Abstract:
:Thirty-six cases of pilocytic astrocytomas treated at the Childrens Hospital of Los Angeles from 1984 through 1995 were reviewed. The mean age at initial presentation was 8 years (range 15 months to 14 years). These patients were followed for an average of 5.5 years. No patient was given chemotherapy or radiation therapy after the initial surgery for pilocytic astrocytoma. Twenty-three patients (64%) had a gross total resection with no residual tumor on immediate postoperative imaging studies. Three of these children had tumor recurrences 2-5 years after their initial surgery, requiring re-excision of their tumors. All 3 patients are subsequently tumor-free, with follow-up ranging from 4 to 10 years. In 4 patients with residual tumor involving the brainstem, there has been neither imaging evidence of tumor enlargement nor progression of clinical findings at 2.5, 4, 6 and 6 years, respectively. Nine of the 13 patients with residual tumor underwent re-excision, either for progression of symptoms or documented tumor growth on imaging studies. The second operation was undertaken an average of 1 year (range 1 month to 6 years) after the first. In 4 of these children (11% of our whole series), the recurrent tumor was classified as anaplastic astrocytoma. Three of these 4 children received radiation and/or chemotherapy, with only 1 patient showing disease progression in the follow-up period. Repeat blinded histopathological examination of these tumors confirmed both diagnoses. However, it was noted that 3 of the 4 pilocytic astrocytomas which subsequently showed anaplastic change initially displayed increased perivascular cellularity, while only 2 of the remaining 32 tumors exhibited this feature. These results encourage continued vigilance in the follow-up of pilocytic astrocytomas, and describe a histological feature which might indicate a more aggressive disease course.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Krieger MD,Gonzalez-Gomez I,Levy ML,McComb JGdoi
10.1159/000121218subject
Has Abstractpub_date
1997-07-01 00:00:00pages
1-11issue
1eissn
1016-2291issn
1423-0305journal_volume
27pub_type
杂志文章,评审abstract:OBJECTIVE:Myxopapillary ependymomas (MPEs) in children are rarely reported low-grade glial tumors; however, MPEs sometimes possess malignant characteristics such as spinal seeding/drop metastasis (SSM). We aimed to present 3 pediatric MPE cases that experienced SSM at 2 neurosurgical centers. MATERIALS AND METHODS:We ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000509061
更新日期:2020-01-01 00:00:00
abstract::Early diagnosis of skull fibrous dysplasia in children is relatively easy, based on a history of painless progressive bony bulging. The therapeutic approach is still controversial, due to the benignity of the lesion. However, the clinical course may be unpredictable, with sudden appearance of symptoms, some of which c...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120649
更新日期:1992-01-01 00:00:00
abstract::Severe diffuse brain injury in children has a devastating influence on their physical and psychological development. This retrospective study was undertaken to analyse the factors that influence outcome in children with such injuries. The short-term outcomes (Glasgow outcome score) of 74 children (age < or =15 years) ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000056002
更新日期:2001-02-01 00:00:00
abstract::Holocord intramedullary low-grade astrocytomas in children and adolescents - involving most or all of the cervical and thoracic spinal cord - are a rare finding. Most of the tumors seem to be pilocytic astrocytomas. Surgical management strategies might not be as clear as in small and circumscribed intramedullary tumor...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000345593
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The Delta valve is a pressure differential valve with a siphon control device. The valve mechanism is normally closed, but is designed to open in response to positive ventricular pressure, thereby avoiding overdrainage of cerebrospinal fluid (CSF). As a result, the incidence of subdural fluid collections as w...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028988
更新日期:2000-08-01 00:00:00
abstract::For over 60 years congenital kyphotic deformities of the spine have been categorized into two distinct groups, depending on the developmental defect. Those arising from a failure of formation of the vertebral bodies were classified as type 1, while those arising from a failure of segmentation were referred to as type ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121178
更新日期:1997-03-01 00:00:00
abstract:PURPOSE:Craniosynostosis patients treated with one-stage cranioplasty often have bleeding from the dura mater, fluid collection in the extradural space, and poor wound healing due to skin overstretching. To avoid these complications, we began using distraction osteogenesis. To determine the advantages and disadvantages...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000094064
更新日期:2006-01-01 00:00:00
abstract::Although some complications have been reported when using endoscopic techniques, epidural hematoma (EDH) has rarely been caused. The authors report a case of EDH complicating a concomitant endoscopic biopsy procedure with ventricular shunt placement in a young, 14-year-old boy harboring a third ventricle tumor with a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000082301
更新日期:2004-09-01 00:00:00
abstract::Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000497149
更新日期:2019-01-01 00:00:00
abstract::Meningeal melanocytoma is an infrequent neoplasm of the central nervous system (CNS), especially in childhood and infancy. It was first described as an entity different from pigmented meningiomas and schwannomas in 1972, and few cases have been published so far. In this article, a 5-month-old male patient with meninge...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028945
更新日期:2000-05-01 00:00:00
abstract::Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000087486
更新日期:2005-09-01 00:00:00
abstract::Primary spinal primitive neuroectodermal tumor (PSPNET) is extremely rare and only 25 cases have been reported in the world literature so far. Three patients of 8, 9 and 18 years of age, who presented with variable grades of neurological deficit were diagnosed as having a dorsal intramedullary lesion, a holocord lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000097517
