当前位置： SCI文献检索 > INTENSIVE CARE MEDICINE期刊下所有文献 > Predictive value of interleukin 6 (IL-6), interleukin 8 (IL-8) and gastric intramucosal pH (pH-i) in major abdominal surgery.

Predictive value of interleukin 6 (IL-6), interleukin 8 (IL-8) and gastric intramucosal pH (pH-i) in major abdominal surgery.

Abstract：

OBJECTIVE:To study plasma concentrations of interleukin 6 (IL-6) and interleukin 8 (IL-8) in patients with splanchnic hypoxia, as documented by gastric intramucosal measurements (pH-i), during major abdominal surgery and the relationship between IL-6 and IL-8 concentrations and postoperative complications as well as clinical outcome. DESIGN:A prospective study. PATIENTS:Twelve patients scheduled for major abdominal surgery with no evidence of coexisting infectious disease. RESULTS:Six out of seven samples from patients with postoperative complications showed intraoperative pH-i levels lower than 7.32 and IL-6 levels higher than 300 pg/ml. Seven out of nine samples from patients without complications showed pH-i levels higher than 7.32 and IL-6 levels lower than 300 pg/ml. The difference in the pattern of distribution was statistically significant (p < 0.01). Only two out of seven samples of patients with postoperative complications showed intraoperative pH-i levels lower than 7.32 and IL-8 levels higher than 60 pg/ml. It was not possible to identify a clear distribution pattern of data points for IL-6 and IL-8 during the postoperative period. CONCLUSIONS:Intraoperative splanchnic ischemia, as documented by gastric intramucosal pH-i, is directly correlated to the increase of IL-6 plasma levels and to the incidence of postoperative complications, while IL-8 levels showed no correlation with surgical complications.

journal_name

Intensive Care Med

journal_title

Intensive care medicine

authors

Donati A,Battisti D,Recchioni A,Paoletti P,Conti G,Caporelli S,Adrario E,Pelaia P,Pietropaoli P

doi

10.1007/s001340050575

subject

Has Abstract

pub_date

1998-04-01 00:00:00

pages

329-35

issue

4

eissn

0342-4642

issn

1432-1238

journal_volume

24

pub_type

杂志文章

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