Abstract:
OBJECT:The evolution and severity of hydrocephalus in animal models varies in the species and mode of induction. This makes comparisons of the physiological system under investigation difficult between models. We noted that injection of kaolin into neonatal rats results in a dichotomous outcome into either an acute or subacute form. We investigated the clinical and functional transmitter system changes to compare these two types of hydrocephalus evolution. METHODS:Hydrocephalus was induced in Wistar neonatal rats (within a week after their birth) by intracisternal injection of 0.02 ml volume of 25% kaolin solution under microscopic guidance. The same volume of sterile saline was injected into 12 neonatal rats as control group. The animals were assigned to either the acute or subacute group according to their head size, and sacrificed at 2, 4 and 8 weeks after injection. Biparietal diameter, ventricular size, cholinergic interneurons in the neostriatum and dopaminergic projection neurons in the substantia nigra were analyzed at each stage. RESULTS:Animals affected with the acute type of hydrocephalus had obvious head enlargement, rapid ventricular enlargement, and all died at about 4 weeks. Animals with subacute type had slowly progressive ventricular enlargement, and all survived until 8 weeks. There appeared to be more kaolin ventral to the brainstem in the acute type. The number of cholinergic neostriatal neurons was significantly reduced at 2 and 4 weeks in the acute type, but only at 8 weeks in the subacute type. The number of dopaminergic nigral neurons was decreased at 4 weeks in the acute type, but unaffected in the subacute type. CONCLUSIONS:The severity of onset of hydrocephalus in this animal model also correlates with the clinical outcome and changes in functional transmitter systems.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Ishizaki R,Tashiro Y,Inomoto T,Hashimoto Ndoi
10.1159/000055975keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
298-305issue
6eissn
1016-2291issn
1423-0305pii
55975journal_volume
33pub_type
杂志文章abstract::Cervical spine injuries occur infrequently in children but are associated with significant disability and mortality. A retrospective analysis was performed of 84 consecutive pediatric spine injuries treated at our institute from January 2002 to December 2011. The mean age was 14.7 years. There were 18 patients (21%) i...
journal_title:Pediatric neurosurgery
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doi:10.1159/000071648
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
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doi:10.1159/000103305
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
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doi:10.1159/000028880
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000095570
更新日期:2006-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121036
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000084862
更新日期:2005-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000321925
更新日期:2010-01-01 00:00:00
abstract::Atlantoaxial rotatory subluxation (AARS) is an uncommon disease with a greater prevalence in children than adults. So far there has only been one report of AARS after surgery related to ventriculoperitoneal (VP) shunting. We present a new case of AARS closed reduction treatment after VP shunt removal in an 8-year-old ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000433601
更新日期:2015-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000488767
更新日期:2018-01-01 00:00:00
abstract::A series of neuroendoscopic third ventriculostomies in children less than 1 year old is reported. Twenty-seven patients underwent the procedure with 21 (77%) failing within a mean of 1.36 months of the procedure. Nineteen were subsequently shunted. The presence or absence of flow through the ventriculostomy and the si...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028693
更新日期:1998-08-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000082301
更新日期:2004-09-01 00:00:00
abstract::Most cerebrospinal fluid (CSF) shunts employed in the treatment of hydrocephalus include in their designs a pump mechanism that has been used in office practice as an indicator of whether the shunt is functioning properly; however, the pumping characteristics of shunts have been shown to correlate poorly with clinical...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121100
更新日期:1996-08-01 00:00:00
abstract:AIM:Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5-1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. METHODS:From 1990 to 2005, 33 patien...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000110661
更新日期:2008-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000485254
更新日期:2018-01-01 00:00:00
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journal_title:Pediatric neurosurgery
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doi:10.1159/000488497
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