当前位置： SCI文献检索 > ALIMENTARY PHARMACOLOGY & THERAPEUTICS期刊下所有文献 > Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males.

Serum pepsinogen 1 and anti-Helicobacter pylori IgG antibodies as predictors of gastric cancer risk in Finnish males.

Abstract：

BACKGROUND:Serum pepsinogen 1 (SPG1) and anti-Helicobacter pylori serology have been used for gastric risk stratification in Asia. AIM:To assess utility of these markers in a Western population. METHODS:SPG1 measurements were available for 21 895 Finnish male smokers in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. We used Cox proportional hazards models adjusted for potential confounders to estimate gastric cancer hazard ratios (HR) and 95% confidence intervals (95% CI) for low SPG1 (<25 μg/L). In a subset (n = 3555) with anti-H. pylori serology, these markers jointly defined the following: Group A (H. pylori[-], SPG1[normal]; reference group), Group B (H. pylori[+], SPG1[normal]), Group C (H. pylori[+], SPG1[low]) and Group D (H. pylori[-], SPG1[low]). Odds ratios (ORs) and 95% CI were calculated using multivariate logistic regression. RESULTS:There were 329 gastric cancers diagnosed an average of 13.9 years after baseline. Pre-diagnostic low SPG1 was significantly associated with increased gastric cancer risk (HR 2.68, 95% CI 1.99-3.61). Among subjects with both SPG1 and H. pylori serology, groups B, C and D had increased gastric cancer ORs (95% CI) of 1.79 (1.21-2.64), 3.85 (2.36-6.28) and 6.35 (2.20-18.34), respectively. CagA seropositives had significantly higher ORs than CagA seronegatives within group B (Pheterogeneity  = 0.01). For groups B and C, repeat SPG1 level at 3 years did not further stratify gastric cancer risk. CONCLUSIONS:Low SPG1 was associated with increased gastric cancer risk in our large Finnish cohort. A single measurement of SPG1 along with H. pylori whole cell and CagA serology provides potentially useful prediction of gastric cancer risk.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Song M,Camargo MC,Weinstein SJ,Murphy G,Freedman ND,Koshiol J,Stolzenberg-Solomon RZ,Abnet CC,Männistö S,Albanes D,Rabkin CS

doi

10.1111/apt.14471

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

494-503

issue

4

eissn

0269-2813

issn

1365-2036

journal_volume

47

pub_type

杂志文章

相关文献

ALIMENTARY PHARMACOLOGY & THERAPEUTICS文献大全
  • Obesity is independently associated with infection in hospitalised patients with end-stage liver disease.

    abstract：BACKGROUND:Infection is the most common cause of mortality in end-stage liver disease (ESLD). The impact of obesity on infection risk in ESLD is not established. AIM:To characterise the impact of obesity on infection risk in ESLD. METHODS:We evaluated the association between infection and obesity in patients with ESL...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.13426

    authors： Sundaram V,Kaung A,Rajaram A,Lu SC,Tran TT,Nissen NN,Klein AS,Jalan R,Charlton MR,Jeon CY

    更新日期：2015-12-01 00:00:00

  • Novel score for prediction of malignant bile duct obstruction based on biochemical and clinical markers.

    abstract：BACKGROUND:Early differentiation of malignant from benign bile duct obstruction is of utmost importance. AIM:To identify biochemical and clinical predictors for malignancy in patients with bile duct obstruction, and establish a predictive model by combining pre-treatment patient characteristics. A web-based applicatio...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.13152

    authors： Meister T,Uphoff MA,Heinecke A,Domagk D,Kunsch S,Lindhorst A,Ellenrieder V,Heinzow HS

    更新日期：2015-05-01 00:00:00

  • Drug-induced acute pancreatitis: results from the hospital-based Berlin case-control surveillance study of 102 cases.

