Spatiotemporal heterogeneity in the induction of ventricular fibrillation by rapid pacing: importance of cardiac restitution properties.

abstract：:The positive inotropic effect of the beta-adrenoceptor agonist isoproterenol is accompanied by inhibition of phosphatase type 1 activity in myocardium. Indirect assays suggest that this effect is due to activation of protein phosphatase inhibitor-1, which inhibits phosphatase activity only when phosphorylated. To test...

journal_title：Circulation research

authors： Neumann J,Gupta RC,Schmitz W,Scholz H,Nairn AC,Watanabe AM

更新日期：1991-12-01 00:00:00

abstract：:Cardiac failure appears rapidly during severe hypoxia and precedes a substantial reduction in adenosine triphosphate content. Reduced adenosine triphosphate turnover, in the presence of nearly normal content, may be the metabolic basis for contractile failure during hypoxia. To measure both the myocardial content and ...

journal_title：Circulation research

authors： Bittl JA,Balschi JA,Ingwall JS

更新日期：1987-06-01 00:00:00

abstract：:We studied the time-dependent changes in the response of heart rate (sinus cycle length) to 30-second trains of vagal stimulation (8 Hz), repeated every 2 minutes, in canine neonates aged 7.1 +/- 2.5 (mean +/- SD) days. The first vagal train prolonged the sinus cycle length by 58 +/- 35%, but the response was attenuat...

journal_title：Circulation research

authors： Yamasaki S,Stolfi A,Mas MS,Fox LS,Pickoff AS

更新日期：1991-08-01 00:00:00

abstract：:This article examines the role of innervation in regulating expression of acetylcholinesterase (AchE), butyrylcholinesterase (BuchE), and the muscarinic acetylcholine receptor (mAchR) in avian heart. Two distinct approaches are taken. The first approach examines the relation between the onsets of parasympathetic and s...

journal_title：Circulation research

authors： Jo SA,Higgins DM,Berman HA

更新日期：1992-04-01 00:00:00

abstract：:If the control of infectious diseases was the public health success story of the first half of the 20th century, then the decline in mortality from coronary heart disease and stroke has been the success story of the century's past 4 decades. The early phase of this decline in coronary heart disease and stroke was unex...

journal_title：Circulation research

authors： Mensah GA,Wei GS,Sorlie PD,Fine LJ,Rosenberg Y,Kaufmann PG,Mussolino ME,Hsu LL,Addou E,Engelgau MM,Gordon D

更新日期：2017-01-20 00:00:00

abstract：RATIONALE:Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor-β super family of secreted factors. A recent study showed that reduced GDF11 blood levels with aging was associated with pathological cardiac hypertrophy (PCH) and restoring GDF11 to normal levels in old mice rescued PCH. ...

journal_title：Circulation research

authors： Smith SC,Zhang X,Zhang X,Gross P,Starosta T,Mohsin S,Franti M,Gupta P,Hayes D,Myzithras M,Kahn J,Tanner J,Weldon SM,Khalil A,Guo X,Sabri A,Chen X,MacDonnell S,Houser SR

更新日期：2015-11-06 00:00:00

abstract：:Inwardly rectifying K+ (Kir) channels are responsible for maintaining endothelial membrane potential and play a key role in endothelium-dependent vasorelaxation. In this study, we show that endothelial Kir channels are suppressed by hypercholesterolemic levels of lipoproteins in vitro and by serum hypercholesterolemia...

journal_title：Circulation research

authors： Fang Y,Mohler ER 3rd,Hsieh E,Osman H,Hashemi SM,Davies PF,Rothblat GH,Wilensky RL,Levitan I

更新日期：2006-04-28 00:00:00

abstract：:The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role in reactive oxygen species-dependent cardiomyocyte apoptosis and postischemic cardiac damage. In the current study, we investigated whether sphingolipid metabolism can account for mediating MAO-A- and reactive oxygen species-depend...

journal_title：Circulation research

authors： Pchejetski D,Kunduzova O,Dayon A,Calise D,Seguelas MH,Leducq N,Seif I,Parini A,Cuvillier O

更新日期：2007-01-05 00:00:00

abstract：:In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus node, using the microelectrode technique. After the electrophysiological experiments, the preparations were subjected to a correlative morphological investigation, using light or electron microscopy. Different criteria for ...

