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Endometrial biopsy during hormone replacement cycle in donor oocyte recipients before in vitro fertilization-embryo transfer.

Abstract：

OBJECTIVE:To examine the usefulness of a trial cycle of hormone replacement therapy (HRT) and endometrial biopsy before the actual ET cycle in recipients of donated oocytes. DESIGN:Retrospective review. SETTING:Clinical practice at the South Texas Fertility Center, San Antonio, Texas. PATIENT(S):Thirty-six concurrent patients who underwent a trial cycle of HRT with endometrial biopsy before the ET cycle with donated oocytes fertilized in vitro. INTERVENTION(S):Patients > or =40 years of age received 100 mg of i.m. progesterone in oil daily; patients <40 years of age received 50 mg daily. Endometrial biopsies were performed during the late luteal phase of the trial cycle. MAIN OUTCOME MEASURE(S):Histologic dating of the biopsy specimens was correlated with the chronologic date of the biopsy. RESULT(S):Five of 20 patients > or =40 years of age had out-of-phase biopsies. All 16 patients <40 years of age had in-phase biopsies. All out-of-phase biopsies subsequently were corrected with higher doses of progesterone. Pregnancy rates after fresh and frozen ETs were not significantly different between the two age groups. CONCLUSION(S):Patients > or =40 years of age are at risk of having out-of-phase endometrial biopsies while they are receiving standard HRT despite receiving higher doses of progesterone. Trial HRT cycles with endometrial biopsies are recommended.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Potter DA,Witz CA,Burns WN,Brzyski RG,Schenken RS

doi

10.1016/s0015-0282(98)00165-4

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

219-21

issue

2

eissn

0015-0282

issn

1556-5653

pii

S0015028298001654

journal_volume

70

pub_type

杂志文章

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