    abstract：BACKGROUND:Drug toxicity is a well-known cause of acute pancreatitis (AP). Although many drugs have been associated with AP, the magnitude of the risk of most of them remains largely unknown. AIM:To determine the pancreatotoxic risk of a wide range of drugs. METHODS:The hospital-based Berlin case-control surveillance...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.12461

    authors： Douros A,Bronder E,Andersohn F,Klimpel A,Thomae M,Ockenga J,Kreutz R,Garbe E

    更新日期：2013-10-01 00:00:00

  • Rat CXC chemokine GRO/CINC-1 paradoxically stimulates the growth of gastric epithelial cells.

    abstract：BACKGROUND:CXC chemokines such as interleukin (IL)-8 are neutrophil chemoattractants, the levels of which increase in Helicobacter pylori-infected gastric mucosa. Many investigators have focused on the chemotactic aspects of IL-8: however, CXC chemokines are also reported to have angiogenic activity and to serve as rem...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.2000.014s1094.x

    authors： Suzuki H,Mori M,Seto K,Shibata F,Nagahashi S,Kawaguchi C,Suzuki M,Matsui H,Watanabe K,Miura S,Ishii H

    更新日期：2000-04-01 00:00:00

  • Bismuth-based quadruple therapy for Helicobacter pylori - a single triple capsule plus lansoprazole.

    abstract：BACKGROUND:Recently a new 'all in one' single capsule with the three components of bismuth-based triple therapy became available in trials for treating Helicobacter pylori. AIM:To investigate the efficacy and tolerability of this new capsule when combined with lansoprazole. METHODS:A total of 66 consecutive infected ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2000.00686.x

    authors： De Boer WA,Van Etten RJ,Van De Wouw BA,Schneeberger PM,Van Oijen AH,Jansen JB

    更新日期：2000-01-01 00:00:00

  • Review article: the management of autoimmune hepatitis beyond consensus guidelines.

    abstract：BACKGROUND:Consensus guidelines aid in the diagnosis and management of autoimmune hepatitis, but they are frequently based on low-quality clinical evidence, conflicting experiences and divergent opinions. Recommendations may be weak, discrepant or non-existent at critical decision points. AIMS:To identify the decision...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/apt.12381

    authors： Czaja AJ

    更新日期：2013-08-01 00:00:00

  • Review article: the treatment of fatty liver disease associated with the metabolic syndrome.

    abstract：:The treatment of non-alcoholic fatty liver disease may be worthwhile to prevent progression to advanced liver failure, but no therapy is definitely evidence-based. Weight loss or lifestyle modifications remain the primary line of intervention, particularly in overweight or obese subjects. In adult non-alcoholic fatty ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2005.02593.x

    authors： Marchesini G,Natale S,Manini R,Agostini F

    更新日期：2005-11-01 00:00:00

  • Review article: proton pump inhibitors with clopidogrel--evidence for and against a clinically-important interaction.

    abstract：BACKGROUND:The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors are frequently recommended for patients receiving clopidogrel in addition to aspirin, to minimise the risk of bleeding. Several studies have shown that proton pump inhibitors can affect the plat...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2011.04585.x

    authors： Disney BR,Watson RD,Blann AD,Lip GY,Anderson MR

    更新日期：2011-04-01 00:00:00

  • Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome.

    abstract：AIM:To update previous overviews of placebo-controlled double-blind trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome. METHODS AND TRIALS: A total of 23 randomized clinical trials were selected for meta-analyses of their efficacy and tolerance. Six drugs were analysed: c...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1046/j.1365-2036.2001.00937.x

    authors： Poynard T,Regimbeau C,Benhamou Y

    更新日期：2001-03-01 00:00:00

  • What is the role of serology in assessing Helicobacter pylori eradication?

    abstract：AIM:To assess the decline in Helicobacter pylori antibodies after eradication of infection. METHODS:The H. pylori status was determined at entry (D0) by culture and histology performed on antral biopsies and after eradication treatment at day 42 (day 42) and after 6 months (M6) by the 13C-urea breath test. The EIA kit...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2003.01716.x

    authors： Bergey B,Marchildon P,Peacock J,Mégraud F

    更新日期：2003-09-15 00:00:00

  • Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy.

