Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine.

abstract：BACKGROUND:Gastroparesis is a chronic disorder caused by stomach pump failure and characterized by profound nausea, vomiting and epigastric pain. Most often, the cause is unapparent and of the known associations, diabetes is the most common. Diagnosis is usually made using an isotope-labelled test meal. Treatment is in...

journal_title：Alimentary pharmacology & therapeutics

authors： Patrick A,Epstein O

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Ustekinumab is a monoclonal antibody targeting interleukins-12 and -23, with efficacy in Crohn's disease (CD) demonstrated in clinical trials. AIM:To assess the real-world clinical, endoscopic and radiographic response and remission outcomes achieved with ustekinumab in medically-refractory CD. METHODS:A r...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Fedorak RN,Kaplan GG,Dieleman LA,Devlin SM,Stern N,Kroeker KI,Seow CH,Leung Y,Novak KL,Halloran BP,Huang VW,Wong K,Blustein PK,Ghosh S,Panaccione R

更新日期：2017-05-01 00:00:00

abstract：:One hundred and twenty-five patients with duodenal ulcer disease were given continuous ranitidine therapy after initial acute healing. Cumulative remission rates indicated that 95% of patients were ulcer-free after 1 year, 89% at 2 years, 81% at 3 years, 70% at 4 years and 60% at 5 and 6 years. Nine patients had a sec...

journal_title：Alimentary pharmacology & therapeutics

authors： Simon B,Schütz E,Müller P,Dixon JS

更新日期：1994-02-01 00:00:00

abstract：:An elevated platelet count is well recognized as a marker of inflammatory bowel disease activity. There is an increased incidence of systemic thromboembolism in this disease. Recent work indicates that platelets exhibit several proinflammatory properties including release of inflammatory mediators, and recruitment, ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Collins CE,Rampton DS

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Gut microflora-mucosal interactions may be involved in the pathogenesis of irritable bowel syndrome (IBS). AIM:To investigate the efficacy of a novel prebiotic trans-galactooligosaccharide in changing the colonic microflora and improve the symptoms in IBS sufferers. METHODS:In all, 44 patients with Rome II...

journal_title：Alimentary pharmacology & therapeutics

authors： Silk DB,Davis A,Vulevic J,Tzortzis G,Gibson GR

更新日期：2009-03-01 00:00:00

abstract：:The systemic and hepatic haemodynamic effects following terlipressin (Glypressin) administration were studied. Bolus intravenous injections of 1.25 and 2 mg significantly decreased wedged hepatic vein pressure gradient by 29% and 31%, respectively. With each dose there was a small increase in mean arterial blood press...

journal_title：Alimentary pharmacology & therapeutics

authors： Freeman JG,Barton JR,Record CO

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease is prevalent in affluent countries and is strongly associated with metabolic syndrome. AIM:To study the prevalence of undiagnosed diabetes and postchallenge hyperglycaemia in Chinese patients with non-alcoholic fatty liver disease. METHODS:73 consecutive patients with biop...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong VW,Hui AY,Tsang SW,Chan JL,Wong GL,Chan AW,So WY,Cheng AY,Tong PC,Chan FK,Sung JJ,Chan HL

更新日期：2006-10-15 00:00:00

abstract：:The choice of medical therapies for Crohn's disease continues to grow. Although our understanding of the mechanisms of the disease is incomplete, increasing knowledge of the pathogenesis of inflammation in general and Crohn's disease in particular allows targeting of therapies at various points in the immunoinflammato...

journal_title：Alimentary pharmacology & therapeutics

authors： Elton E,Hanauer SB

更新日期：1996-02-01 00:00:00

abstract：AIM:To evaluate the efficacy of omeprazole plus clarithromycin and furazolidone in Helicobacter pylori eradication and duodenal ulcer healing in Brazilian patients. METHODS:Forty H. pylori-positive patients with duodenal ulcer were randomized to receive 20 mg omeprazole o.m. or b.d. for 1 month plus 500 mg clarithromy...

journal_title：Alimentary pharmacology & therapeutics

authors： Dani R,Queiroz DM,Dias MG,Franco JM,Magalhães LC,Mendes GS,Moreira LS,De Castro LP,Toppa NH,Rocha GA,Cabral MM,Salles PG

