Abstract:
:Severe diffuse brain injury in children has a devastating influence on their physical and psychological development. This retrospective study was undertaken to analyse the factors that influence outcome in children with such injuries. The short-term outcomes (Glasgow outcome score) of 74 children (age < or =15 years) with severe diffuse brain injury and no focal operable mass lesions on CT scan, admitted between 1992 and 1998 at the National Institute of Mental Health and Neurosciences were analysed. The prognostic factors analysed were age, gender, time after injury to admission, nature of injury, highest post-resuscitation Glasgow coma score (GCS), pupillary reaction, horizontal oculocephalic reflex and CT scan findings. The following factors were found to be independent predictors of poor outcome: GCS 3-5 (p < 0.003), absent verbal response (p < 0.001), motor response score of 1-3 (p < 0.001), absent pupillary reaction (p < 0.001), absent oculocephalic reflex (p < 0.001) and presence of traumatic subarachnoid haemorrhage on CT scan (p < 0.002). These independent variables were then subjected to a stepwise logistic regression analysis, and the most important variables for predicting outcome were oculocephalic reflex and GCS, which together correctly predicted unfavourable outcome with a sensitivity of 79% and a specificity of 65%. An early CT scan or a single CT scan did not have any prognostic significance.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Pillai S,Praharaj SS,Mohanty A,Kolluri VRdoi
10.1159/000056002keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
98-103issue
2eissn
1016-2291issn
1423-0305pii
56002journal_volume
34pub_type
杂志文章abstract::Complications of chemotherapy in pediatric brain tumor patients tend to be acute and short-lived with some special exceptions such as permanent hearing impairment secondary to cisplatin, infertility and an increased risk of second primary neoplasms. Chemotherapy will be better tolerated and probably more effective in ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120601
更新日期:1991-01-01 00:00:00
abstract::An infant sustained a significant depressed skull fracture from a fall. Before the planned surgical repair of the fracture could be carried out, the child sustained a second fall that led to the complete resolution of the depressed fracture. Mechanisms to explain this unusual phenomenon are discussed. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000334279
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Nondysraphic intramedullary lipomas of the spinal cord are rare lesions. They are most commonly seen in the second or third decade of life. Their occurrence in the pediatric age group is even rarer. CASE REPORT:The authors describe a 14-month-old child who presented with delayed motor milestones involving...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000334258
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Craniosynostosis patients treated with one-stage cranioplasty often have bleeding from the dura mater, fluid collection in the extradural space, and poor wound healing due to skin overstretching. To avoid these complications, we began using distraction osteogenesis. To determine the advantages and disadvantages...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000094064
更新日期:2006-01-01 00:00:00
abstract::There are several treatment modalities for Langerhans' cell histiocytosis (LCH) of bone, formerly usually referred to as eosinophilic granuloma, including surgery, radiotherapy and chemotherapy. In spinal lesions, surgery is not recommended generally, because of the potential for reconstitution of vertebral height. We...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000069100
更新日期:2003-04-01 00:00:00
abstract::Hepatic pseudocyst formation is a rare intra-abdominal complication of ventriculoperitoneal shunts. The presence of an intracranial tumor and a history of central nervous system infection are major risk factors for the development of this complication. Hepatic pseudocysts secondary to ventriculoperitoneal shunts can b...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000108795
更新日期:2007-01-01 00:00:00
abstract::Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are dire neurological disorders, characterized by severe damage to the myelin sheath of neurons, which typically result from rapid correction or overcorrection of systemic hyponatremia. For many years, both conditions have been considered universal...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000320146
更新日期:2010-01-01 00:00:00
abstract::Intracranial schwannomas not arising from a cranial nerve are very rare. Schwannomas of the dura are even rarer; in the literature, we found only two cases: a schwannoma of the falx and one of the torcula. We report a third case of a 9-year-old girl with a schwannoma of the tentorium cerebelli. The different theories ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000048371
更新日期:2002-03-01 00:00:00
abstract::The aquaporins (AQPs) are a family of water-transporting proteins that are broadly expressed in mammalian cells. Two AQPs in the central nervous system, AQP1 and AQP4, might play a role in hydrocephalus and are thus potential drug targets. AQP1 is expressed in the ventricular-facing membrane of choroid plexus epitheli...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000452168
更新日期:2017-01-01 00:00:00
abstract::Cerebral sparganosis in childhood is very rare. Until 1996, 2 cases in children up to 15 years of age had been described. We report a case of cerebral sparganosis in a 6-year-old girl who presented with seizures. Sequential brain magnetic resonance imaging scans spaced over 4 months showed a lesion which migrated from...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000121171
更新日期:1997-02-01 00:00:00
abstract::Craniopharyngiomas are the most common pediatric suprasellar tumor. While they are benign by histology, their location in the brain predisposes craniopharyngiomas to be associated with both acute and chronic neurologic, endocrine, visual, neuropsychologic and psychosocial problems. Because of the complexity of problem...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120872
更新日期:1994-01-01 00:00:00
abstract::Wakeboarding is a relatively new and exciting sporting activity which is similar to water-skiing. While there have been several reports of water-skiing-related injuries, there has been nothing reported in the literature so far concerning injuries in wakeboarding. We present the case of a 14-year-old male who sustained...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028957
