Abstract:
:Complications of chemotherapy in pediatric brain tumor patients tend to be acute and short-lived with some special exceptions such as permanent hearing impairment secondary to cisplatin, infertility and an increased risk of second primary neoplasms. Chemotherapy will be better tolerated and probably more effective in brain tumor patients following a major surgical resection, especially when agents such as cisplatin and cyclophosphamide are administered which require intensive intravenous hydration. Neoadjuvant or pre-radiotherapy chemotherapy administration may reduce chemotherapy-related side effects such as leukoencephalopathy secondary to high-dose intravenous methotrexate, neutropenia and thrombocytopenia following intensive chemotherapy, especially when craniospinal radiotherapy is required. The use of bone marrow ablative chemotherapy followed by autologous marrow rescue poses a new spectrum of organ toxicities. New supportive care measures significantly improved tolerance of chemotherapy such as mesna, a drug minimizing hemorrhagic cystitis following ifosfamide, ondonsetron, a highly effective antiemetic, and the hematopoietic growth factors such as G-CSF and GM-CSF which reduce the incidence and severity of symptomatic neutropenia. Chemotherapy may prolong life in patients with recurrent disease and contribute to curative therapy in newly diagnosed patients. The neurooncology community is becoming more familiar with the measures to improve its tolerance and thereby increase its efficacy.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Allen JCdoi
10.1159/000120601subject
Has Abstractpub_date
1991-01-01 00:00:00pages
218-24issue
4eissn
1016-2291issn
1423-0305journal_volume
17pub_type
杂志文章,评审abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000504060
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000495790
更新日期:2019-01-01 00:00:00
abstract::Malignant tumors arising within dysrhaphic malformations are very rare and are mostly teratomas; so far, only one rhabdomyosarcoma has been reported in this context. We report another case of a girl with lipomyelomeningocele who developed a lumbar rhabdomyosarcoma 2 years after birth and primary closure of the neural ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000083742
更新日期:2004-11-01 00:00:00
abstract::Arachnoid cysts (ACs) are relatively common intracranial mass lesions, which occur most often in the middle cranial fossa. While these lesions can present as a mass lesion, many are asymptomatic. Rarely, posttraumatic or spontaneous rupture of ACs can result in intracystic hemorrhage, subdural hematoma or subdural hyg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028918
更新日期:2000-03-01 00:00:00
abstract::Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to pro...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120762
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Pediatric low-grade gliomas comprise a diverse range of central nervous system tumors, sharing the usual course of a slow progression in growth. In individual cases however, the natural history can be variable, and rarely spontaneous regression has been described. This paper describes factors associated with ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000134925
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:Modern neuroimaging and intensive care permit precise delineation and specific treatment of head injury. Children sustaining cranial trauma associated with epidural hematoma (EDH) represent a heterogeneous group with a variety of clinical outcomes. Treatment consists of simple observation or surgical evacuati...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121144
更新日期:1996-12-01 00:00:00
abstract::A case of a 16-year-old male with both a nasal dermoid sinus cyst (NDSC) and a third ventricle colloid cyst is presented. The NDSC was excised via a single-stage combined intracranial-extracranial approach and the third ventricle colloid cyst was resected endoscopically. The pathogenetic theories of NDSC and third ven...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028862
更新日期:1999-10-01 00:00:00
abstract::The incidence of pneumocephalus after supratentorial craniotomy has been reported to be as high as 100%. However, transformation of postoperative pneumocephalus into tension pneumocephalus (symptomatic intracranial air) is a rather rare phenomenon. Tension pneumocephalus after posterior fossa surgery is reported mainl...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000106394
更新日期:2007-01-01 00:00:00
abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000491638
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:The majority of the present distraction osteogenesis techniques involve local site expansion that only produces localized decompression and affords limited decompression and cosmetic results. We designed a new surgical procedure, total calvarial transsutural distraction osteogenesis (TSuDO). METHODS:We pe...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000381860
更新日期:2015-01-01 00:00:00
abstract::Several groups have begun to explore the feasibility and utility of intrauterine closure of myelomeningocele. A subset of these fetuses have defects which fall into the category of myeloschisis, and therefore have inadequate skin to enable primary closure. After considerable discussion, it was decided to utilize biped...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028898
更新日期:2000-01-01 00:00:00
abstract::Traumatic acute subdural hematoma is associated with high mortality in the pediatric population, yet the pathophysiology remains poorly understood. The objective of this study was to develop a pediatric model of acute subdural hematoma, and to evaluate the resultant histopathological changes in the brain. Ten 3-week-o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121109
更新日期:1996-09-01 00:00:00
