HCV liver infection and liver steatosis: evidence for indirect mechanisms in genotype 3?

abstract：BACKGROUND:Interferon might induce mutation in regions of hepatitis B virus DNA that encode for immunologic target of cytotoxic T lymphocytes. AIM:To investigate the short-term effect of steroid priming and interferon therapy on hepatitis B virus, we followed the nucleotide changes in the precore and core region of he...

journal_title：Alimentary pharmacology & therapeutics

authors： How W,Ng WC,Tan MF,Seet BL,Guan R

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Lansoprazole is a new proton pump inhibitor which produces prolonged decrease of gastric acidity. The aim of this study was to compare lansoprazole to a standard dose of ranitidine in the treatment of patients with reflux oesophagitis. METHODS:Two hundred and forty-seven patients with erosive oesophagitis w...

journal_title：Alimentary pharmacology & therapeutics

authors： Robinson M,Sahba B,Avner D,Jhala N,Greski-Rose PA,Jennings DE

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:The epidemiology and pathophysiology of non-erosive gastro-oesophageal reflux disease differs from erosive gastro-oesophageal reflux disease. There is a possibility that non-erosive gastro-oesophageal reflux disease treatment requires a different regimen/approach but it is not yet acknowledged. AIM:To inves...

journal_title：Alimentary pharmacology & therapeutics

authors： Wada T,Sasaki M,Kataoka H,Tanida S,Itoh K,Ogasawara N,Oshima T,Togawa S,Kubota E,Yamada T,Mori Y,Fujita F,Ohara H,Nakao H,Sobue S,Joh T,Itoh M

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Interferon (IFN-alpha)-based regimens have been used with varying success in the treatment of chronic hepatitis C (CHC) for over two decades. The effect of such treatments on the natural course of CHC has been evaluated in small clinical trials with conflicting results. AIM:To investigate the natural course...

journal_title：Alimentary pharmacology & therapeutics

authors： Manesis EK,Papatheodoridis GV,Touloumi G,Karafoulidou A,Ketikoglou J,Kitis GE,Antoniou A,Kanatakis S,Koutsounas SJ,Vafiadis I,HEPNET.Greece Cohort Study.

更新日期：2009-05-15 00:00:00

abstract：BACKGROUND:In vitro studies have shown that pH is an important determinant of mucus structure and function, but the relationship in vivo is unclear. Omeprazole increases intragastric pH and also allows bacterial overgrowth. In this study we have assessed the effect of omeprazole on gastric juice viscosity and examined ...

journal_title：Alimentary pharmacology & therapeutics

authors： Goddard AF,Spiller RC

更新日期：1996-02-01 00:00:00

abstract：:Proton pump inhibitors have dramatically influenced the management of acid-peptic disorders in recent years. They all have a broadly similar mechanism of action and are extensively metabolized in the liver via cytochromes P450 2C19 and 3A4. There is some variation in their potential for drug interactions due to differ...

journal_title：Alimentary pharmacology & therapeutics

authors： Stedman CA,Barclay ML

更新日期：2000-08-01 00:00:00

abstract：:Assessment of intragastric urease activity by the 13C-urea breath test was performed before and after one day of dosing with either De-Noltabs (tripotassium dicitrato bismuthate, one tablet 1 q.d.s.), Pepto-Bismol liquid (bismuth salicylate 30 ml q.d.s.), or Roter tablets (bismuth subnitrate, one tablet q.d.s.) in twe...

journal_title：Alimentary pharmacology & therapeutics

authors： Prewett EJ,Luk YW,Fraser AG,Lam WM,Pounder RE

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease. AIM:To evaluate the role of small intestinal bacterial overgrowth (SIBO) in condition of lactose intolerance and the mechanism by which SIBO may impact lactose tolerance in affected patients. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Zhao J,Fox M,Cong Y,Chu H,Shang Y,Fried M,Dai N

更新日期：2010-04-01 00:00:00

abstract：:The goals of the Baveno workshops were to develop consensus definitions of key events related to portal hypertension and variceal bleeding, and to produce guidelines to facilitate the conduct and reporting of clinical trials. The consensus definitions concern the diagnosis of active bleeding, failure to control bleedi...

journal_title：Alimentary pharmacology & therapeutics

authors： de Franchis R

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Incidence and mortality of gastric cancer (GC) are high in Mongolia despite Helicobacter pylori in the Mongolian population being less virulent. AIM:To evaluate gastric bacterial microbiota profiles in patients with GC and its precursor histological conditions. METHODS:We conducted a case-control study amo...

journal_title：Alimentary pharmacology & therapeutics

authors： Gantuya B,El Serag HB,Matsumoto T,Ajami NJ,Uchida T,Oyuntsetseg K,Bolor D,Yamaoka Y

