The 12-month safety profile of dexlansoprazole, a proton pump inhibitor with a dual delayed release formulation, in patients with gastro-oesophageal reflux disease.

abstract：BACKGROUND:This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD). METHODS:214 patients with symptomatic, non-erosive GERD (moderate to severe daytime and/or night-time heartburn greater than half ...

journal_title：Alimentary pharmacology & therapeutics

authors： Richter JE,Kovacs TO,Greski-Rose PA,Huang section sign B,Fisher R

更新日期：1999-06-01 00:00:00

abstract：AIM:To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. METHODS:The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and LGG: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additiona...

journal_title：Alimentary pharmacology & therapeutics

authors： Szajewska H,Skórka A,Ruszczyński M,Gieruszczak-Białek D

更新日期：2007-04-15 00:00:00

abstract：BACKGROUND:Although enteral nutrition is a recognized form of treatment for intestinal Crohn's disease, there are persisting problems with feed palatability and only limited data as to its mode of action. AIM:To assess the effects of a specific oral polymeric diet (CT3211; Nestle, Vevey, Switzerland), which is rich in...

journal_title：Alimentary pharmacology & therapeutics

authors： Fell JM,Paintin M,Arnaud-Battandier F,Beattie RM,Hollis A,Kitching P,Donnet-Hughes A,MacDonald TT,Walker-Smith JA

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Guidelines recommend that patients with gastro-oesophageal reflux disease are adequately treated with acid-suppressive therapy before undergoing anti-reflux surgery. Little is known of the use of acid-suppressive drugs before anti-reflux surgery. AIM:To determine the use of proton pump inhibitors and H2 -re...

journal_title：Alimentary pharmacology & therapeutics

authors： Lødrup A,Pottegård A,Hallas J,Bytzer P

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown. AIMS:To investigate in HIV-infected patients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phase...

journal_title：Alimentary pharmacology & therapeutics

authors： Fabris P,Pilotto A,Bozzola L,Tositti G,Soffiati G,Manfrin V,de Lalla F

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Following a nil per os (NPO) regimen, most patients with acute pancreatitis (AP) can resume normal oral intake within 1 week. If not tolerated, it is recommended to initiate artificial feeding, preferably by the enteral route. AIM:To evaluate the nutritional management of patients with AP in a Dutch cohort ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spanier BW,Mathus-Vliegen EM,Tuynman HA,Van der Hulst RW,Dijkgraaf MG,Bruno MJ,EARL Study Group.

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The various components of pain and quality of life in duodenal ulcer patients receiving antisecretory drugs have not been studied to date. METHODS:Ninety-five patients with epigastric pain and duodenal ulcer at endoscopy completed this prospective, multicenter, open-study. All were treated with effervescent...

journal_title：Alimentary pharmacology & therapeutics

authors： Rampal P,Ruszniewski P,Boureau F,Richard A,Slama A

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan. AIM:To estimate the preventive effect by normal dose, not high-dose histamine-H2 receptor antagonists (H2RA) for NSAID-induced ulce...

journal_title：Alimentary pharmacology & therapeutics

authors： Miyake K,Ueki N,Suzuki K,Shinji Y,Kusunoki M,Hiratsuka T,Nishigaki H,Tatsuguchi A,Futagami S,Wada K,Tsukui T,Nakajima A,Yoshino S,Sakamoto C

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Distal ulcerative colitis may prove to be resistant to steroids and aminosalicylates, but total colectomy is more difficult to justify than in severe extensive colitis. Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease. AIM:To dete...

journal_title：Alimentary pharmacology & therapeutics

authors： Falasco G,Zinicola R,Forbes A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Butyrate, propionate and acetate are short chain fatty acids (SCFA), important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis. However, they may also regulate immune responses and the composition of the intestinal microbiota. Consequently, their importance in a ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gill PA,van Zelm MC,Muir JG,Gibson PR

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Guidelines and practice standards for sedation in endoscopy have been developed by various national professional societies. No attempt has been made to assess consensus among internationally recognized experts in this field. AIM:To identify areas of consensus and dissent among international experts on a bro...

