Depression in cirrhosis - a prospective evaluation of the prevalence, predictors and development of a screening nomogram.

Abstract:

BACKGROUND:Depression is associated with substantial morbidity and mortality in cirrhosis, but is underdiagnosed and undertreated. AIMS:Using the Mini International Neuropsychiatric Interview (MINI) as a gold-standard, to determine prevalence, predictors, and outcomes of depression, and to develop a screening nomogram for use in cirrhosis patients. METHODS:Cirrhotic outpatients 18-80 years of age, not on anti-depressants, were consecutively recruited from liver clinics at three tertiary care hospitals. Baseline health-related quality of life (HRQoL) and frailty were determined by the chronic liver disease questionnaire, EQ-VAS, Clinical Frailty Scale and Fried Frailty Criteria. Depression was identified using the MINI and participants were followed up to 6 months to determine unplanned hospitalization/death. RESULTS:Of 305 patients, 62% were male; mean age 55(10) years; mean MELD 12.5(5), 61% Child Pugh B/C. Prevalence of depression 18% by MINI. Patients with depression had lower baseline HRQoL and higher frailty scores. Five independently predictive factors were used to develop a clinical nomogram for the diagnosis of clinical depression. These included three Hospital Anxiety and Depression Screening tool variables: "I have lost interest in my appearance" (adjusted odds ratio [aOR] 2.2, P = 0.006), "I look forward with enjoyment to things" (aOR 2.0, P = 0.02), "I feel cheerful" (aOR 2.8, P = 0.002), and two demographic variables: younger age (aOR 0.92, P = 0.001) and not being married or in a common-law relationship (aOR 0.30, P = 0.008). CONCLUSIONS:Depression is common in patients with cirrhosis. It has a significant impact on HRQoL and functional status. The developed clinical nomogram is promising for the rapid screening of depression in patients with cirrhosis.

journal_name

Aliment Pharmacol Ther

authors

Buganza-Torio E,Mitchell N,Abraldes JG,Thomas L,Ma M,Bailey RJ,Tandon P

doi

10.1111/apt.15068

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

194-201

issue

2

eissn

0269-2813

issn

1365-2036

journal_volume

49

pub_type

杂志文章,多中心研究
  • Occupational asbestos exposure and digestive cancers - a cohort study.

    abstract:BACKGROUND:Although the role of asbestos in the genesis of mesothelioma and primary bronchopulmonary cancers has been established, results from studies focusing on the relationship between occupational exposure to asbestos and digestive cancer remain contradictory. AIM:To determine whether occupational asbestos exposu...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2009.04050.x

    authors: Clin B,Morlais F,Dubois B,Guizard AV,Desoubeaux N,Marquignon MF,Raffaelli C,Paris C,Galateau-Salle F,Launoy G,Letourneux M

    更新日期:2009-08-15 00:00:00

  • The sequential organ failure assessment (SOFA) score is an effective triage marker following staggered paracetamol (acetaminophen) overdose.

    abstract:BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2012.05102.x

    authors: Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

    更新日期:2012-06-01 00:00:00

  • Clinico-biochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography.

    abstract:BACKGROUND:Occult biliary stones escape detection on conventional investigations, and clinico-biochemical systems proposed for predicting biliary pancreatitis has low predictive values. AIM:To evaluate the accuracy of clinico-biochemical parameters for prediction of biliary pancreatitis in patients undergoing endoscop...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2005.02580.x

    authors: Liu CL,Fan ST,Lo CM,Tso WK,Wong Y,Poon RT,Lam CM,Wong BC,Wong J

    更新日期:2005-09-01 00:00:00

  • Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders.

    abstract:BACKGROUND:Butyrate, propionate and acetate are short chain fatty acids (SCFA), important for maintaining a healthy colon and are considered as protective in colorectal carcinogenesis. However, they may also regulate immune responses and the composition of the intestinal microbiota. Consequently, their importance in a ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.14689

    authors: Gill PA,van Zelm MC,Muir JG,Gibson PR

    更新日期:2018-07-01 00:00:00

  • Association between the presence of brown adipose tissue and non-alcoholic fatty liver disease in adult humans.

    abstract:BACKGROUND:The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans. AIM:To examine whether the presence and activity of BAT in patients undergoing PET-CT examinations is related to the presence of fatty liver. METHOD:We retrospectively analysed 3666 consecu...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2011.04723.x

    authors: Yilmaz Y,Ones T,Purnak T,Ozguven S,Kurt R,Atug O,Turoglu HT,Imeryuz N

    更新日期:2011-08-01 00:00:00

  • Long-term effect of tacrolimus therapy in patients with refractory ulcerative colitis.