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. CLINICAL PRESENTATION:We present the case o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336877
更新日期:2011-01-01 00:00:00
abstract::Spondylolysis and spondylolisthesis can be associated with significant low back pain, especially in physically active adolescents. Non-operative management is usually successful in improving symptoms, but surgical intervention is occasionally required for those that fail reduction of activity and bracing. In a subpopu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000072471
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:The failure rate following endoscopic third ventriculostomy (ETV) in infants younger than 2 years of age has been reported to be higher compared with that of older children, and it is unclear whether ETV might be superior to shunt placement in this age group. METHODS:Between 2003 and 2009, 23 patients young...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000324913
更新日期:2010-01-01 00:00:00
abstract::Encephaloceles arise from developmental defects in neural tube formation. These lesions contain brain and meninges which herniate through a defect in the skull. These may present as isolated malformations or rarely be associated with brain tumors. We hereby discuss a case of an unusual association of an occipital ence...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339555
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Cephalocele is a central nervous system (CNS) birth defect. Various CNS and extra-CNS anomalies, as well as prognostic factors have been reported with cephalocele. The aim of this study was to discuss prognostic factors and current possible theories explaining associated anomalies seen in a series of 55 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000277622
更新日期:2009-01-01 00:00:00
abstract::During the last decade, rapid progress has been made in understanding the molecular pathways underlying the proliferation of both normal and neoplastic cells. The processes by which messages to initiate protein synthesis, cell cycle progression, and even cell death are transmitted from the cell surface or the cytoplas...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028729
更新日期:1998-11-01 00:00:00
abstract::The existence of air in the spinal canal is referred to as pneumorrhachis. It is classified as extradural (epidural) or intradural (subdural or subarachnoid) according to the location where it is found. Nontraumatic, traumatic, and iatrogenic causes have been attributed to its occurrence. Traumatic pneumorrhachis is v...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000496395
更新日期:2019-01-01 00:00:00
abstract::A case of a 16-year-old male with both a nasal dermoid sinus cyst (NDSC) and a third ventricle colloid cyst is presented. The NDSC was excised via a single-stage combined intracranial-extracranial approach and the third ventricle colloid cyst was resected endoscopically. The pathogenetic theories of NDSC and third ven...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028862
更新日期:1999-10-01 00:00:00
abstract::Although extra-axial hematomas are a well-known complication of ventricular shunting, epidural hematomas are uncommon in this setting. We report an unusual case of multiple epidural hematomas in a patient with hydrocephalus treated by ventriculoperitoneal shunt. The patient became symptomatic 5 days after shunting and...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120704
更新日期:1993-03-01 00:00:00
abstract::Eighteen children under the age of 1 year underwent surgery for lipomeningocele at our institution between 1983 and 1991. All the patients had neurologic exams and urodynamic studies (UDS) including a cystometrogram and electromyography of the external urethral sphincter pre- and postoperatively. The surgical procedur...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120741
更新日期:1993-09-01 00:00:00
abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120605
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000495790
更新日期:2019-01-01 00:00:00
abstract::Skull defects in children may be congenital or acquired after trauma, infection or tumor. For defects that do not close spontaneously a variety of repair (cranioplasty) materials are available including bone, metals and acrylic. Where possible calvarial autogenous bone is preferred, particularly in younger infants, bu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120540
更新日期:1990-01-01 00:00:00
abstract::Posterior fossa syndrome (PFS), also known as cerebellar affective syndrome, is characterized by emotional lability and decreased speech production following injury or surgery to the cerebellum. Rarely, oculomotor dysfunction has been described in association with PFS. Here, we report a case of complete ocular paresis...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339382
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Tumours of the choroid plexus are rare tumours of neuro-ectodermal origin, accounting for less than 1% of all intracranial tumours. Most cases present in children less than 2 years of age. While choroid plexus carcinomas (CPC) are reported to have an extremely poor prognosis, choroid plexus papillomas (CPP) a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028933
更新日期:2000-04-01 00:00:00
abstract::This study was performed to compare the effects of continuous intrathecal baclofen infusion (CIBI) and selective posterior rhizotomy (SPR) on upper extremity (UE) spasticity and range of motion in children with cerebral palsy. Spasticity was assessed with the Ashworth scale of muscle tone and range of motion was evalu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120941
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000335400
更新日期:2011-01-01 00:00:00
abstract::Brainstem gliomas (BSG) with intrinsic and extensive brainstem involvement continue to have a poor outlook despite current treatment approaches. Neuroimaging studies have aided in the differentiation of malignant brainstem tumors from more 'benign' subgroups. A Children's Cancer Group protocol evaluating outcome in ch...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121036
更新日期:1996-01-01 00:00:00