Abstract：
:Functional dyspepsia is highly variable in its clinical presentation and multifactorial in its underlying causes. Since many of the symptoms included in the definition of dyspepsia are intuitively suggestive of different pathogenic mechanisms, it has been proposed that patients with functional dyspepsia be divided into distinct dyspepsia sub-groups according to symptom clusters. The goal was to classify patients more homogeneously for research purposes as well as to target treatment. However, recent epidemiological, pathophysiological, and clinical studies indicate that a priori definitions based on the presence/absence of symptoms or clusters of symptoms have no clinical utility due to the considerable overlap between symptoms, as well as the poor correlation between pathogenic factors and responses to treatment. Attention is now focused on identifying predominant symptoms. Recent studies suggest that the analysis of predominant symptoms, demographic features, and overlapping digestive syndromes can help to identify dyspepsia sub-groups with different underlying pathophysiological features and aid in selecting appropriate treatment. The utility of this approach has been demonstrated in gastro-oesophageal reflux disease, which can be reliably diagnosed and managed on the basis of the presence and severity of the predominant symptom, heartburn. It is likely that precise symptom definitions and history-taking will be of pivotal importance in management strategies for functional dyspepsia.
journal_name
Aliment Pharmacol Therjournal_title
Alimentary pharmacology & therapeuticsauthors
Stanghellini Vdoi
10.1046/j.1365-2036.2001.00906.xsubject
Has Abstractpub_date
2001-02-01 00:00:00pages
145-9issue
2eissn
0269-2813issn
1365-2036pii
apt906journal_volume
15pub_type
杂志文章,评审abstract：:Colorectal cancer is a common cancer and common cause of death. The mortality rate from colorectal cancer can be reduced by identification and removal of cancer precursors, adenomas, or by detection of cancer at an earlier stage. Pilot screening programmes have demonstrated decreased colorectal cancer mortality; as a ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2005.02695.x
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic therapy to show a survival benefit in patients with advanced hepatocellular carcinoma. Since then many drugs failed in the first- and second-lin...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/apt.14913
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:The efficacy of each probiotic should be evaluated separately. Previously, we have shown that Lactobacillus GG (LGG) is effective in treating acute gastroenteritis (AGE) in children. AIM:To update our 2007 meta-analysis on the effectiveness of LGG in treating AGE in children. METHODS:The Cochrane Library, ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.12403
更新日期：2013-09-01 00:00:00
abstract：:Irritable bowel syndrome is a disease that can be diagnosed positively on the basis of an established series of criteria and limited exclusion of organic disease. It is the most common disease diagnosed by gastroenterologists and affects about 20% of all people at any one time. Symptoms fluctuate, and the overall prev...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2036.1997.84256000.x
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND:Historically, the beneficial effects of the nonsystemic oral agent rifaximin on various gastrointestinal (GI) disorders have been attributed to direct antibiotic activity on gut microbiota. However, data are accumulating to suggest that other nonantibacterial effects may be involved in rifaximin efficacy. A...
journal_title：Alimentary pharmacology & therapeutics
pub_type：
doi：10.1111/apt.13406
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Cross-sectional studies suggest insulin resistance is strongly associated with hepatic steatosis and fibrosis in patients with chronic hepatitis C (CHC), which might affect the efficacy of antiviral therapy. Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2008.03823.x
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Cirrhotic patients with spontaneous bacterial peritonitis (SBP) have elevated rates of renal impairment and mortality. It has been shown that cefotaxime plus albumin infusion decrease renal impairment compared with antibiotic treatment alone, in patients with serum bilirubin >4 mg/dL or creatinine >1 mg/dL. ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2010.04309.x
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:The association between myocardial infarction (MI) and co-administration of proton pump inhibitors (PPIs) and clopidogrel remains controversial. AIM:To quantify the association between concomitant use of PPIs and clopidogrel and occurrence of recurrent MI. METHODS:We conducted a case-control study within a...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2010.04485.x
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Depression is associated with substantial morbidity and mortality in cirrhosis, but is underdiagnosed and undertreated. AIMS:Using the Mini International Neuropsychiatric Interview (MINI) as a gold-standard, to determine prevalence, predictors, and outcomes of depression, and to develop a screening nomogram...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/apt.15068
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM:To examine retrospectively the effect of azathioprine (AZA) and mercaptopurine...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/apt.12261
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) is able to improve biochemical markers of cholestasis, with a parallel decrease in transaminases, in various cholestatic liver diseases. AIM:To evaluate the effects of UDCA administration on acute viral hepatitis-related cholestasis and the course of acute viral hepatitis. METHO...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.1999.00592.x
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:The mechanism of hypergastrinaemia during omeprazole therapy is unclear, but is generally assumed to be entirely a consequence of acid suppression. However, direct stimulation of G cells by omeprazole could also be a factor. In order to further investigate the mechanism of omeprazole-induced hypergastrinaemi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.1995.tb00413.x
更新日期：1995-10-01 00:00:00
abstract：:In a double-blind parallel-group study, 98 patients with symptomatic duodenal ulcer received omeprazole 20 mg o.m. and 91 cimetidine 800 mg nocte for 2 or, if then not healed, 4 weeks. After 2 weeks the healing rates on an intention-to-treat basis were: for omeprazole 62% and for cimetidine 33% (P less than 0.001), an...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-2036.1989.tb00193.x