    abstract：BACKGROUND:Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies. AIM:To systematically evaluate whether adding probiotics to anti-H. pylori regimens could improve eradication rates and reduce side effects during anti-H. pylori treatment. METHODS:Eligib...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1365-2036.2006.03179.x

    authors： Tong JL,Ran ZH,Shen J,Zhang CX,Xiao SD

    更新日期：2007-01-15 00:00:00

  • Systematic review with meta-analysis: the efficacy of tranexamic acid in upper gastrointestinal bleeding.

    abstract：BACKGROUND:Upper gastrointestinal bleeding is a common medical emergency associated with substantial mortality. Tranexamic acid may be effective for reducing mortality in upper gastrointestinal bleeding. AIM:To examine the effects of tranexamic acid in upper gastrointestinal bleeding by systematic review and meta-anal...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,meta分析

    doi：10.1111/apt.15761

    authors： Twum-Barimah E,Abdelgadir I,Gordon M,Akobeng AK

    更新日期：2020-06-01 00:00:00

  • Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population-based study.

    abstract：BACKGROUND:Peptic ulcer bleeding remains a major healthcare problem despite decreasing prevalence of peptic ulcer disease. The role of chronic obstructive pulmonary disease (COPD) in the risk of peptic ulcer bleeding has not yet been established. AIM:To determine if COPD patients have a higher risk of peptic ulcer ble...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2012.05028.x

    authors： Huang KW,Luo JC,Leu HB,Lin HC,Lee FY,Chan WL,Lin SJ,Chen JW,Chang FY

    更新日期：2012-04-01 00:00:00

  • Pharmacokinetics of N-acetylcysteine are altered in patients with chronic liver disease.

    abstract：BACKGROUND:The threshold plasma paracetamol concentration at which N-acetylcysteine (NAC) treatment is recommended to treat paracetamol poisoning in a patient with induced liver enzymes (for example, with chronic liver disease or taking anticonvulsant drugs) is 50% lower than in a patient without induced liver enzymes....

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章

    doi：10.1046/j.1365-2036.1997.00209.x

    authors： Jones AL,Jarvie DR,Simpson D,Hayes PC,Prescott LF

    更新日期：1997-08-01 00:00:00

  • Serum pepsinogen and gastrin levels in HIV-positive patients: relationship with CD4+ cell count and Helicobacter pylori infection.

    abstract：BACKGROUND:The relationship between serum parameters of gastric function and Helicobacter pylori infection in human immunodeficiency virus (HIV)-positive patients is almost unknown. AIMS:To investigate in HIV-infected patients: (i) the relationship between serum gastrin and serum pepsinogens over the progressive phase...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.2002.01234.x

    authors： Fabris P,Pilotto A,Bozzola L,Tositti G,Soffiati G,Manfrin V,de Lalla F

    更新日期：2002-04-01 00:00:00

  • Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer?

    abstract：BACKGROUND:Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. AIM:To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. METHODS:A total of 77 patients with H. pylori-positive duodenal ulcer w...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2001.01020.x

    authors： Tepes B,Krizman I,Gorensek M,Gubina M,Orel I

    更新日期：2001-07-01 00:00:00

  • A randomized trial in primary biliary cirrhosis comparing ursodeoxycholic acid in daily doses of either 10 mg/kg or 20 mg/kg. Dutch Multicentre PBC Study Group.

    abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) prolongs transplantation-free survival in primary biliary cirrhosis (PBC). However, the optimal therapeutic dose has not been established. AIM:To compare the effects of UDCA administered in daily doses of 10 vs. 20 mg/kg on symptoms, liver biochemistry and biliary UDCA enrichment...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1365-2036.1998.00395.x

    authors： Van Hoogstraten HJ,De Smet MB,Renooij W,Breed JG,Engels LG,Den Ouden-Muller JW,Rijk MC,Smit AM,Zwertbroek R,Hop WC,van Berge Henegouwen GP,Schalm SW,van Buuren HR

