Clinical trial: long-term use of proton pump inhibitors in primary care patients - a cross sectional analysis of 901 patients.

abstract：BACKGROUND:The accuracy of symptom-based diagnostic criteria for irritable bowel syndrome (IBS) is modest. AIMS:To derive and validate a new test that utilises latent class analysis. METHODS:Symptom, colonoscopy, and histology data were collected from 1981 patients and 360 patients in two cohorts referred to secondar...

journal_title：Alimentary pharmacology & therapeutics

authors： Sood R,Gracie DJ,Gold MJ,To N,Pinto-Sanchez MI,Bercik P,Moayyedi P,Ford AC,Law GR

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Transjugular intrahepatic portosystemic stent shunts (TIPSS) have been used successfully to reduce portal pressure in the context of variceal haemorrhage. Recent interest has focused on the possible use of TIPSS to manage refractory ascites. AIM:To study the effect of TIPSS insertion in 18 patients with ref...

journal_title：Alimentary pharmacology & therapeutics

authors： Forrest EH,Stanley AJ,Redhead DN,McGilchrist AJ,Hayes PC

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:More convenient therapies are needed to treat Helicobacter pylori infection successfully. Clarithromycin and amoxycillin are effective against H. pylori both in vivo and in vitro. Recent success with a high dose amoxycillin-metronidazole combination therapy led us to evaluate clarithromycin-amoxycillin dual ...

journal_title：Alimentary pharmacology & therapeutics

authors： al-Assi MT,Genta RM,Karttunen TJ,Graham DY

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:In 1997-1998, 6127 asymptomatic children aged 2-4 years were screened for coeliac disease (CD) by anti-endomysium (EmA) testing in the Netherlands. After 6 (+/-2) months, biopsies were performed in 57 seropositive children; 31(54%) had villous atrophy, but 26 (46%), all HLA-DQ2/DQ8 positive, had normal histo...

journal_title：Alimentary pharmacology & therapeutics

authors： Hogen Esch CE,Csizmadia GD,van Hoogstraten IM,Schreurs MW,Mearin ML,von Blomberg BM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Antibiotic resistance and duration of therapy influence the success of proton-pump inhibitor-containing Helicobacter pylori eradication therapy. Clarithromycin resistance is associated with treatment failure. AIM:To examine the success of a 7-day rabeprazole-clarithromycin-amoxicillin therapy in the study p...

journal_title：Alimentary pharmacology & therapeutics

authors： Cardenas VM,Graham DY,El-Zimaity HM,Opekun AR,Campos A,Chavez A,Guerrero L

更新日期：2006-01-15 00:00:00

abstract：BACKGROUND:An impairment of cellular immune response may contribute to the persistency of hepatitis C virus infection. AIM:To analyse the Th1/Th2 cytokine profile in peripheral blood CD4(+) and CD8(+) T cells from patients with chronic hepatitis C (CHC) during treatment with pegylated interferon-alpha2a plus ribavirin...

journal_title：Alimentary pharmacology & therapeutics

authors： Trapero-Marugán M,García-Buey L,Muñoz C,Quintana NE,Moreno-Monteagudo JA,Borque MJ,Fernández MJ,Salvanés FR,Medina J,Moreno-Otero R

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...

journal_title：Alimentary pharmacology & therapeutics

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Ockenga J,Kreutz R,Garbe E

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The safety of anti-tumour necrosis factor (TNF) agents during pregnancy is a major concern for child-bearing women and physicians. AIM:To assess the impact of anti-TNF therapy on adverse pregnancy and foetal outcomes in women with inflammatory bowel disease (IBD). METHODS:Pregnancies occurring during anti-...

journal_title：Alimentary pharmacology & therapeutics

authors： Seirafi M,de Vroey B,Amiot A,Seksik P,Roblin X,Allez M,Peyrin-Biroulet L,Marteau P,Cadiot G,Laharie D,Boureille A,De Vos M,Savoye G,Rahier JF,Carbonnel F,Bonaz B,Colombel JF,Bouhnik Y

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Pantoprazole is a new substituted benzimidazole that blocks the H+/K(+)-ATPase in the gastric mucosa and thus inhibits acid secretion. METHODS:Efficacy and tolerability of pantoprazole (40 mg at breakfast) and ranitidine (300 mg at bedtime) in the treatment of uncomplicated acute duodenal ulcer were compare...

journal_title：Alimentary pharmacology & therapeutics

authors： Judmaier G,Koelz HR

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND:We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates. METHODS:A comprehensive search of a...

journal_title：Alimentary pharmacology & therapeutics

authors： Houben MH,van de Beek D,Hensen EF,de Craen AJ,Rauws EA,Tytgat GN

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Bodybuilding supplements can cause a profound cholestatic syndrome. AIM:To describe the drug-Induced liver injury network's experience with liver injury due to bodybuilding supplements. METHODS:Liver injury pattern, severity and outcomes, potential genetic associations, and exposure to anabolic steroids by...

journal_title：Alimentary pharmacology & therapeutics

authors： Stolz A,Navarro V,Hayashi PH,Fontana RJ,Barnhart HX,Gu J,Chalasani NP,Vega MM,Bonkovsky HL,Seeff LB,Serrano J,Avula B,Khan IA,Cirulli ET,Kleiner DE,Hoofnagle JH,DILIN Investigators.

