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Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer?

Abstract：

BACKGROUND:Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. AIM:To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. METHODS:A total of 77 patients with H. pylori-positive duodenal ulcer were included in a prospective, controlled, double-blind study. All patients received a 7-day treatment with omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and amoxicillin 1000 mg b.d. Patients in the omeprazole group underwent an additional 14-day therapy with omeprazole 20 mg; patients in placebo group received placebo. Endoscopy was performed upon inclusion in the study and after 3 and 8 weeks. RESULTS:Seventy-four patients were eligible for a per protocol analysis after 3 weeks, and 65 after 8 weeks. After 3 weeks, the healing rate was 89% in the omeprazole group and 81% in the placebo group (P=0.51). After 8 weeks, the ulcer healed in 97% of the patients in the total group (95% CI: 92.7-100%). H. pylori was eradicated in 88% of patients in the omeprazole group and in 91% in the placebo group (P=1.0). No statistically significant differences between the groups were found in ulcer-related symptoms or in ulcer healing. CONCLUSION:In patients with H. pylori-positive duodenal ulcer, a 7-day triple therapy alone is sufficient to control the disease.

journal_name

Aliment Pharmacol Ther

journal_title

Alimentary pharmacology & therapeutics

authors

Tepes B,Krizman I,Gorensek M,Gubina M,Orel I

doi

10.1046/j.1365-2036.2001.01020.x

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

1037-45

issue

7

eissn

0269-2813

issn

1365-2036

pii

apt1020

journal_volume

15

pub_type

临床试验,杂志文章,随机对照试验

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