Acute and subacute hydrocephalus in a rat neonatal model: correlation with functional injury of neurotransmitter systems.

Abstract:

OBJECT:The evolution and severity of hydrocephalus in animal models varies in the species and mode of induction. This makes comparisons of the physiological system under investigation difficult between models. We noted that injection of kaolin into neonatal rats results in a dichotomous outcome into either an acute or subacute form. We investigated the clinical and functional transmitter system changes to compare these two types of hydrocephalus evolution. METHODS:Hydrocephalus was induced in Wistar neonatal rats (within a week after their birth) by intracisternal injection of 0.02 ml volume of 25% kaolin solution under microscopic guidance. The same volume of sterile saline was injected into 12 neonatal rats as control group. The animals were assigned to either the acute or subacute group according to their head size, and sacrificed at 2, 4 and 8 weeks after injection. Biparietal diameter, ventricular size, cholinergic interneurons in the neostriatum and dopaminergic projection neurons in the substantia nigra were analyzed at each stage. RESULTS:Animals affected with the acute type of hydrocephalus had obvious head enlargement, rapid ventricular enlargement, and all died at about 4 weeks. Animals with subacute type had slowly progressive ventricular enlargement, and all survived until 8 weeks. There appeared to be more kaolin ventral to the brainstem in the acute type. The number of cholinergic neostriatal neurons was significantly reduced at 2 and 4 weeks in the acute type, but only at 8 weeks in the subacute type. The number of dopaminergic nigral neurons was decreased at 4 weeks in the acute type, but unaffected in the subacute type. CONCLUSIONS:The severity of onset of hydrocephalus in this animal model also correlates with the clinical outcome and changes in functional transmitter systems.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Ishizaki R,Tashiro Y,Inomoto T,Hashimoto N

doi

10.1159/000055975

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

298-305

issue

6

eissn

1016-2291

issn

1423-0305

pii

55975

journal_volume

33

pub_type

杂志文章
  • Peculiarities and Patterns of Cervical Spine Injuries in Children and Adolescents: A Retrospective Series of 84 Patients from a Single Institute.

    abstract::Cervical spine injuries occur infrequently in children but are associated with significant disability and mortality. A retrospective analysis was performed of 84 consecutive pediatric spine injuries treated at our institute from January 2002 to December 2011. The mean age was 14.7 years. There were 18 patients (21%) i...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000439540

    authors: Babu RA,Arivazhagan A,Devi BI,Bhat DI,Sampath S,Chandramouli BA

    更新日期:2016-01-01 00:00:00

  • Gorham-Stout disease and cerebrospinal fluid otorrhea.

    abstract:OBJECTIVE AND IMPORTANCE:Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. CLINICAL PRESENTATION:We present the case o...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000336877

    authors: Hernández-Marqués C,Serrano González A,Cordobés Ortega F,Alvarez-Coca J,Sirvent Cerda S,Carceller Lechón F,Azorín Cuadrillero D

    更新日期:2011-01-01 00:00:00

  • Midline suboccipital osteoplastic craniotomy - 'cobra craniotomy'.

    abstract:BACKGROUND:Midline suboccipital craniotomy has been proposed as an alternative to conventional craniectomy for removal of posterior fossa tumors. METHOD:We describe a modified technique for midline suboccipital osteoplastic craniotomy based on the atlantooccipital membrane for a 17-year-old boy with superior vermian a...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000354220

    authors: Maiti T,Bhat DI,Devi BI,Shukla D

    更新日期:2012-01-01 00:00:00

  • Infantile traumatic subdural hematomas: outcome after five years.

    abstract:OBJECTIVE:Although subdural hematomas (SDH) are common in infants, their long-term outcome is poorly documented in the literature. METHODS:Infants operated for SDH were followed prospectively and evaluated during their sixth year with systematic neurological evaluation and standard neuropsychological testing. RESULTS...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000071648

    authors: Vinchon M,Defoort-Dhellemmes S,Nzeyimana C,Vallée L,Dhellemmes P

    更新日期:2003-09-01 00:00:00

  • Atlanto-axial instability in achondroplastic dwarfs: a report of two cases and literature review.

