Abstract:
INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial irradiation (12.6 Gy/7 fractions/1.5 weeks) as a part of INCTR-02-04 protocol in a 3-year-old boy with B-cell ALL. He underwent gross total excision (GTE) of the tumour followed by post-operative intensity modulated RT (59.4 Gy/33 fractions/6.5 weeks) and concurrent and adjuvant (3 cycles) temozolomide. Thereafter, he had rapid disease progression, which entailed re-excision of the recurrent tumour. Subsequently, there was widespread subependymal and leptomeningeal spread of tumour, leading to death 10.5 months after the initial diagnosis. CONCLUSION:RIMG is an aggressive malignancy with a dismal prognosis, and in spite of multimodality management, it exhibits relentless progression, occasionally characterized by subependymal and leptomeningeal dissemination, leading to eventual death within a year of diagnosis.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Biswas A,Kashyap L,Bakhshi Sdoi
10.1159/000511996subject
Has Abstractpub_date
2020-01-01 00:00:00pages
409-417issue
6eissn
1016-2291issn
1423-0305pii
000511996journal_volume
55pub_type
abstract:BACKGROUND:An 11-month-old boy with autosomal recessive infantile osteopetrosis presented, 7 months after bone marrow transplantation, with normal ventricular size and life-threatening intracranial hypertension due to pansynostosis. METHODS:The cranial vault was expanded by using jackscrew distracters to upwardly adva...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098381
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:Modern neuroimaging and intensive care permit precise delineation and specific treatment of head injury. Children sustaining cranial trauma associated with epidural hematoma (EDH) represent a heterogeneous group with a variety of clinical outcomes. Treatment consists of simple observation or surgical evacuati...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121144
更新日期:1996-12-01 00:00:00
abstract::The epidemiology of pediatric brain tumor was studied in a 10-year period from 1986 to 1995 in Yamaguchi prefecture. The total number of pediatric brain tumors was 83, and the incidence was 2.5/100, 000/year, which did not change during the period. The sign most frequently seen was intracranial hypertension, whereas f...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028636
更新日期:1998-03-01 00:00:00
abstract::This report describes a neonatal case in whom a large interhemispheric cyst associated with agenesis of the corpus callosum was revealed by fetal ultrasonography and demonstrated by MRI to be multilobulated. Endoscopic fenestration of cysts was initially designed in view of the development of the patient's brain and s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028972
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:Cephalocele is a central nervous system (CNS) birth defect. Various CNS and extra-CNS anomalies, as well as prognostic factors have been reported with cephalocele. The aim of this study was to discuss prognostic factors and current possible theories explaining associated anomalies seen in a series of 55 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000277622
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The Delta valve is a pressure differential valve with a siphon control device. The valve mechanism is normally closed, but is designed to open in response to positive ventricular pressure, thereby avoiding overdrainage of cerebrospinal fluid (CSF). As a result, the incidence of subdural fluid collections as w...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028988
更新日期:2000-08-01 00:00:00
abstract::We present a case report of a 21-month-old female patient to highlight magnetic resonance (MR) imaging findings associated with papilledema in a pediatric patient with an intracranial tumor. The MR findings included optic disc elevation, dilated perioptic subarachnoid spaces, optic nerve tortuosity and restricted diff...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000270156
更新日期:2009-01-01 00:00:00
abstract::We evaluated the prevalence of pathological visually evoked potentials (VEP) before the appearance of papilledema or other signs of elevated intracranial pressure in children suffering from craniosynostosis. In 52 children (19 girls, 33 boys, median age 7.6 months, mean age 7.6 months, range from 3 to 34 months) preop...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028746
更新日期:1998-12-01 00:00:00
abstract::Epidermoid cysts (ECs) are rare developmental lesions occurring anywhere along the central nervous system. Usually affecting adult patients, the occurrence of supratentorial dorsal cistern ECs has been reported in only 1 certain case of pediatric age. An additional pediatric case is presented. An 11-year-old boy had a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028722
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the head injury in children caused by an unusual projectile, a tear gas cartridge. The study is the only one on this subject which has been done in a teenage population. METHOD:This was a prospective study conducted over a period of 4 years in which all the patients aged ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000314054
更新日期:2010-01-01 00:00:00
abstract::Cavernous malformations (CMs) of the central nervous system are benign, angiographically occult vascular lesions and are diagnosed by magnetic resonance imaging techniques. Giant CMs do not differ from smaller-sized CMs in their clinical, surgical or histopathological presentation but may be radiologically different. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000447407
更新日期:2017-01-01 00:00:00