    更新日期：1998-10-01 00:00:00

  • Citric acid-enhanced Helicobacter pylori urease activity in vivo is unrelated to gastric emptying.

    abstract：BACKGROUND:In a previous study, the use of a citric acid test meal produced a rapid dose-dependent increase in urease activity that was significantly greater than that resulting from a pudding meal, ascorbic acid or sodium citrate. The mechanism was hypothesized to be related to the ability of citric acid to delay gast...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.2001.01096.x

    authors： Shiotani A,Saeed A,Yamaoka Y,Osato MS,Klein PD,Graham DY

    更新日期：2001-11-01 00:00:00

  • Role of inducible nitric oxide synthase in dextran sulphate sodium-induced colitis.

    abstract：BACKGROUND:Different authors have postulated both toxic and protective effects for nitric oxide (NO) in the pathophysiology of active inflammation. AIM:To examine the role of NO, especially that produced by the inducible form of nitric oxide synthase (iNOS), by investigating the effects of NOS inhibitors and NO donors...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1046/j.1365-2036.2000.014s1026.x

    authors： Yoshida Y,Iwai A,Itoh K,Tanaka M,Kato S,Hokari R,Miyahara T,Koyama H,Miura S,Kobayashi M

    更新日期：2000-04-01 00:00:00

  • Review article: endoscopy-related infections.

    abstract：:Endoscopic procedures generate bacteraemia to different degrees. Under certain conditions, most notably valvular heart disease, clinically significant infections may occur. A large body of literature has grown around recommendations for antibiotic prophylaxis to prevent procedure-related infections. Most of this liter...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：

    authors： Schembre D,Bjorkman DJ

    更新日期：1993-08-01 00:00:00

  • Endoscopic ablation of Barrett's oesophagus: a randomized-controlled trial of photodynamic therapy vs. argon plasma coagulation.

    abstract：BACKGROUND:Barrett's oesophagus is the major risk factor for oesophageal adenocarcinoma. 5-Aminlevulinic acid-induced photodynamic therapy and argon plasma coagulation have been shown to be effective for ablating Barrett's oesophagus, but a comparative trial of these two modalities has not been reported. AIMS:To compa...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1111/j.1365-2036.2004.02277.x

    authors： Kelty CJ,Ackroyd R,Brown NJ,Stephenson TJ,Stoddard CJ,Reed MW

    更新日期：2004-12-01 00:00:00

  • Low-dose furazolidone in triple and quadruple regimens for Helicobacter pylori eradication.

    abstract：BACKGROUND:Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective. Unfortunately, the usual dose of furazolidone is not tolerable in many patients. Lower doses of furazolidone are expected to cause fewer adverse effects. AIM:To investigate the efficacy of low-dose furazolidon...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2036.2003.01822.x

    authors： Fakheri H,Merat S,Hosseini V,Malekzadeh R

    更新日期：2004-01-01 00:00:00

  • Review article: dual delayed release formulation of dexlansoprazole MR, a novel approach to overcome the limitations of conventional single release proton pump inhibitor therapy.

    abstract：BACKGROUND:Proton pump inhibitors (PPIs) provide the most effective pharmacotherapy for treating acid-related disorders. However, PPIs do not completely control acid over 24 h with once-daily dosing. AIMS:To discuss limitations inherent in the pharmacokinetics (PK) and pharmacodynamics of conventional PPI formulations...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2036.2009.03984.x

    authors： Metz DC,Vakily M,Dixit T,Mulford D

    更新日期：2009-05-01 00:00:00

  • Lactose intolerance in patients with chronic functional diarrhoea: the role of small intestinal bacterial overgrowth.

