Group A beta-haemolytic streptococcus septicaemia: the toxic strep syndrome. Report of our cases developing septic shock and multiple organ failure.

abstract：OBJECTIVE:We compared two imipenem regimens for prevention of septic complications in patients with severe acute necrotizing pancreatitis (ANP). DESIGN AND SETTING:Prospective, randomized open clinical trial involving intensive care units of 14 Spanish Hospitals. PARTICIPANTS:92 patients with ANP. INTERVENTIONS:Imip...

journal_title：Intensive care medicine

authors： Maraví-Poma E,Gener J,Alvarez-Lerma F,Olaechea P,Blanco A,Domínguez-Muñoz JE,Spanish Group for the Study of Septic Complications in Severe Acute Pancreatitis.

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Reporting neurodevelopmental outcome of 8-year-old children treated with neonatal extracorporeal membrane oxygenation (ECMO). METHODS:In a follow-up study in 135 8-year-old children who received neonatal ECMO between 1996 and 2001 we assessed intelligence (Revised Amsterdam Intelligence Test), concentration (B...

journal_title：Intensive care medicine

authors： Madderom MJ,Reuser JJ,Utens EM,van Rosmalen J,Raets M,Govaert P,Steiner K,Gischler SJ,Tibboel D,van Heijst AF,Ijsselstijn H

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Postoperative pneumonia is a potentially devastating complication associated with high mortality in intensive care unit (ICU)-patients. One of the major predisposing factors is the perioperative occurrence of atelectatic formations in non-dependent lung areas. Perioperative ventilation/perfusion mismatch due ...

journal_title：Intensive care medicine

authors： Hutschala D,Kinstner C,Skhirtladze K,Mayer-Helm BX,Zeitlinger M,Wisser W,Müller M,Tschernko E

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVE:Growing evidence suggests that acute respiratory distress syndrome (ARDS) occurring as a consequence of primary (direct) lung injury differs from that resulting from secondary (indirect) lung injury in terms of radiographic appearance, response to interventions, and outcomes. We examined whether there are dif...

journal_title：Intensive care medicine

authors： Parker CM,Heyland DK,Groll D,Caeser M

更新日期：2006-11-01 00:00:00

abstract：:To examine the right ventricular response to acute respiratory failure, serial studies of biventricular performance were analysed in 34 such patients, specifically detailing the role of associated underlying disease. During the initial study, the 34 patients with acute respiratory failure had a higher right ventricula...

journal_title：Intensive care medicine

authors： Brunet F,Dhainaut JF,Devaux JY,Huyghebaert MF,Villemant D,Monsallier JF

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate the neuropathological outcome of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to i...

journal_title：Intensive care medicine

authors： Fathali N,Lekic T,Zhang JH,Tang J

更新日期：2010-09-01 00:00:00

abstract：:The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with card...

journal_title：Intensive care medicine

authors： McCartney AC,Banks JG,Clements GB,Sleigh JD,Tehrani M,Ledingham IM

更新日期：1983-01-01 00:00:00

abstract：:In hypoxia sensitive cells and tissues, the rates of glucose and O2 consumption are inversely related (Pasteur Effect). Under O2 limiting conditions the demands for glucose (glycogen) in such cells may drastically rise as a means for maintaining ATP turnover close to normoxic rates; nevertheless ion and electrical pot...

journal_title：Intensive care medicine

authors： Hochachka PW

更新日期：1986-01-01 00:00:00

abstract：:Factors influencing nitrogen balance during total parenteral nutrition have been investigated in 34 critically ill injured patients studied during the first 6 days after trauma. Basal nitrogen balance was severely negative (-0.26 +/- 0.12 (SD) g X kg-1), but improved consistently during treatment. Nitrogen intake prov...

journal_title：Intensive care medicine

authors： Iapichino G,Radrizzani D,Solca M,Pesenti A,Gattinoni L,Ferro A,Leoni L,Langer M,Vesconi S,Damia G

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:While using a transcutaneous system for assessment of liver function by indocyanine green plasma disappearance rate (ICG-PDR) in critically ill patients, we compared the agreement between ICG-PDR obtained by the recommended standard ICG dosage (0.5 mg/kg) and a reduced dosage (0.25 mg/kg). DESIGN:Clinical st...

