Dose-response evaluation of the antisecretory effect of continuous infusion intravenous lansoprazole regimens over 48 h.

abstract：BACKGROUND:Lymphogranuloma venereum (LGV) is a recognized cause of proctitis. Symptoms, endoscopy and histology findings are similar in IBD and LGV proctitis. AIMS:To characterize the clinical, endoscopic and histological features seen in men diagnosed initially with IBD and subsequently with LGV proctitis, and to att...

journal_title：Alimentary pharmacology & therapeutics

authors： Soni S,Srirajaskanthan R,Lucas SB,Alexander S,Wong T,White JA

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC chemokines are also reported to have angiogenic activity and to serve as rem...

journal_title：Alimentary pharmacology & therapeutics

authors： Suzuki H,Mori M,Seto K,Shibata F,Nagahashi S,Kawaguchi C,Suzuki M,Matsui H,Watanabe K,Miura S,Ishii H

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Randomized, placebo controlled trials are used to assess the efficacy of therapies for Crohn's disease. The placebo response and remission rates vary among studies. AIM:To analyse how the placebo response and remission rates in Crohn's trials have changed over time in the era of parenteral biologic therapie...

journal_title：Alimentary pharmacology & therapeutics

authors： Gallahan WC,Case D,Bloomfeld RS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Therapy with adalimumab has been shown to be effective in Crohn's disease (CD) patients who have lost response or are intolerant to infliximab. AIM:To determine the efficacy of adalimumab in CD patients who discontinued infliximab through a systematic review. METHODS:Electronic searches of EMBASE and MEDLI...

journal_title：Alimentary pharmacology & therapeutics

authors： Ma C,Panaccione R,Heitman SJ,Devlin SM,Ghosh S,Kaplan GG

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:The success of eradication therapy for Helicobacter pylori might be affected by the age of patients. AIM:To investigate whether disposition of drugs commonly used for H. pylori eradication is age-dependent. METHODS:Trough steady state serum levels of lansoprazole or ranitidine, amoxycillin, clarithromycin ...

journal_title：Alimentary pharmacology & therapeutics

authors： Ammon S,Treiber G,Kees F,Klotz U

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...

journal_title：Alimentary pharmacology & therapeutics

authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Ockenga J,Kreutz R,Garbe E

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:The hepatitis C virus (HCV) care cascade has changed dramatically following the introduction of direct-acting anti-virals (DAAs). Up-to-date estimates of the cascade are needed to monitor progress, identify key gaps and inform policy. AIM:To estimate the current and future HCV care cascade in the United Sta...

journal_title：Alimentary pharmacology & therapeutics

authors： Chhatwal J,Chen Q,Bethea ED,Hur C,Spaulding AC,Kanwal F

更新日期：2019-07-01 00:00:00

abstract：:The goals of the Baveno workshops were to develop consensus definitions of key events related to portal hypertension and variceal bleeding, and to produce guidelines to facilitate the conduct and reporting of clinical trials. The consensus definitions concern the diagnosis of active bleeding, failure to control bleedi...

journal_title：Alimentary pharmacology & therapeutics

authors： de Franchis R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Gastro-oesophageal reflux disease is a common entity. Erosive oesophagitis, ulcers and Barrett's oesophagus, which is found in up to 10% of gastro-oesophageal reflux disease patients, characterize severe gastro-oesophageal reflux disease. Patients with Barrett's oesophagus have 0.5% per patient-year risk of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Eliakim R,Yassin K,Shlomi I,Suissa A,Eisen GM

更新日期：2004-11-15 00:00:00

abstract：BACKGROUND:It is controversial whether chronic hepatitis B (CHB) patients have more non-liver comorbidities than non-CHB subjects. AIM:To characterise the demographics, comorbidity and health utilisation of CHB patients in South Korea and compare them to matched controls. METHODS:Using the Health Insurance Review & A...

journal_title：Alimentary pharmacology & therapeutics

authors： Oh H,Jun DW,Lee IH,Ahn HJ,Kim BO,Jung S,Nguyen MH

更新日期：2020-07-01 00:00:00

abstract：:In a double-blind crossover study, lower oesophageal sphincter pressure (LOSP) and distal oesophageal motility were studied in eight healthy volunteers following a single intravenous dose of omeprazole or placebo. Lower oesophageal sphincter pressure was determined before and at intervals up to 120 min after intraveno...

