Review article: reflux and its consequences--the laryngeal, pulmonary and oesophageal manifestations. Conference held in conjunction with the 9th International Symposium on Human Pepsin (ISHP) Kingston-upon-Hull, UK, 21-23 April 2010.


BACKGROUND:Gastro-oesophageal reflux disease (GERD) is one of the commonest diseases of Western populations, affecting 20 to 30% of adults. GERD is multifaceted and the classical oesophageal symptoms such as heartburn and regurgitation often overlap with atypical symptoms that impact upon the respiratory system and airways. This is referred to as extra-oesophageal reflux disease (EERD), or laryngopharyngeal reflux (LPR), which manifests as chronic cough, laryngitis, hoarseness, voice disorders and asthma. AIM:The 'Reflux and its consequences' conference was held in Hull in 2010 and brought together a multidisciplinary group of experts all with a common interest in the many manifestations of reflux disease to present recent research and clinical progress in GERD and EERD. In particular new techniques for diagnosing reflux were showcased at the conference. METHODS:Both clinical and non-clinical key opinion leaders were invited to write a review on key areas presented at the `Reflux and its consequences' conference for inclusion in this supplement. RESULTS AND CONCLUSION:Eleven chapters contained in this supplement reflected the sessions of the conference and included discussion of the nature of the refluxate (acid, pepsin, bile acids and non-acid reflux); mechanisms of tissue damage and protection in the oesophagus, laryngopharynx and airways. Clinical conditions with a reflux aetiology including asthma, chronic cough, airway disease, LPR, and paediatric EERD were reviewed. In addition methods for diagnosis of reflux disease and treatment strategies, especially with reference to non-acid reflux, were considered.


Aliment Pharmacol Ther


Pearson JP,Parikh S,Orlando RC,Johnston N,Allen J,Tinling SP,Johnston N,Belafsky P,Arevalo LF,Sharma N,Castell DO,Fox M,Harding SM,Morice AH,Watson MG,Shields MD,Bateman N,McCallion WA,van Wijk MP,Wenzl TG,Karkos




Has Abstract


2011-04-01 00:00:00








33 Suppl 1


  • Coeliac disease: a biopsy is not always necessary for diagnosis.

    abstract:BACKGROUND:In view of the high diagnostic accuracy of immunoglobulin-A-tissue transglutaminase antibodies for detecting coeliac disease, we have explored whether a small bowel biopsy is always required to establish the diagnosis. AIM:To define the transglutaminase antibody level giving a positive predictive value for ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Hill PG,Holmes GK

    更新日期:2008-04-01 00:00:00

  • Effect of omeprazole and feeding on plasma gastrin in patients with achlorhydria.

    abstract:BACKGROUND:The mechanism of hypergastrinaemia during omeprazole therapy is unclear, but is generally assumed to be entirely a consequence of acid suppression. However, direct stimulation of G cells by omeprazole could also be a factor. In order to further investigate the mechanism of omeprazole-induced hypergastrinaemi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Banerjee S,Ardill JE,Beattie AD,McColl KE

    更新日期:1995-10-01 00:00:00

  • Review article: can post-operative recurrence in Crohn's disease be prevented?

    abstract::The decision regarding prophylactic treatment after surgery in Crohn's disease (CD) requires a good estimation of the risk of recurrence. It is also important to consider the consequences of recurrence for the patient, and the risks and benefits of treatment, bearing in mind that it will be given over a long period. S...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Lémann M

    更新日期:2006-10-01 00:00:00

  • Meta-analysis: vasoactive medications for the management of acute variceal bleeds.

    abstract:BACKGROUND:Vasoactive medications such as vasopressin, somatostatin and their analogues (terlipressin, vapreotide and octreotide) are commonly used for the treatment of acute variceal bleeding. However, the risks and benefits of these interventions are not well understood. AIM:To undertake a meta-analysis of the effic...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Wells M,Chande N,Adams P,Beaton M,Levstik M,Boyce E,Mrkobrada M

    更新日期:2012-06-01 00:00:00

  • Randomised clinical trial: a 'nudge' strategy to modify endoscopic sedation practice.

    abstract:BACKGROUND:In behavioural economics, a 'nudge' describes configuration of a choice to encourage a certain action without taking away freedom of choice. AIM:To determine the impact of a 'nudge' strategy - prefilling either 3mL or 5mL syringes with midazolam - on endoscopic sedation practice. METHODS:Consecutive patien...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Harewood GC,Clancy K,Engela J,Abdulrahim M,Lohan K,O'Reilly C