    abstract:BACKGROUND:Achondroplasia is the commonest form of human dwarfism. The authors report atlanto-axial instability, in consequence to os odontoideum in this subgroup of patients. METHODS:Two achondroplastic dwarfs harboring atlanto-axial dislocation are described along with radiological findings. RESULTS:Both children u...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000335433

    authors: Mohindra S,Tripathi M,Arora S

    更新日期:2011-01-01 00:00:00

  • Use of bipedicular advancement flaps for intrauterine closure of myeloschisis.

    abstract::Several groups have begun to explore the feasibility and utility of intrauterine closure of myelomeningocele. A subset of these fetuses have defects which fall into the category of myeloschisis, and therefore have inadequate skin to enable primary closure. After considerable discussion, it was decided to utilize biped...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028898

    authors: Mangels KJ,Tulipan N,Bruner JP,Nickolaus D

    更新日期:2000-01-01 00:00:00

  • Moyamoya disease in children with congenital dwarfing conditions.

    abstract::Congenital dwarfisms can be associated with a variety of vascular anomalies. Here, we describe 2 patients with congenital dwarfisms who presented with moyamoya syndrome and underwent indirect intracranial revascularization. The pathogenesis of moyamoya syndrome in this population is not well understood, but it is a ma...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000322017

    authors: Moftakhar P,Smith ER,Choulakian A,Scott RM,Danielpour M

    更新日期:2010-01-01 00:00:00

  • Novalis radiosurgery of optic gliomas in children: preliminary report.

    abstract:AIM:To evaluate the effectiveness of Novalis radiosurgery (RS) in children with optic gliomas. METHODS:Four pediatric patients (1 male and 3 female) were treated for optic gliomas with Novalis RS in our institution between February 2002 and July 2002. Their mean age was 12 (range 5-16) years at presentation for Novali...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000103305

    authors: Han SR,Yoon SW,Yee GT,Choi CY,Sohn MJ,Lee DJ,Whang CJ

    更新日期:2007-01-01 00:00:00

  • Prognostic significance of molecular genetic markers in childhood brain tumors.

    abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000120605

    authors: Cogen PH

    更新日期:1991-01-01 00:00:00

  • Occipitocervical Fetus in Fetu with Extracalvarial Extension: A Case Report.

    abstract::Fetus in fetu (FIF) is an extremely rare congenital anomaly in the pediatric age group. It is defined by the presence of an axial skeleton and well-formed internal organs in a fetiform mass. Only about 15 cases of intracranial FIF have been reported in the literature worldwide. We report a case of temporo-occipitocerv...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000441035

    authors: Padwal AD,Devi BI,Ramachandran S,Bhat DI,Shukla D,Ramu R

    更新日期:2016-01-01 00:00:00

  • Multiple intracranial aneurysms with intraventricular hemorrhage in a child with unilateral fibromuscular dysplasia of the renal artery.

    abstract::A rare case involving multiple intracranial aneurysms with intraventricular hemorrhage (IVH) in a child, accompanied by unilateral fibromuscular dysplasia (FMD) of the renal artery, is reported. A 12-year-old girl presented with secondary hypertension and fourth-ventricle IVH. Cerebral angiography showed multiple aneu...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000180304

    authors: Park DH,Kang SH,Lim DJ,Kwon TH,Park JY,Chung YG,Lee HK

    更新日期:2008-01-01 00:00:00

  • Current patterns of inflicted head injury in children.

    abstract::The purpose of this study was to examine the current patterns of head trauma associated with child abuse. We reviewed the records of all patients admitted to our medical center between 1995 and 1997 with a primary diagnosis of head trauma, and analyzed the clinical presentation, mechanism of injury, socioeconomic stat...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028880

    authors: Dashti SR,Decker DD,Razzaq A,Cohen AR

    更新日期:1999-12-01 00:00:00

  • Pathophysiology of isolated lateral ventriculomegaly in shunted myelodysplastic children.

    abstract::Eight myelodysplastic children developed isolated lateral ventriculomegaly following shunt insertion for progressive hydrocephalus after closure of a myelomeningocele. In all patients a low-pressure distal slit valve (Uni-shunt) system preceded development of an isolated contralateral ventricle. Six of 8 children requ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120547

    authors: Berger MS,Sundsten J,Lemire RJ,Silbergeld D,Newell D,Shurtleff D

    更新日期:1990-01-01 00:00:00

  • Can the requirement of a diversion procedure be predicted after an uncomplicated intracranial hydatid cyst surgery?

