Sleep-related gastro-oesophageal reflux: provocation with a late evening meal and treatment with acid suppression.

Abstract:

BACKGROUND:Two studies were carried out in order to investigate the issue of meal-provoked nocturnal gastrooesophageal reflux. METHODS:In Experiment 1, 20 symptomatic reflux patients underwent both pH and polysomnographic monitoring on two nights. On one night, patients ate a non-provocative meal prior to 19.00 hours, while on the other night patients consumed a late evening meal (21.00 hours). In Experiment 2.17 symptomatic reflux patients were studied using pH and polysomnographic monitoring on two nights subsequent to a late evening provocative meal. On one night, patients received 75 mg of the H2-antagonist ranitidine, while on another night they received a placebo. The data from 12 of the 17 patients studied were used in the analysis. RESULTS:For Experiment 1, no significant differences in the number or duration of reflux events, acid exposure (total %), or polysomnographic measures of per cent of sleep stages between the two nights were observed. The results of the second experiment demonstrated that when given ranitidine, patients experienced significant decrease in acid contact time (total %), and mean duration of reflux events. Subjective reports of discomfort and sleep disturbance were also significantly improved on the drug night. However, significant differences in polysomnographic measures were not observed. CONCLUSIONS:Based on these results, we conclude that in some symptomatic reflux patients a late-night non-provocative meal may not increase the incidence of gastro-oesophageal reflux, and that a low dose of an H2-antagonist is effective in decreasing oesophageal acid contact time following a late evening provocative meal.

journal_name

Aliment Pharmacol Ther

authors

Orr WC,Harnish MJ

doi

10.1046/j.1365-2036.1998.00407.x

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

1033-8

issue

10

eissn

0269-2813

issn

1365-2036

journal_volume

12

pub_type

临床试验,杂志文章
  • Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease generally has a benign course; however, patients with non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma. Currently, there is a lack of consensus about optimal NASH treatment. AIM:To assess the efficacy of insulin-sensitizing agents ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-2036.2010.04467.x

    authors: Rakoski MO,Singal AG,Rogers MA,Conjeevaram H

    更新日期:2010-11-01 00:00:00

  • Review article: tegaserod -- the global experience.

    abstract::Studies from the Western hemisphere have established the efficacy and safety of tegaserod in women with irritable bowel syndrome and constipation. This review summarizes the results of recent studies from around the world that confirm the efficacy and safety of tegaserod, and expand our understanding of the role of th...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2004.02181.x

    authors: Chey WD

    更新日期:2004-11-01 00:00:00

  • Review article: the diagnosis and treatment of haematinic deficiency in gastrointestinal disease.

    abstract::Deficiency of any of the vitamins and minerals essential for normal erythropoiesis (haematinics), including iron, copper, cobalt, vitamins A, B12, B6, C, E, folic acid, riboflavin and nicotinic acid, may be associated with defective erythropoiesis and anaemia. Iron, vitamin B12 and folate are the haematinics for which...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.1998.00368.x

    authors: Pawson R,Mehta A

    更新日期:1998-08-01 00:00:00

  • Renal function and cardiovascular risk profile after conversion from ciclosporin to tacrolimus: prospective study in 80 liver transplant recipients.

    abstract:BACKGROUND:Increased risk of cardiovascular and cerebrovascular disease in liver transplant recipients results in particular from the side effects of calcineurin inhibitor-based immunosuppressive therapy. Several studies have demonstrated a more favourable outcome for patients receiving tacrolimus (TAC) as compared wit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2009.04099.x

    authors: Beckebaum S,Klein C,Varghese J,Sotiropoulos GC,Saner F,Schmitz K,Gerken G,Paul A,Cicinnati VR

    更新日期:2009-10-15 00:00:00

  • Systematic review: macrophage activation syndrome in inflammatory bowel disease.

    abstract:BACKGROUND:Recently, there have been increasingly frequent reports on the occurrence of macrophage activation syndrome (MAS) in patients with inflammatory bowel disease (IBD). Clinically, MAS is characterized mainly by fever, hepatosplenomegaly, cytopenia, and elevated circulating ferritin and CD25. Mortality, even if ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.12305

    authors: Fries W,Cottone M,Cascio A

    更新日期:2013-06-01 00:00:00

  • A distinct subset of chemokines dominates the mucosal chemokine response in inflammatory bowel disease.