    abstract:BACKGROUND:Little is known about long-term outcome of tacrolimus therapy for ulcerative colitis. Aim To evaluate long-term efficacy and safety of tacrolimus in Japanese patients with refractory ulcerative colitis. METHODS:Twenty-seven patients with UC refractory to conventional therapy were administered tacrolimus wit...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.2008.03764.x

    authors: Yamamoto S,Nakase H,Mikami S,Inoue S,Yoshino T,Takeda Y,Kasahara K,Ueno S,Uza N,Kitamura H,Tamaki H,Matsuura M,Inui K,Chiba T

    更新日期:2008-09-01 00:00:00

  • Review article: Medical therapy for fistulizing Crohn's disease.

    abstract:BACKGROUND:Fistulae will develop in approximately one-third of patients with Crohn's disease. With an expected spontaneous healing rate of only 10%, fistulizing Crohn's disease requires a comprehensive strategy with a medical and possible surgical approach. AIM:To summarize the current literature evaluating various me...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2006.03126.x

    authors: Bressler B,Sands BE

    更新日期:2006-11-01 00:00:00

  • Personal view: adequate relief as a primary endpoint in irritable bowel syndrome.

    abstract::The success of a clinical trial is judged by achieving statistical and clinical significance on the primary endpoint. This is particularly relevant in those trials that are initiated to achieve regulatory approval of a new therapeutic agent. Selection of an endpoint for which statistical significance will be too diffi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2006.02839.x

    authors: Mangel AW

    更新日期:2006-04-01 00:00:00

  • Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging.

    abstract:BACKGROUND:Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion. AIM:To determine the effect of PPI therapy on the gastric volume after a standard meal. ME...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2009.03947.x

    authors: Babaei A,Bhargava V,Aalam S,Scadeng M,Mittal RK

    更新日期:2009-04-15 00:00:00

  • Lansoprazole in the treatment of heartburn in patients without erosive oesophagitis.

    abstract:BACKGROUND:This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD). METHODS:214 patients with symptomatic, non-erosive GERD (moderate to severe daytime and/or night-time heartburn greater than half ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2036.1999.00558.x

    authors: Richter JE,Kovacs TO,Greski-Rose PA,Huang section sign B,Fisher R

    更新日期:1999-06-01 00:00:00

  • Review article: systemic treatment of hepatocellular carcinoma.

    abstract:BACKGROUND:The approval of the tyrosine kinase inhibitor sorafenib in 2007 marked a milestone in the treatment of hepatocellular carcinoma, as sorafenib was the first systemic therapy to show a survival benefit in patients with advanced hepatocellular carcinoma. Since then many drugs failed in the first- and second-lin...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/apt.14913

    authors: Pinter M,Peck-Radosavljevic M

    更新日期:2018-09-01 00:00:00

  • Review article: the diagnosis and investigation of obscure gastrointestinal bleeding.

    abstract:BACKGROUND:Obscure gastrointestinal bleeding (OGIB) is a commonly encountered clinical problem in gastroenterology and is associated with significant morbidity and mortality. The investigation and management of OGIB has changed dramatically over the past decade with the advent of newer gastroenterological and radiologi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.2011.04744.x

    authors: Liu K,Kaffes AJ

    更新日期:2011-08-01 00:00:00

  • Comparisons of the distribution of oesophageal acid exposure throughout the sleep period among the different gastro-oesophageal reflux disease groups.

    abstract:BACKGROUND:Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. AIM:To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2007.03347.x

    authors: Dickman R,Parthasarathy S,Malagon IB,Jones P,Han B,Powers J,Fass R

    更新日期:2007-07-01 00:00:00

  • A non-toxic analogue of a coeliac-activating gliadin peptide: a basis for immunomodulation?

    abstract:BACKGROUND:A-gliadin residues 31-49 (peptide A) binds to HLA-DQ2 and is toxic to coeliac small bowel. Analogues of this peptide, which bind to DQ2 molecules but are non-toxic, may be a potential route to inducing tolerance to gliadin in patients with coeliac disease. METHODS:Toxicity was investigated with small bowel ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.1999.00512.x

    authors: Biagi F,Ellis HJ,Parnell ND,Shidrawi RG,Thomas PD,O'Reilly N,Corazza GR,Ciclitira PJ

    更新日期:1999-07-01 00:00:00

  • Review article: the medical management of Crohn's disease.