journal_title：Intensive care medicine

authors： Sakka SG,Koeck H,Meier-Hellmann A

更新日期：2004-03-01 00:00:00

abstract：:Recombinant activated factor VII (rFVIIa, 'NovoSeven') is indicated for the treatment of spontaneous and surgical bleeding in patients with haemophilia A or B with antibodies to factors VIII or IX (FVIII or FIX) worldwide, and in patients with acquired haemophilia in Europe. In vitro cell models have demonstrated that...

journal_title：Intensive care medicine

authors： Von Depka M

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:The primary objective was to test the hypothesis that clinical re-expansion pulmonary edema is predominantly due to increased permeability of the alveolar-capillary barrier. A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema ...

journal_title：Intensive care medicine

authors： Sue RD,Matthay MA,Ware LB

更新日期：2004-10-01 00:00:00

abstract：PURPOSE:Family members of patients who die in the intensive care unit (ICU) may experience symptoms of stress, anxiety, depression, posttraumatic stress disorder (PTSD), and/or prolonged grief. We evaluated whether grief symptoms were alleviated if the physician and the nurse in charge at the time of death sent the clo...

journal_title：Intensive care medicine

authors： Kentish-Barnes N,Chevret S,Champigneulle B,Thirion M,Souppart V,Gilbert M,Lesieur O,Renault A,Garrouste-Orgeas M,Argaud L,Venot M,Demoule A,Guisset O,Vinatier I,Troché G,Massot J,Jaber S,Bornstain C,Gaday V,Robert R

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:Protective mechanical ventilation based on multiple ventilator parameters such as tidal volume, plateau pressure, and driving pressure has been widely used in acute respiratory distress syndrome (ARDS). More recently, mechanical power (MP) was found to be associated with mortality. The study aimed to investigat...

journal_title：Intensive care medicine

authors： Zhang Z,Zheng B,Liu N,Ge H,Hong Y

更新日期：2019-06-01 00:00:00

abstract：:We report the case of a 72-year-old male who suffered a cardiac arrest during an early positive treadmill stress test. After successful resuscitation the patient had evidence of a gastric perforation. Because of his hemodynamic stability, lack of peritoneal signs, and prohibitively high surgical risk, a non-operative ...

journal_title：Intensive care medicine

authors： Low LL,Ripple GR,Bruderer BP,Harrington GR

更新日期：1994-07-01 00:00:00

abstract：PURPOSE:Neurologic and endothelial injury biomarkers are associated with prolonged delirium during critical illness and may reflect injury pathways that lead to poor long-term outcomes. We hypothesized that blood-brain barrier (BBB), neuronal, and endothelial injury biomarkers measured during critical illness are assoc...

journal_title：Intensive care medicine

authors： Hughes CG,Patel MB,Brummel NE,Thompson JL,McNeil JB,Pandharipande PP,Jackson JC,Chandrasekhar R,Ware LB,Ely EW,Girard TD

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Inhalation of nitric oxide (NO) can improve oxygenation and decrease mean pulmonary artery pressure (MPAP) in patients with the acute respiratory distress syndrome (ARDS). It is not known whether inhaled NO exerts a similar effect in hypoxemic patients with chronic obstructive pulmonary disease (COPD). DESIG...

journal_title：Intensive care medicine

authors： Blanch L,Joseph D,Fernández R,Mas A,Martinez M,Vallés J,Diaz E,Baigorri F,Artigas A

更新日期：1997-01-01 00:00:00

abstract：:The measurement of functional residual capacity (FRC) has assumed new importance in the diagnosis of acute respiratory failure. However few reference values exist for FRC in supine positions for both sexes. We measured the FRC in 100 healthy subjects with the helium dilution closed circuit method in the sitting and su...

journal_title：Intensive care medicine

authors： Ibañez J,Raurich JM

更新日期：1982-01-01 00:00:00

abstract：:Total extracorporeal lung assist (ECLA) requires a bypass flow approaching cardiac output. Recirculation of venous blood through the oxygenator is minimized with a veno-right ventricular cannulation technique which separates venous drainage from returned oxygenated blood. A case of posttraumatic ARDS was treated with ...

journal_title：Intensive care medicine

authors： Wetterberg T,Steen S

更新日期：1991-01-01 00:00:00

abstract：:In 9 Goettingen minipigs we studied the effect of E. coli bacteremia on effective pulmonary capillary pressure and the longitudinal distribution of pulmonary vascular resistance. Precapillary pressure gradient (dPa) was calculated as the difference between mean pulmonary artery pressure (MPP) and effective pulmonary c...