    abstract:BACKGROUND:Inflammatory bowel disease (IBD) is characterised by intense mucosal recruitment of activated leukocytes. Chemokines determine inflammatory leukocyte recruitment and retention. AIM:To compare expression of the entire chemokine family within colonic mucosa from IBD patients and uninflamed controls. METHODS:...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2004.02262.x

    authors: Puleston J,Cooper M,Murch S,Bid K,Makh S,Ashwood P,Bingham AH,Green H,Moss P,Dhillon A,Morris R,Strobel S,Gelinas R,Pounder RE,Platt A

    更新日期:2005-01-15 00:00:00

  • The emergence of non-hypervascular hypointense nodules on Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis C.

    abstract:BACKGROUND:Intrahepatic non-hypervascular hypointense nodules (NHHNs) detected during the hepatobiliary phase of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) have the potential to transition into typical hypervascular hepatocellular carcinoma (HCC). However, ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.15490

    authors: Toyoda H,Tada T,Yasuda S,Mizuno K,Sone Y,Kaneoka Y,Maeda A,Akita T,Tanaka J,Kumada T

    更新日期:2019-12-01 00:00:00

  • Review article: liver support systems in acute hepatic failure.

    abstract::The treatment of acute hepatic failure has developed rapidly over the last 40 years, reducing morbidity and mortality from this syndrome. Whilst this has been partly attributed to significant improvements in the specialist medical management of these patients, advances in surgical techniques and pharmaceutical develop...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.1999.00597.x

    authors: Rahman TM,Hodgson HJ

    更新日期:1999-10-01 00:00:00

  • Randomised clinical trial: identification of responders to short-term treatment with esomeprazole for dyspepsia in primary care - a randomised, placebo-controlled study.

    abstract:BACKGROUND:Response to proton pump inhibitor (PPI) treatment in dyspepsia is unpredictable. AIM:To identify symptoms associated with response to esomeprazole in order to target patients for empirical treatment. METHODS:Eight hundred and five uninvestigated, primary care patients with upper GI symptoms that were consi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.2010.04501.x

    authors: Meineche-Schmidt V,Christensen E,Bytzer P

    更新日期:2011-01-01 00:00:00

  • Anti-viral therapy can be delayed or avoided in a significant proportion of HBeAg-negative Caucasian patients in the Grey Zone.

    abstract:BACKGROUND:Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS:To assess the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS:Retrospective analysis of 287 IC an...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.14613

    authors: Bonacci M,Lens S,Mariño Z,Londoño MC,Rodríguez-Tajes S,Mas A,García-López M,Pérez-Del-Pulgar S,Sánchez-Tapias JM,Forns X

    更新日期:2018-05-01 00:00:00

  • Evaluation of omeprazole as a cost-effective diagnostic test for gastro-oesophageal reflux disease.

    abstract:BACKGROUND:There is a need for a simple, therapeutic test that is of diagnostic value and can also provide rapid symptom relief in patients who present with classic, mild symptoms suggestive of gastro-oesophageal reflux disease (GERD), when the diagnosis is based on symptom assessment alone. AIM:To assess the diagnost...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.1999.00429.x

    authors: Bate CM,Riley SA,Chapman RW,Durnin AT,Taylor MD

    更新日期:1999-01-01 00:00:00

  • Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations.

    abstract:BACKGROUND:Epidemiological data of coeliac disease are lacking from the central Asian region. AIMS:To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China. METHODS:2277 in-patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.15737

    authors: Zhou C,Gao F,Gao J,Yuan J,Lu J,Sun Z,Xu M,Engel J,Hui W,Gilissen L,Chen H

    更新日期:2020-06-01 00:00:00

  • Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis.

    abstract:BACKGROUND:Several clinical trials evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol can reduce the incidence of post-ERCP pancreatitis. AIM:To compare proph...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-2036.2008.03756.x

    authors: Bai Y,Gao J,Zhang W,Zou D,Li Z

    更新日期:2008-09-01 00:00:00

  • Dyspepsia workload in urban general practice and implications of the British Society of Gastroenterology Dyspepsia guidelines (1996).

    abstract:AIM:To define the characteristics of patients consulting with active dyspeptic symptoms in urban general practice, and to consider the implications of applying the British Society of Gastroenterology Dyspepsia management guidelines. DESIGN:Prospective observational study over a period of 12 months. SETTING:Two multip...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.2000.00728.x

    authors: Bodger K,Eastwood PG,Manning SI,Daly MJ,Heatley RV

    更新日期:2000-04-01 00:00:00

  • Randomised clinical trial: a herbal preparation of myrrh, chamomile and coffee charcoal compared with mesalazine in maintaining remission in ulcerative colitis--a double-blind, double-dummy study.