    abstract::The choice of medical therapies for Crohn's disease continues to grow. Although our understanding of the mechanisms of the disease is incomplete, increasing knowledge of the pathogenesis of inflammation in general and Crohn's disease in particular allows targeting of therapies at various points in the immunoinflammato...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2036.1996.tb00173.x

    authors: Elton E,Hanauer SB

    更新日期:1996-02-01 00:00:00

  • Night-time intra-oesophageal bile and acid: a comparison between gastro-oesophageal reflux disease patients who failed and those who were treated successfully with a proton pump inhibitor.

    abstract:BACKGROUND:Little is known about the contribution of bile and acid reflux to night-time symptoms generation in patients who failed PPI treatment. AIM:To compare the degree of night-time oesophageal acid and bile [by the surrogate duodenogastroesophageal reflux (DGER)] exposure between gastro-oesophageal reflux disease...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2011.04583.x

    authors: Hershcovici T,Jha LK,Cui H,Powers J,Fass R

    更新日期:2011-04-01 00:00:00

  • Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors.

    abstract::Proton pump inhibitors have dramatically influenced the management of acid-peptic disorders in recent years. They all have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochromes P450 2C19 and 3A4. There is some variation in their potential for drug interactions due to differ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.2000.00788.x

    authors: Stedman CA,Barclay ML

    更新日期:2000-08-01 00:00:00

  • Anti-viral therapy can be delayed or avoided in a significant proportion of HBeAg-negative Caucasian patients in the Grey Zone.

    abstract:BACKGROUND:Grey Zone (GZ) is an ill-defined situation including patients falling between inactive carrier (IC) state and HBeAg-negative chronic hepatitis B (HBeAg-negative CHB). AIMS:To assess the long-term outcomes of GZ patients compared to IC in the absence of treatment. METHODS:Retrospective analysis of 287 IC an...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.14613

    authors: Bonacci M,Lens S,Mariño Z,Londoño MC,Rodríguez-Tajes S,Mas A,García-López M,Pérez-Del-Pulgar S,Sánchez-Tapias JM,Forns X

    更新日期:2018-05-01 00:00:00

  • 13C-Methacetin metabolism in patients with cirrhosis: relation to disease severity, haemoglobin content and oxygen supply.

    abstract:BACKGROUND:Hypoxia may contribute to impairment of liver function and thus interfere with results of liver tests. In patients with cirrhosis, cytochrome P-450 mediated metabolism of substrates is facilitated in the presence of supplemental oxygen. It has not been studied how this relates to liver function and haemoglob...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1046/j.1365-2036.2003.01604.x

    authors: Zipprich A,Meiss F,Steudel N,Sziegoleit U,Fleig WE,Kleber G

    更新日期:2003-06-15 00:00:00

  • Review article: platelets in inflammatory bowel disease--pathogenetic role and therapeutic implications.

    abstract::An elevated platelet count is well recognized as a marker of inflammatory bowel disease activity. There is an increased incidence of systemic thromboembolism in this disease. Recent work indicates that platelets exhibit several proinflammatory properties including release of inflammatory mediators, and recruitment, ch...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.1997.153328000.x

    authors: Collins CE,Rampton DS

    更新日期:1997-04-01 00:00:00

  • The influence of common gene variants of the xenobiotic receptor (PXR) in genetic susceptibility to intrahepatic cholestasis of pregnancy.

    abstract:BACKGROUND:The xenobiotic nuclear pregnane X receptor is implicated in many physiological pathways and diseases, including bile acid detoxification and cholestasis. Aim To estimate the contribution of common gene variants of the xenobiotic receptor (pregnane X receptor, PXR) to genetic susceptibility to intrahepatic ch...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2009.04210.x

    authors: Castaño G,Burgueño A,Fernández Gianotti T,Pirola CJ,Sookoian S

    更新日期:2010-03-01 00:00:00

  • Effects of midazolam on small bowel motility in humans.

    abstract:BACKGROUND:Benzodiazepines are used as sedatives for some intestinal procedures and as hypnotics, and this is the reason for studying their effects on duodenojejunal motility. METHODS:Antroduodenojejunal manometry was performed in 13 healthy volunteers on two different occasions, when placebo or midazolam were given i...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2036.2000.00741.x

    authors: Castedal M,Björnsson E,Abrahamsson H

    更新日期:2000-05-01 00:00:00

  • Combined diffusion tensor imaging and magnetic resonance spectroscopy to predict neurological outcome before transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND:Hepatic encephalopathy (HE) may occur after transjugular intrahepatic portosystemic shunt (TIPSS) placement. Multimodal magnetic resonance imaging (MRI), combining anatomical sequences, diffusion tensor imaging (DTI) and 1 H magnetic resonance spectroscopy, is modified in cirrhotic patients. AIMS:To describ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/apt.14938

    authors: Rudler M,Weiss N,Perlbarg V,Mallet M,Tripon S,Valabregue R,Marjańska M,Cluzel P,Galanaud D,Thabut D

