A double-blind, placebo-controlled study of the efficacy and safety of non-prescription ranitidine 75 mg in the prevention of meal-induced heartburn.

abstract：BACKGROUND:(13)CO(2) is produced on metabolism of (13)C-labelled-pantoprazole ([(13)C]-pantoprazole) by CYP2C19. AIM:To investigate whether the [(13)C]-pantoprazole breath test can predict CYP2C19 status and efficacy of proton pump inhibitors (PPIs) in Japanese. METHODS:We classified 110 healthy volunteers as rapid m...

journal_title：Alimentary pharmacology & therapeutics

authors： Furuta T,Kodaira C,Nishino M,Yamade M,Sugimoto M,Ikuma M,Hishida A,Watanabe H,Umemura K

更新日期：2009-08-01 00:00:00

abstract：AIM:To assess the efficacy of a prokinetic agent in the long-term treatment of chronic intestinal dysmotility and the influence of extrinsic denervation. METHODS:We assessed symptoms, compliance and untoward effects in an open, 1-year trial of cisapride, 20 mg t.d.s., in 37 patients with neuropathic forms of chronic i...

journal_title：Alimentary pharmacology & therapeutics

authors： Camilleri M,Balm RK,Zinsmeister AR

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

journal_title：Alimentary pharmacology & therapeutics

authors： Houlihan DD,Holt A,Elliot C,Ferguson JW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors are frequently recommended for patients receiving clopidogrel in addition to aspirin, to minimise the risk of bleeding. Several studies have shown that proton pump inhibitors can affect the plat...

journal_title：Alimentary pharmacology & therapeutics

authors： Disney BR,Watson RD,Blann AD,Lip GY,Anderson MR

更新日期：2011-04-01 00:00:00

abstract：AIM:To asses the efficacy and safety of ciclosporin in a paediatric population with inflammatory bowel disease. PATIENTS AND METHODS:Twenty-three Italian children treated with ciclosporin were studied retrospectively. The indications for treatment were severe unresponsive colitis, chronic active colitis or severe fist...

journal_title：Alimentary pharmacology & therapeutics

authors： Barabino A,Torrente F,Castellano E,Gandullia P,Calvi A,Cucchiara S,De GL,Fontana M,Lionetti P,De Giacomo C,Gissi A

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Predicting factors for the outcome of conventional Helicobacter pylori triple therapy have been identified. Of these, the presence of the CagA gene is a strong predictor of successful treatment. Our preliminary data show that this factor becomes irrelevant when sequential therapy is used. AIM:To identify pr...

journal_title：Alimentary pharmacology & therapeutics

authors： De Francesco V,Zullo A,Margiotta M,Marangi S,Burattini O,Berloco P,Russo F,Barone M,Di Leo A,Minenna MF,Stoppino V,Morini S,Panella C,Francavilla A,Ierardi E

更新日期：2004-02-15 00:00:00

abstract：BACKGROUND:After ileocaecal resection for Crohn's disease (CD), inflammatory lesions frequently recur on the anastomosis and/or on the neo-terminal ileum. AIM:To identify predictors of early post-operative endoscopic recurrence. METHODS:From September 2010 to September 2017, the REMIND group conducted a prospective n...

journal_title：Alimentary pharmacology & therapeutics

authors： Auzolle C,Nancey S,Tran-Minh ML,Buisson A,Pariente B,Stefanescu C,Fumery M,Marteau P,Treton X,Hammoudi N,REMIND Study Group Investigators.,Jouven X,Seksik P,Allez M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Although highly prevalent, little is known about the economic impact of functional dyspepsia (FD). AIMS:To quantify FD patients' health care utilisation patterns and to estimate direct and indirect costs of FD to patients. METHODS:ICD-9 codes identified adult patients with dyspepsia. A validated questionna...

journal_title：Alimentary pharmacology & therapeutics

authors： Lacy BE,Weiser KT,Kennedy AT,Crowell MD,Talley NJ

更新日期：2013-07-01 00:00:00

abstract：:There is general agreement that Helicobacter pylori eradication is indicated in all infected patients with duodenal ulcer disease and is probably indicated in all infected patients with gastric ulcer disease. However, translation of treatment recommendations into practice leads to some difficult clinical decisions. Th...

journal_title：Alimentary pharmacology & therapeutics

authors： Walsh JH

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Travellers' diarrhoea, a common problem worldwide with significant medical impact, is generally treated with anti-diarrhoeal agents and fluid replacement. Systemic antibiotics are also used in selected cases, but these may be associated with adverse effects, bacterial resistance and drug-drug interactions. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Layer P,Andresen V

