Radiation-Associated Glioblastoma after Prophylactic Cranial Irradiation in a Patient of ALL: Review of Literature and Report of a Rare Case.

Abstract:

INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial irradiation (12.6 Gy/7 fractions/1.5 weeks) as a part of INCTR-02-04 protocol in a 3-year-old boy with B-cell ALL. He underwent gross total excision (GTE) of the tumour followed by post-operative intensity modulated RT (59.4 Gy/33 fractions/6.5 weeks) and concurrent and adjuvant (3 cycles) temozolomide. Thereafter, he had rapid disease progression, which entailed re-excision of the recurrent tumour. Subsequently, there was widespread subependymal and leptomeningeal spread of tumour, leading to death 10.5 months after the initial diagnosis. CONCLUSION:RIMG is an aggressive malignancy with a dismal prognosis, and in spite of multimodality management, it exhibits relentless progression, occasionally characterized by subependymal and leptomeningeal dissemination, leading to eventual death within a year of diagnosis.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Biswas A,Kashyap L,Bakhshi S

doi

10.1159/000511996

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

409-417

issue

6

eissn

1016-2291

issn

1423-0305

pii

000511996

journal_volume

55

pub_type

  • Expansion cranioplasty with jackscrew distracters for craniosynostosis and intracranial hypertension in transplanted osteopetrosis.

    abstract:BACKGROUND:An 11-month-old boy with autosomal recessive infantile osteopetrosis presented, 7 months after bone marrow transplantation, with normal ventricular size and life-threatening intracranial hypertension due to pansynostosis. METHODS:The cranial vault was expanded by using jackscrew distracters to upwardly adva...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000098381

    authors: Dowlati D,Winston KR,Ketch LL,Quinones R,Giller R,Frattini A,van Hove J

    更新日期:2007-01-01 00:00:00

  • Radiological and clinical criteria for the management of epidural hematomas in children.

    abstract:OBJECTIVE:Modern neuroimaging and intensive care permit precise delineation and specific treatment of head injury. Children sustaining cranial trauma associated with epidural hematoma (EDH) represent a heterogeneous group with a variety of clinical outcomes. Treatment consists of simple observation or surgical evacuati...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121144

    authors: Bejjani GK,Donahue DJ,Rusin J,Broemeling LD

    更新日期:1996-12-01 00:00:00

  • Pediatric brain tumors in a 10-year period from 1986 to 1995 in Yamaguchi prefecture: epidemiology and comparison with adult brain tumors.

    abstract::The epidemiology of pediatric brain tumor was studied in a 10-year period from 1986 to 1995 in Yamaguchi prefecture. The total number of pediatric brain tumors was 83, and the incidence was 2.5/100, 000/year, which did not change during the period. The sign most frequently seen was intracranial hypertension, whereas f...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028636

    authors: Nomura S,Nishizaki T,Yamashita K,Ito H

    更新日期:1998-03-01 00:00:00

  • Interhemispheric neuroepithelial cyst associated with agenesis of the corpus callosum. A case report and review of the literature.

    abstract::This report describes a neonatal case in whom a large interhemispheric cyst associated with agenesis of the corpus callosum was revealed by fetal ultrasonography and demonstrated by MRI to be multilobulated. Endoscopic fenestration of cysts was initially designed in view of the development of the patient's brain and s...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000028972

    authors: Uematsu Y,Kubo K,Nishibayashi T,Ozaki F,Nakai K,Itakura T

    更新日期:2000-07-01 00:00:00

  • Cephalocele: report of 55 cases over 8 years.

    abstract:OBJECTIVE:Cephalocele is a central nervous system (CNS) birth defect. Various CNS and extra-CNS anomalies, as well as prognostic factors have been reported with cephalocele. The aim of this study was to discuss prognostic factors and current possible theories explaining associated anomalies seen in a series of 55 patie...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000277622

    authors: Baradaran N,Nejat F,Baradaran N,El Khashab M

    更新日期:2009-01-01 00:00:00

  • The delta valve: how does its clinical performance compare with two other pressure differential valves without antisiphon control?

    abstract:OBJECTIVE:The Delta valve is a pressure differential valve with a siphon control device. The valve mechanism is normally closed, but is designed to open in response to positive ventricular pressure, thereby avoiding overdrainage of cerebrospinal fluid (CSF). As a result, the incidence of subdural fluid collections as w...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028988

    authors: Davis SE,Levy ML,McComb JG,Sposto R

    更新日期:2000-08-01 00:00:00

  • Conventional and diffusion-weighted magnetic resonance imaging findings in a pediatric patient with a posterior fossa brain tumor and papilledema.

    abstract::We present a case report of a 21-month-old female patient to highlight magnetic resonance (MR) imaging findings associated with papilledema in a pediatric patient with an intracranial tumor. The MR findings included optic disc elevation, dilated perioptic subarachnoid spaces, optic nerve tortuosity and restricted diff...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000270156

    authors: Pakzad-Vaezi K,Cochrane D,Sargent M,Singhal A

    更新日期:2009-01-01 00:00:00

  • Visually evoked potentials in 52 children requiring operative repair of craniosynostosis.

