Abstract：
BACKGROUND:Despite similar clinical symptoms, collagenous colitis (CC) and lymphocytic colitis (LC) are considered two distinct disease entities. AIM:To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in CC and LC to establish whether they could be subtypes of the same disease, microscopic colitis (MC). METHODS:The MEDLINE was searched for CC, LC and MC, and clinical studies of >20 patients were included. Pooled results with 95% confidence intervals were calculated based on the number of patients. RESULTS:An abnormal number of intraepithelial lymphocytes are found in 45% (40-50%) with CC, and an abnormal subepithelial collagen band in 16% (13-20%) with LC suggesting a histological overlap. The incidence of CC and LC has increased in parallel. Mean age (CC 63 years; LC 60 years) and clinical presentation are indistinguishable, and females are predominant in CC (77%; 75-79%) as well as LC (68%; 66-70%). Risk factors such as nonsteroid anti-inflammatory drugs consumption CC 39% (36-42%); LC 32% (29-35%) are similar and prevalence of concomitant autoimmune diseases such as coeliac disease (CC 5%; CI: 4-6% and LC 7%; CI: 6-9%) do not differ. Bile acid diarrhoea is highly prevalent in CC (41%; 37-45%) and LC (29%; 24-34%). The effect of budesonide is identical. CONCLUSIONS:CC and LC could be considered histological subtypes of the same disease, MC. To facilitate recruitment to clinical trials, all MC patients could be included in future trials and stratified for subtypes.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Rasmussen MA,Munck LKdoi
10.1111/j.1365-2036.2012.05166.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
79-90issue
2eissn
0269-2813issn
1365-2036journal_volume
36pub_type
杂志文章,评审abstract：BACKGROUND:Real-life long-term data on infliximab treatment in ulcerative colitis are limited. AIM:To study the long-term efficacy and safety of infliximab in chronic active ulcerative colitis and possible predictors of colectomy and response were also examined. METHODS:A retrospective multi-centre study of inflixima...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/apt.13893
更新日期：2017-02-01 00:00:00
abstract：:Forty patients with gastro-oesophageal reflux disease and oesophagitis, documented by endoscopy (grades I to III by the Savary-Miller classification) were randomized to participate in a comparative double-blind trial to receive cisapride (10 mg q.d.s.) or ranitidine (150 mg b.d.) for an 8-week period. Upper gastrointe...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1993.tb00145.x
更新日期：1993-12-01 00:00:00
abstract：:There is general agreement that Helicobacter pylori eradication is indicated in all infected patients with duodenal ulcer disease and is probably indicated in all infected patients with gastric ulcer disease. However, translation of treatment recommendations into practice leads to some difficult clinical decisions. Th...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.1995.tb00781.x
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Subtotal or total colectomy or proctocolectomy with permanent ileostomy (TC-PI) may be a treatment option for medically refractory colonic Crohn's disease (CD). AIM:To perform a systematic review and meta-analysis to evaluate the rate, risk factors and outcomes of CD recurrence after TC-PI. METHODS:In a sy...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1111/apt.13886
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:Irritable bowel syndrome (IBS) has been associated with microbial dysbiosis. AIM:To investigate the efficacy of faecal microbiota transplantation (FMT) in the treatment of IBS. METHODS:Forty-nine IBS patients were randomised to receive autologous or allogenic FMT via colonoscopy. The primary endpoint was a...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/apt.15740
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Distal ulcerative colitis may prove to be resistant to steroids and aminosalicylates, but total colectomy is more difficult to justify than in severe extensive colitis. Immunosuppression is of established benefit in generalized colitis, but there are no data available specific to distal disease. AIM:To dete...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.2002.01170.x
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.14342
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Consensus guidelines aid in the diagnosis and management of autoimmune hepatitis, but they are frequently based on low-quality clinical evidence, conflicting experiences and divergent opinions. Recommendations may be weak, discrepant or non-existent at critical decision points. AIMS:To identify the decision...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/apt.12381
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. AIM:To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2007.03347.x
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:Diagnosis and management of chronic antibiotic-refractory pouchitis and Crohn's disease of the pouch can be challenging. Pyloric gland metaplasia is a histological feature indicative of chronic mucosal inflammation. Its value in diagnosis and prognosis of pouch disorders has not been investigated. AIM:To as...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2010.04249.x
更新日期：2010-04-01 00:00:00
abstract：:Despite implementation of screening and surveillance strategies, a significantly large number of patients with Barrett's oesophagus remain undiagnosed. In those who are identified, the management options include acid reduction therapies with proton pump inhibitors or anti-reflux surgery. Endoscopic ablative therapies ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.0953-0673.2004.01839.x
更新日期：2004-02-01 00:00:00
abstract：BACKGROUND:The incidence of irritable bowel syndrome is uncertain. We aimed to determine the incidence of clinically diagnosed irritable bowel syndrome in the community. METHODS:Using the Rochester Epidemiology Project, all diagnoses of irritable bowel syndrome made among adult residents of Olmsted County, Minnesota, ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2004.01938.x
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:In patients with primary sclerosing cholangitis follow-up magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) is performed by many centres, particularly for the early detection of biliary malignancies and strictures. Clinically meaningful MRI-based definitions of primary ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.14797
更新日期：2018-07-01 00:00:00
