Review article: the limitations of corticosteroid therapy in Crohn's disease.

abstract：BACKGROUND:In cirrhosis, portal hypertension is associated with a spectrum of renal dysfunction that has significant implications for morbidity and mortality. AIM:To discuss recent progress in the patho-physiological mechanisms and therapeutic options for portal hypertension-related renal dysfunction. METHODS:A liter...

journal_title：Alimentary pharmacology & therapeutics

authors： Leithead JA,Hayes PC,Ferguson JW

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Omeprazole maintenance therapy for gastro-oesophageal reflux disease (GERD) has been associated with an increased incidence of atrophic gastritis in H. pylori-infected patients and with a decreased absorption of protein-bound, but not of unbound cobalamin. AIM:: To test the hypothesis that the combination o...

journal_title：Alimentary pharmacology & therapeutics

authors： Schenk BE,Kuipers EJ,Klinkenberg-Knol EC,Bloemena EC,Sandell M,Nelis GF,Snel P,Festen HP,Meuwissen SG

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Owing to the importance of early treatment, simple and reliable methods for monitoring inflammatory bowel disease (IBD) are needed. AIMS:To determine whether circulating microRNAs are reliable biomarkers for IBD monitoring. METHODS:Serum levels of 17 candidate microRNAs were measured by quantitative real-t...

journal_title：Alimentary pharmacology & therapeutics

authors： Chen P,Li Y,Li L,Yu Q,Chao K,Zhou G,Qiu Y,Feng R,Huang S,He Y,Chen B,Chen M,Zeng Z,Zhang S

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and are associated with poor outcomes. AIM:To provide an overview of data on the importance, assessment and management of malnutrition/sarcopenia and frailty in cirrhosis. METHODS:A literature search was conducted in PubMed and other...

journal_title：Alimentary pharmacology & therapeutics

authors： Bunchorntavakul C,Reddy KR

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...

journal_title：Alimentary pharmacology & therapeutics

authors： Niro GA,Ciancio A,Tillman HL,Lagget M,Olivero A,Perri F,Fontana R,Little N,Campbell F,Smedile A,Manns MP,Andriulli A,Rizzetto M

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND:Morphological, haemodynamic and clinical stages of cirrhosis have been proposed, although no definite staging system is yet accepted for clinical practice. AIM:To investigate whether clinical complications of cirrhosis may define different prognostic disease stages. METHODS:Analysis of the database from a ...

journal_title：Alimentary pharmacology & therapeutics

authors： D'Amico G,Pasta L,Morabito A,D'Amico M,Caltagirone M,Malizia G,Tinè F,Giannuoli G,Traina M,Vizzini G,Politi F,Luca A,Virdone R,Licata A,Pagliaro L

更新日期：2014-05-01 00:00:00

abstract：AIM:: To quantify through systematic review the pharmacokinetic profiles of the oral delayed release and sustained release mesalazine (5-aminosalicylate, 5ASA) formulations (Asacol, Salofalk, Mesasal, Claversal, Pentasa) and pro-drugs (sulfasalazine, olsalazine, balsalazide) used in the management of ulcerative colitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Sandborn WJ,Hanauer SB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19), became a global threat to human health. Liver impairment has been frequently reported as a common manifestation, although its clinical significance is still unclear, particularly in pa...

journal_title：Alimentary pharmacology & therapeutics

authors： Garrido I,Liberal R,Macedo G

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Following a nil per os (NPO) regimen, most patients with acute pancreatitis (AP) can resume normal oral intake within 1 week. If not tolerated, it is recommended to initiate artificial feeding, preferably by the enteral route. AIM:To evaluate the nutritional management of patients with AP in a Dutch cohort ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spanier BW,Mathus-Vliegen EM,Tuynman HA,Van der Hulst RW,Dijkgraaf MG,Bruno MJ,EARL Study Group.