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is expected to become a leading aetiology of hepatocellular carcinoma (HCC)-related mortality in the United States. HCC treatments with curative intent (OLT, orthotopic liver transplantation; resection; RFA, radiofrequency ablation) can improve survival in carefully ...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong CR,Njei B,Nguyen MH,Nguyen A,Lim JK

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The long-term time trends of multiple gastrointestinal diseases are characterised by a striking rise and fall. These temporal changes provide important clues about disease aetiology. AIM:To highlight the importance of Helicobacter pylori infection in shaping the temporal trends of many common gastrointestin...

journal_title：Alimentary pharmacology & therapeutics

authors： Sonnenberg A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Direct comparisons are lacking between vedolizumab and tumour necrosis factor (TNF)-antagonist therapy in Crohn's disease (CD). AIM:To compare safety and effectiveness of vedolizumab and TNF-antagonist therapy in adult CD patients. METHODS:Retrospective observational cohort (May 2014-December 2017) propens...

journal_title：Alimentary pharmacology & therapeutics

authors： Bohm M,Xu R,Zhang Y,Varma S,Fischer M,Kochhar G,Boland B,Singh S,Hirten R,Ungaro R,Shmidt E,Lasch K,Jairaith V,Hudesman D,Chang S,Lukin D,Swaminath A,Sands BE,Colombel JF,Kane S,Loftus EV Jr,Shen B,Siegel CA,

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies. AIM:To systematically evaluate whether adding probiotics to anti-H. pylori regimens could improve eradication rates and reduce side effects during anti-H. pylori treatment. METHODS:Eligib...

journal_title：Alimentary pharmacology & therapeutics

authors： Tong JL,Ran ZH,Shen J,Zhang CX,Xiao SD

更新日期：2007-01-15 00:00:00

abstract：BACKGROUND:Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion. AIM:To determine the effect of PPI therapy on the gastric volume after a standard meal. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Babaei A,Bhargava V,Aalam S,Scadeng M,Mittal RK

更新日期：2009-04-15 00:00:00

abstract：BACKGROUND:Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. AIM:To investigate the possible association of herbal medicines with IMP. METHOD:The clinical data of...

journal_title：Alimentary pharmacology & therapeutics

authors： Hiramatsu K,Sakata H,Horita Y,Orita N,Kida A,Mizukami A,Miyazawa M,Hirai S,Shimatani A,Matsuda K,Matsuda M,Ogino H,Fujinaga H,Terada I,Shimizu K,Uchiyama A,Ishizawa S,Abo H,Demachi H,Noda Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:The hepatitis C virus (HCV) care cascade has changed dramatically following the introduction of direct-acting anti-virals (DAAs). Up-to-date estimates of the cascade are needed to monitor progress, identify key gaps and inform policy. AIM:To estimate the current and future HCV care cascade in the United Sta...

journal_title：Alimentary pharmacology & therapeutics

authors： Chhatwal J,Chen Q,Bethea ED,Hur C,Spaulding AC,Kanwal F

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Gastroparesis is a chronic disorder caused by stomach pump failure and characterized by profound nausea, vomiting and epigastric pain. Most often, the cause is unapparent and of the known associations, diabetes is the most common. Diagnosis is usually made using an isotope-labelled test meal. Treatment is in...

journal_title：Alimentary pharmacology & therapeutics

authors： Patrick A,Epstein O

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Microbial translocation from the gut lumen has been involved in the pathogenesis of liver damage in hepatitis C virus (HCV) infection. AIM:To investigate the impact of direct-acting antiviral treatment on microbial translocation and T-cell activation, in patients with hepatitis C-related liver disease. MET...

journal_title：Alimentary pharmacology & therapeutics

authors： Lattanzi B,Baroncelli S,De Santis A,Galluzzo CM,Mennini G,Michelini Z,Lupo M,Ginanni Corradini S,Rossi M,Palmisano L,Merli M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Following a nil per os (NPO) regimen, most patients with acute pancreatitis (AP) can resume normal oral intake within 1 week. If not tolerated, it is recommended to initiate artificial feeding, preferably by the enteral route. AIM:To evaluate the nutritional management of patients with AP in a Dutch cohort ...

journal_title：Alimentary pharmacology & therapeutics

authors： Spanier BW,Mathus-Vliegen EM,Tuynman HA,Van der Hulst RW,Dijkgraaf MG,Bruno MJ,EARL Study Group.

