Prognostic significance of molecular genetic markers in childhood brain tumors.

Abstract:

:Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology of neoplasms of the adult colon, breast, lung, and brain. For several of these tumors, identifiable mutations of these genes in association with multiple chromosomal losses have been linked to a poor clinical outcome. Using RFLP and other techniques, we have determined that one or more tumor suppressor genes on chromosome 17p is involved in the etiology of both medulloblastoma and astrocytoma in children. Loss of chromosome 17p sequences is indicative of prognosis negative for these children. Molecular genetic data therefore supplement and in some cases surpass clinical criteria in predicting prognosis for these childhood tumors.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Cogen PH

doi

10.1159/000120605

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

245-50

issue

5

eissn

1016-2291

issn

1423-0305

journal_volume

17

pub_type

杂志文章,评审
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  • Pediatric intracranial meningiomas--do they differ from their counterparts in adults?

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  • Radiation-Associated Glioblastoma after Prophylactic Cranial Irradiation in a Patient of ALL: Review of Literature and Report of a Rare Case.

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    abstract::Intracranial capillary hemangiomas are very rare, though several spinal capillary hemangiomas have recently been reported. We report here a case of intracranial capillary hemangioma with multiple cysts and review the current literature of similar cases. A 4-month-old girl was referred to our hospital for treatment of ...

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    更新日期:2008-01-01 00:00:00

  • An unusual variant of a growing skull fracture in an adolescent.

    abstract::A great majority of growing skull fractures occur in infancy and earlychildhood. Since the growth of brain is necessary as a driving force for these lesions to occur, almost all reported cases have been before the first 3 years of life. Although a number of uncommon locations, such as basiooccipital and skull base are...

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    abstract::A 1-month-old boy was evaluated after a fall from a height of 3 feet and found to have right parietal skull fracture as well as right and left frontal traumatic hemorrhage. Ten days after the injury, he represented with a persistent left gaze preference. Further workup including MRI and EEG determined that this findin...

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  • Severely symptomatic craniovertebral junction abnormalities in children: long-term reliability of aggressive management.

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    更新日期:1995-01-01 00:00:00

  • Extradural hematomas in children.

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    更新日期:1994-01-01 00:00:00

  • Pontine extraventricular neurocytoma in a child.

    abstract::Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. Pontine neurocytomas represent an extremely rare subset of extraventricular neurocytomas, and reports are limited to 2 adults followed under 28 months. The authors present the case of a ...

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  • Acute and subacute hydrocephalus in a rat neonatal model: correlation with functional injury of neurotransmitter systems.

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  • Experimental split cord malformations.

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  • An approach to radical excision of craniopharyngioma by the temporal route.

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  • Expansion cranioplasty with jackscrew distracters for craniosynostosis and intracranial hypertension in transplanted osteopetrosis.

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  • Skull repair in children.

    abstract::Skull defects in children may be congenital or acquired after trauma, infection or tumor. For defects that do not close spontaneously a variety of repair (cranioplasty) materials are available including bone, metals and acrylic. Where possible calvarial autogenous bone is preferred, particularly in younger infants, bu...

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  • Pediatric Hangman's Fracture: A Comprehensive Review.

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  • Significance of FDG-PET Hypermetabolism in Children with Intractable Focal Epilepsy.

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  • Pediatric hemifacial spasm: the efficacy of microvascular decompression.

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