Abstract:
OBJECTIVE/AIM:Hydrocephalus is defined as an incapacitating neurological disorder characterized by ventricular enlargement in children, but the effects of melatonin on this hydrocephalus have not yet been fully elucidated. In the present experiment, we attempted to investigate the effects of exogenous melatonin administration on hydrocephalus-induced hippocampal changes in infantile rats. METHODS:In this study, we randomly divided 45 Swiss albino rats aged 2 weeks into 3 groups: group I, the control group received a sham injection with needle insertion only; groups II and III were given kaolin injections before treatment - group II, the hydrocephalus group, was treated with an isotonic NaCl solution, and group III, the hydrocephalus plus melatonin group, was treated with 0.5 mg/100 g body weight of exogenous melatonin. Both immunohistochemical and histological analyses were performed after hydrocephalus induction and melatonin administration. Immunohistochemical staining consisted anti-glial fibrillary acidic protein staining. The TUNEL technique was used for defining quantitate apoptosis. RESULTS:Melatonin administration significantly attenuated chronic hydrocephalus-induced histopathological changes in the hippocampal subregions of infantile rats. Compared to hydrocephalic rats treated with saline solution, melatonin significantly decreased the number of apoptotic cells and pyknotic index values of each hippocampal subregion after the kaolin-induced hydrocephalus (p < 0.001). CONCLUSION:The present results demonstrate that the chronic hydrocephalus-induced histopathological changes in the hippocampus were partially reversible with melatonin treatment, suggesting its neuroprotective effects in infantile rats. However, these findings need to be confirmed by further experimental studies and clinical trials.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Turgut M,Baka M,Uyanıkgil Ydoi
10.1159/000488497subject
Has Abstractpub_date
2018-01-01 00:00:00pages
229-237issue
4eissn
1016-2291issn
1423-0305pii
000488497journal_volume
53pub_type
杂志文章abstract::Tumors of the pineal region in children often belong to 2 categories, namely germ cell tumors and pineal parenchymal tumors. Very rare pathologies have previously been reported in this region. Most of these tumors may be similar radiologically, while their management differs. The present series reports 2 children with...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000369033
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Endoscopic third ventriculostomy (ETV) has gained wide popularity as a first-line treatment for obstructive hydrocephalus (OHC). We have been performing ETV since 1998. We report our experience with this technique in the management of OHC. METHODS:Between 1998 and 2007, we performed 49 ETV procedures in 46 ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000257525
更新日期:2009-01-01 00:00:00
abstract::Posterior fossa syndrome (PFS), also known as cerebellar affective syndrome, is characterized by emotional lability and decreased speech production following injury or surgery to the cerebellum. Rarely, oculomotor dysfunction has been described in association with PFS. Here, we report a case of complete ocular paresis...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339382
更新日期:2012-01-01 00:00:00
abstract::Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or "premature dysjunction" theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000056007
更新日期:2001-03-01 00:00:00
abstract::Hepatic pseudocyst formation is a rare intra-abdominal complication of ventriculoperitoneal shunts. The presence of an intracranial tumor and a history of central nervous system infection are major risk factors for the development of this complication. Hepatic pseudocysts secondary to ventriculoperitoneal shunts can b...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000108795
更新日期:2007-01-01 00:00:00
abstract::We discuss the surgical approach used for and outcome in 11 infants (< or =3 years) who were treated at our institution for ependymomas arising in the cerebellar-pontine (C-P) angle. The median age of the group was 19 months (range: 6-26 months). Of these 11 patients, the initial surgery for 8 was performed at our cen...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121232
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND/AIMS:Central nervous system germ cell tumors (CNS-GCTs) are relatively rare. While their incidence was thought to be higher in East Asia than the USA, recent evidence suggests the difference between Japan and the USA is not statistically significant. The aim of this study was to determine the rate of pediatr...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1159/000358806
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:We review our experience of endoscopic third ventriculocisternostomy (ETV) in children with hydrocephalus from central nervous system (CNS) infection or intraventricular hemorrhage to better elucidate success rates and predictors of success in these children. METHODS:We performed a retrospective review of 12...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000072871
更新日期:2003-11-01 00:00:00
abstract:UNLABELLED:Since 1990, 110 retrograde ventriculo-sinus (RVS) shunts were implanted; 98 patients (89.1%) benefited - 1 of them (0.9%) after shunt revision. The manifestations of high intra cranial pressure (ICP) disappeared, there were no problems related to improper cerebrospinal fluid (CSF) drainage, and the transcran...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000088733
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:Tumours of the choroid plexus are rare tumours of neuro-ectodermal origin, accounting for less than 1% of all intracranial tumours. Most cases present in children less than 2 years of age. While choroid plexus carcinomas (CPC) are reported to have an extremely poor prognosis, choroid plexus papillomas (CPP) a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028933
更新日期:2000-04-01 00:00:00
abstract::The optimal treatment for Dandy-Walker malformation is still controversial. Ventriculoperitoneal shunting, cystoperitoneal shunting or combinations are the most common surgical options in the management of this clinical entity. Endoscopic procedures like ventriculocystostomy, 3rd ventriculostomy or endoscopy-assisted ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000353610
更新日期:2012-01-01 00:00:00
abstract::Inflicted traumatic brain injury (TBI) is a frequent consequence of physical child abuse in infants and children. Twenty-eight children who were 2-42 months of age when hospitalized for moderate to severe TBI were enrolled in a prospective, longitudinal study of neurobehavioral outcome following acquired brain injury....