更新日期：2008-11-01 00:00:00

abstract：:In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o.m. and 91 cimetidine 800 mg nocte for 2 or, if then not healed, 4 weeks. After 2 weeks the healing rates on an intention-to-treat basis were: for omeprazole 62% and for cimetidine 33% (P less than 0.001), an...

journal_title：Alimentary pharmacology & therapeutics

authors： Crowe JP,Wilkinson SP,Bate CM,Willoughby CP,Peers EM,Richardson PD

更新日期：1989-02-01 00:00:00

abstract：:Eighteen healthy volunteers were included in a cross-over, double-blind study where 500 mg naproxen b.d. was given for 1 week with 20 mg famotidine b.d., 40 mg nocte or placebo. Endoscopic evaluation of the gastroduodenal mucosa was performed before and after each treatment period, with separate evaluation of the mid-...

journal_title：Alimentary pharmacology & therapeutics

authors： Aabakken L,Bjørnbeth BA,Weberg R,Viksmoen L,Larsen S,Osnes M

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Tacrolimus is a calcineurin inhibitor commonly used for prophylaxis of rejection in renal and liver transplantation. There are limited but favourable data regarding its possible use in patients with inflammatory bowel disease (IBD). AIMS:To evaluate the efficacy and safety of tacrolimus in patients with IBD...

journal_title：Alimentary pharmacology & therapeutics

authors： Rodríguez-Lago I,Castro-Poceiro J,Fernández-Clotet A,Mesonero F,López-Sanromán A,López-García A,Márquez L,Clos-Parals A,Cañete F,Vicuña M,Nantes Ó,Merino O,Matallana V,Gordillo J,Elorza A,Vicente R,Casanova MJ,Ferreiro-

更新日期：2020-05-01 00:00:00

abstract：:The mode of transmission of Helicobacter pylori is largely unknown and is a matter of circumstantial evidence and speculation rather than fact. However, the principle evidence is of two sorts: the epidemiological data, providing evidence of possible risk factors associated with transmission, and the identification of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Vaira D,Holton J,Ricci C,Menegatti M,Gatta L,Berardi S,Tampieri A,Miglioli M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Helicobacter-negative gastritis has been increasingly reported. Molecular techniques as the polymerase chain reaction (PCR) may detect bacterial DNA in histologically negative gastritis. AIM:To evaluate of Helicobacter PCR in gastric biopsies for the daily diagnostics of Helicobacter-negative gastritis. ME...

journal_title：Alimentary pharmacology & therapeutics

authors： Kiss S,Zsikla V,Frank A,Willi N,Cathomas G

更新日期：2016-04-01 00:00:00

abstract：:Coeliac disease is a chronic inflammatory condition associated with small intestinal injury that results in the malabsorption of different nutrients. The damaging factor is gluten present in wheat, barley and rye. The diagnosis relies on the clinical picture of the patient, serological markers for coeliac disease, cha...

journal_title：Alimentary pharmacology & therapeutics

authors： Abdulkarim AS,Murray JA

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:In patients with chronic hepatitis C virus infection and persistently normal alanine aminotransferase levels, liver fibrosis has been reported in 0-22% of cases and advanced liver disease in 5-10% of cases. AIM:To determine whether patients with persistently normal alanine aminotransferase levels clear infe...

journal_title：Alimentary pharmacology & therapeutics

authors： Mangia A,Spinzi G,Vuturo O,Pazienza V,Iacobellis A,Piattelli M,Giacobbe A,Leandro G,Piermanni V,Minoli G,Montalto G,Andriulli A

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The presence of antibodies towards infliximab (ATI) is associated with lower infliximab (IFX) trough concentrations and loss of response. IFX treatment intensification is effective for restoring response in most, but not all patients with Crohn's disease (CD). AIM:To compare outcome, pharmacokinetics and im...

journal_title：Alimentary pharmacology & therapeutics

authors： Dreesen E,Van Stappen T,Ballet V,Peeters M,Compernolle G,Tops S,Van Steen K,Van Assche G,Ferrante M,Vermeire S,Gils A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:There has been growing interest in the use of faecal microbiota transplantation (FMT) for the treatment of gastrointestinal and nongastrointestinal diseases. AIM:To review systematically the reported efficacy and safety of FMT in the management of gastrointestinal and nongastrointestinal disorders in adults...

journal_title：Alimentary pharmacology & therapeutics

authors： Sha S,Liang J,Chen M,Xu B,Liang C,Wei N,Wu K

更新日期：2014-05-01 00:00:00