Double-blind placebo-controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection.

abstract：BACKGROUND:Strong suppression of viral replication and normalization of alanine aminotransferase is feasible with nucleos(t)ide analogues. It is estimated viral replication and liver inflammation can be controlled in 90% of patients with chronic hepatitis B with the current available treatments. AIM:To review the stud...

journal_title：Alimentary pharmacology & therapeutics

authors： Leemans WF,Ter Borg MJ,de Man RA

更新日期：2007-12-01 00:00:00

abstract：:Despite the fact that non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely used drugs in medicine today, 2-10% of patients must discontinue their use primarily due to gastrointestinal (GI) side-effects. While the development of non-aspirin NSAIDs (NA-NSAIDs) has significantly reduced GI side-effect...

journal_title：Alimentary pharmacology & therapeutics

authors： Butt JH,Barthel JS,Hosokawa MC,Moore RA

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAIDs) are a leading cause of drug-induced liver injury (DILI) across the world. Ibuprofen is one of the most commonly used and safest NSAIDs, nevertheless reports on ibuprofen-induced hepatotoxicity are available. AIM:To analyse previously published information on ibu...

journal_title：Alimentary pharmacology & therapeutics

authors： Zoubek ME,Lucena MI,Andrade RJ,Stephens C

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Pneumatic dilation has re-emerged as a first line treatment for achalasia, but conclusions are limited by the relatively small numbers of patients studied and the lack of long term follow-up. AIM:To summarise and analyse 29 available studies evaluating pneumatic dilation for achalasia with focus on efficacy...

journal_title：Alimentary pharmacology & therapeutics

authors： Katzka DA,Castell DO

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Low-dose thiopurine-allopurinol (LDTA) combination therapy is a commonly applied optimisation strategy in IBD patients with a skewed thiopurine metabolism. AIM:To assess continued LDTA maintenance treatment at annual intervals and explore risk factors for treatment cessation METHODS: Adult IBD patients trea...

journal_title：Alimentary pharmacology & therapeutics

authors： Kreijne JE,de Veer RC,de Boer NK,Dijkstra G,West R,Moorsel SAW,de Jong DJ,van der Woude CJ,de Vries AC,of the Dutch Initiative on Crohn, Colitis (ICC).

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Gastrimmune is an immunogenic form of gastrin. It raises in situ antibodies against two proliferative forms of gastrin: amidated and glycine-extended gastrin-17. It has been shown to have a therapeutic action in several in vivo tumour models. Following immunization, due to the complex equilibrium that exists...

journal_title：Alimentary pharmacology & therapeutics

authors： Smith AM,Morris T,Justin T,Michaeli D,Watson SA

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:The prevalence of coeliac disease (CD) may be increased in individuals with dyspepsia, but evidence is conflicting. AIMS:To conduct a systematic review and meta-analysis of studies reporting prevalence of CD in dyspepsia. METHODS:MEDLINE, EMBASE, and CINAHL were searched up to February 2009. Case series an...

journal_title：Alimentary pharmacology & therapeutics

authors： Ford AC,Ching E,Moayyedi P

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Recurrent hepatitis C represents a major challenge for the liver transplant community. Given the potentially significant impact that hepatitis C recurrence has on graft and patient survival, several treatment strategies have been utilized to prevent/slow the progression to hepatitis C-related graft failure. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Arjal RR,Burton JR Jr,Villamil F,Rosen HR

更新日期：2007-07-15 00:00:00

abstract：BACKGROUND:Non-cardiac chest pain is one of the most common functional gastrointestinal disorders. By recognising that gastro-oesophageal reflux disease (GERD), oesophageal dysmotility and oesophageal hypersensitivity are the main underlying mechanisms of NCCP, a more directed therapeutic approach has been developed. ...

journal_title：Alimentary pharmacology & therapeutics

authors： George N,Abdallah J,Maradey-Romero C,Gerson L,Fass R

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Lubiprostone (8 μg b.d.) received US Food and Drug Administration (FDA) approval in 2008 for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) in women aged ≥18 years. In 2012, the FDA issued new guidance for IBS-C clinical trials, recommending a composite endpoint incorporating both...

journal_title：Alimentary pharmacology & therapeutics

authors： Chang L,Chey WD,Drossman D,Losch-Beridon T,Wang M,Lichtlen P,Mareya S

更新日期：2016-11-01 00:00:00

abstract：:Variceal haemorrhage is a common medical emergency with a high mortality (30-50%). Adequate resuscitation is vital, and once stabilised the patient should be moved to a high-dependency area. Antibiotics reduce mortality, and the vasoactive drug terlipressin should be administered if early endoscopy is unavailable. Ear...