    更新日期:2011-07-01 00:00:00

  • Systematic review: health-related quality of life in children and adults with eosinophilic oesophagitis-instruments for measurement and determinant factors.

    abstract:BACKGROUND:Several measures have been used to assess the health-related quality of life (HRQoL) of patients with eosinophilic oesophagitis (EoE). AIMS:To systematically review these HRQoL measures, to appraise measurement properties of specific instruments and to evaluate determinant factors influencing HRQoL in paedi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Lucendo AJ,Arias-González L,Molina-Infante J,Arias Á

    更新日期:2017-08-01 00:00:00

  • Low-dose furazolidone in triple and quadruple regimens for Helicobacter pylori eradication.

    abstract:BACKGROUND:Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective. Unfortunately, the usual dose of furazolidone is not tolerable in many patients. Lower doses of furazolidone are expected to cause fewer adverse effects. AIM:To investigate the efficacy of low-dose furazolidon...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fakheri H,Merat S,Hosseini V,Malekzadeh R

    更新日期:2004-01-01 00:00:00

  • Gastric mucosal injury and adaptation to oral and rectal administration of naproxen.

    abstract:INTRODUCTION:Oral nonsteroidal anti-inflammatory drugs (NSAIDs) cause acute gastric mucosal injury but the relative importance of systemic and topical effect of NSAIDs to overall gastric damage remains uncertain. METHODS:Twenty-four healthy volunteers were allocated either oral or rectal naproxen 500 mg b.d. and gastr...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Lipscomb GR,Rees WD

    更新日期:1996-04-01 00:00:00

  • Clinical trial: percutaneous acetic acid injection vs. percutaneous ethanol injection for small hepatocellular carcinoma--a long-term follow-up study.

    abstract:BACKGROUND:The long-term outcome of percutaneous acetic acid injection (PAI) and percutaneous ethanol injection (PEI) for treating small hepatocellular carcinoma (HCC) remains unclear. AIM:To compare the long-term outcome of PAI vs. PEI for treating small HCC. METHODS:From July 1998 to July 2004, 125 patients with sm...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Tsai WL,Cheng JS,Lai KH,Lin CP,Lo GH,Hsu PI,Yu HC,Lin CK,Chan HH,Chen WC,Chen TA,Li WL,Liang HL

    更新日期:2008-08-01 00:00:00

  • The use of adalimumab in the management of refractory Crohn's disease.

    abstract:BACKGROUND:Adalimumab is a humanized monoclonal antibody targeting tumour necrosis factor-alpha. Recent clinical trials have demonstrated its efficacy in Crohn's disease; however, experience in clinical practice remains limited. AIM:To investigate the efficacy and safety of adalimumab in the clinical setting. METHODS...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章


    authors: Ho GT,Smith L,Aitken S,Lee HM,Ting T,Fennell J,Lees CW,Palmer KR,Penman ID,Shand AG,Arnott ID,Satsangi J

    更新日期:2008-02-15 00:00:00

  • Collagen proportionate area predicts clinical outcomes in patients with alcohol-related liver disease.

    abstract:BACKGROUND:No prognostic tools are established for alcohol-related liver disease (ALD). Collagen proportionate area (CPA) measurement is a technique that quantifies fibrous tissue in liver biopsies using digital image analysis. AIM:To assess the predictive value of CPA on hepatic decompensation and liver-related morta...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,多中心研究


    authors: Israelsen M,Guerrero Misas M,Koutsoumourakis A,Huang Y,Thiele M,Hall A,Rasmussen D,Covelli C,Buzzetti E,Prat LI,Roccarina D,Detlefsen S,Luong TV,Quaglia A,Krag A,Jeffrey G,Pinzani M,Tsochatzis EA

    更新日期:2020-12-01 00:00:00

  • Review article: gastric electrical stimulation for gastroparesis--physiological foundations, technical aspects and clinical implications.

    abstract:BACKGROUND:Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention. AIM:To rev...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Soffer E,Abell T,Lin Z,Lorincz A,McCallum R,Parkman H,Policker S,Ordog T

    更新日期:2009-10-01 00:00:00

  • The role of screening and antibiotic prophylaxis in the prevention of percutaneous gastrostomy site infection caused by methicillin-resistant Staphylococcus aureus.

    abstract:BACKGROUND:Peristomal wound infections are common complications of percutaneous endoscopic gastrostomy (PEG), especially in hospitals where methicillin-resistant Staphylococcus aureus (MRSA) is endemic. Evidence suggests that antibiotic prophylaxis at PEG insertion may reduce infection rates. AIM:To examine rates of p...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Thomas S,Cantrill S,Waghorn DJ,McIntyre A

