Abstract:
OBJECTIVE:To evaluate the surgical outcome for intractable, MRI-negative infantile spasms (IS), and to identify diagnostic targets in the focal epileptogenic area by methods other than MRI. METHODS:We retrospectively studied 9 patients who had had surgery for intractable IS, and whose lesions did not appear on MRI. We analyzed video/electroencephalography (EEG), single photon emission computed tomography (SPECT) and positron emission tomography (PET) findings and their surgical outcomes. In 7 patients who were seizure free after surgery, we analyzed the EEG parameters for characteristics expected in the primary epileptogenic region. RESULTS:All patients underwent resective surgery including frontal lobectomy and multilobar resection. Seven patients showed an Engel class I outcome, and 2 patients showed a class III outcome. Interictal SPECT results showed 66.7% concordance for the hemisphere affected (lateralization), and 55.6% for lesion location (localization). Ictal SPECT showed 71.4% concordance for lateralization and localization. PET showed 66.7% concordance for lateralization, and 55.6% for localization. EEG parameters, including localized paroxysmal fast activities, spindle-shaped fast activities, repetitive or rhythmic sharp/spike wave discharges, and subclinical seizures showed highly localized specificity, and may serve to identify the epileptogenic lesion. CONCLUSION:Surgical treatment of MRI-negative IS should be justified using a combination of diagnostic methods.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Hur YJ,Lee JS,Kim DS,Hwang T,Kim HDdoi
10.1159/000321925subject
Has Abstractpub_date
2010-01-01 00:00:00pages
182-7issue
3eissn
1016-2291issn
1423-0305pii
000321925journal_volume
46pub_type
杂志文章abstract::Attempts at radical excision of craniopharyngioma has been made increasingly possible by the advent of neuroradiological imaging and the use of microscopic technique. Between 1977 and 1993, 62 patients of The National Hospital for Neurology and Neurosurgery, London, have undergone surgical excision of craniopharyngiom...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120864
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Arachnoid cysts are intra-arachnoidal cerebrospinal fluid collections most frequently seen in the middle cranial fossa. The optimal method of treatment for symptomatic arachnoid cysts remains controversial and includes cyst shunting, open craniotomy and endoscopic fenestration. All these techniques, however,...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098833
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Traumatic posterior fossa extradural hematomas (PFEDH) are rare lesions constituting <10% of all extradural hematomas. Reliance on clinical findings alone is not recommended as these are nonspecific; for all suspicious cases, it is advisable to conduct a CT scan. Only a handful of pediatric studies have be...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000438488
更新日期:2015-01-01 00:00:00
abstract::Although the transsphenoidal approach offers a narrow operative field and poor visual control through a small sellar opening, this approach has the advantage of being associated with minimal surgical trauma, especially in children. We share our experience of good surgical outcome achieved by the transsphenoidal approa...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000071321
更新日期:2003-07-01 00:00:00
abstract::We report two children with hemihypertrophy and Chiari I malformation (CIM) and review the extant medical literature regarding CIM and overgrowth disorders. We propose that these two entities do not represent a spurious association but rather share a common dysembryology of mesoderm. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000069820
更新日期:2003-05-01 00:00:00
abstract::Spinal dysraphism is characterized by a lack of fusion of the vertebral arches that occurs in the absence of spinous processes with variable amounts of lamina. Here, we retrospectively present the importance of cutaneous lesions and their correlation with clinical presentation, radiological examination and urodynamic ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000149901
更新日期:2008-01-01 00:00:00
abstract::A three-year old girl who initially presented at 16 months with epistaxis from an anterior skull base vascular anomaly returned with near-fatal epistaxis despite embolization of the internal maxillary artery at the time of initial presentation. Repeat angiography demonstrated blood supply to the vascular lesion coming...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050432
更新日期:2001-11-01 00:00:00
abstract::Craniopharyngiomas are the most common pediatric suprasellar tumor. While they are benign by histology, their location in the brain predisposes craniopharyngiomas to be associated with both acute and chronic neurologic, endocrine, visual, neuropsychologic and psychosocial problems. Because of the complexity of problem...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120872
更新日期:1994-01-01 00:00:00
abstract::We discuss the surgical approach used for and outcome in 11 infants (< or =3 years) who were treated at our institution for ependymomas arising in the cerebellar-pontine (C-P) angle. The median age of the group was 19 months (range: 6-26 months). Of these 11 patients, the initial surgery for 8 was performed at our cen...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121232
更新日期:1997-08-01 00:00:00
abstract:AIM:Meningiomas are very rare in children comprising only 0.44.1% of pediatric age tumors and only 1.5-1.8% of all intracranial neoplasms. We analyzed the clinical, pathological and management profile of these rare tumors and elucidated their differences from meningiomas in adults. METHODS:From 1990 to 2005, 33 patien...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000110661
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000487088
更新日期:2018-01-01 00:00:00
abstract::Tumors located in the region of the foramen of Monro often present with signs and symptoms of obstructive hydrocephalus. Various types of lesions occur in this location. We describe a case of a dysembryoplastic neuroepithelial tumor of the septum pellucidum presenting with obstructive hydrocephalus and its successful ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000090464
更新日期:2006-01-01 00:00:00
abstract::A 16-year-old male presented with obstructive hydrocephalus secondary to pineal germinoma. There have been many reported cases of abdominal metastasis of pineal germinoma after ventriculoperitoneal shunting. Endoscopic ventriculostomy was preferred in our case, thus avoiding iatrogenic peritoneal seeding, but spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000089508