journal_title：Alimentary pharmacology & therapeutics

authors： Ferguson JW,Tripathi D,Hayes PC

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND:Phenolphthalein is widely used as a safe and effective laxative. After oral administration, phenolphthalein is absorbed in the small bowel and is conjugated in the liver to phenolphthalein glucuronide which passes into the colon where it is deconjugated and the active compound, phenolphthalein, is released. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Anand BS,Torres E,Operkun A,Graham DY

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results. METHODS:Three different studies were performed. First, a 13C-UBT was performed in 41 Helicobacter pylori infected subjects ...

journal_title：Alimentary pharmacology & therapeutics

authors： Perri F,Maes B,Geypens B,Ghoos Y,Hiele M,Rutgeerts P

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Drugs for the management of cardiovascular disease may provoke gastrointestinal discomfort and complications. AIM:To evaluate whether upper gastrointestinal symptoms affect the health status of patients with cardiovascular disease. METHODS:Two weeks after discharge, 958 consecutive patients, who had been a...

journal_title：Alimentary pharmacology & therapeutics

authors： Laheij RJ,Van Rossum LG,Krabbe PF,Jansen JB,Verheugt FW

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Ursodeoxycholic acid (UDCA) is able to improve biochemical markers of cholestasis, with a parallel decrease in transaminases, in various cholestatic liver diseases. AIM:To evaluate the effects of UDCA administration on acute viral hepatitis-related cholestasis and the course of acute viral hepatitis. METHO...

journal_title：Alimentary pharmacology & therapeutics

authors： Fabris P,Tositti G,Mazzella G,Zanetti AR,Nicolin R,Pellizzer G,Benedetti P,de Lalla F

更新日期：1999-09-01 00:00:00

abstract：:Proton pump inhibitor-based triple therapy is the most commonly used treatment for eradication of Helicobacter pylori, with pooled eradication rates of approximately 90%. In the USA, per protocol eradication rates with 10-day proton pump inhibitor-based triple therapy are approximately 85%. Esomeprazole, a new proton ...

journal_title：Alimentary pharmacology & therapeutics

authors： Laine L

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Re-bleeding of Helicobacter pylori-associated peptic ulcer disease is reduced by H. pylori eradication. AIM:To validate a non-invasive test, the Premium Platinum HpSA stool test, in patients with upper gastrointestinal bleeding. METHODS:Stool samples of consecutive patients with relevant bleeding from gast...

journal_title：Alimentary pharmacology & therapeutics

authors： Peitz U,Leodolter A,Kahl S,Agha-Amiri K,Wex T,Wolle K,Günther T,Steinbrink B,Malfertheiner P

更新日期：2003-04-01 00:00:00

abstract：:In a randomly allocated, double-blind, endoscopically controlled study, 98 patients with gastric ulcers were treated with either (a synthetic prostaglandin of E2-like structure) enprostil 70 micrograms b.d. or 150 mg ranitidine b.d. The healing rates at 4, 8 and 12 weeks were enprostil 57, 91 and 94% and for ranitidin...

journal_title：Alimentary pharmacology & therapeutics

authors： Morgan AG,Pacsoo C,Taylor P,McAdam WA

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Endocytoscopy (EC) enables in vivo microscopic imaging at 1400-fold magnification, thereby allowing the analysis of mucosal structures at the cellular level. In contrast to fluorescence imaging with confocal laser endomicroscopy which allows analysis of mucosal structures up to 250 μm in depth, EC is based o...

journal_title：Alimentary pharmacology & therapeutics

authors： Neumann H,Fuchs FS,Vieth M,Atreya R,Siebler J,Kiesslich R,Neurath MF

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Some patients requiring acid suppression may be unable to take oral medications. AIM:To compare the gastric acid inhibition effects of lansoprazole 30 mg administered either intravenous or orally in erosive oesophagitis patients. METHODS:The study included 87 Helicobacter pylori-negative patients with eros...

journal_title：Alimentary pharmacology & therapeutics

authors： Kovacs TO,Lee CQ,Chiu YL,Pilmer BL,Metz DC

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:Recent data suggest a role for high-dose oral proton pump inhibition in ulcer bleeding. AIM:To compare the cost-effectiveness of oral high-dose proton pump inhibition to both high-dose intravenous proton pump inhibition and placebo administration. METHODS:The model adopted a 30-day time horizon, and focuse...