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:An impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection. AIM:To analyse the Th1/Th2 cytokine profile in peripheral blood CD4(+) and CD8(+) T cells from patients with chronic hepatitis C (CHC) during treatment with pegylated interferon-alpha2a plus ribavirin...

journal_title：Alimentary pharmacology & therapeutics

authors： Trapero-Marugán M,García-Buey L,Muñoz C,Quintana NE,Moreno-Monteagudo JA,Borque MJ,Fernández MJ,Salvanés FR,Medina J,Moreno-Otero R

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Despite similar clinical symptoms, collagenous colitis (CC) and lymphocytic colitis (LC) are considered two distinct disease entities. AIM:To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in CC and LC to establish whether they could be s...

journal_title：Alimentary pharmacology & therapeutics

authors： Rasmussen MA,Munck LK

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Budd-Chiari syndrome (BCS) is a rare but fatal disease caused by obstruction in the hepatic venous outflow tract. AIM:To provide an update of the pathophysiology, aetiology, diagnosis, management and follow-up of BCS. METHODS:Analysis of recent literature by using Medline, PubMed and EMBASE databases. RES...

journal_title：Alimentary pharmacology & therapeutics

authors： Khan F,Armstrong MJ,Mehrzad H,Chen F,Neil D,Brown R,Cain O,Tripathi D

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Response to proton pump inhibitor (PPI) treatment in dyspepsia is unpredictable. AIM:To identify symptoms associated with response to esomeprazole in order to target patients for empirical treatment. METHODS:Eight hundred and five uninvestigated, primary care patients with upper GI symptoms that were consi...

journal_title：Alimentary pharmacology & therapeutics

authors： Meineche-Schmidt V,Christensen E,Bytzer P

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The Th2 allergic pathway in eosinophilic oesophagitis (EoE) responds to food antigen exposure. AIM:To compare the presence and temporal pattern of food antigen penetration in oesophageal mucosa in active and inactive EoE and controls METHODS: Thirty-two patients with EoE (20 active) and 10 controls were ask...

journal_title：Alimentary pharmacology & therapeutics

authors： Ravi A,Marietta EV,Alexander JA,Peterson K,Lavey C,Geno DM,Murray JA,Katzka DA

更新日期：2021-02-01 00:00:00

abstract：:Resistance of Helicobacter pylori to antibiotics included in current regimens used to eradicate H. pylori is a major reason for failure. The definition of resistance is not simple, and the clinical relevance of in vitro results must be considered. The different methods of testing antibiotics cannot apply in all cases....

journal_title：Alimentary pharmacology & therapeutics

authors： Mégraud F

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial. AIM:To investigate the effects of multispecies probiotic supplementation (Lactobacillus rhamnosus GG, L. rhamnosus Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifi...

journal_title：Alimentary pharmacology & therapeutics

authors： Kajander K,Myllyluoma E,Rajilić-Stojanović M,Kyrönpalo S,Rasmussen M,Järvenpää S,Zoetendal EG,de Vos WM,Vapaatalo H,Korpela R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Local delivery of therapeutic agents to the stomach may be a useful strategy in the treatment of Helicobacter pylori infection. We aimed to see whether the intragastric distribution and gastric retention of a therapeutic agent could be improved, either by giving omeprazole or by dosing after a meal. METHODS...

journal_title：Alimentary pharmacology & therapeutics

authors： Atherton JC,Washington N,Bracewell MA,Sutton LJ,Greaves JL,Perkins AC,Hawkey CJ,Spiller RC

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Direct-acting anti-virals (DAA) are safe, effective treatment of hepatitis C virus (HCV). Suboptimal linkage to specialists and access to DAAs are the leading barriers to treatment; however, data are limited. AIM:To determine predictors of follow-up, receipt of DAAs, and reasons for the lack thereof. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Lin M,Kramer J,White D,Cao Y,Tavakoli-Tabasi S,Madu S,Smith D,Asch SM,El-Serag HB,Kanwal F

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Morphological, haemodynamic and clinical stages of cirrhosis have been proposed, although no definite staging system is yet accepted for clinical practice. AIM:To investigate whether clinical complications of cirrhosis may define different prognostic disease stages. METHODS:Analysis of the database from a ...

journal_title：Alimentary pharmacology & therapeutics

authors： D'Amico G,Pasta L,Morabito A,D'Amico M,Caltagirone M,Malizia G,Tinè F,Giannuoli G,Traina M,Vizzini G,Politi F,Luca A,Virdone R,Licata A,Pagliaro L