journal_title：Alimentary pharmacology & therapeutics

authors： Chakraborty TK,De Caestecker JS,Pryde A,Heading RC

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Magnetic resonance entero-colonography enables accurate assessment of ileocolonic Crohn's disease, but the need for bowel cleansing and rectal enema limits considerably its use in daily practice. AIM:We evaluated the accuracy of diffusion-weighted magnetic resonance entero-colonography with neither bowel cl...

journal_title：Alimentary pharmacology & therapeutics

authors： Buisson A,Hordonneau C,Goutte M,Boyer L,Pereira B,Bommelaer G

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Radiotherapy is an established treatment modality for prostate cancer; however, up to a third of patients develops a radiation-induced proctopathy. AIM:To assess the effect of topical beclomethasone dipropionate (BDP) in the prevention of radiation-induced proctopathy in patients undergoing radiotherapy for...

journal_title：Alimentary pharmacology & therapeutics

authors： Fuccio L,Guido A,Laterza L,Eusebi LH,Busutti L,Bunkheila F,Barbieri E,Bazzoli F

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

journal_title：Alimentary pharmacology & therapeutics

authors： Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Travellers' diarrhoea, a common problem worldwide with significant medical impact, is generally treated with anti-diarrhoeal agents and fluid replacement. Systemic antibiotics are also used in selected cases, but these may be associated with adverse effects, bacterial resistance and drug-drug interactions. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Layer P,Andresen V

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Epidemiological data concerning hepatitis B are scarce in France. AIM:To describe epidemiological, clinical, virological and histological features of HBsAg-positive patients followed at non-academic hospitals in France. METHODS:Clinical, biological, virological and histological data of all HBsAg-positive c...

journal_title：Alimentary pharmacology & therapeutics

authors： Cadranel JF,Lahmek P,Causse X,Bellaiche G,Bettan L,Fontanges T,Medini A,Henrion J,Chousterman M,Condat B,Hervio P,Periac P,Eugène C,Moindrot H,Grasset D,Nouel O,Pilette C,Szostak-Talbodec N,Cayla JM,Si-Ahmed SN,Du

更新日期：2007-08-15 00:00:00

abstract：AIM:To evaluate (i) the diagnostic usefulness of a delayed test in initially negative patients; and (ii) the reliability of the rapid urease test, histology or a combination of the two to diagnose Helicobacter pylori during emergency endoscopy in a large clinical practice series. PATIENTS AND METHODS:Records of patien...

journal_title：Alimentary pharmacology & therapeutics

authors： Güell M,Artigau E,Esteve V,Sánchez-Delgado J,Junquera F,Calvet X

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Gastrimmune is an immunogenic form of gastrin. It raises in situ antibodies against two proliferative forms of gastrin: amidated and glycine-extended gastrin-17. It has been shown to have a therapeutic action in several in vivo tumour models. Following immunization, due to the complex equilibrium that exists...

journal_title：Alimentary pharmacology & therapeutics

authors： Smith AM,Morris T,Justin T,Michaeli D,Watson SA

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:HCV-TARGET is a longitudinal observational study of chronic hepatitis C virus (HCV) patients treated with direct-acting anti-viral agents (DAAs) in a US consortium of 90 academic and community medical centres. AIM:To assess utilisation of response-guided therapy (RGT) and sustained virological response (SVR...

journal_title：Alimentary pharmacology & therapeutics

authors： Sterling RK,Kuo A,Rustgi VK,Sulkowski MS,Stewart TG,Fenkel JM,El-Genaidi H,Mah'moud MA,Abraham GM,Stewart PW,Akushevich L,Nelson DR,Fried MW,Di Bisceglie AM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Bismuth compounds prevent gastric injury from the short-term administration of nonsteroidal anti-inflammatory drugs. We studied the mechanisms underlying the gastroprotective actions of bismuth subsalicylate against indomethacin-induced injury in rats. METHODS:An in vivo microscopic technique was used in wh...

journal_title：Alimentary pharmacology & therapeutics

authors： Tanaka S,Guth PH,Carryl OR,Kaunitz JD

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:Patients with coronary artery disease (CAD) treated with stents require dual antiplatelet therapy (DAPT). For cirrhotics, who often have varices and coagulopathy, it is not clear if the risk of gastrointestinal bleeding (GIB) should preclude use of DAPT. AIM:To compare GIB and mortality rates in cirrhotics ...