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

journal_title：Alimentary pharmacology & therapeutics

authors： Mönkemüller KE,Hirschowitz BI

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:There are limited data concerning infliximab drug monitoring during de-escalation of the treatment of inflammatory bowel disease (IBD). AIM:To define the rate and the predictors of relapse following infliximab de-escalation in IBD patients in remission. METHODS:All IBD patients at a single referral centre ...

journal_title：Alimentary pharmacology & therapeutics

authors： Lucidarme C,Petitcollin A,Brochard C,Siproudhis L,Dewitte M,Landemaine A,Bellissant E,Bouguen G

更新日期：2019-01-01 00:00:00

abstract：:Alginate-based raft-forming formulations have been marketed word-wide for over 30 years under various brand names, including Gaviscon. They are used for the symptomatic treatment of heartburn and oesophagitis, and appear to act by a unique mechanism which differs from that of traditional antacids. In the presence of g...

journal_title：Alimentary pharmacology & therapeutics

authors： Mandel KG,Daggy BP,Brodie DA,Jacoby HI

更新日期：2000-06-01 00:00:00

abstract：:An analysis carried out in 1994 by the WHO International Agency for Research on Cancer (IARC) resulted in Helicobacter pylori being designated as a Group 1 carcinogen and thus clearly having an association with the development of gastric cancer. In the case of H. pylori, the evaluation was made solely on the basis of ...

journal_title：Alimentary pharmacology & therapeutics

authors： Asaka M,Kudo M,Kato M,Sugiyama T,Takeda H

更新日期：1998-02-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is very common in India, as in other developing countries, but few data exist on the susceptibility of H. pylori to antimicrobial agents commonly used for eradication here. AIM:To determine the antimicrobial susceptibility of H. pylori strains from Kolkata, in eastern India. M...

journal_title：Alimentary pharmacology & therapeutics

authors： Datta S,Chattopadhyay S,Patra R,De R,Ramamurthy T,Hembram J,Chowdhury A,Bhattacharya SK,Berg DE,Nair GB,Mukhopadhyay AK

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:HCV-TARGET is a longitudinal observational study of chronic hepatitis C virus (HCV) patients treated with direct-acting anti-viral agents (DAAs) in a US consortium of 90 academic and community medical centres. AIM:To assess utilisation of response-guided therapy (RGT) and sustained virological response (SVR...

journal_title：Alimentary pharmacology & therapeutics

authors： Sterling RK,Kuo A,Rustgi VK,Sulkowski MS,Stewart TG,Fenkel JM,El-Genaidi H,Mah'moud MA,Abraham GM,Stewart PW,Akushevich L,Nelson DR,Fried MW,Di Bisceglie AM

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus may lead to increased serum ammonia and systemic inflammation thereby promoting hepatic encephalopathy (HE). AIM:To investigate the potential association between diabetes mellitus/glycaemic control and the presence of covert HE as well as the development of overt HE in a prospective settin...

journal_title：Alimentary pharmacology & therapeutics

authors： Labenz C,Nagel M,Kremer WM,Hilscher M,Schilling CA,Toenges G,Kuchen R,Schattenberg JM,Galle PR,Wörns MA

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) infection is associated with the appearance of liver steatosis. AIM:To search for a correlation between the number of HCV infected hepatocytes and the presence, amount and distribution of steatosis. METHODS:A total of 124 frozen liver biopsies from HCV patients (genotype 3 = 21) wer...

journal_title：Alimentary pharmacology & therapeutics

authors： Grassi A,Ballardini G,Susca M,Bianchini F,Bonoli S,Bianchi FB,Lenzi M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:H2-receptor antagonists are becoming widely available as over-the-counter medications for the treatment of heartburn and excess gastric acidity. AIM:To determine the effects of single low doses of ranitidine on intragastric acidity. METHODS:Intragastric pH was measured for 9 h after lunch in five studies i...

journal_title：Alimentary pharmacology & therapeutics

authors： Wyeth JW,Pounder RE,Sercombe JC,Snell CC

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Liver-related mortality varies across developed nations. AIM:To assess the relative role of various risk factors in relation to liver-related mortality in an ecological study approach. METHODS:Data for liver-related mortality, prevalence data for hepatitis B and C, human immunodeficiency virus (HIV), alcoh...

journal_title：Alimentary pharmacology & therapeutics

authors： von Wulffen M,Clark PJ,Macdonald GA,Raj AS,Kendall BJ,Powell EE,Jones MP,Holtmann G

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND:Accuracy of intraepithelial lymphocytes counts for diagnosing mild enteropathy coeliac disease in absence of villous atrophy can be limited by inappropriate controls included in the studies. AIM:To determine the diagnostic accuracy of intraepithelial lymphocytes counts utilising controls lacking HLA coeliac...