abstract::Optimal treatment for hydrocephalus related to Dandy-Walker syndrome (DWS) remains elusive. Patients with DWS-related hydrocephalus often require combinations of shunting systems to effectively drain both the supratentorial ventricles and posterior fossa cyst. We describe an endoscopic technique, whereby a frontally p...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000087486
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000335400
更新日期:2011-01-01 00:00:00
abstract::Craniopharyngiomas can be divided into sellar, prechiasmatic, retrochiasmatic and giant tumors. The initial approach to a craniopharyngioma should be an attempt at its removal. Only if surgical therapy fails to deal with the tumor should more conservative approaches utilizing radiotherapy be used. The use of intracyst...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120861
更新日期:1994-01-01 00:00:00
abstract::A retrospective study of fractures of peritoneal catheters of ventriculoperitoneal shunts is described. Fracture of the peritoneal catheter accounts for 21.2% of shunt revisions. During the time period of January 1985 through July 1993, 401 PS Medical peritoneal catheters were installed and 23 fractures occurred. The ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120884
更新日期:1995-01-01 00:00:00
abstract::The cloverleaf skull deformity, or Kleeblattschädel, is a rare malformation caused by synostosis of multiple cranial sutures. This anomaly has been reported to carry a dismal prognosis both in terms of neurological outcome as well as cosmetic appearance if treatment is delayed. Due to the paucity of data concerning th...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121296
更新日期:1995-01-01 00:00:00
abstract::Primary germ cell tumors confined to the optic nerves and chiasm without suprasellar extension are uncommon. These tumors appear similar to chiasmatic gliomas on both computed tomography and magnetic resonance imaging, potentially resulting in treatment errors if the diagnosis is based on radiologic criteria alone. Un...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120927
更新日期:1995-01-01 00:00:00
abstract::Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000048342
更新日期:2002-01-01 00:00:00
abstract::Twelve patients underwent endoscopic biopsy of a tumor involving the third ventricle. Nine patients had no significant medical history while 3 had a history of cancer. Unique characteristics of each case dictated the optimal surgical technique. Endoscopic tumor biopsy was combined with additional procedures in 9 cases...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028994
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:As prior studies analysed predictive factors for various post-laminectomy spinal deformities in mixed spinal regions, age groups or pathologies, their validity and conclusions were unclear. The objective of this study was to determine predictive factors for worsened cervical or thoracic spinal sagi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050444
更新日期:2001-12-01 00:00:00
abstract::Thirty-six cases of pilocytic astrocytomas treated at the Childrens Hospital of Los Angeles from 1984 through 1995 were reviewed. The mean age at initial presentation was 8 years (range 15 months to 14 years). These patients were followed for an average of 5.5 years. No patient was given chemotherapy or radiation ther...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000121218
更新日期:1997-07-01 00:00:00
abstract::The Meckel-Gruber syndrome is a rare, congenital, and lethal malformation characterized by typical manifestations such as encephalocele, polycystic kidneys, and polydactyly. Herein, we present a case of a patient with the typical triad as well as facial, ocular, liver, and genital abnormalities who lived for almost 5 ...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000500766
更新日期:2019-01-01 00:00:00
abstract::Arachnoid cysts (ACs) are relatively common intracranial mass lesions, which occur most often in the middle cranial fossa. While these lesions can present as a mass lesion, many are asymptomatic. Rarely, posttraumatic or spontaneous rupture of ACs can result in intracystic hemorrhage, subdural hematoma or subdural hyg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028918
更新日期:2000-03-01 00:00:00
abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000491638
更新日期:2018-01-01 00:00:00
abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120605
更新日期:1991-01-01 00:00:00
abstract::A 3-year-old boy with chronic papilledema, bilateral coronal synostosis and Pfeiffer syndrome underwent an orbitofrontal advancement. One month postoperatively, his papilledema had resolved, however, his vision progressively deteriorated over the ensuing 3 months to legal blindness. He had no symptoms or signs of incr...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120913
更新日期:1995-01-01 00:00:00
abstract:AIM:Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5-1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. METHODS:From 1990 to 2005, 33 patien...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000110661
更新日期:2008-01-01 00:00:00
abstract::The object of the study are 126 children with internal hydrocephalus treated within the period 1978-1990. The children were preoperatively divided into six groups according to the etiology of the hydrocephalus. Disorders of the visual functions accompanying elevated intracranial pressure (setting sun 51, syndrome of t...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120617
更新日期:1991-01-01 00:00:00
abstract::Six patients with hydrocephalus who were treated with cerebrospinal fluid (CSF) shunts became refractory to serosal absorption of CSF. All were subsequently treated with ventriculo-gallbladder shunts. The surgical technique and long-term results were evaluated by retrospective review of the hospital records. Detailed ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121191
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000504060
更新日期:2020-01-01 00:00:00