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis C virus (HCV) infection. AIM:To evaluate the efficacy and safety of pegylated interferon (pegIFN) plus ribavirin (RBV) therapy in geriatric HCV-infected patients. METHODS:Ninety-one geria...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu CC,Lin CL,Kuo YL,Chien CH,Chen SW,Yen CL,Lin CY,Chien RN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori is one of the most prevalent global pathogens and can lead to gastrointestinal disease including peptic ulcers, gastric marginal zone lymphoma and gastric carcinoma. AIM:To review recent trends in H. pylori antibiotic resistance rates, and to discuss diagnostics and treatment paradigms. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Thung I,Aramin H,Vavinskaya V,Gupta S,Park JY,Crowe SE,Valasek MA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Deregulation of mammalian target of rapamycin (mTOR) signalling is common in human hepatocellular carcinoma (HCC). AIM:To determine the maximum tolerated dose (MTD) of the oral mTOR inhibitor everolimus in advanced HCC patients. METHODS:Patients with locally advanced or metastatic HCC (Child-Pugh class A o...

journal_title：Alimentary pharmacology & therapeutics

authors： Shiah HS,Chen CY,Dai CY,Hsiao CF,Lin YJ,Su WC,Chang JY,Whang-Peng J,Lin PW,Huang JD,Chen LT

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Patients with chronic hepatitis B (CHB) need long-term antiviral treatment with nucleos(t)ide analogues (NA). Animal studies suggest that some NA may increase cancer risk, but human data are lacking. AIM:To investigate cancer risks in patients with or without NA treatment. METHODS:We conducted a territory-...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong GL,Tse YK,Yip TC,Chan HL,Tsoi KK,Wong VW

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) genotype 6 is common among patients from Southeast Asia and the surrounding regions, where HCV prevalence is also high. HCV genotype 6 has great genetic diversity and different response to antiviral therapy compared with the more commonly known genotype 1. AIM:Our goal was to provide...

journal_title：Alimentary pharmacology & therapeutics

authors： Chao DT,Abe K,Nguyen MH

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The duration of Helicobacter pylori eradication regimens has decreased to 1 week with cure rates of over 90%. This can be attributed to the use of triple drug regimens including potent inhibitors of gastric acid secretion and clarithromycin. There is no theoretical reason why shorter regimens should not be p...

journal_title：Alimentary pharmacology & therapeutics

authors： Grimley CE,Penny A,O'sullivan M,Shebani M,Lismore JR,Cross R,Illing RC,Loft DE,Nwokolo CU

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well recognised. However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of se...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Guzman-Perez R,Gainer V,Cai T,Churchill S,Kohane I,Plenge RM,Murphy S

更新日期：2012-04-01 00:00:00

abstract：:Upper gastrointestinal symptoms are highly prevalent; usually those consulting have multiple symptoms, confounding management. Here, common clinically relevant management issues are considered based on the best available evidence. Regardless of the presenting symptoms, determine if there are any alarm features; these ...

journal_title：Alimentary pharmacology & therapeutics

authors： Talley NJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. AIM:To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy...

journal_title：Alimentary pharmacology & therapeutics

authors： Katzka DA,Castell DO

更新日期：2011-10-01 00:00:00

abstract：:In a Swedish double-blind multicentre study, omeprazole (30 mg o.m.) was compared with the H2-receptor antagonist cimetidine (400 mg b.d.) in 152 patients. Clinical assessments and laboratory investigations were carried out at 2 and 4 weeks, and again at 6 weeks in unhealed patients. Endoscopy was performed at 2 weeks...

journal_title：Alimentary pharmacology & therapeutics

authors： Dahlgren S,Domellöf L,Hradsky M,Norryd C,Brunkwall J,Svensson G,Svensson JO,Karlsson J,Knutson U,Gasslander T

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Dexlansoprazole MR is a Dual Delayed Release formulation of dexlansoprazole, an enantiomer of lansoprazole, designed to extend the duration of acid suppression. AIM:To assess the 12-month safety of dexlansoprazole MR in patients with symptomatic gastro-oesophageal reflux disease (GERD). METHODS:In this ran...

journal_title：Alimentary pharmacology & therapeutics

authors： Dabholkar AH,Han C,Paris MM,Perez MC,Atkinson SN,Peura DA

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Treatment with interferon-alpha has been shown to be effective in one-third of hepatitis B e antigen-positive chronic hepatitis B patients, but is clinically associated with relevant adverse events. AIM:To investigate the safety of pegylated interferon alpha-2b in 300 hepatitis B e antigen-positive patients...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zonneveld M,Flink HJ,Verhey E,Senturk H,Zeuzem S,Akarca US,Cakaloglu Y,Simon C,So TM,Gerken G,de Man RA,Hansen BE,Schalm SW,Janssen HL,HBV 99-01 Study Group.

