The integrin alphavbeta6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin.

abstract：:Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at the cell surface. Mammalian non-activated Notch receptor is internalized, ubiquitylated by the It...

journal_title：Journal of cell science

authors： Puca L,Chastagner P,Meas-Yedid V,Israël A,Brou C

更新日期：2013-10-01 00:00:00

abstract：:The vacuolar H(+)-ATPase (V-ATPase) is a multi-subunit enzyme that plays important roles in eukaryotic cells. In Dictyostelium, it is found primarily in membranes of the contractile vacuole complex, where it energizes fluid accumulation by this osmoregulatory organelle and also in membranes of endolysosomes, where it ...

journal_title：Journal of cell science

authors： Clarke M,Köhler J,Arana Q,Liu T,Heuser J,Gerisch G

更新日期：2002-07-15 00:00:00

abstract：:A monoclonal antibody, specific to phosphoproteins in mitotic HeLa cells was found to crossreact with a similar set of proteins in embryos of the nematode, Caenorhabditis elegans. In C. elegans, as in mammalian cells, the highly conserved antigenic epitope is associated with a family of high molecular weight polypepti...

journal_title：Journal of cell science

authors： Hecht RM,Berg-Zabelshansky M,Rao PN,Davis FM

更新日期：1987-03-01 00:00:00

abstract：:Axin and conductin (also known as axin2) are structurally related inhibitors of Wnt/β-catenin signalling that promote degradation of β-catenin. Whereas axin is constitutively expressed, conductin is a Wnt target gene implicated in Wnt negative-feedback regulation. Here, we show that axin and conductin differ in their ...

journal_title：Journal of cell science

authors： Bernkopf DB,Hadjihannas MV,Behrens J

更新日期：2015-01-01 00:00:00

abstract：:Keratins 8 and 18 (collectively referred to as K8/K18) are the major components of intermediate filaments of simple epithelial cells. Recent studies have revealed the function of K8/K18 in apoptosis modulation. Here, we show that eIF3k, originally identified as the smallest subunit of eukaryotic translation initiation...

journal_title：Journal of cell science

authors： Lin YM,Chen YR,Lin JR,Wang WJ,Inoko A,Inagaki M,Wu YC,Chen RH

更新日期：2008-07-15 00:00:00

abstract：:Mammalian cochlear outer hair cells generate high-frequency forces in response to electrical stimulation. Force generation occurs in the lateral cortex of the cell, which includes the plasma membrane, a two-dimensional 'cortical lattice' of filamentous protein, and a multi-layered membrane system, the lateral cisterna...

journal_title：Journal of cell science

authors： Holley MC,Ashmore JF

更新日期：1990-06-01 00:00:00

abstract：:Tenascin, an extracellular matrix protein that modulates cell adhesion, exists as a unique six-armed structure called a hexabrachion. The human hexabrachion is composed of six identical 320 kDa subunits and the structure is stabilized by inter-subunit disulfide bonds between amino-terminal segments. We have examined t...

journal_title：Journal of cell science

authors： Redick SD,Schwarzbauer JE

更新日期：1995-04-01 00:00:00

abstract：:The role of the haemolytic activity of Sendai virus in cell-cell fusion has been examined in monolayers of human erythrocytes and erythrocyte ghosts fused with either haemolytic or non-haemolytic virus. Morphological observations indicate that cell swelling and haemolysis is a distinct event in cell-cell fusion irresp...

journal_title：Journal of cell science

authors： Knutton S,Bächi T

更新日期：1980-04-01 00:00:00

abstract：:The protozoan parasite Giardia lamblia has the unusual morphology of bearing two equal-sized nuclei. This organism probably represents the earliest diverging lineage of eukaryotes, suggesting that its biological tactics may be transitional. To begin to understand the role played by the two equal-sized nuclei in this o...

journal_title：Journal of cell science

authors： Kabnick KS,Peattie DA

更新日期：1990-03-01 00:00:00

abstract：:Neurite outgrowth is known as a slow (days) process occurring in nerve cells and neurons during neurotrophin treatment and upon transfer to culture, respectively. Using Y27632, a drug that induces activation of Rac1, a downstream step of the neurotrophin signaling cascade, we have identified a new form of outgrowth, w...

journal_title：Journal of cell science

authors： Racchetti G,Lorusso A,Schulte C,Gavello D,Carabelli V,D'Alessandro R,Meldolesi J