    abstract：BACKGROUND:Many studies report a high prevalence of lactose intolerance in patients with functional, gastrointestinal disease. AIM:To evaluate the role of small intestinal bacterial overgrowth (SIBO) in condition of lactose intolerance and the mechanism by which SIBO may impact lactose tolerance in affected patients. ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2010.04252.x

    authors： Zhao J,Fox M,Cong Y,Chu H,Shang Y,Fried M,Dai N

    更新日期：2010-04-01 00:00:00

  • Increased risk of developing Crohn's disease or ulcerative colitis in 17 018 patients while under treatment with anti-TNFα agents, particularly etanercept, for autoimmune diseases other than inflammatory bowel disease.

    abstract：BACKGROUND:Anti-TNFα agents have revolutionised management of chronic inflammatory diseases. Paradoxically, these agents might provoke development of de novo autoimmune diseases. AIM:To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.15370

    authors： Korzenik J,Larsen MD,Nielsen J,Kjeldsen J,Nørgård BM

    更新日期：2019-08-01 00:00:00

  • Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire.

    abstract：BACKGROUND:The reflux disease questionnaire (RDQ) is a short, patient-completed instrument. AIMS:To investigate the psychometric characteristics of the RDQ in patients with heartburn-predominant (HB) and non-heartburn predominant (NHB) dyspepsia. METHODS:HB (n = 388) and NHB (n = 733) patients were randomized to esom...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2036.2007.03271.x

    authors： van Zanten SV,Armstrong D,Barkun A,Junghard O,White RJ,Wiklund IK

    更新日期：2007-05-01 00:00:00

  • Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data.

    abstract：BACKGROUND:Limited therapeutic options exist for severe gastroparesis, where severe nausea and vomiting can lead to weight loss, dehydration and malnutrition due to inadequate caloric and fluid intake. TZP-101 (ulimorelin) is a ghrelin receptor agonist that accelerates gastric emptying and improves upper gastrointestin...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1365-2036.2010.04567.x

    authors： Wo JM,Ejskjaer N,Hellström PM,Malik RA,Pezzullo JC,Shaughnessy L,Charlton P,Kosutic G,McCallum RW

    更新日期：2011-03-01 00:00:00

  • Review article: can bugs be drugs? The potential of probiotics and prebiotics as treatment for non-alcoholic fatty liver disease.

    abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver condition. A major current research effort is ongoing to find potential strategies to treat NAFLD-non-alcoholic steatohepatitis (NASH), with special attention to the gut microbiota. Multiple animal studies and pilot clinical t...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章,评审

    doi：10.1111/apt.15416

    authors： Koopman N,Molinaro A,Nieuwdorp M,Holleboom AG

    更新日期：2019-09-01 00:00:00

  • Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis C patients receiving peginterferon alpha-2b plus ribavirin.

    abstract：BACKGROUND:Cross-sectional studies suggest insulin resistance is strongly associated with hepatic steatosis and fibrosis in patients with chronic hepatitis C (CHC), which might affect the efficacy of antiviral therapy. Aim To investigate retrospectively the impact of insulin resistance on treatment response in Chinese ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/j.1365-2036.2008.03823.x

    authors： Chu CJ,Lee SD,Hung TH,Lin HC,Hwang SJ,Lee FY,Lu RH,Yu MI,Chang CY,Yang PL,Lee CY,Chang FY

    更新日期：2009-01-01 00:00:00

  • Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations.

    abstract：BACKGROUND:Epidemiological data of coeliac disease are lacking from the central Asian region. AIMS:To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China. METHODS:2277 in-patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 ...

    journal_title：Alimentary pharmacology & therapeutics

    pub_type： 杂志文章

    doi：10.1111/apt.15737

    authors： Zhou C,Gao F,Gao J,Yuan J,Lu J,Sun Z,Xu M,Engel J,Hui W,Gilissen L,Chen H

    更新日期：2020-06-01 00:00:00