    abstract::Intracranial hydatidosis is mainly a pediatric disease. Surgical evacuation of the mass in toto is the gold standard of therapy. No concise data related to the requirement of diversion procedures after uncomplicated hydatid cyst removal is encountered in the literature. The aim of this report is to focus on this idea ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000095570

    authors: Onal C,Erguvan-Onal R,Yakinci C,Karayol A,Atambay M,Daldal N

    更新日期:2006-01-01 00:00:00

  • Extradural hematomas in children.

    abstract::The authors studied 58 patients, under 12 years of age, admitted to the Emergency Room of the Sao Paulo University Hospital between September 1987 and November 1991 with the diagnosis of traumatic extradural hematoma. Emphasis was given to the etiology of injury, the time interval from head injury to emergency room ev...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120814

    authors: dos Santos AL,Plese JP,Ciquini Júnior O,Shu EB,Manreza LA,Marino Júnior R

    更新日期:1994-01-01 00:00:00

  • Brainstem gliomas in children. A Children's Cancer Group review of 119 cases.

    abstract::Brainstem gliomas (BSG) with intrinsic and extensive brainstem involvement continue to have a poor outlook despite current treatment approaches. Neuroimaging studies have aided in the differentiation of malignant brainstem tumors from more 'benign' subgroups. A Children's Cancer Group protocol evaluating outcome in ch...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121036

    authors: Kaplan AM,Albright AL,Zimmerman RA,Rorke LB,Li H,Boyett JM,Finlay JL,Wara WM,Packer RJ

    更新日期:1996-01-01 00:00:00

  • Hydrocephalus as the initial presentation of a spinal cord astrocytoma associated with leptomeningeal spread.

    abstract::A 3-year-old boy presented with headaches, vomiting, lethargy and papilledema. Communicating hydrocephalus along with transependymal fluid absorption and meningeal contrast enhancement was identified on CT. The enhancement was initially thought to be the result of a partially treated meningitis (child was previously o...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000084862

    authors: Vassilyadi M,Michaud J

    更新日期:2005-01-01 00:00:00

  • Electroencephalography features of primary epileptogenic regions in surgically treated MRI-negative infantile spasms.

    abstract:OBJECTIVE:To evaluate the surgical outcome for intractable, MRI-negative infantile spasms (IS), and to identify diagnostic targets in the focal epileptogenic area by methods other than MRI. METHODS:We retrospectively studied 9 patients who had had surgery for intractable IS, and whose lesions did not appear on MRI. We...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000321925

    authors: Hur YJ,Lee JS,Kim DS,Hwang T,Kim HD

    更新日期:2010-01-01 00:00:00

  • Atlantoaxial Rotatory Subluxation after Removal of a Ventriculoperitoneal Shunt in the Supine-Lateral Position.

    abstract::Atlantoaxial rotatory subluxation (AARS) is an uncommon disease with a greater prevalence in children than adults. So far there has only been one report of AARS after surgery related to ventriculoperitoneal (VP) shunting. We present a new case of AARS closed reduction treatment after VP shunt removal in an 8-year-old ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000433601

    authors: Hashide S,Aihara Y,Nagahara A,Mitsuyama T,Okada Y

    更新日期:2015-01-01 00:00:00

  • Skull repair in children.

    abstract::Skull defects in children may be congenital or acquired after trauma, infection or tumor. For defects that do not close spontaneously a variety of repair (cranioplasty) materials are available including bone, metals and acrylic. Where possible calvarial autogenous bone is preferred, particularly in younger infants, bu...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000120540

    authors: Hockley AD,Goldin JH,Wake MJ,Iqbal J

    更新日期:1990-01-01 00:00:00

  • Traumatic Pediatric Posterior Fossa Extradural Hematomas: A Tertiary-Care Trauma Center Experience from India.

    abstract:INTRODUCTION:Traumatic posterior fossa extradural hematomas (PFEDH) are rare lesions constituting <10% of all extradural hematomas. Reliance on clinical findings alone is not recommended as these are nonspecific; for all suspicious cases, it is advisable to conduct a CT scan. Only a handful of pediatric studies have be...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000438488

    authors: Prasad GL,Gupta DK,Sharma BS,Mahapatra AK

    更新日期:2015-01-01 00:00:00

  • Endoscopic biopsy for tumors of the third ventricle.

    abstract::Twelve patients underwent endoscopic biopsy of a tumor involving the third ventricle. Nine patients had no significant medical history while 3 had a history of cancer. Unique characteristics of each case dictated the optimal surgical technique. Endoscopic tumor biopsy was combined with additional procedures in 9 cases...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028994

    authors: Souweidane MM,Sandberg DI,Bilsky MH,Gutin PH

    更新日期:2000-09-01 00:00:00

  • Inflicted traumatic brain injury: relationship of developmental outcome to severity of injury.

    abstract::Inflicted traumatic brain injury (TBI) is a frequent consequence of physical child abuse in infants and children. Twenty-eight children who were 2-42 months of age when hospitalized for moderate to severe TBI were enrolled in a prospective, longitudinal study of neurobehavioral outcome following acquired brain injury....

