Review article: gastro-oesophageal reflux and laryngeal symptoms.

Abstract:

:There is some evidence from clinical, experimental and multiprobe ambulatory pH studies that gastro-oesophageal reflux is more common in patients with laryngeal symptoms and could potentially play a role in the causation of these symptoms. The proportion of unselected patients with laryngeal symptoms who have gastro-oesophageal reflux as the primary aetiology may be overestimated in some series. The symptom that has been most evaluated is hoarseness, but even for this symptom the proportion of patients who have significant reflux varies widely. There is even less agreement for other symptoms, and the data on globus sensation remains confused. It is likely that these patients present to ear, nose and throat (ENT) clinics because of the relative insensitivity of the oesophageal mucosa to acid exposure. Given the lack of specificity for routine diagnostic tests for gastro-oesophageal reflux, it is necessary to perform ambulatory pH monitoring for a secure diagnosis in these patients. Treatment studies have been surprisingly few and inadequate in design. It is suspected that there is a strong placebo response for these symptoms. No clear information on efficacy can be provided until placebo-controlled randomised studies are available.

journal_name

Aliment Pharmacol Ther

authors

Fraser AG

doi

10.1111/j.1365-2036.1994.tb00287.x

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

265-72

issue

3

eissn

0269-2813

issn

1365-2036

journal_volume

8

pub_type

杂志文章,评审
  • Hepatitis vaccination in patients with hepatitis C: practice and validation of codes at a large Veterans Administration Medical Centre.

    abstract:BACKGROUND:Hepatitis vaccination is recommended in patients with chronic liver disease. AIM:To validate Current Procedural Terminology (CPT) codes and drug codes for hepatitis vaccination in administrative databases and determine vaccination rates in hepatitis C virus (HCV)-infected patients in a single large Veterans...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2008.03827.x

    authors: Hachem CY,Kramer JR,Kanwal F,El-Serag HB

    更新日期:2008-11-01 00:00:00

  • An open trial of long-term therapy with lansoprazole in patients with peptic ulceration resistant to extended high-dose ranitidine treatment.

    abstract::Forty-two patients with peptic ulceration of the duodenum, stomach or oesophagus, who had not responded to 3 or more months of high-dose treatment with ranitidine (450 or 600 mg/day), were treated with oral lansoprazole at 30-60 mg daily. In 40 patients (95.2%) the ulcers healed within 2-12 weeks. In the remaining 2 p...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2036.1993.tb00589.x

    authors: Brunner G,Arnold R,Hennig U,Fuchs W

    更新日期:1993-01-01 00:00:00

  • Maternal and foetal adverse events with tumour necrosis factor-alpha inhibitors in inflammatory bowel disease.

    abstract:BACKGROUND:Transplacental transfer of tumour necrosis factor-alpha (TNF-α) inhibitors has been shown in mothers receiving therapy for inflammatory bowel disease (IBD). AIM:To examine reports of adverse events of these medications in pregnancy. METHODS:Individual Safety Reports of adverse events (Jan 2003-June 2012) w...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12936

    authors: Deepak P,Stobaugh DJ

    更新日期:2014-11-01 00:00:00

  • Prevalence, clinical spectrum and atypical symptoms of gastro-oesophageal reflux in Argentina: a nationwide population-based study.

    abstract:BACKGROUND:Population-based data on gastro-oesophageal reflux in Latin America are lacking. AIM:To assess gastro-oesophageal reflux symptom prevalence, clinical spectrum and association with the atypical symptoms in our country. METHODS:Gastro-oesophageal reflux self-report questionnaires validated at Mayo Clinic, US...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2005.02565.x

    authors: Chiocca JC,Olmos JA,Salis GB,Soifer LO,Higa R,Marcolongo M,ARGENTINEAN GASTRO-OESOPHAGEAL REFLUX STUDY GROUP.