    abstract::We evaluated the prevalence of pathological visually evoked potentials (VEP) before the appearance of papilledema or other signs of elevated intracranial pressure in children suffering from craniosynostosis. In 52 children (19 girls, 33 boys, median age 7.6 months, mean age 7.6 months, range from 3 to 34 months) preop...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028746

    authors: Mursch K,Brockmann K,Lang JK,Markakis E,Behnke-Mursch J

    更新日期:1998-12-01 00:00:00

  • Supratentorial dorsal cistern epidermoid cyst in childhood.

    abstract::Epidermoid cysts (ECs) are rare developmental lesions occurring anywhere along the central nervous system. Usually affecting adult patients, the occurrence of supratentorial dorsal cistern ECs has been reported in only 1 certain case of pediatric age. An additional pediatric case is presented. An 11-year-old boy had a...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000028722

    authors: Caruso G,Germanó A,Caffo M,Belvedere M,La Torre D,Tomasello F

    更新日期:1998-10-01 00:00:00

  • Head injury caused by tear gas cartridge in teenage population.

    abstract:OBJECTIVES:The aim of this study was to assess the head injury in children caused by an unusual projectile, a tear gas cartridge. The study is the only one on this subject which has been done in a teenage population. METHOD:This was a prospective study conducted over a period of 4 years in which all the patients aged ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000314054

    authors: Wani AA,Zargar J,Ramzan AU,Malik NK,Qayoom A,Kirmani AR,Nizami FA,Wani MA

    更新日期:2010-01-01 00:00:00

  • Giant Cavernous Malformations in Childhood: A Case Report and Review of the Literature.

    abstract::Cavernous malformations (CMs) of the central nervous system are benign, angiographically occult vascular lesions and are diagnosed by magnetic resonance imaging techniques. Giant CMs do not differ from smaller-sized CMs in their clinical, surgical or histopathological presentation but may be radiologically different. ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000447407

    authors: Ozsoy KM,Oktay K,Gezercan Y,Cetinalp NE,Olguner SK,Erman T

    更新日期:2017-01-01 00:00:00

  • Endoscopic, single-catheter treatment of Dandy-Walker syndrome hydrocephalus: technical case report and review of treatment options.

    abstract::Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000087486

    authors: Sikorski CW,Curry DJ

    更新日期:2005-09-01 00:00:00

  • Protective effects of edaravone on experimental spinal cord injury in rats.

    abstract:BACKGROUND:Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000335400

    authors: Ozgiray E,Serarslan Y,Oztürk OH,Altaş M,Aras M,Söğüt S,Yurtseven T,Oran I,Zileli M

    更新日期:2011-01-01 00:00:00

  • Surgical management of craniopharyngioma.

    abstract::Craniopharyngiomas can be divided into sellar, prechiasmatic, retrochiasmatic and giant tumors. The initial approach to a craniopharyngioma should be an attempt at its removal. Only if surgical therapy fails to deal with the tumor should more conservative approaches utilizing radiotherapy be used. The use of intracyst...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000120861

    authors: Hoffman HJ

    更新日期:1994-01-01 00:00:00

  • Fractures of the peritoneal catheter of cerebrospinal fluid shunts.

    abstract::A retrospective study of fractures of peritoneal catheters of ventriculoperitoneal shunts is described. Fracture of the peritoneal catheter accounts for 21.2% of shunt revisions. During the time period of January 1985 through July 1993, 401 PS Medical peritoneal catheters were installed and 23 fractures occurred. The ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120884

    authors: Cuka GM,Hellbusch LC

    更新日期:1995-01-01 00:00:00

  • Surgical management of the cloverleaf skull deformity.

    abstract::The cloverleaf skull deformity, or Kleeblattschädel, is a rare malformation caused by synostosis of multiple cranial sutures. This anomaly has been reported to carry a dismal prognosis both in terms of neurological outcome as well as cosmetic appearance if treatment is delayed. Due to the paucity of data concerning th...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121296

    authors: Resnick DK,Pollack IF,Albright AL

    更新日期:1995-01-01 00:00:00

  • Primary diffuse chiasmatic germinomas: differentiation from optic chiasm gliomas.

    abstract::Primary germ cell tumors confined to the optic nerves and chiasm without suprasellar extension are uncommon. These tumors appear similar to chiasmatic gliomas on both computed tomography and magnetic resonance imaging, potentially resulting in treatment errors if the diagnosis is based on radiologic criteria alone. Un...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120927

    authors: Wilson JT,Wald SL,Aitken PA,Mastromateo J,Vieco PT

    更新日期:1995-01-01 00:00:00

  • Intracranial Salmonella infections: meningitis, subdural collections and brain abscess. A series of six surgically managed cases with follow-up results.

    abstract::Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000048342

    authors: Mahapatra AK,Pawar SJ,Sharma RR

    更新日期:2002-01-01 00:00:00

  • Endoscopic biopsy for tumors of the third ventricle.

