E-cadherin and catenins: molecules with versatile roles in normal and neoplastic epithelial cell biology.

Abstract:

:E-cadherin and its associated cytoplasmic proteins alpha-, beta-, and gamma-catenin, play a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. Perturbation in the expression or function of any of these molecules results in loss of intercellular adhesion, with possible consequent cell transformation and tumour progression. The catenins are connected to many structural and functional proteins, which in turn influence their functions. Among these molecules are type 1 growth factor receptors, which along with other molecules are believed to alter the function of catenins through tyrosine phosphorylation. A recent finding is the association between the catenins and the adenomatous polyposis coli gene product (APC). APC mutation is an early event in colorectal carcinogenesis. It may possibly do so through perturbation of the critical cadherin/catenin complex. Further studies of the cadherin/catenin complex and its connections may give insight into the early molecular interactions critical to the initiation and progression oftumours, which should aid in the development of novel therapeutic strategies for both prevention and treatment.

journal_name

Microsc Res Tech

authors

El-Bahrawy MA,Pignatelli M

doi

10.1002/(SICI)1097-0029(19981101)43:3<224::AID-JEM

subject

Has Abstract

pub_date

1998-11-01 00:00:00

pages

224-32

issue

3

eissn

1059-910X

issn

1097-0029

pii

10.1002/(SICI)1097-0029(19981101)43:3<224::AID-JEM

journal_volume

43

pub_type

杂志文章,评审
  • Image processing techniques in a preliminary morphometric characterization of corneal epithelium by scanning electron microscopy.

    abstract::Several processing techniques of digital images allowed us to quantify the percentage of cell surface covered by microprojections (microvilli or microplicae) (SCM), the adhesion between epithelial cells by the parameter intercellular junctions (IJ), the size (cell area), shape (cell shape) and shade (cell shade) of ce...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20833

    authors: Julio G,Merindano D,Canals M,Ralló M

    更新日期:2010-10-01 00:00:00

  • Development of histamine-immunoreactivity in the Central nervous system of the two locust species Schistocerca gregaria and Locusta migratoria.

    abstract::Locusts are attractive model preparations for cellular investigations of neurodevelopment. In this study, we investigate the immunocytochemical localization of histamine in the developing ventral nerve cord of two locust species, Schistocerca gregaria and Locusta migratoria. Histamine is the fast neurotransmitter of p...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20980

    authors: Pätschke A,Bicker G

    更新日期:2011-10-01 00:00:00

  • Dissociation of memory retrieval and search processes: an event-related fMRI study.

    abstract::A cognitive task can often be subdivided into several subprocesses, which follow a specific temporal order. Here, we report an event-related functional magnetic resonance imaging (fMRI) experiment on memory search, in which the temporal onset of search in primary memory was varied relative to retrieval from secondary ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/1097-0029(20001001)51:1<29::AID-JEMT3>3.0.

    authors: Pollmann S,Zysset S,Wiggins CJ,Von Cramon DY

    更新日期:2000-10-01 00:00:00

  • Retinal characterization in the eyes of two bats endemic in the Egyptian fauna, the Egyptian fruit bat (Rousettus aegyptiacus) and insectivorous bat (Pipistrellus kuhlii), using the light microscope and transmission electron microscope.

    abstract::Bats are the only mammals that can fly in the dark without eye usage. This study was conducted to describe the structural and functional adaptations of the retina of two bats very common in the Egyptian fauna having a different lifestyle: the Egyptian fruit bat (Rousettus aegyptiacus) and insectivorous bat (Pipistrell...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.23530

    authors: Aboelnour A,Noreldin AE,Massoud D Dr,Abumandour MMA

    更新日期:2020-11-01 00:00:00

  • Efficacy of calcium- and fluoride-containing materials for the remineralization of primary teeth with early enamel lesion.

    abstract::The aim of the study was to determine the efficacy of different products containing fluoride, calcium and phosphate for enamel remineralization in eroded primary teeth. A total of 90 sound primary canine teeth were randomly divided into 5 groups of 18 teeth each: 1) control (polished enamel), 2) 5% DuraShield sodium f...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22543

    authors: Memarpour M,Soltanimehr E,Sattarahmady N

    更新日期:2015-09-01 00:00:00

  • Postembryonic development of hard jaws (trophi) in a species belonging to the Brachionus plicatilis complex (Rotifera, Monogononta): a morphometric analysis.