    更新日期:2005-08-15 00:00:00

  • How accurate is the determination of blood in gastric juice? Comparison of peroxidase and porphyrin methods.

    abstract:BACKGROUND:Mucosal bleeding is frequently used as a measure of gastric mucosal integrity. We compared the orthotolidine method for quantifying haemoglobin in gastric juice with a method based on measurement of fluorescent porphyrins extracted from haem. We also investigated whether acid or pepsin had a deleterious effe...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.0953-0673.1996.00333.x

    authors: Woods KL,Kiefe C,Graham DY

    更新日期:1996-06-01 00:00:00

  • Hepatitis C virus therapy is associated with lower health care costs not only in noncirrhotic patients but also in patients with end-stage liver disease.

    abstract:BACKGROUND:The effect of anti-viral treatment on downstream costs for hepatitis C virus (HCV)-infected patients is unknown. AIM:To evaluate follow-up costs in patients with chronic HCV, stratified by liver disease severity. METHODS:Using a US private insurance database, mean all-cause per-patient-per-month (PPPM) US ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12454

    authors: Gordon SC,Hamzeh FM,Pockros PJ,Hoop RS,Buikema AR,Korner EJ,Terrault NA

    更新日期:2013-10-01 00:00:00

  • Autoimmune cholestatic liver disease in people with coeliac disease: a population-based study of their association.

    abstract:BACKGROUND:Population data supporting an association between the autoimmune cholestatic liver diseases, primary biliary cirrhosis and primary sclerosing cholangitis and coeliac disease, is limited and at times contradictory. AIM:To explore the relationship between coeliac disease and both primary biliary cirrhosis and...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2005.02328.x

    authors: Lawson A,West J,Aithal GP,Logan RF

    更新日期:2005-02-15 00:00:00

  • Review article: the efficacy of biomarkers in chronic fibroproliferative diseases - early diagnosis and prognosis, with liver fibrosis as an exemplar.

    abstract:BACKGROUND:Nearly 45% of all deaths are associated with chronic fibroproliferative diseases, of which the primary characteristic is altered remodelling of the extracellular matrix. A major difficulty in developing anti-fibrotic therapies is the lack of accurate and established techniques to estimate dynamics of fibrosi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.12820

    authors: Karsdal MA,Krarup H,Sand JM,Christensen PB,Gerstoft J,Leeming DJ,Weis N,Schaffalitzky de Muckadell OB,Krag A

    更新日期:2014-08-01 00:00:00

  • The prevalence of inflammatory sacroiliitis assessed on magnetic resonance imaging of inflammatory bowel disease: a retrospective study performed on 186 patients.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) colonography or enterography is increasingly used to assess disease activity and complications in inflammatory bowel disease (IBD). However, no study has evaluated the role of this imaging technique to assess sacroiliitis. AIM:The primary objective was to assess the prevalen...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12680

    authors: Leclerc-Jacob S,Lux G,Rat AC,Laurent V,Blum A,Chary-Valckenaere I,Peyrin-Biroulet L,Loeuille D

    更新日期:2014-05-01 00:00:00

  • Review article: management of chronic hepatitis C in patients with contraindications to anti-viral therapy.

    abstract:BACKGROUND:There are patients with chronic hepatitis C who are not eligible for the current interferon-based therapies or refuse to be treated due to secondary effects. AIM:To provide information on alternative treatments for the management of these patients. METHODS:A PubMed search was performed to identify relevant...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.12562

    authors: Carreño V

    更新日期:2014-01-01 00:00:00

  • Review Article: pain versus discomfort--is differentiation clinically useful?

    abstract::Functional dyspepsia is highly variable in its clinical presentation and multifactorial in its underlying causes. Since many of the symptoms included in the definition of dyspepsia are intuitively suggestive of different pathogenic mechanisms, it has been proposed that patients with functional dyspepsia be divided int...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.2001.00906.x

    authors: Stanghellini V

    更新日期:2001-02-01 00:00:00

  • Systematic review: cardiovascular safety profile of 5-HT(4) agonists developed for gastrointestinal disorders.

    abstract:BACKGROUND:The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs). AIM:To perform a systematic review of the safety profile, particularly cardiovascular, of 5-HT(4) agonists developed for gastrointestinal disorders, and a nonsystematic summary ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2012.05011.x

    authors: Tack J,Camilleri M,Chang L,Chey WD,Galligan JJ,Lacy BE,Müller-Lissner S,Quigley EM,Schuurkes J,De Maeyer JH,Stanghellini V

    更新日期:2012-04-01 00:00:00

  • Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis.

    abstract:BACKGROUND:This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD). METHODS:214 patients with symptomatic, non-erosive GERD (moderate to severe daytime and/or night-time heartburn greater than half ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2036.1999.00558.x

    authors: Richter JE,Kovacs TO,Greski-Rose PA,Huang section sign B,Fisher R

    更新日期:1999-06-01 00:00:00

  • Review article: alginate-raft formulations in the treatment of heartburn and acid reflux.

