Review article: non-alcoholic fatty liver disease and osteoporosis--clinical and molecular crosstalk.

abstract：:Despite implementation of screening and surveillance strategies, a significantly large number of patients with Barrett's oesophagus remain undiagnosed. In those who are identified, the management options include acid reduction therapies with proton pump inhibitors or anti-reflux surgery. Endoscopic ablative therapies ...

journal_title：Alimentary pharmacology & therapeutics

authors： Jankowski J,Sharma P

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:Bovine colostrum is a rich source of nutrients, antibodies and growth factors. AIM:To examine the efficacy of colostrum enemas in the treatment of distal colitis using a randomized, double-blind, controlled protocol. METHODS:Fourteen patients (eight female), with a mean age of 45 years (range, 16-75 years)...

journal_title：Alimentary pharmacology & therapeutics

authors： Khan Z,Macdonald C,Wicks AC,Holt MP,Floyd D,Ghosh S,Wright NA,Playford RJ

更新日期：2002-11-01 00:00:00

abstract：:We compared the effects of fasting and feeding on the antisecretory actions of ranitidine in 19 patients whose duodenal ulcers remained unhealed or relapsed despite treatment with the drug. Nine of the patients received, and continued with, 150 mg ranitidine b.d. and 10 took 300 mg ranitidine b.d. In all patients, gas...

journal_title：Alimentary pharmacology & therapeutics

authors： Johnston DA,Wormsley KG

更新日期：1989-10-01 00:00:00

abstract：AIM:To assess the efficacy of the 8-week therapy with esomeprazole 40 mg vs. pantoprazole 40 mg for healing erosive oesophagitis (EE) as part of a management study. METHODS:Patients had a history of gastro-oesophageal reflux disease symptoms (> or =6 months) and had suffered heartburn on at least 4 of the 7 days prece...

journal_title：Alimentary pharmacology & therapeutics

authors： Labenz J,Armstrong D,Lauritsen K,Katelaris P,Schmidt S,Schütze K,Wallner G,Juergens H,Preiksaitis H,Keeling N,Nauclér E,Eklund S,Expo Study Investigators.

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Increased risk of cardiovascular and cerebrovascular disease in liver transplant recipients results in particular from the side effects of calcineurin inhibitor-based immunosuppressive therapy. Several studies have demonstrated a more favourable outcome for patients receiving tacrolimus (TAC) as compared wit...

journal_title：Alimentary pharmacology & therapeutics

authors： Beckebaum S,Klein C,Varghese J,Sotiropoulos GC,Saner F,Schmitz K,Gerken G,Paul A,Cicinnati VR

更新日期：2009-10-15 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel disease (IBD) are at increased risk of osteoporosis. A number of studies have emerged in recent years indicating that tumour necrosis factor (TNF) blockade appears to have a beneficial effect on bone mineral density (BMD) in IBD patients. AIMS:To provide a review of the avai...

journal_title：Alimentary pharmacology & therapeutics

authors： Veerappan SG,O'Morain CA,Daly JS,Ryan BM

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Drug toxicity is the leading cause of acute liver failure in the United States. Further understanding of hepatotoxicity is becoming increasingly important as more drugs come to market. AIMS:(i) To provide an update on recent advances in our understanding of hepatotoxicity of select commonly used drug classe...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang CY,Schiano TD

更新日期：2007-05-15 00:00:00

abstract：BACKGROUND:Gastro-oesophageal reflux disease (GERD) and irritable bowel syndrome may occur more often than expected by chance, but little community data exists and risk factors are unknown. AIM:To determine prevalence and risk factors for overlap of GERD and irritable bowel disease. METHODS:Population-based, cross-se...

journal_title：Alimentary pharmacology & therapeutics

authors： Jung HK,Halder S,McNally M,Locke GR 3rd,Schleck CD,Zinsmeister AR,Talley NJ

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:The use of proton pump inhibitors (PPIs) is extensive. While the incidence of new treatments remains stable, the prevalence of long-term treatment is rising. Studies have shown that up to 70% of patients on chronic acid suppression lack a verified indication for treatment. AIMS:To investigate primary care p...

journal_title：Alimentary pharmacology & therapeutics

authors： Reimer C,Bytzer P

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:In developed countries, hepatitis E is a porcine zoonosis caused by hepatitis E virus (HEV) genotype 3. In developing countries, hepatitis E is mainly caused by genotype 1, and causes increased mortality in patients with pre-existing chronic liver disease (CLD). AIM:To determine the role of HEV in patients ...