abstract::Cystoperitoneal (CP) shunting is minimally invasive and achieves a high rate of resolution on neuroimaging. However, in the absence of definite symptoms, shunting should be reconsidered, because some patients can experience shunt dependency after CP shunting. In this study, the risk of shunt dependency in patients wit...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000065393
更新日期:2002-10-01 00:00:00
abstract::Fifty consecutive children are described with spastic cerebral palsy treated with selective functional lumbar and sacral rhizotomy and followed for a minimum of 6 months. In all patients, spasticity improved postoperatively, but this was not necessarily accompanied by a functional improvement. Eighteen children who co...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120639
更新日期:1992-01-01 00:00:00
abstract::To compare the functional development of the fourth ventricular outlet in the myeloschisis-Chiari malformation complex with that of a normal brain, the chronological development of the outlet in C57BL/6J non-neural-tube defect mouse embryos was examined as the first step. Then we compared the results with those of hom...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121248
更新日期:1997-10-01 00:00:00
abstract::Congenital dermal sinus tract of the spine is an unusual developmental defect which represents a failure of the surface ectoderm and dermal elements to separate from the neuroectoderm. A 15-month-old female presented with high fever, severe right hemiparesis, difficulty breathing and cranial nerve deficits. Magnetic r...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000439539
更新日期:2015-01-01 00:00:00
abstract::Wakeboarding is a relatively new and exciting sporting activity which is similar to water-skiing. While there have been several reports of water-skiing-related injuries, there has been nothing reported in the literature so far concerning injuries in wakeboarding. We present the case of a 14-year-old male who sustained...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028957
更新日期:2000-06-01 00:00:00
abstract::A three-year old girl who initially presented at 16 months with epistaxis from an anterior skull base vascular anomaly returned with near-fatal epistaxis despite embolization of the internal maxillary artery at the time of initial presentation. Repeat angiography demonstrated blood supply to the vascular lesion coming...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050432
更新日期:2001-11-01 00:00:00
abstract::In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range 1.5-5.6) years after diagnosis from 16 survivors of 51 consecutively diagnosed children with brain stem glioma between 1983 and 1991. Among 11 children with dorsa...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120795
更新日期:1994-01-01 00:00:00
abstract::Surgical pathology of the pediatric cranial base is uncommon, but in affected children, traditional operative techniques and management philosophies predominate. While the creation of multidisciplinary skull base teams synergistically pools the talents of individual specialties, a better understanding of the developme...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000067558
更新日期:2003-01-01 00:00:00
abstract::The Chiari I malformation is associated with a hydromyelic cavity in 55-75% of patients. In the author's series (1977-1991), hydromelia occurred in 111 of 131 patients (85%). There were 35 children. Posterior fossa decompression with duraplasty and fourth ventricle to subarachnoid shunt was made in all patients with C...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120586
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Midline suboccipital craniotomy has been proposed as an alternative to conventional craniectomy for removal of posterior fossa tumors. METHOD:We describe a modified technique for midline suboccipital osteoplastic craniotomy based on the atlantooccipital membrane for a 17-year-old boy with superior vermian a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000354220
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Initial therapy for craniopharyngioma remains controversial. Population-based datasets indicate that traditional algorithms [gross total resection (GTR) vs. subtotal resection (STR) +/- radiation therapy (XRT)] are often not employed. We investigated neurosurgical practice patterns. METHODS:A ten-question s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000357783
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. CLINICAL PRESENTATION:We present the case o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336877
更新日期:2011-01-01 00:00:00
abstract::Congenital dwarfisms can be associated with a variety of vascular anomalies. Here, we describe 2 patients with congenital dwarfisms who presented with moyamoya syndrome and underwent indirect intracranial revascularization. The pathogenesis of moyamoya syndrome in this population is not well understood, but it is a ma...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000322017
更新日期:2010-01-01 00:00:00
abstract::Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000087486
更新日期:2005-09-01 00:00:00
abstract:INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial ir...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000511996
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Nondysraphic intramedullary lipomas of the spinal cord are rare lesions. They are most commonly seen in the second or third decade of life. Their occurrence in the pediatric age group is even rarer. CASE REPORT:The authors describe a 14-month-old child who presented with delayed motor milestones involving...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000334258
更新日期:2011-01-01 00:00:00
abstract::Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. Pontine neurocytomas represent an extremely rare subset of extraventricular neurocytomas, and reports are limited to 2 adults followed under 28 months. The authors present the case of a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000351576
更新日期:2012-01-01 00:00:00