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Chronic constipation may result in disabling symptoms, is often unsatisfactorily treated by laxatives and negatively impacts quality of life (QoL). AIM:A randomized, double-blind, placebo-controlled, phase III trial to evaluate the efficacy and safety of a selective, high-affinity 5-HT(4) receptor agonist, ...

journal_title：Alimentary pharmacology & therapeutics

authors： Quigley EM,Vandeplassche L,Kerstens R,Ausma J

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Although little mortality is associated with irritable bowel syndrome, curative therapy does not exist and thus the economic impact of this disorder may be considerable. METHODS:A systematic review of the literature was performed. Studies were included if their focus was irritable bowel syndrome, and direct...

journal_title：Alimentary pharmacology & therapeutics

authors： Inadomi JM,Fennerty MB,Bjorkman D

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM:To assess utility of these markers in a Western population. METHODS:SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prev...

journal_title：Alimentary pharmacology & therapeutics

authors： Song M,Camargo MC,Weinstein SJ,Murphy G,Freedman ND,Koshiol J,Stolzenberg-Solomon RZ,Abnet CC,Männistö S,Albanes D,Rabkin CS

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Gastrointestinal (GI) symptoms are common in soldiers in combat or high-pressure operational situations and often lead to compromised performance. Underlying mechanisms are unclear, but neuroendocrine dysregulation, immune activation and increased intestinal permeability may be involved in stress-related GI ...

journal_title：Alimentary pharmacology & therapeutics

authors： Li X,Kan EM,Lu J,Cao Y,Wong RK,Keshavarzian A,Wilder-Smith CH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Strong acid inhibition using esomeprazole increases cure rates with triple therapy and 10-day treatments are more effective than 7-day ones. The combination of amoxicillin plus metronidazole at full doses, and using a physiologically-correct schedule three times a day, and has been shown to overcome metronid...

journal_title：Alimentary pharmacology & therapeutics

authors： Sánchez-Delgado J,García-Iglesias P,Castro-Fernández M,Bory F,Barenys M,Bujanda L,Lisozain J,Calvo MM,Torra S,Gisbert JP,Calvet X

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Upper gastrointestinal bleeding is a common medical emergency associated with substantial mortality. Tranexamic acid may be effective for reducing mortality in upper gastrointestinal bleeding. AIM:To examine the effects of tranexamic acid in upper gastrointestinal bleeding by systematic review and meta-anal...

journal_title：Alimentary pharmacology & therapeutics

authors： Twum-Barimah E,Abdelgadir I,Gordon M,Akobeng AK

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:There is a need for effective and inexpensive therapy for Helicobacter pylori with good patient compliance. AIM:To evaluate a simplified twice daily schedule for treating H. pylori. METHODS:Patients infected with H. pylori (positive by CLO- and 13C-urea breath tests [UBT]) and not previously treated with a...

journal_title：Alimentary pharmacology & therapeutics

authors： Mönkemüller KE,Hirschowitz BI

更新日期：1999-05-01 00:00:00

abstract：AIM:: To quantify through systematic review the pharmacokinetic profiles of the oral delayed release and sustained release mesalazine (5-aminosalicylate, 5ASA) formulations (Asacol, Salofalk, Mesasal, Claversal, Pentasa) and pro-drugs (sulfasalazine, olsalazine, balsalazide) used in the management of ulcerative colitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Sandborn WJ,Hanauer SB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Nocturnal gastro-oesophageal reflux diseases (GERD) can lead to oesophageal mucosal injury and extra-oesophageal complications. AIM:To compare distribution of oesophageal acid exposure during sleep time among patients with non-erosive reflux disease and abnormal pH test (NERD-positive), erosive oesophagitis...

journal_title：Alimentary pharmacology & therapeutics

authors： Dickman R,Parthasarathy S,Malagon IB,Jones P,Han B,Powers J,Fass R

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Hepatic encephalopathy (HE) may occur after transjugular intrahepatic portosystemic shunt (TIPSS) placement. Multimodal magnetic resonance imaging (MRI), combining anatomical sequences, diffusion tensor imaging (DTI) and 1 H magnetic resonance spectroscopy, is modified in cirrhotic patients. AIMS:To describ...

journal_title：Alimentary pharmacology & therapeutics

authors： Rudler M,Weiss N,Perlbarg V,Mallet M,Tripon S,Valabregue R,Marjańska M,Cluzel P,Galanaud D,Thabut D

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Oral aloe vera gel is widely used by patients with inflammatory bowel disease and is under therapeutic evaluation for this condition. AIM:To assess the effects of aloe vera in vitro on the production of reactive oxygen metabolites, eicosanoids and interleukin-8, all of which may be pathogenic in inflammator...