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND:Drug development in hepatocellular carcinoma (HCC) is limited by disease heterogeneity, with hepatic reserve being a major source of variation in survival outcomes. The albumin-bilirubin (ALBI) grade is a validated index of liver function in patients with HCC. AIM:To test the accuracy of the ALBI grade in p...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/apt.13904
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:In behavioural economics, a 'nudge' describes configuration of a choice to encourage a certain action without taking away freedom of choice. AIM:To determine the impact of a 'nudge' strategy - prefilling either 3mL or 5mL syringes with midazolam - on endoscopic sedation practice. METHODS:Consecutive patien...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2036.2011.04703.x
更新日期：2011-07-01 00:00:00
abstract：:An analysis carried out in 1994 by the WHO International Agency for Research on Cancer (IARC) resulted in Helicobacter pylori being designated as a Group 1 carcinogen and thus clearly having an association with the development of gastric cancer. In the case of H. pylori, the evaluation was made solely on the basis of ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.1998.00007.x
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:One-week triple therapy consisting of omeprazole 20 mg b.d., clarithromycin 250 mg b.d. and tinidazole 500 mg b.d. is an effective therapy for H. pylori infection with a cure rate of 93%. We therefore compared two similar 1-week regimens consisting of a lansoprazole, clarithromycin and either metronidazole o...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.0953-0673.1996.00275.x
更新日期：1996-06-01 00:00:00
abstract：BACKGROUND:Intravenous esomeprazole may be beneficial for patients who cannot take oral medications. AIM:To compare intravenous esomeprazole with oral esomeprazole for effects on maximal acid output during pentagastrin stimulation in patients with gastro-oesophageal reflux disease symptoms. METHODS:In four separate o...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-2036.2005.02659.x
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:In view of the high diagnostic accuracy of immunoglobulin-A-tissue transglutaminase antibodies for detecting coeliac disease, we have explored whether a small bowel biopsy is always required to establish the diagnosis. AIM:To define the transglutaminase antibody level giving a positive predictive value for ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2008.03609.x
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism (VTE). AIM:To provide a quantitative assessment of the association of IBD with venous thromboembo...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.12294
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:One-week proton pump inhibitor-based triple therapies are very popular in the US despite limited US data documenting efficacy. We assessed 1-week proton pump inhibitor triple therapies for Helicobacter pylori, and compared them to dual antibiotic therapies (to assess benefit of omeprazole) and to omeprazole-...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-2036.1997.00230.x
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:A variety of tests have been proposed for colorectal cancer (CRC), giving rise to uncertainty regarding the optimal approach. The efficacy and effectiveness of different tests are related to both screened participation and the detection rate. AIM:To perform a meta-analysis on adherence and detection rates o...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析
doi：10.1111/apt.12071
更新日期：2012-11-01 00:00:00
abstract：AIM:To determine whether a 5-day regimen with rabeprazole, clarithromycin and amoxicillin (RCA) was as effective as a 7-day regimen. METHODS:A total of 139 H. pylori-infected patients were randomized to receive either a 5-day or 7-day course of rabeprazole 10 mg b.d., clarithromycin 400 mg b.d. and amoxicillin 750 mg ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-2036.2000.00892.x
更新日期：2000-12-01 00:00:00
abstract：:The goals of the Baveno workshops were to develop consensus definitions of key events related to portal hypertension and variceal bleeding, and to produce guidelines to facilitate the conduct and reporting of clinical trials. The consensus definitions concern the diagnosis of active bleeding, failure to control bleedi...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2036.2004.02108.x
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:Non-cardiac chest pain is one of the most common functional gastrointestinal disorders. By recognising that gastro-oesophageal reflux disease (GERD), oesophageal dysmotility and oesophageal hypersensitivity are the main underlying mechanisms of NCCP, a more directed therapeutic approach has been developed. ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,评审
doi：10.1111/apt.13458
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The most common complication after ileal pouch anal anastomosis in up to 50% of patients is an acute pouchitis. The majority of patients respond to antibiotic treatment. However, 10%-15% develops chronic antibiotic-dependent or refractory pouchitis which is usually hard to treat. AIM:To evaluate the effecti...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1111/apt.14479
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Lymphogranuloma venereum (LGV) is a recognized cause of proctitis. Symptoms, endoscopy and histology findings are similar in IBD and LGV proctitis. AIMS:To characterize the clinical, endoscopic and histological features seen in men diagnosed initially with IBD and subsequently with LGV proctitis, and to att...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/j.1365-2036.2010.04313.x
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC chemokines are also reported to have angiogenic activity and to serve as rem...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1046/j.1365-2036.2000.014s1094.x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Morphological, haemodynamic and clinical stages of cirrhosis have been proposed, although no definite staging system is yet accepted for clinical practice. AIM:To investigate whether clinical complications of cirrhosis may define different prognostic disease stages. METHODS:Analysis of the database from a ...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章
doi：10.1111/apt.12721
更新日期：2014-05-01 00:00:00
abstract：AIM:To review evidence for the effectiveness of Lactobacillus GG (LGG) in treating acute infectious diarrhoea in children. METHODS:The following electronic databases were searched through August 2006 for studies relevant to acute infectious diarrhoea and LGG: MEDLINE, EMBASE, CINAHL and The Cochrane Library; additiona...
journal_title：Alimentary pharmacology & therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1365-2036.2007.03282.x
更新日期：2007-04-15 00:00:00