journal_title：Intensive care medicine

authors： Fretschner R,Klöss T,Guggenberger H,Heuser D,Schmid HJ,Widmann M

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of intravenous sildenafil for immediate postoperative pulmonary hypertension (PH) in pediatric patients undergoing congenital heart surgery. METHODS:A double-blind, multicenter, placebo-controlled, dose-ranging, parallel-group trial was conducted. Patients were randomized to...

journal_title：Intensive care medicine

authors： Fraisse A,Butrous G,Taylor MB,Oakes M,Dilleen M,Wessel DL

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that levosimendan increases systemic and intestinal oxygen delivery (DO(2)) and prevents intramucosal acidosis in septic shock. DESIGN:Prospective, controlled experimental study. SETTING:University-based research laboratory. SUBJECTS:Nineteen anesthetized, mechanically ventilated she...

journal_title：Intensive care medicine

authors： Dubin A,Murias G,Sottile JP,Pozo MO,Barán M,Edul VS,Canales HS,Etcheverry G,Maskin B,Estenssoro E

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:To compare isoflurane with midazolam for prolonged sedation in ventilated patients. DESIGN:Randomised controlled study. SETTING:General intensive care unit in university teaching hospital. PATIENTS:Sixty patients aged 17-80 years who required mechanical ventilation for more than 24 h. INTERVENTIONS:Sedati...

journal_title：Intensive care medicine

authors： Spencer EM,Willatts SM

更新日期：1992-01-01 00:00:00

abstract：:Knowledge translation is an important step for translational research. In this issue of Intensive Care Medicine, a new mini-series of basic research-related reviews is published. Three invited reviews focus on the role of extracellular matrix in ventilator-induced lung injury and mechanotransduction. The major challen...

journal_title：Intensive care medicine

authors： Liu M

更新日期：2008-04-01 00:00:00

abstract：:The increase of the inflationary lung volume created by a respiratory maneuver is critical for preventing postoperative alveolar collapse. We measured this volume as achieved with IPPB or incentive spirometry (IS) in 20 postoperative surgical patients. Using IPPB, with gas flow and peak airway pressures carefully adju...

journal_title：Intensive care medicine

authors： Pfenninger J,Roth F

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND:Candidemia is a life-threatening infection in the ICU whose prognosis is highly dependent on the stage at which it is recognized. Procalcitonin (PCT) levels have been shown to accurately distinguish between bacteremia and noninfectious inflammatory states in critically ill patients with clinical signs of sep...

journal_title：Intensive care medicine

authors： Charles PE,Dalle F,Aho S,Quenot JP,Doise JM,Aube H,Olsson NO,Blettery B

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:To compare the effects of patient-initiated, pressure-regulated, volume-controlled ventilation (PRVC) with pressure-preset intermittent mandatory ventilation (IMV) in neonates with respiratory failure. DESIGN:Randomised, prospective study. SETTING:Intensive care unit (14 beds) in a 300-bed paediatric teachi...

journal_title：Intensive care medicine

authors： Piotrowski A,Sobala W,Kawczyński P

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the origin of H+ ions participating in the generation of CO2 coming from sodium bicarbonate infusion during metabolic acidosis. We hypothesized that these H+ ions come from a back-titration of the main non-bicarbonate buffers present in the blood, i. e. the hemoglobin and the albumin, and thus pos...

journal_title：Intensive care medicine

authors： Levraut J,Garcia P,Giunti C,Ichai C,Bouregba M,Ciebiera JP,Payan P,Grimaud D

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To investigate whether ultrasound determination of the inferior vena cava diameter (IVCD) and its collapsibility index (IVCCI) could be used to optimize the fluid removal rate while avoiding hypotension during slow continuous ultrafiltration (SCUF). METHODS:Twenty-four consecutive patients [13 men and 11 wom...

journal_title：Intensive care medicine

authors： Guiotto G,Masarone M,Paladino F,Ruggiero E,Scott S,Verde S,Schiraldi F

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:To describe changes in hemodynamic variables, sedation, and pain score after discontinuation of prolonged infusions of dexmedetomidine in a pediatric population of critically ill cardiac patients. METHODS:Retrospective case series of patients who received continuous infusions of dexmedetomidine for longer than...

journal_title：Intensive care medicine

authors： Burbano NH,Otero AV,Berry DE,Orr RA,Munoz RA

更新日期：2012-02-01 00:00:00