journal_title：Alimentary pharmacology & therapeutics

authors： Blasco-Perrin H,Madden RG,Stanley A,Crossan C,Hunter JG,Vine L,Lane K,Devooght-Johnson N,Mclaughlin C,Petrik J,Stableforth B,Hussaini H,Phillips M,Mansuy JM,Forrest E,Izopet J,Blatchford O,Scobie L,Peron JM,Dalton H

更新日期：2015-09-01 00:00:00

abstract：:An analysis carried out in 1994 by the WHO International Agency for Research on Cancer (IARC) resulted in Helicobacter pylori being designated as a Group 1 carcinogen and thus clearly having an association with the development of gastric cancer. In the case of H. pylori, the evaluation was made solely on the basis of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Asaka M,Kudo M,Kato M,Sugiyama T,Takeda H

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Third-generation cephalosporins (TGC) constitute the empirical first-line therapy for spontaneous bacterial peritonitis (SBP). Hospitalisation, invasive procedures and use of antibiotics may challenge this concept due to an increase in enterococci and other TGC-resistant microorganisms. AIM:To determine pre...

journal_title：Alimentary pharmacology & therapeutics

authors： Reuken PA,Pletz MW,Baier M,Pfister W,Stallmach A,Bruns T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM:To highlight the importance of Helicobacter pylori infection in shaping the temporal trends of many common gastrointestin...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Mesalazine suppositories are recommended and widely used as the standard therapy in induction and maintenance of remission for proctitis. AIM:To evaluate the efficacy of mesalazine suppositories in patients with ulcerative colitis (UC) and rectal inflammation; and in patient groups categorised by the extent...

journal_title：Alimentary pharmacology & therapeutics

authors： Watanabe M,Nishino H,Sameshima Y,Ota A,Nakamura S,Hibi T

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:No prognostic tools are established for alcohol-related liver disease (ALD). Collagen proportionate area (CPA) measurement is a technique that quantifies fibrous tissue in liver biopsies using digital image analysis. AIM:To assess the predictive value of CPA on hepatic decompensation and liver-related morta...

journal_title：Alimentary pharmacology & therapeutics

authors： Israelsen M,Guerrero Misas M,Koutsoumourakis A,Huang Y,Thiele M,Hall A,Rasmussen D,Covelli C,Buzzetti E,Prat LI,Roccarina D,Detlefsen S,Luong TV,Quaglia A,Krag A,Jeffrey G,Pinzani M,Tsochatzis EA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Symptoms of lactose intolerance are often attributed to lactose malabsorption but, as this relationship has not been demonstrated when a small dose of lactose similar to that contained in one cup of milk is ingested by intolerant patients, psychological factors may play a role in altered symptom perception. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tomba C,Baldassarri A,Coletta M,Cesana BM,Basilisco G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease is prevalent in affluent countries and is strongly associated with metabolic syndrome. AIM:To study the prevalence of undiagnosed diabetes and postchallenge hyperglycaemia in Chinese patients with non-alcoholic fatty liver disease. METHODS:73 consecutive patients with biop...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong VW,Hui AY,Tsang SW,Chan JL,Wong GL,Chan AW,So WY,Cheng AY,Tong PC,Chan FK,Sung JJ,Chan HL

更新日期：2006-10-15 00:00:00

abstract：BACKGROUND:Proton pump inhibitor (PPI)-refractory heartburn may be due to persistent gastro-oesophageal reflux, oesophageal hypersensitivity or functional heartburn (FH). The differentiation between non-erosive reflux disease (NERD) and FH may be very difficult. However, this differentiation is important for appropriat...

journal_title：Alimentary pharmacology & therapeutics

authors： Kandulski A,Jechorek D,Caro C,Weigt J,Wex T,Mönkemüller K,Malfertheiner P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Attainment of intragastric pH < 6.0 may require high-dose continuously infused proton pump therapy. AIM:To assess the pharmacokinetic and pharmacodynamic dose-responses of continuous infusion regimens of lansoprazole. METHODS:Healthy adult subjects were assigned to lansoprazole 60-mg intravenous bolus, fol...