journal_title：Alimentary pharmacology & therapeutics

authors： Barkun AN,Herba K,Adam V,Kennedy W,Fallone CA,Bardou M

更新日期：2004-07-15 00:00:00

abstract：:Gastrin releasing peptide (GRP) has proved to be a particularly valuable tool in detecting disturbances of gastric secretory function associated with duodenal ulcer disease and Helicobacter pylori infection, and it has furthered understanding of the pathophysiology of these conditions. Its attractiveness lies in the f...

journal_title：Alimentary pharmacology & therapeutics

authors： McColl KE,el-Omar E

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:The safety of anti-tumour necrosis factor (TNF) agents during pregnancy is a major concern for child-bearing women and physicians. AIM:To assess the impact of anti-TNF therapy on adverse pregnancy and foetal outcomes in women with inflammatory bowel disease (IBD). METHODS:Pregnancies occurring during anti-...

journal_title：Alimentary pharmacology & therapeutics

authors： Seirafi M,de Vroey B,Amiot A,Seksik P,Roblin X,Allez M,Peyrin-Biroulet L,Marteau P,Cadiot G,Laharie D,Boureille A,De Vos M,Savoye G,Rahier JF,Carbonnel F,Bonaz B,Colombel JF,Bouhnik Y

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Intra-oesophageal impedance monitoring can be used to assess the clearance of a swallowed bolus (oesophageal transit) and to detect gastro-oesophageal reflux independent of its acidity. AIM:To discuss the clinical application of the impedance technique for the assessment of bolus transit and gastro-oesophag...

journal_title：Alimentary pharmacology & therapeutics

authors： Conchillo JM,Smout AJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans. AIM:To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis. METHODS:Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments ...

journal_title：Alimentary pharmacology & therapeutics

authors： Russo A,Stevens JE,Giles N,Krause G,O'Donovan DG,Horowitz M,Jones KL

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors have been found to be effective in numerous studies in patients with peptic ulcer disease, particularly associated with Helicobacter pylori and gastro-oesophogeal reflux disorders. Optimal healing rates of antisecretory therapy for peptic acid disease is dependent upon the degree and d...

journal_title：Alimentary pharmacology & therapeutics

authors： Blum RA,Hunt RH,Kidd SL,Shi H,Jennings DE,Greski-Rose PA

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease is prevalent in affluent countries and is a cause of cirrhosis and possibly hepatocellular carcinoma. AIM:To examine the clinical and histological features of biopsy-proven non-alcoholic fatty liver disease and investigate the predictors of severe histological disease in Ch...

journal_title：Alimentary pharmacology & therapeutics

authors： Wong VW,Chan HL,Hui AY,Chan KF,Liew CT,Chan FK,Sung JJ

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:Furazolidone-based regimens for the eradication of Helicobacter pylori are low cost and effective. Unfortunately, the usual dose of furazolidone is not tolerable in many patients. Lower doses of furazolidone are expected to cause fewer adverse effects. AIM:To investigate the efficacy of low-dose furazolidon...

journal_title：Alimentary pharmacology & therapeutics

authors： Fakheri H,Merat S,Hosseini V,Malekzadeh R

更新日期：2004-01-01 00:00:00

abstract：:The pathogenesis of cholesterol gallstones is now recognized as a multifactorial process, including saturation of bile with cholesterol, destabilization of bile leading to cholesterol crystals and hypomotility permitting crystal growth, and agglomeration and retention of microstones which then grow to macroscopic gall...

journal_title：Alimentary pharmacology & therapeutics

authors： Pauletzki J,Paumgartner G

更新日期：2000-05-01 00:00:00

abstract：AIM:To asses the efficacy and safety of ciclosporin in a paediatric population with inflammatory bowel disease. PATIENTS AND METHODS:Twenty-three Italian children treated with ciclosporin were studied retrospectively. The indications for treatment were severe unresponsive colitis, chronic active colitis or severe fist...

journal_title：Alimentary pharmacology & therapeutics

authors： Barabino A,Torrente F,Castellano E,Gandullia P,Calvi A,Cucchiara S,De GL,Fontana M,Lionetti P,De Giacomo C,Gissi A

更新日期：2002-08-01 00:00:00