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:There are conflicting reports on the role of gastro-oesophageal reflux disease (GERD) and Helicobacter pylori infection in the aetiology of carditis. AIM:The role of reflux and H. pylori infection in causing carditis was assessed in 113 consecutive patients with GERD and in 25 controls. METHODS:All subject...

journal_title：Alimentary pharmacology & therapeutics

authors： Zentilin P,Mastracci L,Dulbecco P,Gambaro C,Bilardi C,Ceppa P,Spaggiari P,Iiritano E,Mansi C,Vigneri S,Fiocca R,Savarino V

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Controversy exists on how to measure patient-reported outcomes in irritable bowel syndrome (IBS) clinical trials effectively. Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS. AIM:To test the psychometrics of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spiegel B,Bolus R,Harris LA,Lucak S,Naliboff B,Esrailian E,Chey WD,Lembo A,Karsan H,Tillisch K,Talley J,Mayer E,Chang L

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

journal_title：Alimentary pharmacology & therapeutics

authors： van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy. AIM:To compare the clinical course, patterns of survival and causes of death by etiology during long-term follow-up in a large population-based co...

journal_title：Alimentary pharmacology & therapeutics

authors： Nilsson E,Anderson H,Sargenti K,Lindgren S,Prytz H

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective. Unfortunately, the usual dose of furazolidone is not tolerable in many patients. Lower doses of furazolidone are expected to cause fewer adverse effects. AIM:To investigate the efficacy of low-dose furazolidon...

journal_title：Alimentary pharmacology & therapeutics

authors： Fakheri H,Merat S,Hosseini V,Malekzadeh R

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Inflammatory bowel disease (IBD) comprising ulcerative colitis (UC) and Crohn's disease (CD) is multigenic disorder. Tremendous progress has been achieved in unravelling the genetic background of IBD. It has led to the discovery of mutations in NOD2 associated with ileal CD and numerous other genes have be...

journal_title：Alimentary pharmacology & therapeutics

authors： Weersma RK,van Dullemen HM,van der Steege G,Nolte IM,Kleibeuker JH,Dijkstra G

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS:To assess the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS:Retrospective analysis of 287 IC an...

journal_title：Alimentary pharmacology & therapeutics

authors： Bonacci M,Lens S,Mariño Z,Londoño MC,Rodríguez-Tajes S,Mas A,García-López M,Pérez-Del-Pulgar S,Sánchez-Tapias JM,Forns X

更新日期：2018-05-01 00:00:00

abstract：:The study investigated the oral absorption of two antifungal agents, fluconazole and itraconazole, under conditions of low intragastric acidity. Twelve healthy male volunteers received each of 4 dosing regimens: 200 mg itraconazole alone, 200 mg itraconazole and famotidine, 100 mg fluconazole alone, and 100 mg flucona...

journal_title：Alimentary pharmacology & therapeutics

authors： Lim SG,Sawyerr AM,Hudson M,Sercombe J,Pounder RE

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:The use of healthcare resources for the management of constipation is not well-known. AIM:To analyse healthcare seeking for constipation, defined by three different criteria, and its related factors and to assess the frequency of use of laxatives, suppositories and enemas for the treatment of constipation. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Gálvez C,Garrigues V,Ortiz V,Ponce M,Nos P,Ponce J

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Irritable bowel syndrome is a widespread disorder with a marked socioeconomic burden. Previous studies support the proposal that a subset of patients with features compatible with diarrhoea-predominant IBS (IBS-D) have bile acid malabsorption (BAM). AIM:To perform a systematic review and meta-analysis to as...

journal_title：Alimentary pharmacology & therapeutics

authors： Slattery SA,Niaz O,Aziz Q,Ford AC,Farmer AD

更新日期：2015-07-01 00:00:00

abstract：:In a double-blind crossover study, lower oesophageal sphincter pressure (LOSP) and distal oesophageal motility were studied in eight healthy volunteers following a single intravenous dose of omeprazole or placebo. Lower oesophageal sphincter pressure was determined before and at intervals up to 120 min after intraveno...

journal_title：Alimentary pharmacology & therapeutics

authors： Chakraborty TK,De Caestecker JS,Pryde A,Heading RC

更新日期：1987-12-01 00:00:00