journal_title：Alimentary pharmacology & therapeutics

authors： Langmead L,Makins RJ,Rampton DS

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The incidence rates of gastric and oesophageal adenocarcinoma are changing significantly, but little is known about specific sub-sites. AIM:To use a population-based approach to describe the trends in the site-specific incidence of oesophageal and gastric adenocarcinoma. METHODS:Using the Rochester Epidemi...

journal_title：Alimentary pharmacology & therapeutics

authors： Crane SJ,Richard Locke G 3rd,Harmsen WS,Diehl NN,Zinsmeister AR,Joseph Melton L 3rd,Romero Y,Talley NJ

更新日期：2007-02-15 00:00:00

abstract：BACKGROUND:The association between ulcerative colitis and cytomegalovirus (CMV) has been recognised for over 50 years; and the role of CMV in ulcerative colitis in general, and steroid resistance in particular, remains a topic of ongoing controversy. The outcome for patients with CMV reactivation appears worse than tha...

journal_title：Alimentary pharmacology & therapeutics

authors： Sager K,Alam S,Bond A,Chinnappan L,Probert CS

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:A simulated upper gastrointestinal (UGI) bleed in cirrhotic patients has been shown to induce hyperammonaemia. The kidney was the site of this exaggerated ammoniagenesis with alanine as substrate. Administration of alanine to decompensated cirrhotic patients did not change hepatic gluconeogenesis, but result...

journal_title：Alimentary pharmacology & therapeutics

authors： Mpabanzi L,Deutz N,Hayes PC,Dejong CH,Olde Damink SW,Jalan R

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Adverse events leading to discontinuation or dose reduction of thiopurine therapy occur in 9-28% of patients with inflammatory bowel disease. AIMS:To evaluate the influence of thiopurine methyltransferase status and thiopurine metabolites in a large patient population for the risk of developing adverse even...

journal_title：Alimentary pharmacology & therapeutics

authors： Hindorf U,Lindqvist M,Hildebrand H,Fagerberg U,Almer S

更新日期：2006-07-15 00:00:00

abstract：BACKGROUND:Epidemiological data concerning hepatitis B are scarce in France. AIM:To describe epidemiological, clinical, virological and histological features of HBsAg-positive patients followed at non-academic hospitals in France. METHODS:Clinical, biological, virological and histological data of all HBsAg-positive c...

journal_title：Alimentary pharmacology & therapeutics

authors： Cadranel JF,Lahmek P,Causse X,Bellaiche G,Bettan L,Fontanges T,Medini A,Henrion J,Chousterman M,Condat B,Hervio P,Periac P,Eugène C,Moindrot H,Grasset D,Nouel O,Pilette C,Szostak-Talbodec N,Cayla JM,Si-Ahmed SN,Du

更新日期：2007-08-15 00:00:00

abstract：BACKGROUND:Clostridium difficile (C. difficile) infection in hospitals in developed countries continues to be a major public health hazard despite increased control measures including review of antibiotic policies and hygiene measures. Patients with colitis are thought to be particularly vulnerable to C. difficile asso...

journal_title：Alimentary pharmacology & therapeutics

authors： Jen MH,Saxena S,Bottle A,Aylin P,Pollok RC

更新日期：2011-06-01 00:00:00

abstract：:Renal function abnormalities and ascites in cirrhosis are the final consequence of a circulatory dysfunction characterized by marked splanchnic arterial vasodilation. This causes a reduction in effective arterial blood volume and the homoeostatic activation of vasoconstrictor and sodium-retaining systems. Albumin is v...

journal_title：Alimentary pharmacology & therapeutics

authors： Ginès P,Guevara M,De Las Heras D,Arroyo V

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Hepatitis vaccination is recommended in patients with chronic liver disease. AIM:To validate Current Procedural Terminology (CPT) codes and drug codes for hepatitis vaccination in administrative databases and determine vaccination rates in hepatitis C virus (HCV)-infected patients in a single large Veterans...

journal_title：Alimentary pharmacology & therapeutics

authors： Hachem CY,Kramer JR,Kanwal F,El-Serag HB

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:The global burden of hepatitis C (HCV) infection is mostly found in Africa, the Middle East and Asia, where HCV genotypes 4, 5 and 6 are common. The literature on these genotypes is sparse and this synopsis will review characteristics of patients infected with these genotypes. AIM:To review characteristics ...

journal_title：Alimentary pharmacology & therapeutics

authors： Wantuck JM,Ahmed A,Nguyen MH

更新日期：2014-01-01 00:00:00