    abstract::The presence of hard jaws (trophi), with species-specific shape and size, is a taxonomic feature of Rotifera, a group of microscopic metazoans. Since trophi are used to discriminate among species, it is important to know whether these structures change in taxonomically important ways during postembryonic development. ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20319

    authors: Fontaneto D,Melone G

    更新日期:2006-04-01 00:00:00

  • Dynamic imaging of structural changes in silver catalysts by environmental scanning electron microscopy.

    abstract::Polycrystalline silver catalysts are used extensively for the partial oxidation of methanol to formaldehyde, which is then primarily incorporated in the synthesis process for adhesives and resins. In order to maximize formaldehyde production it is essential to gain a comprehensive understanding of the complex microstr...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19970301)36:5<382::AID-JEM

    authors: Uwins PJ,Millar GJ,Nelson ML

    更新日期:1997-03-01 00:00:00

  • Organ culture of the bovine subcommissural organ: evidence for synthesis and release of the secretory material.

    abstract::The subcommissural organ (SCO) is a brain circumventricular organ formed by ependymal and hypendymal secretory cells. It secretes glycoproteins into the cerebrospinal fluid of the third ventricle where they condense into a thread-like structure known as Reissner's fiber (RF). The present study was designed to investig...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/1097-0029(20010301)52:5<496::AID-JEMT1035>

    authors: Schöbitz K,Gonzalez C,Peruzzo B,Yulis CR,Rodríguez EM

    更新日期:2001-03-01 00:00:00

  • Nanoparticle embedded chitosan film for agglomeration free TEM images.

    abstract::Transmission electron microscopy (TEM) is a very useful and commonly used microscopy technique, used especially for the characterization of nanoparticles. However, the identification of the magnetic nanoparticle could be thought problematic in TEM analysis, due to the fact that the magnetic nanoparticles are usually f...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22792

    authors: Dogan Ü,Çiftçi H,Cetin D,Suludere Z,Tamer U

    更新日期:2017-02-01 00:00:00

  • Surface damage induced by FIB milling and imaging of biological samples is controllable.

    abstract::Focused ion beam (FIB) techniques are among the most important tools for the nanostructuring of surfaces. We used the FIB/SEM (scanning electron microscope) for milling and imaging of digestive gland cells. The aim of our study was to document the interactions of FIB with the surface of the biological sample during FI...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20494

    authors: Drobne D,Milani M,Leser V,Tatti F

    更新日期:2007-10-01 00:00:00

  • Combination of normal light and fluorescence microscopy for authentication of five Lonicera species flower buds.

    abstract::The flower buds of five Lonicera species, Lonicera japonica Thunb., L. macranthoides Hand.-Mazz., L. hypoglauca Miq., L. confusa DC. and L. fulvotomentosa Hsu et S.C. Cheng are confusable and usually utilized under the same name "Jinyinhua" in different areas for morphological similarity. Studies found that these five...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20882

    authors: Chu C,Liu HJ,Qi LW,Liu EH,Li P

    更新日期:2011-02-01 00:00:00

  • Granulated metrial gland cells: a natural killer cell subset of the pregnant murine uterus.

    abstract::The metrial gland develops in the uterus of many rodent species during normal pregnancy. It is a maternally-derived tissue that contains stromal and vascular elements plus a population of large cells, striking in their light microscopic appearance due to the presence of numerous cytoplasmic granules. These cells, whic...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/jemt.1070250302

    authors: Croy BA,Kiso Y

    更新日期:1993-06-15 00:00:00

  • A descriptive study to provide evidence of the teratogenic and cellular effects of sibutramine and ephedrine on cardiac- and liver-tissue of chick embryos.

    abstract::Exposure to drugs during pregnancy is a major concern, as some teratogenic compounds can influence normal foetal development. Although the use of drugs during pregnancy should generally be avoided, exposure of the developing foetus to teratogens may occur unknowingly since these compounds may be hidden in products tha...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22539

    authors: Oberholzer HM,Van Der Schoor C,Taute H,Bester MJ

    更新日期:2015-08-01 00:00:00

  • Mitochondrial alterations and autofluorescent conversion of Candida albicans induced by histatins.

