Abstract：
:DNA replication in eukaryotic cells initiates from multiple replication origins that are distributed throughout the genome. Coordinating the usage of these origins is crucial to ensure complete and timely replication of the entire genome precisely once in each cell cycle. Replication origins fire according to a cell-type-specific temporal programme, which is established in the G1 phase of each cell cycle. In response to conditions causing the slowing or stalling of DNA replication forks, the programme of origin firing is altered in two contrasting ways, depending on chromosomal context. First, inactive or 'dormant' replication origins in the vicinity of the stalled replication fork become activated and, second, the S phase checkpoint induces a global shutdown of further origin firing throughout the genome. Here, we review our current understanding on the role of dormant origins and the S phase checkpoint in the rescue of stalled forks and the completion of DNA replication in the presence of replicative stress.
journal_name
J Cell Scijournal_title
Journal of cell scienceauthors
Yekezare M,Gómez-González B,Diffley JFdoi
10.1242/jcs.096701subject
Has Abstractpub_date
2013-03-15 00:00:00pages
1297-306issue
Pt 6eissn
0021-9533issn
1477-9137pii
126/6/1297journal_volume
126pub_type
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