journal_title：Alimentary pharmacology & therapeutics

authors： Cohen LB,Ladas SD,Vargo JJ,Paspatis GA,Bjorkman DJ,Van der Linden P,Axon AT,Axon AE,Bamias G,Despott E,Dinis-Ribeiro M,Fassoulaki A,Hofmann N,Karagiannis JA,Karamanolis D,Maurer W,O'Connor A,Paraskeva K,Schreiber F,

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Choosing the optimum pancreatic enzyme replacement therapy for patients with exocrine insufficiency remains a problem. An enteric coated enzyme microsphere pancreatic enzyme preparation (Pancrease) has been marketed with several levels of lipase activity, implying that there is a dose-response relationship b...

journal_title：Alimentary pharmacology & therapeutics

authors： Opekun AR Jr,Sutton FM Jr,Graham DY

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Delta virus (HDV)-related chronic hepatitis is difficult to treat. AIMS:To evaluate the efficacy of lamivudine 100 mg daily on serum HDV-RNA, hepatitis D virus antibodies and alanine aminotransferase levels, liver histology, and on hepatitis B surface antigen seroconversion. METHODS:Thirty-one hepatitis B ...

journal_title：Alimentary pharmacology & therapeutics

authors： Niro GA,Ciancio A,Tillman HL,Lagget M,Olivero A,Perri F,Fontana R,Little N,Campbell F,Smedile A,Manns MP,Andriulli A,Rizzetto M

更新日期：2005-08-01 00:00:00

abstract：:In a double-blind crossover study, lower oesophageal sphincter pressure (LOSP) and distal oesophageal motility were studied in eight healthy volunteers following a single intravenous dose of omeprazole or placebo. Lower oesophageal sphincter pressure was determined before and at intervals up to 120 min after intraveno...

journal_title：Alimentary pharmacology & therapeutics

authors： Chakraborty TK,De Caestecker JS,Pryde A,Heading RC

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM:To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after TC-PI. METHODS:In a sy...

journal_title：Alimentary pharmacology & therapeutics

authors： Fumery M,Dulai PS,Meirick P,Farrell AM,Ramamoorthy S,Sandborn WJ,Singh S

更新日期：2017-02-01 00:00:00

abstract：:The treatment of acute hepatic failure has developed rapidly over the last 40 years, reducing morbidity and mortality from this syndrome. Whilst this has been partly attributed to significant improvements in the specialist medical management of these patients, advances in surgical techniques and pharmaceutical develop...

journal_title：Alimentary pharmacology & therapeutics

authors： Rahman TM,Hodgson HJ

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND:Benign epithelial gastric polyps have been reported to be more common in atrophic body gastritis. The role of Helicobacter pylori infection in the induction of gastric atrophy is well-known. The development of hyperplastic polyps may be in relation to H. pylori infection. AIM:To investigate occurrence of be...

journal_title：Alimentary pharmacology & therapeutics

authors： Di Giulio E,Lahner E,Micheletti A,Milione M,D'Ambra G,Bordi C,Delle Fave G,Annibale B

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is a major cause of the progress of gastric glandular atrophy, a high-risk background factor in the development of gastric cancer. Regression of gastric atrophy is critical to prevention of cancer by H. pylori eradication treatment. However, it is controversial whether gastric a...

journal_title：Alimentary pharmacology & therapeutics

authors： Sugiyama T,Sakaki N,Kozawa H,Sato R,Fujioka T,Satoh K,Sugano K,Sekine H,Takagi A,Ajioka Y,Takizawa T,H. Pylori Forum Gastritis Study Group.

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena. AIMS:To examine the association between H. pylori colonisation in children and risk of asthma and related conditions at s...

journal_title：Alimentary pharmacology & therapeutics

authors： den Hollander WJ,Sonnenschein-van der Voort AM,Holster IL,de Jongste JC,Jaddoe VW,Hofman A,Perez-Perez GI,Moll HA,Blaser MJ,Duijts L,Kuipers EJ

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:The role of 5-hydroxytryptamine in the control of gastric fundus tone in humans is still unknown. Selective 5-hydroxytryptamine re-uptake inhibitors act both centrally and peripherally to enhance the availability of physiologically released 5-hydroxytryptamine. AIM:To study the influence of a selective 5-hy...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Broekaert D,Coulie B,Fischler B,Janssens J