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028872

    authors: Ewing-Cobbs L,Prasad M,Kramer L,Landry S

    更新日期:1999-11-01 00:00:00

  • Primary Spinal Intradural Extraosseous Ewing Sarcoma in a Pediatric Patient: Case Report and Review of the Literature.

    abstract::Ewing sarcoma (ES) is an aggressive, primary bone malignancy with occasional soft tissue extension. Purely extra-osseous ES is rare. A primary intraspinal, intradural ES without bone involvement is exceedingly rare. ES may be differentiated from other primitive neuroectodermal tumors by molecular analysis. The authors...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1159/000488767

    authors: Scantland JT,Gondim MJ,Koivuniemi AS,Fulkerson DH,Shih CS

    更新日期:2018-01-01 00:00:00

  • Neuroendoscopic third ventriculostomy in patients less than 1 year old.

    abstract::A series of neuroendoscopic third ventriculostomies in children less than 1 year old is reported. Twenty-seven patients underwent the procedure with 21 (77%) failing within a mean of 1.36 months of the procedure. Nineteen were subsequently shunted. The presence or absence of flow through the ventriculostomy and the si...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000028693

    authors: Buxton N,Macarthur D,Mallucci C,Punt J,Vloeberghs M

    更新日期:1998-08-01 00:00:00

  • Epidural hematoma as a complication of endoscopic biopsy and shunt placement in a patient harboring a third ventricle tumor.

    abstract::Although some complications have been reported when using endoscopic techniques, epidural hematoma (EDH) has rarely been caused. The authors report a case of EDH complicating a concomitant endoscopic biopsy procedure with ventricular shunt placement in a young, 14-year-old boy harboring a third ventricle tumor with a ...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000082301

    authors: Hamlat A,Heckly A,Doumbouya N,Seigneuret E,Brassier G

    更新日期:2004-09-01 00:00:00

  • Pumping the shunt revisited. A longitudinal study.

    abstract::Most cerebrospinal fluid (CSF) shunts employed in the treatment of hydrocephalus include in their designs a pump mechanism that has been used in office practice as an indicator of whether the shunt is functioning properly; however, the pumping characteristics of shunts have been shown to correlate poorly with clinical...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000121100

    authors: Piatt JH Jr

    更新日期:1996-08-01 00:00:00

  • Pediatric intracranial meningiomas--do they differ from their counterparts in adults?

    abstract:AIM:Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5-1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. METHODS:From 1990 to 2005, 33 patien...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000110661

    authors: Arivazhagan A,Devi BI,Kolluri SV,Abraham RG,Sampath S,Chandramouli BA

    更新日期:2008-01-01 00:00:00

  • Effect of Posterior Fossa Decompression for Chiari Malformation-I on Scoliosis.

    abstract:BACKGROUND/AIMS:Scoliosis is common in patients with Chiari malformation-I (CM-I). This study examined the change in scoliosis severity after posterior fossa decompression (PFD) for CM-I. METHODS:We conducted a retrospective review at a single tertiary center for children undergoing PFD with untreated scoliosis, and i...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000485254

    authors: Chotai S,Basem J,Gannon S,Dewan M,Shannon CN,Wellons JC,Bonfield CM

    更新日期:2018-01-01 00:00:00

  • Melatonin Attenuates Histopathological Changes in the Hippocampus of Infantile Rats with Kaolin-Induced Hydrocephalus.

    abstract:OBJECTIVE/AIM:Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated. In the present experiment, we attempted to investigate the effects of exogenous melatonin adminis...

    journal_title:Pediatric neurosurgery

    pub_type: 杂志文章

    doi:10.1159/000488497

    authors: Turgut M,Baka M,Uyanıkgil Y

    更新日期:2018-01-01 00:00:00