journal_title：Circulation research

authors： Bleeker WK,Mackaay AJ,Masson-Pévet M,Bouman LN,Becker AE

更新日期：1980-01-01 00:00:00

abstract：RATIONALE:Although the health effects of beta carotene have been studied extensively, a systematic examination of serum concentrations and long-term mortality, including cardiovascular disease mortality, has not been reported. OBJECTIVE:Explore whether serum beta carotene is associated with overall and cause-specific ...

journal_title：Circulation research

authors： Huang J,Weinstein SJ,Yu K,Männistö S,Albanes D

更新日期：2018-12-07 00:00:00

abstract：RATIONALE:MicroRNA (miR)-1 and -133 play a crucial role in skeletal and cardiac muscle biology and pathophysiology. However, their expression and regulation in vascular cell physiology and disease is currently unknown. OBJECTIVE:The aim of the present study was to evaluate the role, if any, of miR-1 and miR-133 in vas...

journal_title：Circulation research

authors： Torella D,Iaconetti C,Catalucci D,Ellison GM,Leone A,Waring CD,Bochicchio A,Vicinanza C,Aquila I,Curcio A,Condorelli G,Indolfi C

更新日期：2011-09-30 00:00:00

abstract：:Propagation in cardiac muscle is faster in the longitudinal than in the transverse axis of the cells. Yet, as a result of the larger upstroke velocity of action potentials propagating transversely, it has been suggested that longitudinal propagation is more vulnerable to block. To study the relation between conduction...

journal_title：Circulation research

authors： Delmar M,Michaels DC,Johnson T,Jalife J

更新日期：1987-05-01 00:00:00

abstract：:Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calci...

journal_title：Circulation research

authors： Collett GD,Canfield AE

更新日期：2005-05-13 00:00:00

abstract：:Power ratios were derived from the principle of ultrasonic Doppler velocimetry to determine a ratio of the volume of vortices to the total vessel volume under the ultrasonic beam. This ratio also equals the ratio of the cross-sectional area of vortices to the vessel lumen. In vitro pulsatile flow experiments were perf...

journal_title：Circulation research

authors： Tamura T,Fronek A

更新日期：1990-07-01 00:00:00

abstract：:The effect of hypercapnia on coronary vascular resistance (CVR) was studied in seven open-chest dogs. Coronary blood flow was supplied to the cannulated left main coronary artery from the femoral artery by a precision pump. Coronary arterial PCO2 was locally controlled with a small membrane oxygenator in the coronary ...

journal_title：Circulation research

authors： Case RB,Greenberg H

更新日期：1976-10-01 00:00:00

abstract：:The release of acetylcholine from autonomic nerves in those tissues that receive a cholinergic innervation is widely believed to dilate blood vessels. Exogenously administered acetylcholine in vivo does dilate vascular beds and produce hypotension; however, this latter effect is indirect and probably the result of lib...

journal_title：Circulation research

authors： Kalsner S

更新日期：1989-08-01 00:00:00

abstract：:We have previously shown that VEGF165 gene delivery into ischemic skeletal muscle exerts not only proangiogenic, but also remarkable antiapoptotic and proregenerative activity. The aim of this study was to determine whether recombinant adeno-associated virus (rAAV)-mediated gene delivery of VEGF165 into cardiac muscle...

journal_title：Circulation research

authors： Ferrarini M,Arsic N,Recchia FA,Zentilin L,Zacchigna S,Xu X,Linke A,Giacca M,Hintze TH

更新日期：2006-04-14 00:00:00

abstract：:To determine whether calcium channel agonists and antagonists bind to distinct pharmacologically active sites, the binding of dihydropyridine calcium channel agonists and antagonists was related to calcium flux and contractile state in primary monolayer cultures of spontaneously contracting chick embryo ventricular ce...

journal_title：Circulation research

authors： Lee RT,Smith TW,Marsh JD

更新日期：1987-05-01 00:00:00

abstract：:Neuropeptide Y is stored in sympathetic nerve terminals throughout the heart and has direct and indirect effects on cardiac function. Although neuropeptide Y has been shown to be released upon intense (16-30 Hz) cardiac sympathetic stimulation, we sought to determine whether effective quantities of neuropeptide Y were...

journal_title：Circulation research

authors： Warner MR,Levy MN

更新日期：1989-05-01 00:00:00

abstract：:Cells with endothelial phenotype generated from adult peripheral blood have emerging diagnostic and therapeutic potential. This study examined the lineage relationship between, and angiogenic function of, early endothelial progenitor cells (EPCs) and late outgrowth endothelial cells (OECs) in culture. Culture conditio...