    更新日期:2018-10-01 00:00:00

  • Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture.

    abstract:BACKGROUND:There has been increasing interest in small intestinal bacterial overgrowth (SIBO) after reports of a link with irritable bowel syndrome (IBS), yet our understanding of this entity is limited. AIM:Our aim was to estimate the yield of patients undergoing duodenal aspirate culture, and to identify symptoms an...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2011.04625.x

    authors: Choung RS,Ruff KC,Malhotra A,Herrick L,Locke GR 3rd,Harmsen WS,Zinsmeister AR,Talley NJ,Saito YA

    更新日期:2011-05-01 00:00:00

  • Post-prandial reflux suppression by a raft-forming alginate (Gaviscon Advance) compared to a simple antacid documented by magnetic resonance imaging and pH-impedance monitoring: mechanistic assessment in healthy volunteers and randomised, controlled, doub

    abstract:BACKGROUND:Alginates form a raft above the gastric contents, which may suppress gastro-oesophageal reflux; however, inconsistent effects have been reported in mechanistic and clinical studies. AIMS:To visualise reflux suppression by an alginate-antacid [Gaviscon Advance (GA), Reckitt Benckiser, UK] compared with a non...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/apt.12318

    authors: Sweis R,Kaufman E,Anggiansah A,Wong T,Dettmar P,Fried M,Schwizer W,Avvari RK,Pal A,Fox M

    更新日期:2013-06-01 00:00:00

  • Meta-analysis: allopurinol in the prevention of postendoscopic retrograde cholangiopancreatography pancreatitis.

    abstract:BACKGROUND:Several clinical trials evaluating the prophylactic effect of allopurinol on postendoscopic retrograde cholangiopancreatography (ERCP) pancreatitis have been published; however, there is no consensus on whether prophylactic allopurinol can reduce the incidence of post-ERCP pancreatitis. AIM:To compare proph...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-2036.2008.03756.x

    authors: Bai Y,Gao J,Zhang W,Zou D,Li Z

    更新日期:2008-09-01 00:00:00

  • Gastro-oesophageal reflux disease in chronic laryngitis: prevalence and response to acid-suppressive therapy.

    abstract:BACKGROUND:Gastro-oesophageal reflux is thought to cause chronic laryngitis through laryngopharyngeal reflux. Response of laryngitis to treatment with acid-suppressive therapy supports this causal link. AIM:To determine the prevalence of gastro-oesophageal reflux disease in patients with chronic laryngitis and respons...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2006.03185.x

    authors: Qua CS,Wong CH,Gopala K,Goh KL

    更新日期:2007-02-01 00:00:00

  • A population-based study of coeliac disease, neurodegenerative and neuroinflammatory diseases.

    abstract:BACKGROUND:It has been suggested that coeliac disease (CD) is associated with several neurological diseases. However, the evidence of such an association is inconclusive as earlier research has often been based on small numbers with retrospective data collection. AIM:To use Cox regression to examine the risk of neurol...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章

    doi:10.1111/j.1365-2036.2007.03329.x

    authors: Ludvigsson JF,Olsson T,Ekbom A,Montgomery SM

    更新日期:2007-06-01 00:00:00

  • Review article: maintenance treatment of Crohn's disease.

    abstract::The aetiology of Crohn's disease is unknown and therefore no curative treatments are available for the disease. The natural history of Crohn's disease is characterized by recurrent flare-ups of symptoms. Several drug treatments are effective in inducing clinical remission. However, no drug treatments are available in ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2036.17.s2.20.x

    authors: Biancone L,Tosti C,Fina D,Fantini M,De Nigris F,Geremia A,Pallone F

    更新日期:2003-06-01 00:00:00

  • Patterns of 24-hour oesophageal acid exposure after acute withdrawal of acid suppression.

    abstract:AIM:To measure 24-h ambulatory oesophageal pH data in patients with gastro-oesophageal reflux disease prior to, during and after acute treatment with comparable doses of omeprazole and ranitidine. METHODS:The subjects were 20 adults with at least 8% acid contact time. Ten subjects were treated for 1 week with omeprazo...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2036.1995.tb00423.x

    authors: Orr WC,Mellow MH,Grossman MR

    更新日期:1995-10-01 00:00:00