    更新日期:2007-03-01 00:00:00

  • Colonic delivery of 4-aminosalicylic acid using amylose-ethylcellulose-coated hydroxypropylmethylcellulose capsules.

    abstract:BACKGROUND:4-Aminosalicylic acid has the potential for use in the treatment of diseases of the colon. AIM:To assess the feasibility of delivering 4-aminosalicylic acid directly to the colon using a hydroxypropylmethylcellulose capsule coated with a mixture of amylose, a polysaccharide metabolized by bacterial enzymes ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Tuleu C,Basit AW,Waddington WA,Ell PJ,Newton JM

    更新日期:2002-10-01 00:00:00

  • Association between diabetes mellitus and hepatic encephalopathy in patients with cirrhosis.

    abstract:BACKGROUND:Diabetes mellitus may lead to increased serum ammonia and systemic inflammation thereby promoting hepatic encephalopathy (HE). AIM:To investigate the potential association between diabetes mellitus/glycaemic control and the presence of covert HE as well as the development of overt HE in a prospective settin...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Labenz C,Nagel M,Kremer WM,Hilscher M,Schilling CA,Toenges G,Kuchen R,Schattenberg JM,Galle PR,Wörns MA

    更新日期:2020-08-01 00:00:00

  • Influence of the timing of administration of 300 mg ranitidine on 24-hour gastric pH in patients acute duodenal ulcer.

    abstract::The 24-hour intragastric pH of 12 patients with an acute duodenal ulcer was recorded with the aim of comparing the effects of two different times of administration of 300 mg ranitidine: post evening meal, or bedtime. This double-blind crossover trial involved 3 centres. Twenty-four-hour gastric pH was measured under s...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cortot A,Guillemot F,Moreau J,Soule JC,Veyrac M,Alberola B,Pappo M

    更新日期:1992-08-01 00:00:00

  • Effect of splitting the dose of esomeprazole on gastric acidity and nocturnal acid breakthrough.

    abstract:BACKGROUND:Twice-daily dosing is increasingly used to improve gastric acid control, although not all proton-pump inhibitors are more effective when doses are split. Standard dose esomeprazole provides better gastric acid control than other standard dose proton-pump inhibitors. AIMS:To compare the effect of standard do...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hammer J,Schmidt B

    更新日期:2004-05-15 00:00:00

  • Practice patterns for the evaluation and treatment of eosinophilic oesophagitis.

    abstract:BACKGROUND:Although consensus guidelines for eosinophilic oesophagitis have been published, it remains unclear whether gastroenterologists follow these recommendations. AIM:To assess academic and community practice patterns for the evaluation and treatment of eosinophilic oesophagitis and to compare these practices wi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Peery AF,Shaheen NJ,Dellon ES

    更新日期:2010-12-01 00:00:00

  • The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study.

    abstract:BACKGROUND:Retrospective accounts suggest that therapeutic doses of paracetamol can produce severe hepatic injury in patients with putative high-risk conditions, including alcoholism and infectious hepatitis. Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also hav...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,随机对照试验


    authors: Dart RC,Green JL,Kuffner EK,Heard K,Sproule B,Brands B

    更新日期:2010-08-01 00:00:00

  • Initial potency of lansoprazole and omeprazole tablets on pentagastrin-stimulated gastric acid secretion-a placebo-controlled study in healthy volunteers.

    abstract:BACKGROUND:The new tablet formulation of omeprazole (Losec MUPS), is thought to have a stronger acid inhibition than the previously marketed capsules. METHODS:The effects of the proton pump inhibitors lansoprazole and omeprazole tablets on pentagastrin-stimulated acid secretion were compared in Helicobacter pylori-neg...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章


    authors: Müller P,Göksu MA,Fuchs W,Schlüter F,Simon B

    更新日期:2000-09-01 00:00:00

  • Review article: rifaximin, a minimally absorbed oral antibacterial, for the treatment of travellers' diarrhoea.

    abstract:BACKGROUND:Travellers' diarrhoea, a common problem worldwide with significant medical impact, is generally treated with anti-diarrhoeal agents and fluid replacement. Systemic antibiotics are also used in selected cases, but these may be associated with adverse effects, bacterial resistance and drug-drug interactions. ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Layer P,Andresen V

    更新日期:2010-06-01 00:00:00

  • Meta-analysis: colonoscopic post-polypectomy bleeding in patients on continued clopidogrel therapy.