    abstract::Alginate-based raft-forming formulations have been marketed word-wide for over 30 years under various brand names, including Gaviscon. They are used for the symptomatic treatment of heartburn and oesophagitis, and appear to act by a unique mechanism which differs from that of traditional antacids. In the presence of g...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.2000.00759.x

    authors: Mandel KG,Daggy BP,Brodie DA,Jacoby HI

    更新日期:2000-06-01 00:00:00

  • Review article: anti-inflammatory mechanisms of action of Saccharomyces boulardii.

    abstract:BACKGROUND:Saccharomyces boulardii, a well-studied probiotic, can be effective in inflammatory gastrointestinal diseases with diverse pathophysiology, such as inflammatory bowel disease (IBD), and bacterially mediated or enterotoxin-mediated diarrhoea and inflammation. AIM:To discuss the mechanisms of action involved ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2009.04102.x

    authors: Pothoulakis C

    更新日期:2009-10-15 00:00:00

  • Nested case-control study: hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) risk after resolving chronic hepatitis B virus (HBV) infection is unclear. AIM:To compare HCC risk between Alaska Native (AN) patients with and without hepatitis B surface antigen (HBsAg) seroclearance. METHODS:We selected persons with (case-patients) and without (control-pat...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.13621

    authors: Gounder PP,Bulkow LR,Snowball M,Negus S,Spradling PR,Simons BC,McMahon BJ

    更新日期:2016-06-01 00:00:00

  • Prospective evaluation of ranitidine bismuth citrate-based triple therapy for the treatment of Helicobacter pylori infection.

    abstract:BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.1999.00509.x

    authors: Mönkemüller KE,Hirschowitz BI

    更新日期:1999-05-01 00:00:00

  • The impact of eosinophilia and hepatic necrosis on prognosis in patients with drug-induced liver injury.

    abstract:BACKGROUND:Drug-induced liver injury may be immunologically mediated or metabolically induced. Peripheral eosinophilia and liver eosinophilia in suspected drug-induced liver injury generally supports the role of drug aetiology. AIM:To assess the importance of eosinophilia and hepatic necrosis on outcome in patients wi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2007.03330.x

    authors: Björnsson E,Kalaitzakis E,Olsson R

    更新日期:2007-06-15 00:00:00

  • Occurrence and risk factors for benign epithelial gastric polyps in atrophic body gastritis on diagnosis and follow-up.

    abstract:BACKGROUND:Benign epithelial gastric polyps have been reported to be more common in atrophic body gastritis. The role of Helicobacter pylori infection in the induction of gastric atrophy is well-known. The development of hyperplastic polyps may be in relation to H. pylori infection. AIM:To investigate occurrence of be...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2005.02399.x

    authors: Di Giulio E,Lahner E,Micheletti A,Milione M,D'Ambra G,Bordi C,Delle Fave G,Annibale B

    更新日期:2005-03-01 00:00:00

  • Novel score for prediction of malignant bile duct obstruction based on biochemical and clinical markers.

    abstract:BACKGROUND:Early differentiation of malignant from benign bile duct obstruction is of utmost importance. AIM:To identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based applicatio...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.13152

    authors: Meister T,Uphoff MA,Heinecke A,Domagk D,Kunsch S,Lindhorst A,Ellenrieder V,Heinzow HS

    更新日期:2015-05-01 00:00:00

  • Lack of dose-response with Pancrease MT for the treatment of exocrine pancreatic insufficiency in adults.

    abstract:BACKGROUND:Choosing the optimum pancreatic enzyme replacement therapy for patients with exocrine insufficiency remains a problem. An enteric coated enzyme microsphere pancreatic enzyme preparation (Pancrease) has been marketed with several levels of lipase activity, implying that there is a dose-response relationship b...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2036.1997.00245.x

    authors: Opekun AR Jr,Sutton FM Jr,Graham DY

    更新日期:1997-10-01 00:00:00

  • Colonisation by Faecalibacterium prausnitzii and maintenance of clinical remission in patients with ulcerative colitis.

    abstract:BACKGROUND:Although incrimination of the intestinal microbiota in the pathogenesis of IBD is widely accepted, few data are available about the role of specific bacteria. Potentially, Faecalibacterium prausnitzii, bacteria with anti-inflammatory properties, might be deficient in ulcerative colitis (UC). AIM:To quantify...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.12365

    authors: Varela E,Manichanh C,Gallart M,Torrejón A,Borruel N,Casellas F,Guarner F,Antolin M

