Complications of chemotherapy in patients with brain and spinal cord tumors.

Abstract:

:Complications of chemotherapy in pediatric brain tumor patients tend to be acute and short-lived with some special exceptions such as permanent hearing impairment secondary to cisplatin, infertility and an increased risk of second primary neoplasms. Chemotherapy will be better tolerated and probably more effective in brain tumor patients following a major surgical resection, especially when agents such as cisplatin and cyclophosphamide are administered which require intensive intravenous hydration. Neoadjuvant or pre-radiotherapy chemotherapy administration may reduce chemotherapy-related side effects such as leukoencephalopathy secondary to high-dose intravenous methotrexate, neutropenia and thrombocytopenia following intensive chemotherapy, especially when craniospinal radiotherapy is required. The use of bone marrow ablative chemotherapy followed by autologous marrow rescue poses a new spectrum of organ toxicities. New supportive care measures significantly improved tolerance of chemotherapy such as mesna, a drug minimizing hemorrhagic cystitis following ifosfamide, ondonsetron, a highly effective antiemetic, and the hematopoietic growth factors such as G-CSF and GM-CSF which reduce the incidence and severity of symptomatic neutropenia. Chemotherapy may prolong life in patients with recurrent disease and contribute to curative therapy in newly diagnosed patients. The neurooncology community is becoming more familiar with the measures to improve its tolerance and thereby increase its efficacy.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Allen JC

doi

10.1159/000120601

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

218-24

issue

4

eissn

1016-2291

issn

1423-0305

journal_volume

17

pub_type

杂志文章,评审
  • Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon.

    abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000504060

    authors: Cuoco JA,Klein BJ,Busch CM,Gosnell HL,Kar A,Marvin EA,Apfel LS

    更新日期:2020-01-01 00:00:00

  • Big Data Research in Pediatric Neurosurgery: Content, Statistical Output, and Bibliometric Analysis.

    abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000495790

    authors: Oravec CS,Motiwala M,Reed K,Jones TL,Klimo P Jr

    更新日期:2019-01-01 00:00:00

  • Spinal rhabdomyosarcoma in a child with lipomyelomeningocele.

    abstract::Malignant tumors arising within dysrhaphic malformations are very rare and are mostly teratomas; so far, only one rhabdomyosarcoma has been reported in this context. We report another case of a girl with lipomyelomeningocele who developed a lumbar rhabdomyosarcoma 2 years after birth and primary closure of the neural ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000083742

    authors: Wagner W,Koch D

    更新日期:2004-11-01 00:00:00

  • Arachnoid cyst rupture with concurrent subdural hygroma.

    abstract::Arachnoid cysts (ACs) are relatively common intracranial mass lesions, which occur most often in the middle cranial fossa. While these lesions can present as a mass lesion, many are asymptomatic. Rarely, posttraumatic or spontaneous rupture of ACs can result in intracystic hemorrhage, subdural hematoma or subdural hyg...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028918

    authors: Donaldson JW,Edwards-Brown M,Luerssen TG

    更新日期:2000-03-01 00:00:00

  • Change in spinal curvature following release of tethered spinal cord associated with spina bifida.

    abstract::Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to pro...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120762

    authors: Reigel DH,Tchernoukha K,Bazmi B,Kortyna R,Rotenstein D

    更新日期:1994-01-01 00:00:00

  • Spontaneous regression of low-grade gliomas in pediatric patients without neurofibromatosis.

    abstract:OBJECTIVE:Pediatric low-grade gliomas comprise a diverse range of central nervous system tumors, sharing the usual course of a slow progression in growth. In individual cases however, the natural history can be variable, and rarely spontaneous regression has been described. This paper describes factors associated with ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000134925

    authors: Rozen WM,Joseph S,Lo PA

    更新日期:2008-01-01 00:00:00

  • Radiological and clinical criteria for the management of epidural hematomas in children.

    abstract:OBJECTIVE:Modern neuroimaging and intensive care permit precise delineation and specific treatment of head injury. Children sustaining cranial trauma associated with epidural hematoma (EDH) represent a heterogeneous group with a variety of clinical outcomes. Treatment consists of simple observation or surgical evacuati...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121144

    authors: Bejjani GK,Donahue DJ,Rusin J,Broemeling LD

    更新日期:1996-12-01 00:00:00

  • Intracranial nasal dermoid sinus cyst associated with colloid cyst of the third ventricle. Case report and new concepts.

    abstract::A case of a 16-year-old male with both a nasal dermoid sinus cyst (NDSC) and a third ventricle colloid cyst is presented. The NDSC was excised via a single-stage combined intracranial-extracranial approach and the third ventricle colloid cyst was resected endoscopically. The pathogenetic theories of NDSC and third ven...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028862

    authors: Cheng ML,Chang SD,Pang D,Adler JR

    更新日期:1999-10-01 00:00:00

  • Postoperative brain stem tension pneumocephalus causing transient locked-in syndrome.