    abstract::Twelve patients underwent endoscopic biopsy of a tumor involving the third ventricle. Nine patients had no significant medical history while 3 had a history of cancer. Unique characteristics of each case dictated the optimal surgical technique. Endoscopic tumor biopsy was combined with additional procedures in 9 cases...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028994

    authors: Souweidane MM,Sandberg DI,Bilsky MH,Gutin PH

    更新日期:2000-09-01 00:00:00

  • Spinal sagittal malalignment following surgery for primary intramedullary tumours in children.

    abstract:BACKGROUND/OBJECTIVE:As prior studies analysed predictive factors for various post-laminectomy spinal deformities in mixed spinal regions, age groups or pathologies, their validity and conclusions were unclear. The objective of this study was to determine predictive factors for worsened cervical or thoracic spinal sagi...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000050444

    authors: Yeh JS,Sgouros S,Walsh AR,Hockley AD

    更新日期:2001-12-01 00:00:00

  • Recurrence patterns and anaplastic change in a long-term study of pilocytic astrocytomas.

    abstract::Thirty-six cases of pilocytic astrocytomas treated at the Childrens Hospital of Los Angeles from 1984 through 1995 were reviewed. The mean age at initial presentation was 8 years (range 15 months to 14 years). These patients were followed for an average of 5.5 years. No patient was given chemotherapy or radiation ther...

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    pub_type: 杂志文章,评审

    doi:10.1159/000121218

    authors: Krieger MD,Gonzalez-Gomez I,Levy ML,McComb JG

    更新日期:1997-07-01 00:00:00

  • Meckel-Gruber Syndrome: A Case Who Lived for 5 Months.

    abstract::The Meckel-Gruber syndrome is a rare, congenital, and lethal malformation characterized by typical manifestations such as encephalocele, polycystic kidneys, and polydactyly. Herein, we present a case of a patient with the typical triad as well as facial, ocular, liver, and genital abnormalities who lived for almost 5 ...

    journal_title:Pediatric neurosurgery

    pub_type:

    doi:10.1159/000500766

    authors: Aydin Ozturk P,Asena M,Katar S,Ozturk U

    更新日期:2019-01-01 00:00:00

  • Arachnoid cyst rupture with concurrent subdural hygroma.

    abstract::Arachnoid cysts (ACs) are relatively common intracranial mass lesions, which occur most often in the middle cranial fossa. While these lesions can present as a mass lesion, many are asymptomatic. Rarely, posttraumatic or spontaneous rupture of ACs can result in intracystic hemorrhage, subdural hematoma or subdural hyg...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028918

    authors: Donaldson JW,Edwards-Brown M,Luerssen TG

    更新日期:2000-03-01 00:00:00

  • Update on Endoscopic Third Ventriculostomy in Children.

    abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000491638

    authors: Feng Z,Li Q,Gu J,Shen W

    更新日期:2018-01-01 00:00:00

  • Prognostic significance of molecular genetic markers in childhood brain tumors.

    abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000120605

    authors: Cogen PH

    更新日期:1991-01-01 00:00:00

  • Intracranial hypertension after cranial vault decompression for craniosynostosis.

    abstract::A 3-year-old boy with chronic papilledema, bilateral coronal synostosis and Pfeiffer syndrome underwent an orbitofrontal advancement. One month postoperatively, his papilledema had resolved, however, his vision progressively deteriorated over the ensuing 3 months to legal blindness. He had no symptoms or signs of incr...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120913

    authors: Campbell JW,Albright AL,Losken HW,Biglan AW

    更新日期:1995-01-01 00:00:00

  • Pediatric intracranial meningiomas--do they differ from their counterparts in adults?

    abstract:AIM:Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5-1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. METHODS:From 1990 to 2005, 33 patien...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000110661

    authors: Arivazhagan A,Devi BI,Kolluri SV,Abraham RG,Sampath S,Chandramouli BA

    更新日期:2008-01-01 00:00:00

  • Neuroophthalmological symptoms in children treated for internal hydrocephalus.

    abstract::The object of the study are 126 children with internal hydrocephalus treated within the period 1978-1990. The children were preoperatively divided into six groups according to the etiology of the hydrocephalus. Disorders of the visual functions accompanying elevated intracranial pressure (setting sun 51, syndrome of t...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120617

    authors: Tzekov C,Cherninkova S,Gudeva T

    更新日期:1991-01-01 00:00:00

  • A closer look at the ventriculo-gallbladder shunt for the treatment of hydrocephalus.

    abstract::Six patients with hydrocephalus who were treated with cerebrospinal fluid (CSF) shunts became refractory to serosal absorption of CSF. All were subsequently treated with ventriculo-gallbladder shunts. The surgical technique and long-term results were evaluated by retrospective review of the hospital records. Detailed ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121191

    authors: Novelli PM,Reigel DH

    更新日期:1997-04-01 00:00:00

  • Neurosurgical Management of Lateral Meningocele Syndrome: A Clinical Update for the Pediatric Neurosurgeon.

    abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000504060

    authors: Cuoco JA,Klein BJ,Busch CM,Gosnell HL,Kar A,Marvin EA,Apfel LS

    更新日期:2020-01-01 00:00:00