Inhibin-B: the physiologic basis of the clomiphene citrate challenge test for ovarian reserve screening.

Abstract:

OBJECTIVE:To determine inhibin-B concentrations during ovarian reserve screening in women with normal and diminished ovarian reserve as determined by the clomiphene citrate challenge test. DESIGN:Retrospective. SETTING:Tertiary fertility center. PATIENT(S):Women undergoing ovarian reserve screening for a routine fertility evaluation. INTERVENTION(S):Clomiphene citrate challenge test. MAIN OUTCOME MEASURE(S):Inhibin-B concentrations on menstrual days 3 and 10. RESULT(S):Nineteen patients with normal ovarian reserve and 15 with diminished ovarian reserve had serum inhibin-B concentrations determined during ovarian reserve screening. For all patients, day 10 inhibin-B concentrations were higher than day 3. Women with normal ovarian reserve had higher inhibin-B concentrations on both days 3 and 10 than women with diminished ovarian reserve. Inhibin-B concentrations demonstrated a negative correlation with FSH levels on both cycle days 3 and 10 and a positive correlation with E2 on cycle day 10. CONCLUSION(S):Women with diminished ovarian reserve during ovarian reserve screening had reduced granulosa cell inhibin-B production compared with women with normal ovarian reserve. The lower inhibin-B concentrations may be responsible for the elevated FSH concentrations and may be indicative of the aging follicular apparatus.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Hofmann GE,Danforth DR,Seifer DB

doi

10.1016/s0015-0282(97)00531-1

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

474-7

issue

3

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(97)00531-1

journal_volume

69

pub_type

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