    abstract::The incidence of pneumocephalus after supratentorial craniotomy has been reported to be as high as 100%. However, transformation of postoperative pneumocephalus into tension pneumocephalus (symptomatic intracranial air) is a rather rare phenomenon. Tension pneumocephalus after posterior fossa surgery is reported mainl...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000106394

    authors: Biyani N,Silbiger A,Ben-Ari J,Constantini S

    更新日期:2007-01-01 00:00:00

  • Update on Endoscopic Third Ventriculostomy in Children.

    abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000491638

    authors: Feng Z,Li Q,Gu J,Shen W

    更新日期:2018-01-01 00:00:00

  • The Total Calvarial Remodeling with Transsutural Distraction Osteogenesis of 21 Cases of Craniosynostosis: New, Efficient, Safe and Natural Method in Craniosynostosis Surgery.

    abstract:INTRODUCTION:The majority of the present distraction osteogenesis techniques involve local site expansion that only produces localized decompression and affords limited decompression and cosmetic results. We designed a new surgical procedure, total calvarial transsutural distraction osteogenesis (TSuDO). METHODS:We pe...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000381860

    authors: Park DH,Yoon SH

    更新日期:2015-01-01 00:00:00

  • Use of bipedicular advancement flaps for intrauterine closure of myeloschisis.

    abstract::Several groups have begun to explore the feasibility and utility of intrauterine closure of myelomeningocele. A subset of these fetuses have defects which fall into the category of myeloschisis, and therefore have inadequate skin to enable primary closure. After considerable discussion, it was decided to utilize biped...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028898

    authors: Mangels KJ,Tulipan N,Bruner JP,Nickolaus D

    更新日期:2000-01-01 00:00:00

  • Experimental acute subdural hematoma in infant piglets.

    abstract::Traumatic acute subdural hematoma is associated with high mortality in the pediatric population, yet the pathophysiology remains poorly understood. The objective of this study was to develop a pediatric model of acute subdural hematoma, and to evaluate the resultant histopathological changes in the brain. Ten 3-week-o...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121109

    authors: Shaver EG,Duhaime AC,Curtis M,Gennarelli LM,Barrett R

    更新日期:1996-09-01 00:00:00

  • Shunt dependency in shunted arachnoid cyst: a reason to avoid shunting.

    abstract::Cystoperitoneal (CP) shunting is minimally invasive and achieves a high rate of resolution on neuroimaging. However, in the absence of definite symptoms, shunting should be reconsidered, because some patients can experience shunt dependency after CP shunting. In this study, the risk of shunt dependency in patients wit...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000065393

    authors: Kim SK,Cho BK,Chung YN,Kim HS,Wang KC

    更新日期:2002-10-01 00:00:00

  • Selective functional posterior rhizotomy for treatment of spastic cerebral palsy in children. Review of 50 consecutive cases.

    abstract::Fifty consecutive children are described with spastic cerebral palsy treated with selective functional lumbar and sacral rhizotomy and followed for a minimum of 6 months. In all patients, spasticity improved postoperatively, but this was not necessarily accompanied by a functional improvement. Eighteen children who co...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120639

    authors: Steinbok P,Reiner A,Beauchamp RD,Cochrane DD,Keyes R

    更新日期:1992-01-01 00:00:00

  • Functional opening of the fourth ventricular outlet in C57BL/6J and delayed splotch mouse embryos.

    abstract::To compare the functional development of the fourth ventricular outlet in the myeloschisis-Chiari malformation complex with that of a normal brain, the chronological development of the outlet in C57BL/6J non-neural-tube defect mouse embryos was examined as the first step. Then we compared the results with those of hom...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121248

    authors: Wang KC,Higbee R,Knepper PA,McLone DG

    更新日期:1997-10-01 00:00:00

  • Dermal Sinus Tract of the Thoracic Spine Presenting with Intramedullary Abscess and Cranial Nerve Deficits.

    abstract::Congenital dermal sinus tract of the spine is an unusual developmental defect which represents a failure of the surface ectoderm and dermal elements to separate from the neuroectoderm. A 15-month-old female presented with high fever, severe right hemiparesis, difficulty breathing and cranial nerve deficits. Magnetic r...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000439539

    authors: Papaevangelou G,Tsitsopoulos PP,Flaris N,Iliadis C,Tsonidis C

    更新日期:2015-01-01 00:00:00

  • An unusual case of traumatic intracranial hemorrhage caused by wakeboarding.

    abstract::Wakeboarding is a relatively new and exciting sporting activity which is similar to water-skiing. While there have been several reports of water-skiing-related injuries, there has been nothing reported in the literature so far concerning injuries in wakeboarding. We present the case of a 14-year-old male who sustained...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028957

    authors: Chia JK,Goh KY,Chan C

    更新日期:2000-06-01 00:00:00

  • Endovascular particulate and alcohol embolization for near-fatal epistaxis from a skull base vascular malformation.

    abstract::A three-year old girl who initially presented at 16 months with epistaxis from an anterior skull base vascular anomaly returned with near-fatal epistaxis despite embolization of the internal maxillary artery at the time of initial presentation. Repeat angiography demonstrated blood supply to the vascular lesion coming...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000050432

    authors: Koebbe CJ,Horowitz M,Levy EI,Adelson D,Jungries C

    更新日期:2001-11-01 00:00:00

  • Quality of survival among children treated for brain stem glioma.

