Abstract：
BACKGROUND:4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. AIM:To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes in the colon, and ethylcellulose. METHODS:Seven healthy male volunteers received, on three separate occasions, an uncoated or amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsule containing 4-aminosalicylic acid Na (550 mg), or an intravenous injection of 4-aminosalicylic acid Na (135 mg). The capsules were radiolabelled with 99mTc to allow their positions in the gastrointestinal tract to be followed using a gamma camera. Plasma and urine samples were collected and assayed for 4-aminosalicylic acid and metabolite concentrations. RESULTS:The uncoated capsules broke down within 10 min in the stomach, allowing rapid and complete absorption of the drug. The coated capsules remained intact in the upper gastrointestinal tract, and had a median gastric emptying time of 61 min (interquartile range, 77 min) and a median colon arrival time of 363 min (interquartile range, 185 min). For the coated capsules, only the metabolite was detected in the plasma and/or urine after the capsules had reached the colon. CONCLUSIONS:The specific coating protected the drug until the capsule reached the colon, where 4-aminosalicylic acid was slowly released and absorbed. Thus, such a formulation has the potential for use in the treatment of inflammatory bowel disease.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Tuleu C,Basit AW,Waddington WA,Ell PJ,Newton JMdoi
10.1046/j.1365-2036.2002.01327.xsubject
Has Abstractpub_date
2002-10-01 00:00:00pages
1771-9issue
10eissn
0269-2813issn
1365-2036pii
1327journal_volume
16pub_type
杂志文章abstract：AIM:To determine whether 4 days of quadruple therapy using bismuth, tetracycline and metronidazole combined with omeprazole is effective treatment for Helicobacter pylori infection. METHODS:Non-ulcer dyspepsia, as well as chronic peptic ulcer patients with biopsy-proven H. pylori infection received 4 days of quadruple...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-2036.1995.tb00432.x
更新日期：1995-12-01 00:00:00
abstract：:The treatment of severe and active Crohn's disease is currently based on immunosuppression, but also involves the management of nutrition, appropriate selection of patients for surgery, and maintenance of remission in the long term. Corticosteroids remain the drug of the first choice, particularly in the acute setting...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.2001.00963.x
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.12365
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.1995.tb00347.x
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...
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doi：10.1111/apt.14342
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journal_title：Alimentary pharmacology & therapeutics
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doi：10.1046/j.1365-2036.2002.01209.x
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2003.01682.x
更新日期：2003-10-15 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1997-12-01 00:00:00
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更新日期：2006-01-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
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更新日期：2009-07-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.14797
更新日期：2018-07-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2007.03457.x
更新日期：2007-10-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2019-04-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2012.05090.x
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-02-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.0953-0673.1996.00333.x
更新日期：1996-06-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2007.03307.x
更新日期：2007-05-15 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2036.2000.00823.x
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:Helicobacter pylori prevalence in Western countries has been declining simultaneously with increases in childhood asthma and allergic diseases; prior studies have linked these phenomena. AIMS:To examine the association between H. pylori colonisation in children and risk of asthma and related conditions at s...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.13572
更新日期：2016-04-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
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更新日期：2009-07-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2000-06-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/apt.13852
更新日期：2017-01-01 00:00:00
abstract：:The mode of transmission of Helicobacter pylori is largely unknown and is a matter of circumstantial evidence and speculation rather than fact. However, the principle evidence is of two sorts: the epidemiological data, providing evidence of possible risk factors associated with transmission, and the identification of ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
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更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Helicobacter-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis. AIM:To evaluate of Helicobacter PCR in gastric biopsies for the daily diagnostics of Helicobacter-negative gastritis. ME...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.13564
更新日期：2016-04-01 00:00:00
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journal_title：Alimentary pharmacology & therapeutics
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doi：10.1111/j.1365-2036.2008.03898.x
更新日期：2009-02-15 00:00:00
abstract：BACKGROUND:The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and coeliac disease-associated genetics. It remains unclear whether this approach is also applicable for adults with various clinical presentations. AIM:To evaluate the ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.15109
更新日期：2019-02-01 00:00:00