journal_title：Alimentary pharmacology & therapeutics

authors： Pellegrino S,Villanacci V,Sansotta N,Scarfì R,Bassotti G,Vieni G,Princiotta A,Sferlazzas C,Magazzù G,Tuccari G

更新日期：2011-03-01 00:00:00

abstract：:In a Swedish double-blind multicentre study, omeprazole (30 mg o.m.) was compared with the H2-receptor antagonist cimetidine (400 mg b.d.) in 152 patients. Clinical assessments and laboratory investigations were carried out at 2 and 4 weeks, and again at 6 weeks in unhealed patients. Endoscopy was performed at 2 weeks...

journal_title：Alimentary pharmacology & therapeutics

authors： Dahlgren S,Domellöf L,Hradsky M,Norryd C,Brunkwall J,Svensson G,Svensson JO,Karlsson J,Knutson U,Gasslander T

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Budd-Chiari syndrome (BCS) is a rare but fatal disease caused by obstruction in the hepatic venous outflow tract. AIM:To provide an update of the pathophysiology, aetiology, diagnosis, management and follow-up of BCS. METHODS:Analysis of recent literature by using Medline, PubMed and EMBASE databases. RES...

journal_title：Alimentary pharmacology & therapeutics

authors： Khan F,Armstrong MJ,Mehrzad H,Chen F,Neil D,Brown R,Cain O,Tripathi D

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Hepatic disturbances in the context of intestinal failure and parenteral nutrition (PN) are frequently encountered and carry a significant burden of morbidity and sometimes mortality. The term intestinal failure-associated liver disease (IFALD) refers to liver injury due to intestinal failure and associated ...

journal_title：Alimentary pharmacology & therapeutics

authors： Bond A,Huijbers A,Pironi L,Schneider SM,Wanten G,Lal S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Little is known about the distinctive characteristics of subjects with frequent (at least weekly) and occasional gastro-oesophageal reflux symptoms. AIM:To compare the characteristics and disease management of subjects complaining of at least weekly and less frequent gastro-oesophageal reflux symptoms. MET...

journal_title：Alimentary pharmacology & therapeutics

authors： Bretagne JF,Honnorat C,Richard-Molard B,Caekaert A,Barthélemy P

更新日期：2006-03-01 00:00:00

abstract：:Eighteen healthy volunteers were included in a cross-over, double-blind study where 500 mg naproxen b.d. was given for 1 week with 20 mg famotidine b.d., 40 mg nocte or placebo. Endoscopic evaluation of the gastroduodenal mucosa was performed before and after each treatment period, with separate evaluation of the mid-...

journal_title：Alimentary pharmacology & therapeutics

authors： Aabakken L,Bjørnbeth BA,Weberg R,Viksmoen L,Larsen S,Osnes M

更新日期：1990-06-01 00:00:00

abstract：AIM:To compare, in a randomized controlled trial, the efficacy and tolerability of two 1-week triple therapies for Helicobacter pylori eradication. METHODS:One hundred and thirty-four consecutive patients with non-ulcer dyspepsia and H. pylori infection were randomized to receive lansoprazole 30 mg once daily, clarith...

journal_title：Alimentary pharmacology & therapeutics

authors： Bazzoli F,Zagari RM,Pozzato P,Fossi S,Ricciardiello L,Nicolini G,De Luca L,Berretti D,Alampi G,Di Pietro C,Morelli P,Roda E

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:This randomized, double-blind, multicentre study compared lansoprazole with placebo for symptomatic relief of patients with non-erosive gastro-oesophageal reflux disease (GERD). METHODS:214 patients with symptomatic, non-erosive GERD (moderate to severe daytime and/or night-time heartburn greater than half ...

journal_title：Alimentary pharmacology & therapeutics

authors： Richter JE,Kovacs TO,Greski-Rose PA,Huang section sign B,Fisher R

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Optimal management approach is not well defined for subjects who fail initial first- and second-line Helicobacter pylori eradication attempts and are dealt on a case-by-case basis by the specialists. AIM:To evaluate the efficacy and safety of standard and 'rescue' eradication therapies at primary and second...

journal_title：Alimentary pharmacology & therapeutics

authors： Qasim A,Sebastian S,Thornton O,Dobson M,McLoughlin R,Buckley M,O'Connor H,O'Morain C

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Currently, the relationship between depression and non-alcoholic fatty liver disease (NAFLD) is not clearly defined. AIM:To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample. METHODS:We performed a cross-sectional analysis using the 2007-...

journal_title：Alimentary pharmacology & therapeutics

authors： Kim D,Yoo ER,Li AA,Tighe SP,Cholankeril G,Harrison SA,Ahmed A

更新日期：2019-09-01 00:00:00