Viral nucleotide changes in asymptomatic hepatitis B carriers undergoing interferon treatment.

Abstract:

BACKGROUND:Interferon might induce mutation in regions of hepatitis B virus DNA that encode for immunologic target of cytotoxic T lymphocytes. AIM:To investigate the short-term effect of steroid priming and interferon therapy on hepatitis B virus, we followed the nucleotide changes in the precore and core region of hepatitis B virus DNA in seven healthy asymptomatic carriers who underwent steroid priming followed by recombinant alpha interferon for 3 months. METHODS:Hepatitis B virus DNA from serial sera of the patients were polymerase chain reaction-amplified, and the precore and core region directly sequenced and analysed. RESULTS:Analysis revealed no serial changes in the hepatitis B virus nucleotide sequence in any of the patients. CONCLUSIONS:Steroid priming and short-term treatment with interferon in healthy asymptomatic patients does not select for hepatitis B virus with mutations in the precore and core region.

journal_name

Aliment Pharmacol Ther

authors

How W,Ng WC,Tan MF,Seet BL,Guan R

doi

10.1046/j.1365-2036.1996.718898000.x

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

199-202

issue

2

eissn

0269-2813

issn

1365-2036

journal_volume

10

pub_type

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