    abstract:BACKGROUND:Current guidelines recommend the cessation of clopidogrel therapy 5 days and 7-10 days prior to colonoscopic polypectomy. Recent studies have advocated for continued clopidogrel as post-polypectomy bleeding (PPB) rates have been similar to those in the general population not on antithrombotic therapy. AIM:T...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,meta分析


    authors: Gandhi S,Narula N,Mosleh W,Marshall JK,Farkouh M

    更新日期:2013-05-01 00:00:00

  • Review article: the diagnosis and investigation of obscure gastrointestinal bleeding.

    abstract:BACKGROUND:Obscure gastrointestinal bleeding (OGIB) is a commonly encountered clinical problem in gastroenterology and is associated with significant morbidity and mortality. The investigation and management of OGIB has changed dramatically over the past decade with the advent of newer gastroenterological and radiologi...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Liu K,Kaffes AJ

    更新日期:2011-08-01 00:00:00

  • A novel diagnostic tool for detecting oesophageal pathology: the PillCam oesophageal video capsule.

    abstract:BACKGROUND:Gastro-oesophageal reflux disease is a common entity. Erosive oesophagitis, ulcers and Barrett's oesophagus, which is found in up to 10% of gastro-oesophageal reflux disease patients, characterize severe gastro-oesophageal reflux disease. Patients with Barrett's oesophagus have 0.5% per patient-year risk of ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Eliakim R,Yassin K,Shlomi I,Suissa A,Eisen GM

    更新日期:2004-11-15 00:00:00

  • Clinical response after transjugular intrahepatic portosystemic stent shunt insertion for refractory ascites in cirrhosis.

    abstract:BACKGROUND:Transjugular intrahepatic portosystemic stent shunts (TIPSS) have been used successfully to reduce portal pressure in the context of variceal haemorrhage. Recent interest has focused on the possible use of TIPSS to manage refractory ascites. AIM:To study the effect of TIPSS insertion in 18 patients with ref...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Forrest EH,Stanley AJ,Redhead DN,McGilchrist AJ,Hayes PC

    更新日期:1996-10-01 00:00:00

  • Diastolic dysfunction on echocardiography does not predict survival after transjugular intrahepatic portosystemic stent-shunt in patients with cirrhosis.

    abstract:BACKGROUND:Cardiac dysfunction is frequently observed in patients with cirrhosis. There remains a paucity of data from routine clinical practice regarding the role of echocardiography in the pre-assessment of transjugular intrahepatic portosystemic stent-shunt. AIM:Our study aimed to investigate if echocardiography pa...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Armstrong MJ,Gohar F,Dhaliwal A,Nightingale P,Baker G,Greaves D,Mangat K,Zia Z,Karkhanis S,Olliff S,Mehrzad H,Steeds RP,Tripathi D

    更新日期:2019-03-01 00:00:00

  • Review article: proton pump inhibitors with clopidogrel--evidence for and against a clinically-important interaction.

    abstract:BACKGROUND:The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors are frequently recommended for patients receiving clopidogrel in addition to aspirin, to minimise the risk of bleeding. Several studies have shown that proton pump inhibitors can affect the plat...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章,评审


    authors: Disney BR,Watson RD,Blann AD,Lip GY,Anderson MR

    更新日期:2011-04-01 00:00:00

  • Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations.

    abstract:BACKGROUND:Epidemiological data of coeliac disease are lacking from the central Asian region. AIMS:To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China. METHODS:2277 in-patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 ...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Zhou C,Gao F,Gao J,Yuan J,Lu J,Sun Z,Xu M,Engel J,Hui W,Gilissen L,Chen H

    更新日期:2020-06-01 00:00:00

  • Survival benefit of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma larger than 10 cm in diameter.

    abstract:BACKGROUND:The safety and survival benefit of transcatheter arterial chemoembolization for patients with huge hepatocellular carcinoma is uncertain. AIM:To evaluate the role of embolization in unresectable hepatocellular carcinomas larger than 10 cm. METHODS:Twenty-six consecutive patients who had an unresectable hep...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 杂志文章


    authors: Huang YH,Wu JC,Chen SC,Chen CH,Chiang JH,Huo TI,Lee PC,Chang FY,Lee SD

    更新日期:2006-01-01 00:00:00

  • Effect of mefenamic acid on bowel transit time in healthy adult volunteers.

    abstract::The effect of mefenamic acid on bowel transit time was investigated. Seven healthy adult male subjects of age 39 +/- 2.4 years (mean +/- S.E.M.) received placebo or mefenamic acid (500 mg t.d.s) orally in randomized order for five days, with a 7-day washout between studies. On the third morning after starting the drug...

    journal_title:Alimentary pharmacology & therapeutics

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rashid MU,Bateman DN

    更新日期:1990-08-01 00:00:00