journal_title：Alimentary pharmacology & therapeutics

authors： Krill T,Brown G,Weideman RA,Cipher DJ,Spechler SJ,Brilakis E,Feagins LA

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:There has been growing interest in the use of faecal microbiota transplantation (FMT) for the treatment of gastrointestinal and nongastrointestinal diseases. AIM:To review systematically the reported efficacy and safety of FMT in the management of gastrointestinal and nongastrointestinal disorders in adults...

journal_title：Alimentary pharmacology & therapeutics

authors： Sha S,Liang J,Chen M,Xu B,Liang C,Wei N,Wu K

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:The efficacy of each probiotic should be evaluated separately. Previously, we have shown that Lactobacillus GG (LGG) is effective in treating acute gastroenteritis (AGE) in children. AIM:To update our 2007 meta-analysis on the effectiveness of LGG in treating AGE in children. METHODS:The Cochrane Library, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Szajewska H,Skórka A,Ruszczyński M,Gieruszczak-Białek D

更新日期：2013-09-01 00:00:00

abstract：:Despite the fact that non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs in medicine today, 2-10% of patients must discontinue their use primarily due to gastrointestinal (GI) side-effects. While the development of non-aspirin NSAIDs (NA-NSAIDs) has significantly reduced GI side-effect...

journal_title：Alimentary pharmacology & therapeutics

authors： Butt JH,Barthel JS,Hosokawa MC,Moore RA

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:A lack of reliable treatments for abdominal pain-related functional gastrointestinal disorders prompts interest in new therapies. AIM:To evaluate systematically the effect of Lactobacillus rhamnosus GG (LGG) for treating abdominal pain-related functional gastrointestinal disorders in children. METHODS:MEDL...

journal_title：Alimentary pharmacology & therapeutics

authors： Horvath A,Dziechciarz P,Szajewska H

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) risk after resolving chronic hepatitis B virus (HBV) infection is unclear. AIM:To compare HCC risk between Alaska Native (AN) patients with and without hepatitis B surface antigen (HBsAg) seroclearance. METHODS:We selected persons with (case-patients) and without (control-pat...

journal_title：Alimentary pharmacology & therapeutics

authors： Gounder PP,Bulkow LR,Snowball M,Negus S,Spradling PR,Simons BC,McMahon BJ

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:The efficacy of many pharmacological agents for preventing post-ERCP pancreatitis (PEP) has been evaluated in randomised controlled trials (RCTs), but it is unclear which agent(s) should be used in clinical practice. Network meta-analyses of RCTs are used to simultaneously compare several agents to determine...

journal_title：Alimentary pharmacology & therapeutics

authors： Akshintala VS,Hutfless SM,Colantuoni E,Kim KJ,Khashab MA,Li T,Elmunzer BJ,Puhan MA,Sinha A,Kamal A,Lennon AM,Okolo PI,Palakurthy MK,Kalloo AN,Singh VK

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Differentiating symptoms of irritable bowel syndrome from those of organic intestinal disease is a common clinical problem. Several neutrophil-derived proteins have been proposed as a marker of inflammatory bowel disease. AIM:To compare the diagnostic value of faecal calprotectin, lactoferrin and polymorpho...

journal_title：Alimentary pharmacology & therapeutics

authors： Schröder O,Naumann M,Shastri Y,Povse N,Stein J

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Five oral nucleos(t)ide analogues are available to treat chronic hepatitis B (CHB). With the availability of newer agents, their efficacy on incidence of hepatocellular carcinoma (HCC) is not well described. AIM:To determine the efficacy of oral anti-viral agents in reducing HCC risk in relationship with ot...

journal_title：Alimentary pharmacology & therapeutics

authors： Singal AK,Salameh H,Kuo YF,Fontana RJ

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Autoimmune atrophic gastritis (AAG) is characterised by a wide clinical spectrum that could delay its diagnosis. AIMS:To quantify the diagnostic delay in patients suffering from AAG and to explore possible risk factors for longer diagnostic delay. METHODS:Consecutive patients with AAG evaluated at our gast...

journal_title：Alimentary pharmacology & therapeutics

authors： Lenti MV,Miceli E,Cococcia S,Klersy C,Staiani M,Guglielmi F,Giuffrida P,Vanoli A,Luinetti O,De Grazia F,Di Stefano M,Corazza GR,Di Sabatino A

更新日期：2019-07-01 00:00:00