    更新日期:2013-07-01 00:00:00

  • Clinical trial: the effects of adding ranitidine at night to twice daily omeprazole therapy on nocturnal acid breakthrough and acid reflux in patients with systemic sclerosis--a randomized controlled, cross-over trial.

    abstract:BACKGROUND:Gastro-oesophageal reflux disease (GERD) is an important problem in systemic sclerosis due to impaired salivation and oesophageal function. AIM:To determine the efficacy of adding ranitidine at bedtime to control nocturnal acid breakthrough (NAB) and GERD in patients with systemic sclerosis already prescrib...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.2007.03469.x

    authors: Janiak P,Thumshirn M,Menne D,Fox M,Halim S,Fried M,Brühlmann P,Distler O,Schwizer W

    更新日期:2007-11-01 00:00:00

  • The influence of isolated doses of drugs, feeding and colonic bacterial ureolysis on urea breath test results.

    abstract:BACKGROUND:Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results. METHODS:Three different studies were performed. First, a 13C-UBT was performed in 41 Helicobacter pylori infected subjects ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.1995.tb00442.x

    authors: Perri F,Maes B,Geypens B,Ghoos Y,Hiele M,Rutgeerts P

    更新日期:1995-12-01 00:00:00

  • Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire.

    abstract:BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.2007.03271.x

    authors: van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

    更新日期:2007-05-01 00:00:00

  • Review article: molecular, pathological and therapeutic features of human enteric neuropathies.

    abstract:BACKGROUND:Considerable information has been gathered on the functional organization of enteric neuronal circuitries regulating gastrointestinal motility. However, little is known about the neuropathophysiological mechanisms underlying gastrointestinal motor disorders. AIM:To analyse the most important pathological fi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2008.03707.x

    authors: Di Nardo G,Blandizzi C,Volta U,Colucci R,Stanghellini V,Barbara G,Del Tacca M,Tonini M,Corinaldesi R,De Giorgio R

    更新日期:2008-07-01 00:00:00

  • Different effects of short-term omeprazole, lansoprazole or pantoprazole on the accuracy of the (13)C-urea breath test.

    abstract:BACKGROUND:Proton pump inhibitors may interfere with the accuracy of the (13)C-urea breath test, but little information is available on the effect of standard doses of various proton pump inhibitors on this test. AIM:To evaluate the effect of short-term standard doses of omeprazole, lansoprazole and pantoprazole on th...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2036.2002.01192.x

    authors: Parente F,Sainaghi M,Sangaletti O,Imbesi V,Maconi G,Anderloni A,Bianchi Porro G

    更新日期:2002-03-01 00:00:00

  • Association between diabetes mellitus and hepatic encephalopathy in patients with cirrhosis.

    abstract:BACKGROUND:Diabetes mellitus may lead to increased serum ammonia and systemic inflammation thereby promoting hepatic encephalopathy (HE). AIM:To investigate the potential association between diabetes mellitus/glycaemic control and the presence of covert HE as well as the development of overt HE in a prospective settin...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.15915

    authors: Labenz C,Nagel M,Kremer WM,Hilscher M,Schilling CA,Toenges G,Kuchen R,Schattenberg JM,Galle PR,Wörns MA

    更新日期:2020-08-01 00:00:00

  • NSAIDs: a clinical approach to the problems of gastrointestinal side-effects.

    abstract::Despite the fact that non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs in medicine today, 2-10% of patients must discontinue their use primarily due to gastrointestinal (GI) side-effects. While the development of non-aspirin NSAIDs (NA-NSAIDs) has significantly reduced GI side-effect...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.1988.tb00771.x

    authors: Butt JH,Barthel JS,Hosokawa MC,Moore RA

    更新日期:1988-01-01 00:00:00

  • Pregnancy outcome in inflammatory bowel disease: prospective European case-control ECCO-EpiCom study, 2003-2006.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) frequently affects women during their reproductive years. Pregnancy outcome in women with IBD is well described, particularly in retrospective studies. AIM:To evaluate the pregnancy outcome in patients with IBD in a prospective European multicentre case-control study. METHO...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2036.2011.04794.x

    authors: Bortoli A,Pedersen N,Duricova D,D'Inca R,Gionchetti P,Panelli MR,Ardizzone S,Sanroman AL,Gisbert JP,Arena I,Riegler G,Marrollo M,Valpiani D,Corbellini A,Segato S,Castiglione F,Munkholm P,European Crohn-Colitis Organisat

    更新日期:2011-10-01 00:00:00