    abstract:BACKGROUND:The herbal treatment with myrrh, dry extract of chamomile flowers and coffee charcoal has anti-inflammatory and antidiarrhoeal potential and might benefit patients with UC. Aminosalicylates are used as standard treatment for maintaining remission in ulcerative colitis (UC). AIM:To compare the efficacy of th...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/apt.12397

    authors: Langhorst J,Varnhagen I,Schneider SB,Albrecht U,Rueffer A,Stange R,Michalsen A,Dobos GJ

    更新日期:2013-09-01 00:00:00

  • Pharmacodynamics and kinetics of omeprazole MUPS 20 mg and pantoprazole 40 mg during repeated oral administration in Helicobacter pylori-negative subjects.

    abstract:BACKGROUND:Omeprazole has become available in a tablet formulation, a Multiple Unit Pellet System (MUPS) containing a large number of small individually enteric-coated micropellets. AIM:To compare the acid-inhibitory effect of omeprazole MUPS 20 mg with pantoprazole 40 mg and to describe the pharmacokinetics of both d...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2036.2000.00806.x

    authors: Geus WP,Mathôt RA,Mulder PG,Lamers CB

    更新日期:2000-08-01 00:00:00

  • The significance of histological activity measurements in immune checkpoint inhibitor colitis.

    abstract:BACKGROUND:Colitis is a significant complication of immune checkpoint inhibitors (ICI). Currently, clinical and endoscopic severity are used to guide therapy. AIMS:To investigate associations between clinical, endoscopic, and histological features with outcomes METHODS: We identified 149 patients from seven institutio...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.16142

    authors: Pai RK,Pai RK,Brown I,Choi WT,Schaeffer DF,Farnell D,Kumarasinghe MP,Gunawardena D,Kim BH,Friedman M,Ghayouri M,Lauwers GY

    更新日期:2021-01-01 00:00:00

  • Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth.

    abstract:BACKGROUND:Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease. AIM:To evaluate the role of small intestinal bacterial overgrowth (SIBO) in condition of lactose intolerance and the mechanism by which SIBO may impact lactose tolerance in affected patients. ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2010.04252.x

    authors: Zhao J,Fox M,Cong Y,Chu H,Shang Y,Fried M,Dai N

    更新日期:2010-04-01 00:00:00

  • Review article: gastric electrical stimulation for gastroparesis--physiological foundations, technical aspects and clinical implications.

    abstract:BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2009.04082.x

    authors: Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

    更新日期:2009-10-01 00:00:00

  • Development of a clinical hepatic encephalopathy staging scale.

    abstract:AIM:To develop a scale to assess the severity of hepatic encephalopathy using simple dichotomic items. METHODS:A list of 48 items was created by selecting items that are simple to recognize and categorize; it was applied to thirty-six cirrhotic in-patients with episodic encephalopathy, in addition to the adapted-West-...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2007.03394.x

    authors: Ortiz M,Córdoba J,Doval E,Jacas C,Pujadas F,Esteban R,Guardia J

    更新日期:2007-09-15 00:00:00

  • Review article: inflammatory bowel disease--empowering the patient and improving outcome.

    abstract::Inflammatory bowel disease, in common with most chronic diseases, is managed by specialist clinicians during regular clinic follow-up visits. Patients spend approximately 1 h per year with clinicians, with few provisions made for patient participation in their own management for the remainder of the year, resulting in...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2004.02061.x

    authors: Robinson A

    更新日期:2004-10-01 00:00:00

  • Smoking behaviour and knowledge of the health effects of smoking in patients with inflammatory bowel disease.

    abstract:BACKGROUND:The detrimental effect of smoking on development and progression of Crohn's disease (CD) is generally accepted. AIM:To evaluate the awareness of smoking risks in a Belgian inflammatory bowel disease (IBD) population. METHODS:In the out-patient clinic of a tertiary referral centre, 625 consecutive patients ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.13423

    authors: De Bie C,Ballet V,Hendriks N,Coenen S,Weyts E,Van Assche G,Vermeire S,Ferrante M

