Rispo A,Di Girolamo E,Cozzolino A,Manguso F,Grassia R,Mazzacca G

更新日期：2003-12-01 00:00:00

abstract：AIM:To study the effect of prokinetic treatment with cisapride in patients with constipation-predominant irritable bowel syndrome. PATIENTS AND METHODS:Ninety-six patients were randomly assigned to treatment with either cisapride 5 mg three times daily or placebo three times daily for a period of 12 weeks. The dosage ...

journal_title：Alimentary pharmacology & therapeutics

authors： Schütze K,Brandstätter G,Dragosics B,Judmaier G,Hentschel E

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs). AIM:To perform a systematic review of the safety profile, particularly cardiovascular, of 5-HT(4) agonists developed for gastrointestinal disorders, and a nonsystematic summary ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Camilleri M,Chang L,Chey WD,Galligan JJ,Lacy BE,Müller-Lissner S,Quigley EM,Schuurkes J,De Maeyer JH,Stanghellini V

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Benign epithelial gastric polyps have been reported to be more common in atrophic body gastritis. The role of Helicobacter pylori infection in the induction of gastric atrophy is well-known. The development of hyperplastic polyps may be in relation to H. pylori infection. AIM:To investigate occurrence of be...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Giulio E,Lahner E,Micheletti A,Milione M,D'Ambra G,Bordi C,Delle Fave G,Annibale B

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Uninvestigated dyspepsia is common in family practice. The prevalence of clinically significant upper gastrointestinal findings (CSFs) in adult uninvestigated dyspepsia patients, and their predictability based on history, is unknown. METHODS:Prompt endoscopy was performed within 10 days of referral, in 1040...

journal_title：Alimentary pharmacology & therapeutics

authors： Thomson AB,Barkun AN,Armstrong D,Chiba N,White RJ,Daniels S,Escobedo S,Chakraborty B,Sinclair P,Van Zanten SJ

更新日期：2003-06-15 00:00:00

abstract：BACKGROUND:Diagnosis and management of chronic antibiotic-refractory pouchitis and Crohn's disease of the pouch can be challenging. Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated. AIM:To as...

journal_title：Alimentary pharmacology & therapeutics

authors： Kariv R,Plesec TP,Gaffney K,Lian L,Fazio VW,Remzi FH,Lopez R,Goldblum JR,Shen B

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic therapy to show a survival benefit in patients with advanced hepatocellular carcinoma. Since then many drugs failed in the first- and second-lin...

journal_title：Alimentary pharmacology & therapeutics

authors： Pinter M,Peck-Radosavljevic M

更新日期：2018-09-01 00:00:00

abstract：AIM:To estimate the cost-effectiveness over a 4-year duration of lamivudine and adefovir dipivoxil for patients with hepatitis B 'e' antigen-negative chronic hepatitis B. METHODS:A decision analysis model has been used to perform a cost-effectiveness analysis of lamivudine and adefovir dipivoxil from the perspective o...

journal_title：Alimentary pharmacology & therapeutics

authors： Buti M,Casado MA,Calleja JL,Salmerón J,Aguilar J,Rueda M,Esteban R

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:An impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection. AIM:To analyse the Th1/Th2 cytokine profile in peripheral blood CD4(+) and CD8(+) T cells from patients with chronic hepatitis C (CHC) during treatment with pegylated interferon-alpha2a plus ribavirin...

journal_title：Alimentary pharmacology & therapeutics

authors： Trapero-Marugán M,García-Buey L,Muñoz C,Quintana NE,Moreno-Monteagudo JA,Borque MJ,Fernández MJ,Salvanés FR,Medina J,Moreno-Otero R

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

journal_title：Alimentary pharmacology & therapeutics

authors： Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：:Corticosteroids are highly effective in inducing clinical remission in patients with active Crohn's disease. However, the role of corticosteroids in the treatment of this disease is primarily ameliorative because they are ineffective in maintaining remission or healing mucosal lesions. Nearly half of the patients who ...

journal_title：Alimentary pharmacology & therapeutics

authors： Rutgeerts PJ

更新日期：2001-10-01 00:00:00

abstract：:The 24-hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of administration of 300 mg ranitidine: post evening meal, or bedtime. This double-blind crossover trial involved 3 centres. Twenty-four-hour gastric pH was measured under s...

journal_title：Alimentary pharmacology & therapeutics

authors： Cortot A,Guillemot F,Moreau J,Soule JC,Veyrac M,Alberola B,Pappo M

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. Aim To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Castaño G,Burgueño A,Fernández Gianotti T,Pirola CJ,Sookoian S

更新日期：2010-03-01 00:00:00

abstract：:One hundred and twenty-five patients with duodenal ulcer disease were given continuous ranitidine therapy after initial acute healing. Cumulative remission rates indicated that 95% of patients were ulcer-free after 1 year, 89% at 2 years, 81% at 3 years, 70% at 4 years and 60% at 5 and 6 years. Nine patients had a sec...

journal_title：Alimentary pharmacology & therapeutics

authors： Simon B,Schütz E,Müller P,Dixon JS

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:Different authors have postulated both toxic and protective effects for nitric oxide (NO) in the pathophysiology of active inflammation. AIM:To examine the role of NO, especially that produced by the inducible form of nitric oxide synthase (iNOS), by investigating the effects of NOS inhibitors and NO donors...

journal_title：Alimentary pharmacology & therapeutics

authors： Yoshida Y,Iwai A,Itoh K,Tanaka M,Kato S,Hokari R,Miyahara T,Koyama H,Miura S,Kobayashi M

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:In vitro studies have shown that pH is an important determinant of mucus structure and function, but the relationship in vivo is unclear. Omeprazole increases intragastric pH and also allows bacterial overgrowth. In this study we have assessed the effect of omeprazole on gastric juice viscosity and examined ...

journal_title：Alimentary pharmacology & therapeutics

authors： Goddard AF,Spiller RC

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:Helicobacter-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis. AIM:To evaluate of Helicobacter PCR in gastric biopsies for the daily diagnostics of Helicobacter-negative gastritis. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Kiss S,Zsikla V,Frank A,Willi N,Cathomas G

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The guaiac faecal occult blood test (G-FOBT), HemoccultSENSA, is sensitive for significant neoplasms [colorectal cancer (CRC), advanced adenomatous polyps (AAP)], but faulted by non-specificity for human haemoglobin (Hb). Quantified, Hb- specific, immunochemical faecal occult blood tests (I-FOBT) are now use...

journal_title：Alimentary pharmacology & therapeutics

authors： Rozen P,Levi Z,Hazazi R,Waked A,Vilkin A,Maoz E,Birkenfeld S,Niv Y

更新日期：2009-02-15 00:00:00

abstract：:Both duodenal and gastric ulcer disease are closely associated with Helicobacter pylori infection. An infected individual has an estimated lifetime risk of 10-20% for the development of peptic ulcer disease, which is at least 3-4 fold higher than in non-infected subjects. H. pylori infection can be diagnosed in 90-100...

journal_title：Alimentary pharmacology & therapeutics

authors： Kuipers EJ,Thijs JC,Festen HP

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:The treatment of HBeAg-negative chronic hepatitis B (CHB) is considered to be open-ended, with no guidelines for treatment cessation. AIM:To evaluate biochemical and virological relapse requiring retreatment in noncirrhotic HBeAg-negative CHB in patients who stopped treatment following a period of prolonged...

journal_title：Alimentary pharmacology & therapeutics

authors： Patwardhan VR,Sengupta N,Bonder A,Lau D,Afdhal NH

更新日期：2014-10-01 00:00:00