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Factors associated with mortality and disease progression in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are poorly understood. AIMS:To assess the impact of liver disease severity, demographics and comorbidities on all-cause mortality and liver disease progression in a...

journal_title：Alimentary pharmacology & therapeutics

authors： Canbay A,Kachru N,Haas JS,Sowa JP,Meise D,Ozbay AB

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) frequently affects women during their reproductive years. Pregnancy outcome in women with IBD is well described, particularly in retrospective studies. AIM:To evaluate the pregnancy outcome in patients with IBD in a prospective European multicentre case-control study. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Bortoli A,Pedersen N,Duricova D,D'Inca R,Gionchetti P,Panelli MR,Ardizzone S,Sanroman AL,Gisbert JP,Arena I,Riegler G,Marrollo M,Valpiani D,Corbellini A,Segato S,Castiglione F,Munkholm P,European Crohn-Colitis Organisat

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The detrimental effect of smoking on development and progression of Crohn's disease (CD) is generally accepted. AIM:To evaluate the awareness of smoking risks in a Belgian inflammatory bowel disease (IBD) population. METHODS:In the out-patient clinic of a tertiary referral centre, 625 consecutive patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： De Bie C,Ballet V,Hendriks N,Coenen S,Weyts E,Van Assche G,Vermeire S,Ferrante M

更新日期：2015-12-01 00:00:00

abstract：:Resistance of Helicobacter pylori to antibiotics included in current regimens used to eradicate H. pylori is a major reason for failure. The definition of resistance is not simple, and the clinical relevance of in vitro results must be considered. The different methods of testing antibiotics cannot apply in all cases....

journal_title：Alimentary pharmacology & therapeutics

authors： Mégraud F

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Abnormal barrier function may be genetically determined in Crohn's disease. AIM:To examine the role of abnormal intestinal permeability in genetic predisposition in multiplex vs. sporadic Crohn's disease families. METHODS:Intestinal permeability was measured in patients, relatives and partners by means of ...

journal_title：Alimentary pharmacology & therapeutics

authors： D'Incà R,Annese V,di Leo V,Latiano A,Quaino V,Abazia C,Vettorato MG,Sturniolo GC

更新日期：2006-05-15 00:00:00

abstract：:Ranitidine hydrochloride, a histamine H2-receptor antagonist, was intravenously administered to 61 pregnant women at a dose of 50 mg as premedication for caesarean section; its effects on gastric secretion were studied in the mother and the newborn. The volume of the maternal gastric juice collected immediately after ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ikenoue T,Iito J,Matsuda Y,Hokanishi H

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:To determine whether flumecinol (3-trifluoromethyl-alpha-ethylbenzhydrol, Zixoryn) is effective in ameliorating pruritus of cholestasis, particularly in primary bilary cirrhosis. METHODS AND RESULTS:50 patients (46 with primary biliary cirrhosis, PBC) took oral flumecinol 600 mg or identical placebo once wee...

journal_title：Alimentary pharmacology & therapeutics

authors： Turner IB,Rawlins MD,Wood P,James OF

更新日期：1994-06-01 00:00:00

abstract：:Variceal bleeding is a consequence of portal hypertension, which in turn is the major complication of hepatic cirrhosis. Given the high rate of mortality of the first bleeding episode, primary prophylaxis to prevent bleeding from varices and portal hypertensive gastropathy is the current optimal therapeutic approach. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Vlachogiannakos J,Goulis J,Patch D,Burroughs AK

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Gastrimmune is an immunogenic form of gastrin. It raises in situ antibodies against two proliferative forms of gastrin: amidated and glycine-extended gastrin-17. It has been shown to have a therapeutic action in several in vivo tumour models. Following immunization, due to the complex equilibrium that exists...

journal_title：Alimentary pharmacology & therapeutics

authors： Smith AM,Morris T,Justin T,Michaeli D,Watson SA

更新日期：2001-12-01 00:00:00