更新日期：2010-01-15 00:00:00

abstract：:The formation and maturation of membrane carriers that transport cargo from the ER to the Golgi complex involves the sequential action of the coat protein complexes COPII and COPI. Recruitment of COPI to nascent carriers requires activation of ADP-ribosylation factors by a BrefeldinA-sensitive guanine nucleotide excha...

journal_title：Journal of cell science

authors： Zhao X,Claude A,Chun J,Shields DJ,Presley JF,Melançon P

更新日期：2006-09-15 00:00:00

abstract：:It remains unclear how GPI-anchored proteins (GPIAPs), which lack cytoplasmic domains, transduce signals triggered by specific ligation. Such signal transduction has been speculated to require the ligated GPIAP to associate with membrane-spanning proteins that communicate with obligate cytoplasmic proteins. Transient ...

journal_title：Journal of cell science

authors： Chen Y,Veracini L,Benistant C,Jacobson K

更新日期：2009-11-01 00:00:00

abstract：:Rab proteins comprise a family of monomeric GTPases that control cellular membrane traffic. Rab21 is a poorly characterised member with no known function. Human Rab21 cDNA from K562 cells was subcloned into GFP expression vectors to generate Rab21 and Rab21 mutants defective in either GTP hydrolysis (Rab21 Q78L) or bi...

journal_title：Journal of cell science

authors： Simpson JC,Griffiths G,Wessling-Resnick M,Fransen JA,Bennett H,Jones AT

更新日期：2004-12-15 00:00:00

abstract：:DNA replication in eukaryotic cells initiates from multiple replication origins that are distributed throughout the genome. Coordinating the usage of these origins is crucial to ensure complete and timely replication of the entire genome precisely once in each cell cycle. Replication origins fire according to a cell-t...

journal_title：Journal of cell science

authors： Yekezare M,Gómez-González B,Diffley JF

更新日期：2013-03-15 00:00:00

abstract：:Euglena gracilis is a suitable model system to investigate the role of zinc in the process of cell division. In zinc-deficient organisms there is a characteristic arrest of cellular proliferation, the DNA content of the cells doubles, whereas RNA and protein contents decrease. The present investigations include the gr...

journal_title：Journal of cell science

authors： Falchuk KH,Fawcett DW,Vallee BL

更新日期：1975-01-01 00:00:00

abstract：:We have followed the migration of GFP-labelled nuclei in multinucleate hyphae of Ashbya gossypii. For the first time we could demonstrate that the mode of long range nuclear migration consists of oscillatory movements of nuclei with, on average, higher amplitudes in the direction of the growing tip. We could also show...

journal_title：Journal of cell science

authors： Alberti-Segui C,Dietrich F,Altmann-Jöhl R,Hoepfner D,Philippsen P

更新日期：2001-03-01 00:00:00

abstract：:Immediately following embryonic cleavage, the cells of Astrephomene have four equal-sized basal bodies, two of which are connected by a striated distal fibre and two striated proximal fibres. The four microtubular rootlets, which alternate between having 3/1 and 2 members, are arranged cruciately. The two basal bodies...

journal_title：Journal of cell science

authors： Hoops HJ,Floyd GL

更新日期：1983-09-01 00:00:00

abstract：:Increases in RNA, protein and cell size were determined cytophotometrically during the cell division cycle of Tetrahymena. For these parameters different patterns were found. RNA accumulates slowly during G1 period and faster during macronuclear S. This agrees with the changing uridine incorporation rate which is at l...

journal_title：Journal of cell science

authors： Cleffmann G,Reuter WO,Seyfert HM

更新日期：1979-06-01 00:00:00

abstract：:Pregnancy-associated plasma protein A2 (PAPP-A2, also known as pappalysin-2) is a large metalloproteinase that is known to be required for normal postnatal growth and bone development in mice. We here report the detection of zebrafish papp-a2 mRNA in the chordamesoderm, notochord and lower jaw of zebrafish (Danio reri...

journal_title：Journal of cell science

authors： Kjaer-Sorensen K,Engholm DH,Jepsen MR,Morch MG,Weyer K,Hefting LL,Skov LL,Laursen LS,Oxvig C

更新日期：2014-12-01 00:00:00

abstract：:Using finite aperture theory we have shown that localized very dark areas in the interference reflection images of Dictyostelium discoideum amoebae are due to the close intracellular approach of vesicles and tubular elements of the contractile vacuole system to the plasma membrane adjacent to the substratum. Vesicles ...