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND/AIMS:The object of this report is to review the management of patients having the composite type of aplasia cutis congenita in the context of the relevant literature on this condition. METHODS:Clinical records, neuroimaging and photographic documentation of identified cases of composite type aplasia cutis c...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000442989
更新日期:2016-01-01 00:00:00
abstract::Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to pro...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120762
更新日期:1994-01-01 00:00:00
abstract::Between June 1989 and January 1994, 14 patients with recurrent (n = 11) or posttreatment residual (n = 3) medulloblastoma were enrolled in a program to evaluate the efficacy and toxicity of stereotactic radiosurgery (SR). Initial treatment consisted of subtotal surgical resection in 12 patients and complete surgical r...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120901
更新日期:1995-01-01 00:00:00
abstract::Prepontine arachnoid cysts are rare developmental anomalies that occur almost exclusively in children. The symptomatic child typically suffers from hydrocephalus, visual impairment, endocrine dysfunction and/or cranial neuropathies. Some cysts, however, are discovered incidentally upon prenatal or postnatal imaging fo...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000064394
更新日期:2002-09-01 00:00:00
abstract::Encephaloceles arise from developmental defects in neural tube formation. These lesions contain brain and meninges which herniate through a defect in the skull. These may present as isolated malformations or rarely be associated with brain tumors. We hereby discuss a case of an unusual association of an occipital ence...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339555
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:There are currently no clear guidelines for the management and radiological monitoring of pediatric patients with epidural hematomas (EDH). We aim to compare clinical and radiographic characteristics of pediatric EDH patients managed with observation alone versus surgical evacuation and to describe results o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000363143
更新日期:2013-01-01 00:00:00
abstract::During the last decade, rapid progress has been made in understanding the molecular pathways underlying the proliferation of both normal and neoplastic cells. The processes by which messages to initiate protein synthesis, cell cycle progression, and even cell death are transmitted from the cell surface or the cytoplas...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028729
更新日期:1998-11-01 00:00:00
abstract::Most cerebrospinal fluid (CSF) shunts employed in the treatment of hydrocephalus include in their designs a pump mechanism that has been used in office practice as an indicator of whether the shunt is functioning properly; however, the pumping characteristics of shunts have been shown to correlate poorly with clinical...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121100
更新日期:1996-08-01 00:00:00
abstract::Intracranial congenital arachnoid cysts are benign intra-arachnoidal fluid collections with a wall composed of arachnoid cells encompassing a cavity containing a fluid similar to cerebrospinal fluid. This cavity frequently communicates with the subarachnoid space. Arachnoid cysts are reported to account for about 1% o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000103314
更新日期:2007-01-01 00:00:00
abstract::Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. Pontine neurocytomas represent an extremely rare subset of extraventricular neurocytomas, and reports are limited to 2 adults followed under 28 months. The authors present the case of a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000351576
更新日期:2012-01-01 00:00:00
abstract::Although some complications have been reported when using endoscopic techniques, epidural hematoma (EDH) has rarely been caused. The authors report a case of EDH complicating a concomitant endoscopic biopsy procedure with ventricular shunt placement in a young, 14-year-old boy harboring a third ventricle tumor with a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000082301
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Neurological complications occur commonly in children with meningomyelocele and can cause significant morbidity and mortality. An earlier study suggested that acute changes in grip and pinch strength could be used to identify individuals at increased risk for developing a neurological complication. OBJECTIV...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000092356
更新日期:2006-01-01 00:00:00
abstract::Central pontine myelinolysis occurs inconsistently as a complication of severe and prolonged hyponatremia, particularly when corrected too rapidly. It is a concentrated, frequently symmetric, noninflammatory demyelination within the central basis pontis. We describe a head injury patient who suffered this clinical ent...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000315003
更新日期:2010-01-01 00:00:00
abstract::A needle for intravenous fluid administration in a newborn was accidentally placed in the sagittal sinus and resulted in dural sinus air embolism. CT findings are described and the risks for venous air embolism are discussed. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120606
更新日期:1991-01-01 00:00:00
abstract::A rare case of a patient with Laurence-Moon-Biedl syndrome associated with hypothalamic hamartoma is described. The English-language literature contains no cases of patients with this association. The clinical manifestations of this syndrome, those of hypothalamic hamartomas, and the appearance of the tumors on magnet...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120563
更新日期:1991-01-01 00:00:00
abstract::Hemifacial spasm (HFS), generally a disease of the elderly, is caused by vascular compression of the seventh nerve. Vascular compression is thought to result from atherosclerotic changes within the vessels of the posterior fossa, and therefore rarely presents in childhood. Here we describe our experience with 12 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121260
更新日期:1997-11-01 00:00:00
abstract::In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range 1.5-5.6) years after diagnosis from 16 survivors of 51 consecutively diagnosed children with brain stem glioma between 1983 and 1991. Among 11 children with dorsa...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120795
更新日期:1994-01-01 00:00:00
abstract::A series of neuroendoscopic third ventriculostomies in children less than 1 year old is reported. Twenty-seven patients underwent the procedure with 21 (77%) failing within a mean of 1.36 months of the procedure. Nineteen were subsequently shunted. The presence or absence of flow through the ventriculostomy and the si...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028693
更新日期:1998-08-01 00:00:00