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial ir...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000511996
更新日期:2020-01-01 00:00:00
abstract::Spinal cord injuries are a well-known cause of neurological bladder and a well-known complication of high-velocity trauma. They can, however, be difficult to diagnose in young children, in whom the absence of initial neurological symptoms and normality of the radiological workup can be falsely reassuring. Management o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000360402
更新日期:2013-01-01 00:00:00
abstract::Pineal region lesions consist of a wide variety of rare tumor types, including deep midline cysts, intrinsic pineal tumors, germ cell tumors and vascular lesions. Advances in microsurgical, endoscopic and stereotactic techniques have helped to lower morbidity and mortality in the care of patients harboring these lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000070415
更新日期:2003-06-01 00:00:00
abstract::The epidemiology of cerebrospinal fluid (CSF) shunting in the United States is not well known; however, with recent national surveys, the prevalence, incidence, and cost of these procedures can be estimated. The prevalence of CSF shunts in the United States appears to be greater than 125,000, though this is likely an ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120968
更新日期:1995-01-01 00:00:00
abstract::Although extra-axial hematomas are a well-known complication of ventricular shunting, epidural hematomas are uncommon in this setting. We report an unusual case of multiple epidural hematomas in a patient with hydrocephalus treated by ventriculoperitoneal shunt. The patient became symptomatic 5 days after shunting and...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120704
更新日期:1993-03-01 00:00:00
abstract::Complications of chemotherapy in pediatric brain tumor patients tend to be acute and short-lived with some special exceptions such as permanent hearing impairment secondary to cisplatin, infertility and an increased risk of second primary neoplasms. Chemotherapy will be better tolerated and probably more effective in ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120601
更新日期:1991-01-01 00:00:00
abstract::A case is presented illustrating the usefulness of computerized tomography (CT) with 3-dimensional (3-D) reconstruction for evaluation of a subdental synchondrosis fracture in a child. Odontoid fractures in children less than 7 years of age occur at the subdental synchondrosis and are typically diagnosed with plain x-...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121135
更新日期:1996-11-01 00:00:00
abstract::Intracranial and intraspinal ependymomas are uncommon tumors of the central nervous system. These tumors have a variety of imaging characteristics, some of which are fairly specific for ependymoma. We discuss the MRI features of ependymomas for each of the typical locations within the neuraxis, and provide MR imaging ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028630
更新日期:1998-02-01 00:00:00
abstract::Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000048342
更新日期:2002-01-01 00:00:00
abstract::Associated cranial abnormalities with spinal dysraphism are not uncommon. We came across an unusual case of a 1-year-old male child with spinal dysraphism having lumbar meningomyelocele, who also had split cord malformation (hemicord with intervening bony spur) with lipoma of one of the hemicord and filum terminale. T...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000091862
更新日期:2006-01-01 00:00:00
abstract::Primary germ cell tumors confined to the optic nerves and chiasm without suprasellar extension are uncommon. These tumors appear similar to chiasmatic gliomas on both computed tomography and magnetic resonance imaging, potentially resulting in treatment errors if the diagnosis is based on radiologic criteria alone. Un...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120927
更新日期:1995-01-01 00:00:00
abstract::Tumors of the pineal region in children often belong to 2 categories, namely germ cell tumors and pineal parenchymal tumors. Very rare pathologies have previously been reported in this region. Most of these tumors may be similar radiologically, while their management differs. The present series reports 2 children with...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000369033
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The ability to provide an accurate prognosis for children with traumatic brain injury (TBI) would be useful for the children's families and the caregivers. In this study we examined whether an appropriate mathematical model can predict survival in this patient population. METHODS:Data from the Children's Ho...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000340068
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Gorham-Stout disease is a rare entity characterized by vascular proliferation causing local destruction of bone tissue. Owing to its low incidence and variable clinical presentation, the diagnosis requires a high degree of awareness by the clinician. CLINICAL PRESENTATION:We present the case o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336877
更新日期:2011-01-01 00:00:00
abstract::For over 60 years congenital kyphotic deformities of the spine have been categorized into two distinct groups, depending on the developmental defect. Those arising from a failure of formation of the vertebral bodies were classified as type 1, while those arising from a failure of segmentation were referred to as type ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121178
更新日期:1997-03-01 00:00:00
abstract::Eight myelodysplastic children developed isolated lateral ventriculomegaly following shunt insertion for progressive hydrocephalus after closure of a myelomeningocele. In all patients a low-pressure distal slit valve (Uni-shunt) system preceded development of an isolated contralateral ventricle. Six of 8 children requ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120547
更新日期:1990-01-01 00:00:00
abstract::Between June 1989 and January 1994, 14 patients with recurrent (n = 11) or posttreatment residual (n = 3) medulloblastoma were enrolled in a program to evaluate the efficacy and toxicity of stereotactic radiosurgery (SR). Initial treatment consisted of subtotal surgical resection in 12 patients and complete surgical r...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120901
更新日期:1995-01-01 00:00:00