    更新日期:2015-12-01 00:00:00

  • A systematic review of Helicobacter pylori eradication therapy--the impact of antimicrobial resistance on eradication rates.

    abstract:BACKGROUND:We systematically reviewed all available data in the literature to determine the overall eradication rates of currently advised Helicobacter pylori eradication regimens and to resolve conflicting evidence on the impact of antimicrobial resistance on the eradication rates. METHODS:A comprehensive search of a...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.1999.00555.x

    authors: Houben MH,van de Beek D,Hensen EF,de Craen AJ,Rauws EA,Tytgat GN

    更新日期:1999-08-01 00:00:00

  • Redefining the intraepithelial lymphocytes threshold to diagnose gluten sensitivity in patients with architecturally normal duodenal histology.

    abstract:BACKGROUND:Accuracy of intraepithelial lymphocytes counts for diagnosing mild enteropathy coeliac disease in absence of villous atrophy can be limited by inappropriate controls included in the studies. AIM:To determine the diagnostic accuracy of intraepithelial lymphocytes counts utilising controls lacking HLA coeliac...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2011.04578.x

    authors: Pellegrino S,Villanacci V,Sansotta N,Scarfì R,Bassotti G,Vieni G,Princiotta A,Sferlazzas C,Magazzù G,Tuccari G

    更新日期:2011-03-01 00:00:00

  • Scintigraphic assessment of the intragastric distribution and gastric emptying of an encapsulated drug: the effect of feeding and of a proton pump inhibitor.

    abstract:BACKGROUND:Local delivery of therapeutic agents to the stomach may be a useful strategy in the treatment of Helicobacter pylori infection. We aimed to see whether the intragastric distribution and gastric retention of a therapeutic agent could be improved, either by giving omeprazole or by dosing after a meal. METHODS...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.1994.tb00320.x

    authors: Atherton JC,Washington N,Bracewell MA,Sutton LJ,Greaves JL,Perkins AC,Hawkey CJ,Spiller RC

    更新日期:1994-10-01 00:00:00

  • The cost-effectiveness of high-dose oral proton pump inhibition after endoscopy in the acute treatment of peptic ulcer bleeding.

    abstract:BACKGROUND:Recent data suggest a role for high-dose oral proton pump inhibition in ulcer bleeding. AIM:To compare the cost-effectiveness of oral high-dose proton pump inhibition to both high-dose intravenous proton pump inhibition and placebo administration. METHODS:The model adopted a 30-day time horizon, and focuse...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2004.02035.x

    authors: Barkun AN,Herba K,Adam V,Kennedy W,Fallone CA,Bardou M

    更新日期:2004-07-15 00:00:00

  • Inflammatory manifestations at colonoscopy in patients with colonic diverticular disease.

    abstract:BACKGROUND:Ulcerative colitis with diverticulosis (UCD), segmental colitis associated with diverticulosis (SCAD) and acute uncomplicated diverticulitis (AUD) may affect the same colonic regions, but the real incidence of these entities in clinical practice is unknown. AIM:To assess the incidence and the endoscopic fin...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2010.04530.x

    authors: Tursi A,Elisei W,Giorgetti GM,Aiello F,Brandimarte G

    更新日期:2011-02-01 00:00:00

  • Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis.

    abstract:BACKGROUND:KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans. AIM:To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis. METHODS:Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1365-2036.2004.02066.x

    authors: Russo A,Stevens JE,Giles N,Krause G,O'Donovan DG,Horowitz M,Jones KL

    更新日期:2004-08-01 00:00:00

  • Review article: liver transplantation for the pulmonary disorders of portal hypertension.

    abstract:BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.12140

    authors: Houlihan DD,Holt A,Elliot C,Ferguson JW

    更新日期:2013-01-01 00:00:00

  • The use of ciclosporin in paediatric inflammatory bowel disease: an Italian experience.

    abstract:AIM:To asses the efficacy and safety of ciclosporin in a paediatric population with inflammatory bowel disease. PATIENTS AND METHODS:Twenty-three Italian children treated with ciclosporin were studied retrospectively. The indications for treatment were severe unresponsive colitis, chronic active colitis or severe fist...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1365-2036.2002.01308.x

    authors: Barabino A,Torrente F,Castellano E,Gandullia P,Calvi A,Cucchiara S,De GL,Fontana M,Lionetti P,De Giacomo C,Gissi A

    更新日期:2002-08-01 00:00:00