journal_title：Alimentary pharmacology & therapeutics

authors： Howden CW,Metz DC,Hunt B,Vakily M,Kukulka M,Amer F,Samra N

更新日期：2006-04-01 00:00:00

abstract：:Proton pump inhibitor-based triple therapy is the most commonly used treatment for eradication of Helicobacter pylori, with pooled eradication rates of approximately 90%. In the USA, per protocol eradication rates with 10-day proton pump inhibitor-based triple therapy are approximately 85%. Esomeprazole, a new proton ...

journal_title：Alimentary pharmacology & therapeutics

authors： Laine L

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. Aim To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Castaño G,Burgueño A,Fernández Gianotti T,Pirola CJ,Sookoian S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The therapeutic effect of enteral nutrition in Crohn's disease (CD) and the epidemiological associations between diet and inflammatory bowel disease (IBD) implicate diet in IBD causation. There is little evidence, however, to support specific dietary changes and patients often receive contradictory advice. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Richman E,Rhodes JM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is a major cause of the progress of gastric glandular atrophy, a high-risk background factor in the development of gastric cancer. Regression of gastric atrophy is critical to prevention of cancer by H. pylori eradication treatment. However, it is controversial whether gastric a...

journal_title：Alimentary pharmacology & therapeutics

authors： Sugiyama T,Sakaki N,Kozawa H,Sato R,Fujioka T,Satoh K,Sugano K,Sekine H,Takagi A,Ajioka Y,Takizawa T,H. Pylori Forum Gastritis Study Group.

更新日期：2002-04-01 00:00:00

abstract：:In a randomly allocated, double-blind, endoscopically controlled study, 98 patients with gastric ulcers were treated with either (a synthetic prostaglandin of E2-like structure) enprostil 70 micrograms b.d. or 150 mg ranitidine b.d. The healing rates at 4, 8 and 12 weeks were enprostil 57, 91 and 94% and for ranitidin...

journal_title：Alimentary pharmacology & therapeutics

authors： Morgan AG,Pacsoo C,Taylor P,McAdam WA

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake. TZP-101 (ulimorelin) is a ghrelin receptor agonist that accelerates gastric emptying and improves upper gastrointestin...

journal_title：Alimentary pharmacology & therapeutics

authors： Wo JM,Ejskjaer N,Hellström PM,Malik RA,Pezzullo JC,Shaughnessy L,Charlton P,Kosutic G,McCallum RW

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:In the past decade, a number of population-based studies have examined the prevalence of coeliac disease in individuals with type 1 diabetes but prevalences have differed considerably. AIM:To examine the prevalence of coeliac disease in individuals with type 1 diabetes. METHODS:A systematic review of Engli...

journal_title：Alimentary pharmacology & therapeutics

authors： Elfström P,Sundström J,Ludvigsson JF

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:A variety of tests have been proposed for colorectal cancer (CRC), giving rise to uncertainty regarding the optimal approach. The efficacy and effectiveness of different tests are related to both screened participation and the detection rate. AIM:To perform a meta-analysis on adherence and detection rates o...

journal_title：Alimentary pharmacology & therapeutics

authors： Hassan C,Giorgi Rossi P,Camilloni L,Rex DK,Jimenez-Cendales B,Ferroni E,Borgia P,Zullo A,Guasticchi G,HTA Group.

更新日期：2012-11-01 00:00:00

abstract：:There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-o...

journal_title：Alimentary pharmacology & therapeutics

authors： Fraser AG

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Patients with inflammatory bowel diseases (IBD) have an increased risk of clostridium difficile infection (CDI). Cathelicidins are anti-microbial peptides that attenuate colitis and inhibit the effect of clostridial toxins. Plasma calcifediol [25(OH)D] stimulates production of cathelicidins. AIM:To examine ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Cagan A,Gainer VS,Cheng SC,Cai T,Szolovits P,Shaw SY,Churchill S,Karlson EW,Murphy SN,Kohane I,Liao KP

更新日期：2014-05-01 00:00:00

abstract：:The common response to infection is infiltration of the affected tissue by inflammatory cells. It is now recognized that the epithelium plays a crucial role in this immunological process by producing an array of proinflammatory cytokines including interleukin-8, tumour necrosis factor-alpha, monocyte chemotactic prote...

journal_title：Alimentary pharmacology & therapeutics

authors： Hecht G,Savkovic SD

更新日期：1997-12-01 00:00:00