journal_title：Journal of cell science

authors： Gingell D,Todd I,Owens N

更新日期：1982-04-01 00:00:00

abstract：:We have used cell-surface-specific labelling techniques and two-dimensional gel electrophoresis to identify proteins on embryonic chick neural retina cells and to determine the effects of Ca2+ on their accessibility to labelling and tryptic removal. A number of proteins on these cells are, in the presence of Ca2+, rel...

journal_title：Journal of cell science

authors： Cook JH,Lilien J

更新日期：1982-06-01 00:00:00

abstract：:The integrin beta1 cytoplasmic domain plays a key role in a variety of integrin-mediated events including adhesion, migration and signaling. A number of studies suggest that phosphorylation may modify the functional state of the cytoplasmic domain, but these studies frequently only examine the effect of substituting a...

journal_title：Journal of cell science

authors： Mulrooney JP,Hong T,Grabel LB

更新日期：2001-07-01 00:00:00

abstract：:Electron-microscope autoradiography has been used to obtain information on the localization of DNA labelled with [3H]thymidine in chloroplasts known to be replicating and concomitantly synthesizing and segregating DNA, in cultured leaf disks. The studies were made using both Microdol-X developer and a 'compact' develo...

journal_title：Journal of cell science

authors： Rose RJ,Possingham JV

更新日期：1976-03-01 00:00:00

abstract：:We have previously shown that chymotrypsin-cleaved soluble uPAR (D2D3(88-274)) elicits migration of monocytic cells through interaction with FPRL-1, a G protein-coupled receptor that is homologous to the fMLP receptor. Here, we report that D2D3(88-274) also modulates the ability of monocytes to migrate in response to ...

journal_title：Journal of cell science

authors： Furlan F,Orlando S,Laudanna C,Resnati M,Basso V,Blasi F,Mondino A

更新日期：2004-06-15 00:00:00

abstract：:NF-kappaB plays a central role in mediating pathogen and cytokine-stimulated gene transcription. NF-kappaB repressing factor (NRF) has been shown to interact with specific negative regulatory DNA elements (NRE) to mediate transcriptional repression by inhibition of the NF-kappaB activity at certain promoters. mRNA abl...

journal_title：Journal of cell science

authors： Niedick I,Froese N,Oumard A,Mueller PP,Nourbakhsh M,Hauser H,Köster M

更新日期：2004-07-15 00:00:00

abstract：:Cadherins and integrins are intrinsically linked through the actin cytoskeleton and share common signaling molecules. Although mechanosensing by the integrin-actin axis has long been appreciated, a growing body of literature now demonstrates that cadherins also transduce and respond to mechanical forces. Mounting evid...

journal_title：Journal of cell science

authors： Mui KL,Chen CS,Assoian RK

更新日期：2016-03-15 00:00:00

abstract：:Patients with myotonic dystrophy type 1 exhibit a diversity of symptoms that affect many different organs. Among these are cognitive dysfunctions, the origin of which has remained elusive, partly because of the difficulty in accessing neural cells. Here, we have taken advantage of pluripotent stem cell lines derived f...

journal_title：Journal of cell science

authors： Denis JA,Gauthier M,Rachdi L,Aubert S,Giraud-Triboult K,Poydenot P,Benchoua A,Champon B,Maury Y,Baldeschi C,Scharfmann R,Piétu G,Peschanski M,Martinat C

更新日期：2013-04-15 00:00:00

abstract：:Neutrophils enter sites of inflammation by crossing the endothelial lining of the blood vessel wall. VE-cadherin is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. We have generated a monoclonal antibody against mouse VE-cadherin which inhibits electrical resistance of endoth...

journal_title：Journal of cell science

authors： Gotsch U,Borges E,Bosse R,Böggemeyer E,Simon M,Mossmann H,Vestweber D

更新日期：1997-03-01 00:00:00

abstract：:The lymphatic endothelial cell (LEC) fate decision program during development has been described. However, the mechanism underlying the maintenance of differentiated LEC identity remains largely unknown. Here, we show that fibroblast growth factor 2 (FGF2) plays a fundamental role in maintaining a differentiated LEC t...

journal_title：Journal of cell science

authors： Ichise T,Yoshida N,Ichise H

更新日期：2014-02-15 00:00:00

abstract：:Assembly of contractile apparatuses in striated muscle requires precisely regulated reorganization of the actin cytoskeletal proteins into sarcomeric organization. Regulation of actin filament dynamics is one of the essential processes of myofibril assembly, but the mechanism of actin regulation in striated muscle is ...

journal_title：Journal of cell science

authors： Nomura K,Ono K,Ono S

更新日期：2012-09-01 00:00:00