    abstract::The mechanism of the candidacidal activity of histatins 3 and 5 (Hst) is still a matter of debate. Previous studies have indicated that Hst induce cell permeabilization, generation of reactive oxygen species (ROS) by mitochondria, inhibition of the respiratory chain, and energy-dependent cytotoxic release of ATP. On t...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20161

    authors: Diaz G,Polonelli L,Conti S,Messana I,Cabras T,Putzolu M,Falchi AM,Fadda ME,Cosentino S,Isola R

    更新日期:2005-04-01 00:00:00

  • Effects of aerobic training, resistance training, or combined resistance-aerobic training on the left ventricular myocardium in a rat model.

    abstract::This study follows the left ventricular (LV) hypertrophy in rats undergoing aerobic training alone (A), resistance training alone (R), or combined resistance and aerobic training (RA) (usually referred as concurrent training) program. A sedentary control group (C) was included. LV remodeling was evaluated using electr...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22394

    authors: De Souza MR,Pimenta L,Pithon-Curi TC,Bucci M,Fontinele RG,De Souza RR

    更新日期:2014-09-01 00:00:00

  • Laser-based in situ techniques: novel methods for generating extreme conditions in TEM samples.

    abstract::The dynamic transmission electron microscope (DTEM) is introduced as a novel tool for in situ processing of materials. Examples of various types of dynamic studies outline the advantages and differences of laser-based heating in the DTEM in comparison to conventional (resistive) heating in situ TEM methods. We demonst...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20664

    authors: Taheri ML,Lagrange T,Reed BW,Armstrong MR,Campbell GH,DeHope WJ,Kim JS,King WE,Masiel DJ,Browning ND

    更新日期:2009-03-01 00:00:00

  • Plasticity in the electrophysiological properties of oxytocin neurons.

    abstract::In mammals, the neurohypophysial hormone oxytocin (OT) is released into the bloodstream during labor and lactation to promote uterine contraction and milk ejection, respectively. Electrophysiological studies have established that OT neurons fire in brief, synchronized bursts during this release. During pregnancy and l...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/jemt.10019

    authors: Armstrong WE,Stern JE,Teruyama R

    更新日期:2002-01-15 00:00:00

  • Efficacy of different irrigant protocols and application systems on sealer penetration using a stepwise CLSM analysis.

    abstract::This study compared several irrigation protocols and application systems for sealer penetration into dentinal tubules. Single-rooted-human teeth were divided into 5 experimental groups (n = 15) and a control group (n = 5), according to final irrigation protocols: standard needle irrigation (SNI); Vibringe; Vibringe + ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22944

    authors: Aksel H,Küçükkaya Eren S,Puralı N,Serper A,Azim AA

    更新日期:2017-12-01 00:00:00

  • String mitochondria in mouse soleus muscle.

    abstract::Red myofibers in mouse soleus muscle have two spatially distinct populations of mitochondria: one where these organelles are disposed in large clusters just inside the sarcolemma and the other situated between the myofibrils. In most cases, the interfibrillar mitochondria (IFM), which are much smaller than the subsarc...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22158

    authors: Fujioka H,Tandler B,Haldar SM,Jain MK,Hoppel CL

    更新日期:2013-03-01 00:00:00

  • Sexual diversity of the lipid metabolism in the Harderian gland of the golden hamster.

    abstract::Fatty acid and alkyl compositions of 1-alkyl-2,3-diacylglycerols (ADG) in the Harderian gland of the golden hamster were determined. Fatty acids of male ADG consisted of straight chain saturated acids ranging from C12 to C22. Both even- and odd-numbered acids were observed, indicating that acetyl- and propionyl-CoAs w...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0029(19960501)34:1<71::AID-JEMT

    authors: Seyama Y,Otsuka H,Ohashi K,Vivien-Roels B,Pevet P

    更新日期:1996-05-01 00:00:00

  • Optimization of Picrosirius red staining protocol to determine collagen fiber orientations in vaginal and uterine cervical tissues by Mueller polarized microscopy.

    abstract::Polarized microscopy provides unique information on anisotropic samples. In its most complete implementation, namely Mueller microscopy, this technique is well suited for the visualization of fibrillar proteins orientations, with collagen in the first place. However, the intrinsic optical anisotropy of unstained tissu...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22530

    authors: Nazac A,Bancelin S,Teig B,Ibrahim BH,Fernandez H,Schanne-Klein MC,De Martino A

    更新日期:2015-08-01 00:00:00

  • Impact of screening on prostate cancer rates and trends.