journal_title：Circulation research

authors： Gulati R,Jevremovic D,Peterson TE,Chatterjee S,Shah V,Vile RG,Simari RD

更新日期：2003-11-28 00:00:00

abstract：RATIONALE:Inhibition of glycogen synthase kinase-3 (GSK-3) protects the heart during ischemia/reperfusion (I/R), yet the underlying mechanisms of cardioprotection afforded by beta isoform-specific inhibition GSK-3 remain to be elucidated. OBJECTIVE:We studied the molecular mechanism mediating the effect of GSK-3β acti...

journal_title：Circulation research

authors： Zhai P,Sciarretta S,Galeotti J,Volpe M,Sadoshima J

更新日期：2011-08-19 00:00:00

abstract：:Direct binding of apolipoprotein (apo)B-containing lipoproteins to proteoglycans is the initiating event in atherosclerosis, but the processes involved at later stages of development are unclear. Here, we investigated the importance of the apoB-proteoglycan interaction in the development of atherosclerosis over time a...

journal_title：Circulation research

authors： Gustafsson M,Levin M,Skålén K,Perman J,Fridén V,Jirholt P,Olofsson SO,Fazio S,Linton MF,Semenkovich CF,Olivecrona G,Borén J

更新日期：2007-10-12 00:00:00

abstract：:Pharmacological modulation of [K+]o accumulation and action potential changes during acute myocardial ischemia is under evaluation as a promising new antiarrhythmic and cardioprotective strategy during myocardial ischemia and reperfusion. We studied the effects of cromakalim, a K+ channel opener that activates ATP-sen...

journal_title：Circulation research

authors： Venkatesh N,Stuart JS,Lamp ST,Alexander LD,Weiss JN

更新日期：1992-12-01 00:00:00

abstract：:Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggest...

journal_title：Circulation research

authors： Gkaliagkousi E,Ritter J,Ferro A

更新日期：2007-09-28 00:00:00

abstract：:We compared the blocking effects of the local anesthetics, lidocaine and benzocaine, on the sodium current, using single rat ventricular cells to obtain further information about the voltage dependence and kinetics of local anesthetic interaction with cardiac sodium channels. We used a hybrid voltage clamp system whic...

journal_title：Circulation research

authors： Sanchez-Chapula J,Tsuda Y,Josephson IR

更新日期：1983-05-01 00:00:00

abstract：:An animal model was used to test the hypothesis that in heart failure the decrease in the ability to resynthesize ATP through the creatine kinase (CK) reaction (which we call energy reserve) contributes to the inability of the heart to maintain its normal function and contractile reserve. One-week-old turkey poults we...

journal_title：Circulation research

authors： Liao R,Nascimben L,Friedrich J,Gwathmey JK,Ingwall JS

更新日期：1996-05-01 00:00:00

abstract：:The spatial and dynamic properties of ventricular fibrillation (VF) may be random or related to cellular electrical properties of the normal heart. Local activation intervals (AIs) in VF may depend on the local refractory period (RP), and sustained VF may require a steep action potential (AP) restitution curve. In gui...

journal_title：Circulation research

authors： Choi BR,Liu T,Salama G

更新日期：2001-03-16 00:00:00

abstract：:The action potential model presented in our accompanying article in this journal is used to investigate phenomena that involve dynamic changes of [Ca2+]i, as described below. Delayed afterdepolarizations (DADs) are induced by spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), which, in turn, activates both...

journal_title：Circulation research

authors： Luo CH,Rudy Y

更新日期：1994-06-01 00:00:00

abstract：:Choline acetyltransferase activity, which is rate limiting in acetylcholine biosynthesis, was measured in the four heart chambers of guinea pigs subjected to (1) sham surgery, (2) constriction of the ascending aorta, (3) constriction of the descending thoracic aorta, and (4) constriction of the pulmonary artery. After...

journal_title：Circulation research

authors： Roskoski R Jr,Schmid PG,Mayer HE,Abboud FM

更新日期：1975-04-01 00:00:00

abstract：:This review reflects and expands on the contents of my presentation at the Thomas W. Smith Memorial Lecture at American Heart Association Scientific Sessions, 2011. "Decoding the cardiac message" refers to accumulating results from ongoing microRNA research that is altering longstanding concepts of the mechanisms for,...

journal_title：Circulation research

authors： Dorn GW 2nd

更新日期：2012-03-02 00:00:00