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:Laparoscopic cholecystectomy (LC) is recommended for patients with choledocholithiasis after ERCP with sphincterotomy (ES) and stone extraction. AIM:We designed a decision model to address whether ES alone versus ES followed by LC (ES + LC) is the optimal treatment in high-risk patients with choledocholithi...

journal_title：Alimentary pharmacology & therapeutics

authors： Siddiqui AA,Mitroo P,Kowalski T,Loren D

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:Studies on the use of low-dose proton pump inhibitor for the maintenance therapy of gastro-oesophageal reflux disease have shown that it might be comparable with standard-dose proton pump inhibitor treatment and superior to standard-dose histamine-2 receptor antagonist therapy. AIM:To compare the impact of ...

journal_title：Alimentary pharmacology & therapeutics

authors： You JH,Lee AC,Wong SC,Chan FK

更新日期：2003-03-15 00:00:00

abstract：BACKGROUND:The best technique to estimate portal hypertension (PHT) is to measure the hepatic venous pressure gradient (HVPG), which is an invasive method. AIM:To assess the relationship between the Fibrotest (Biopredictive, Paris, France) and the presence and degree of PHT in patients with liver disease, and to deter...

journal_title：Alimentary pharmacology & therapeutics

authors： Thabut D,Imbert-Bismut F,Cazals-Hatem D,Messous D,Muntenau M,Valla DC,Moreau R,Poynard T,Lebrec D

更新日期：2007-08-01 00:00:00

abstract：:We compared the effects of fasting and feeding on the antisecretory actions of ranitidine in 19 patients whose duodenal ulcers remained unhealed or relapsed despite treatment with the drug. Nine of the patients received, and continued with, 150 mg ranitidine b.d. and 10 took 300 mg ranitidine b.d. In all patients, gas...

journal_title：Alimentary pharmacology & therapeutics

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:The threshold plasma paracetamol concentration at which N-acetylcysteine (NAC) treatment is recommended to treat paracetamol poisoning in a patient with induced liver enzymes (for example, with chronic liver disease or taking anticonvulsant drugs) is 50% lower than in a patient without induced liver enzymes....

journal_title：Alimentary pharmacology & therapeutics

authors： Jones AL,Jarvie DR,Simpson D,Hayes PC,Prescott LF

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND:Treatment with a continuous i.v. proton pump inhibitor is presumed to promote clot formation and stability by sustaining intragastric pH > or = 6. AIM:We postulated that very frequent oral dosing of proton pump inhibitors should simulate i.v. infusion and achieve similar pH control. METHODS:Twenty healthy ...

journal_title：Alimentary pharmacology & therapeutics

authors： Pais SA,Nathwani RA,Dhar V,Nowain A,Laine L

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses. AIM:To determine the relationship between gastrointestinal and other symptoms and me...

journal_title：Alimentary pharmacology & therapeutics

authors： Bernstein MT,Graff LA,Targownik LE,Downing K,Shafer LA,Rawsthorne P,Bernstein CN,Avery L

更新日期：2012-07-01 00:00:00

abstract：:Faecal impaction with or without encopresis is a very common problem. We performed a randomized, open-label, prospective study to compare the efficacy and acceptability of the treatment of faecal impaction using either mineral oil or pineapple-flavoured isotonic intestinal lavage solution containing polyethylene glyco...

journal_title：Alimentary pharmacology & therapeutics

authors： Tolia V,Lin CH,Elitsur Y

更新日期：1993-10-01 00:00:00

abstract：:Maintenance of adequate nutrition is of obvious importance in the management of patients with Crohn's disease. Exclusive parenteral nutrition can achieve high rates of remission, but this is not usually necessary since exclusive elemental and polymeric enteral regimes can yield similarly good results. Comparison of ex...

journal_title：Alimentary pharmacology & therapeutics

authors： Forbes A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Obscure gastrointestinal bleeding (OGIB) is a commonly encountered clinical problem in gastroenterology and is associated with significant morbidity and mortality. The investigation and management of OGIB has changed dramatically over the past decade with the advent of newer gastroenterological and radiologi...

journal_title：Alimentary pharmacology & therapeutics

authors： Liu K,Kaffes AJ

更新日期：2011-08-01 00:00:00