    abstract::Widespread implementation of prostate cancer screening has affected several epidemiologic features of the disease including incidence, tumor and patient characteristics, patterns of care and outcomes. Some of these changes have been interpreted as evidence of the success of PSA testing as a cancer control strategy. Da...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0029(20001201)51:5<415::AID-JEMT2>3.0

    authors: Mettlin C

    更新日期:2000-12-01 00:00:00

  • Analysis of the mechanism for acetylcholine release at the synapse formed between rat sympathetic neurons in culture.

    abstract::Superior cervical ganglion neurons (SCGNs) were isolated from 7-day-old rat SCG and cultured in MEM containing horse serum, fetal calf serum, and nerve growth factor. In this culture condition, it is well known that the SCGNs form cholinergic synapse. In 3-4 weeks cultured neurons, immunofluorescent staining for synap...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070290206

    authors: Mochida S,Nonomura Y,Kobayashi H

    更新日期:1994-10-01 00:00:00

  • Ultrastructure and three-dimensional study of the lymphatic stomata in the costal pleura of the rabbit.

    abstract::The aim of this report was to investigate the ultrastructure and three-dimensional organization of the pleural lymphatic stomata in the adult rabbit costal pleura by electron microscopy. A computer image processing system attached to the scanning electron microscopy was used to get statistical evaluation of the dimens...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.10388

    authors: Li YY,Li JC

    更新日期:2003-10-15 00:00:00

  • Cell-cell interactions in the testis of teleosts and elasmobranchs.

    abstract::In this paper we present the state of knowledge on cell-cell interactions in the testis of two groups of anamniote vertebrates--teleosts and elasmobranchs--which include most fish. In these fish, the structural organization of the testis differs fundamentally from that which characterizes amniotes in which the germina...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章,评审

    doi:10.1002/jemt.1070320606

    authors: Loir M,Sourdaine P,Mendis-Handagama SM,Jégou B

    更新日期:1995-12-15 00:00:00

  • Section staining for electron microscopy using tannic acid as a mordant: a simple method for visualization of glycogen and collagen.

    abstract::The possibility that tannic acid and other classical mordants can be used in the electron microscopical section staining technique has been tested. A mordant can be defined as a chemical that combines with both a certain specific tissue component and the staining substance and thereby permits a staining reaction that ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070210110

    authors: Afzelius BA

    更新日期:1992-03-01 00:00:00

  • Flagellar apparatus of south-seeking many-celled magnetotactic prokaryotes.

    abstract::Magnetotactic bacteria orient and migrate along geomagnetic field lines. Each cell contains membrane-enclosed, nano-scale, iron-mineral particles called magnetosomes that cause alignment of the cell in the geomagnetic field as the bacteria swim propelled by flagella. In this work we studied the ultrastructure of the f...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20380

    authors: Silva KT,Abreu F,Almeida FP,Keim CN,Farina M,Lins U

    更新日期:2007-01-01 00:00:00

  • Methods for characterizing plant fibers.

    abstract::The effectiveness of different microscopy techniques for measuring the dimensions of ultimate fibers from harakeke (Phormium tenax, New Zealand flax) was investigated using a factorial experimental design. Constant variables were geographical location, location of specimens along the leaf, season (winter), individual ...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.20206

    authors: Cruthers N,Carr D,Niven B,Girvan E,Laing R

    更新日期:2005-08-01 00:00:00

  • Intramandibular glands in different castes of leaf-cutting ant, Atta laevigata (Fr. Smith, 1858) (Formicidae: Attini).

    abstract::Intramandibular glands have been poorly studied in polymorphic ants, where the differences between castes were unsufficiently scrutinized. Leaf-cutting ants possess one of the most complex systems of communication and labor division, which is polymorphic well as age polyethism, and makes them an ideal model for the st...

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.22516

    authors: Martins LC,Della Lucia TM,Gonçalves WG,Delabie JH,Zanuncio JC,Serrão JE

    更新日期:2015-07-01 00:00:00

  • Biomineralization: new directions in crystal science.

    abstract::Effective protocols for controlling crystal structure, size, and morphology attract considerable interest given the requirement for particles of modal size and shape in many areas of materials fabrication and the importance of crystallochemical selectivity in determining the exploitable properties of inorganic solids....

    journal_title:Microscopy research and technique

    pub_type: 杂志文章

    doi:10.1002/jemt.1070270504

    authors: Heywood BR

    更新日期:1994-04-01 00:00:00