Abstract:
PURPOSE:To determine the incidence of and risk factors for adverse cardiac events during catecholamine vasopressor therapy in surgical intensive care unit patients with cardiovascular failure. METHODS:The occurrence of any of seven predefined adverse cardiac events (prolonged elevated heart rate, tachyarrhythmia, myocardial cell damage, acute cardiac arrest or death, pulmonary hypertension-induced right heart dysfunction, reduction of systemic blood flow) was prospectively recorded during catecholamine vasopressor therapy lasting at least 12 h. RESULTS:Fifty-four of 112 study patients developed a total of 114 adverse cardiac events, an incidence of 48.2 % (95 % CI, 38.8-57.6 %). New-onset tachyarrhythmia (49.1 %), prolonged elevated heart rate (23.7 %), and myocardial cell damage (17.5 %) occurred most frequently. Aside from chronic liver diseases, factors independently associated with the occurrence of adverse cardiac events included need for renal replacement therapy, disease severity (assessed by the Simplified Acute Physiology Score II), number of catecholamine vasopressors (OR, 1.73; 95 % CI, 1.08-2.77; p = 0.02) and duration of catecholamine vasopressor therapy (OR, 1.01; 95 % CI, 1-1.01; p = 0.002). Patients developing adverse cardiac events were on catecholamine vasopressors (p < 0.001) and mechanical ventilation (p < 0.001) for longer and had longer intensive care unit stays (p < 0.001) and greater mortality (25.9 vs. 1.7 %; p < 0.001) than patients who did not. CONCLUSIONS:Adverse cardiac events occurred in 48.2 % of surgical intensive care unit patients with cardiovascular failure and were related to morbidity and mortality. The extent and duration of catecholamine vasopressor therapy were independently associated with and may contribute to the pathogenesis of adverse cardiac events.
journal_name
Intensive Care Medjournal_title
Intensive care medicineauthors
Schmittinger CA,Torgersen C,Luckner G,Schröder DC,Lorenz I,Dünser MWdoi
10.1007/s00134-012-2531-2subject
Has Abstractpub_date
2012-06-01 00:00:00pages
950-8issue
6eissn
0342-4642issn
1432-1238journal_volume
38pub_type
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01692549
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
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更新日期:1991-01-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00134-003-1911-z
更新日期:2003-10-01 00:00:00
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/BF01709279
更新日期:1993-01-01 00:00:00
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journal_title:Intensive care medicine
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doi:10.1007/s00134-007-0834-5
更新日期:2008-01-01 00:00:00
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journal_title:Intensive care medicine
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更新日期:1985-01-01 00:00:00
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pub_type: 信件
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更新日期:2002-11-01 00:00:00
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journal_title:Intensive care medicine
pub_type: 杂志文章
doi:10.1007/s00134-002-1512-2
更新日期:2002-11-01 00:00:00
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更新日期:2011-10-01 00:00:00
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更新日期:2003-09-01 00:00:00
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pub_type: 历史文章,杂志文章
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章,已发布勘误
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更新日期:2018-02-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2008-03-01 00:00:00