    abstract::In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range 1.5-5.6) years after diagnosis from 16 survivors of 51 consecutively diagnosed children with brain stem glioma between 1983 and 1991. Among 11 children with dorsa...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120795

    authors: Mulhern RK,Heideman RL,Khatib ZA,Kovnar EH,Sanford RA,Kun LE

    更新日期:1994-01-01 00:00:00

  • Pediatric skull base surgery. 1. Embryology and developmental anatomy.

    abstract::Surgical pathology of the pediatric cranial base is uncommon, but in affected children, traditional operative techniques and management philosophies predominate. While the creation of multidisciplinary skull base teams synergistically pools the talents of individual specialties, a better understanding of the developme...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000067558

    authors: Gruber DP,Brockmeyer D

    更新日期:2003-01-01 00:00:00

  • Chiari I malformations and hydromyelia--complications.

    abstract::The Chiari I malformation is associated with a hydromyelic cavity in 55-75% of patients. In the author's series (1977-1991), hydromelia occurred in 111 of 131 patients (85%). There were 35 children. Posterior fossa decompression with duraplasty and fourth ventricle to subarachnoid shunt was made in all patients with C...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000120586

    authors: Menezes AH

    更新日期:1991-01-01 00:00:00

  • Midline suboccipital osteoplastic craniotomy - 'cobra craniotomy'.

    abstract:BACKGROUND:Midline suboccipital craniotomy has been proposed as an alternative to conventional craniectomy for removal of posterior fossa tumors. METHOD:We describe a modified technique for midline suboccipital osteoplastic craniotomy based on the atlantooccipital membrane for a 17-year-old boy with superior vermian a...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000354220

    authors: Maiti T,Bhat DI,Devi BI,Shukla D

    更新日期:2012-01-01 00:00:00

  • Patterns of care for craniopharyngioma: survey of members of the american association of neurological surgeons.

    abstract:BACKGROUND:Initial therapy for craniopharyngioma remains controversial. Population-based datasets indicate that traditional algorithms [gross total resection (GTR) vs. subtotal resection (STR) +/- radiation therapy (XRT)] are often not employed. We investigated neurosurgical practice patterns. METHODS:A ten-question s...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000357783

    authors: Hankinson TC,Palmeri NO,Williams SA,Torok MR,Serrano CA,Foreman NK,Handler MH,Liu AK

    更新日期:2013-01-01 00:00:00

  • Gorham-Stout disease and cerebrospinal fluid otorrhea.

    abstract:OBJECTIVE AND IMPORTANCE:Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. CLINICAL PRESENTATION:We present the case o...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000336877

    authors: Hernández-Marqués C,Serrano González A,Cordobés Ortega F,Alvarez-Coca J,Sirvent Cerda S,Carceller Lechón F,Azorín Cuadrillero D

    更新日期:2011-01-01 00:00:00

  • Moyamoya disease in children with congenital dwarfing conditions.

    abstract::Congenital dwarfisms can be associated with a variety of vascular anomalies. Here, we describe 2 patients with congenital dwarfisms who presented with moyamoya syndrome and underwent indirect intracranial revascularization. The pathogenesis of moyamoya syndrome in this population is not well understood, but it is a ma...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000322017

    authors: Moftakhar P,Smith ER,Choulakian A,Scott RM,Danielpour M

    更新日期:2010-01-01 00:00:00

  • Endoscopic, single-catheter treatment of Dandy-Walker syndrome hydrocephalus: technical case report and review of treatment options.

    abstract::Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000087486

    authors: Sikorski CW,Curry DJ

    更新日期:2005-09-01 00:00:00

  • Radiation-Associated Glioblastoma after Prophylactic Cranial Irradiation in a Patient of ALL: Review of Literature and Report of a Rare Case.

    abstract:INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial ir...

    journal_title:Pediatric neurosurgery

    pub_type:

    doi:10.1159/000511996

    authors: Biswas A,Kashyap L,Bakhshi S

    更新日期:2020-01-01 00:00:00

  • Successful surgical excision of a nondysraphic holodorsal intramedullary lipoma in a 14-month-old child.

    abstract:INTRODUCTION:Nondysraphic intramedullary lipomas of the spinal cord are rare lesions. They are most commonly seen in the second or third decade of life. Their occurrence in the pediatric age group is even rarer. CASE REPORT:The authors describe a 14-month-old child who presented with delayed motor milestones involving...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000334258

    authors: Kumar A,Chandra PS,Bisht A,Garg A,Mahapatra AK,Sharma MC

    更新日期:2011-01-01 00:00:00

  • Pontine extraventricular neurocytoma in a child.

    abstract::Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. Pontine neurocytomas represent an extremely rare subset of extraventricular neurocytomas, and reports are limited to 2 adults followed under 28 months. The authors present the case of a ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000351576

    authors: Hawasli AH,Haydon DH,Dahiya S,Smyth MD

    更新日期:2012-01-01 00:00:00