abstract：:The treatment of acute hepatic failure has developed rapidly over the last 40 years, reducing morbidity and mortality from this syndrome. Whilst this has been partly attributed to significant improvements in the specialist medical management of these patients, advances in surgical techniques and pharmaceutical develop...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.1999.00597.x
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Mycophenolate mofetil has been claimed to be effective and well tolerated in refractory inflammatory bowel disease although there is little information regarding its use in clinical practice. AIM:To review our experience in achieving and maintaining remission in refractory inflammatory bowel disease and to ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.2003.01581.x
更新日期：2003-06-01 00:00:00
abstract：:All vertebrates secrete gastric acid. Acid denatures the proteins in the food and thus makes them more accessible to proteolytic enzymes, and it kills swallowed micro-organisms. Gastric acid plays an important pathogenetic role in peptic ulcer disease and reflux oesophagitis. In these diseases, drugs that inhibit secr...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.1993.tb00139.x
更新日期：1993-12-01 00:00:00
abstract：:More than 15 years after the launch of omeprazole in 1988, proton-pump inhibitors remain central to the management of acid-suppression disorders and are unchallenged with regard to their efficacy and popularity among doctors and patients. They are considered safe despite early concerns about the possibility of an asso...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2005.02611.x
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Proton pump inhibitor (PPI) use is associated with an increased risk of Clostridium difficile infection (CDI), though the mechanism is unclear. PPI induced alterations to the gut microbiome may facilitate the emergence of CDI, though the effects of PPIs on gut microbiota are not well characterised. [Correcti...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.13568
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Proton pump inhibitors effectively suppress intragastric acid. Nocturnal acid breakthrough occurs on any dosing regimen of oral proton pump inhibitors. Histamine(2)-receptor antagonists (H(2)RA) suppress intragastric acidity independently of meals and help to control nocturnal acid breakthrough. Because prot...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2002.01171.x
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Haemorrhage from ruptured oesophageal varices is a common cause of death in people with cirrhosis. Guidelines recommend screening for varices at time of cirrhosis diagnosis and throughout the course of the disease. Conventional gastroscopy is the criterion standard for variceal screening; however, is invasiv...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.15282
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:There is a renewed interest in use of combination therapies in treatment-naïve chronic hepatitis B (CHB) because of limitations of monotherapies. AIM:To discuss the current status of combination therapies in treatment-naïve CHB. METHODS:PubMed search was done using 'combination', 'sequential' and 'chronic ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2008.03695.x
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is known to be associated with polycystic ovary syndrome (PCOS). However, most studies investigated the prevalence of NAFLD in obese PCOS patients. AIM:To compare the prevalence of non-obese NAFLD in women with or without PCOS, and to assess an independent associati...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.14058
更新日期：2017-06-01 00:00:00
abstract：:The present study examined whether histamine could affect the growth of the enterochromaffin-like (ECL) cell and the parietal cell. The effects of the unsurmountable histamine H2-receptor antagonist loxtidine (80 mg/kg) and the H+, K(+)-ATPase inhibitor omeprazole (100 mumol/kg) were compared in female Sprague-Dawley ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.1992.tb00055.x
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND:Liver transplantation (LT) offers a possible cure for carefully selected patients with hepatocellular carcinoma (HCC). Studies report that preoperative alpha-fetoprotein (AFP) is a prognostic indicator that can predict survival and recurrence in these patients. AIM:To undertake a systematic review of availa...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2012.05060.x
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:Helicobacter pylori eradication is a challenge in patients allergic to penicillin, especially those who have failed a first-eradication trial. AIM:To assess the efficacy and tolerability of H. pylori first-line treatment and rescue options in patients allergic to penicillin. METHODS:Prospective single cent...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2005.02687.x
更新日期：2005-11-15 00:00:00
abstract：BACKGROUND:The most commonly used second-line Helicobacter pylori eradication regimens are bismuth-containing quadruple therapy and levofloxacin-containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens. AIMS:To evaluate the ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1111/apt.13128
更新日期：2015-04-01 00:00:00
abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.12461
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:A direct role for neutrophils in the pathophysiology of indomethacin-induced gastric damage is controversial. Therefore, such damage was evaluated in hamsters. METHODS:Gastric antral damage was evaluated 4 h after the oro-gastric administration of indomethacin (30 mg/kg). Prior to indomethacin, hamsters wer...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.1999.00444.x
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Liver-related mortality varies across developed nations. AIM:To assess the relative role of various risk factors in relation to liver-related mortality in an ecological study approach. METHODS:Data for liver-related mortality, prevalence data for hepatitis B and C, human immunodeficiency virus (HIV), alcoh...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.13657
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Obscure gastrointestinal bleeding (OGIB) is a commonly encountered clinical problem in gastroenterology and is associated with significant morbidity and mortality. The investigation and management of OGIB has changed dramatically over the past decade with the advent of newer gastroenterological and radiologi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2011.04744.x
更新日期：2011-08-01 00:00:00