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028872
更新日期:1999-11-01 00:00:00
abstract::Craniopharyngioma is one of the leading causes of hypothalamic-pituitary dysfunction in childhood, caused either by the tumor itself or the consequences of treatment. Tumor management in terms of recurrence rate, quality of life and complications is still controversial. Sixty-six patients with craniopharyngioma at ped...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000079852
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND/AIMS:The perception of a surgical complication may differ between surgeons and patients. In pediatric spine surgery, the perception of the parent or primary caregiver may also differ. In order to better define these relationships, we performed a pilot study surveying a convenience sample of pediatric spinal ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000319364
更新日期:2010-01-01 00:00:00
abstract::The authors studied 58 patients, under 12 years of age, admitted to the Emergency Room of the Sao Paulo University Hospital between September 1987 and November 1991 with the diagnosis of traumatic extradural hematoma. Emphasis was given to the etiology of injury, the time interval from head injury to emergency room ev...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120814
更新日期:1994-01-01 00:00:00
abstract::Eight myelodysplastic children developed isolated lateral ventriculomegaly following shunt insertion for progressive hydrocephalus after closure of a myelomeningocele. In all patients a low-pressure distal slit valve (Uni-shunt) system preceded development of an isolated contralateral ventricle. Six of 8 children requ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120547
更新日期:1990-01-01 00:00:00
abstract::This is a report of a prenatal sonographic diagnosis of a lateral ventricle choroid plexus papilloma in an in vitro fertilization (IVF)-induced pregnancy of a 40-year-old woman. The baby was delivered at 35 weeks of gestation and surgery was performed 5 days later with a good outcome. Several cases of malignancies ass...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000066210
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVES:The treatment of symptomatic cranio-vertebral junction (CVJ) instability in children affected by CVJ abnormalities is a challenge. A series of severely symptomatic children has been reviewed to understand the controversial long-term effectiveness of the aggressive management of CVJ abnormalities, in terms of...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000202621
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Achondroplasia is the commonest form of human dwarfism. The authors report atlanto-axial instability, in consequence to os odontoideum in this subgroup of patients. METHODS:Two achondroplastic dwarfs harboring atlanto-axial dislocation are described along with radiological findings. RESULTS:Both children u...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000335433
更新日期:2011-01-01 00:00:00
abstract::A 1-month-old boy was evaluated after a fall from a height of 3 feet and found to have right parietal skull fracture as well as right and left frontal traumatic hemorrhage. Ten days after the injury, he represented with a persistent left gaze preference. Further workup including MRI and EEG determined that this findin...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000441680
更新日期:2016-01-01 00:00:00
abstract::Fifty consecutive children are described with spastic cerebral palsy treated with selective functional lumbar and sacral rhizotomy and followed for a minimum of 6 months. In all patients, spasticity improved postoperatively, but this was not necessarily accompanied by a functional improvement. Eighteen children who co...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120639
更新日期:1992-01-01 00:00:00
abstract::Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000497149
更新日期:2019-01-01 00:00:00
abstract::A 16-year-old male presented with obstructive hydrocephalus secondary to pineal germinoma. There have been many reported cases of abdominal metastasis of pineal germinoma after ventriculoperitoneal shunting. Endoscopic ventriculostomy was preferred in our case, thus avoiding iatrogenic peritoneal seeding, but spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000089508
更新日期:2006-01-01 00:00:00
abstract::Skull defects in children may be congenital or acquired after trauma, infection or tumor. For defects that do not close spontaneously a variety of repair (cranioplasty) materials are available including bone, metals and acrylic. Where possible calvarial autogenous bone is preferred, particularly in younger infants, bu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120540
更新日期:1990-01-01 00:00:00
abstract::Changes in spinal curvature, scoliosis, kyphosis and lordosis are associated with the growth of patients with myelomeningocele. Previous investigators have stated that progressive developmental scoliosis is related to tethered spinal cord. In order to investigate the relationship of tethered spinal cord release to pro...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120762
更新日期:1994-01-01 00:00:00
abstract::Intracranial metastasis without pulmonary involvement of Wilms' tumor is very rare, and most previously reported metastatic sites have been in the cerebral parenchyma. We experienced a rare case of metastasis of Wilms' tumor in the tectal plate without pulmonary involvement. A 3-month-old boy was admitted to our hospi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028819
更新日期:1999-06-01 00:00:00
abstract::Spinal dysraphism is characterized by a lack of fusion of the vertebral arches that occurs in the absence of spinous processes with variable amounts of lamina. Here, we retrospectively present the importance of cutaneous lesions and their correlation with clinical presentation, radiological examination and urodynamic ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000149901
更新日期:2008-01-01 00:00:00
abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000491638
更新日期:2018-01-01 00:00:00
abstract::Central pontine myelinolysis occurs inconsistently as a complication of severe and prolonged hyponatremia, particularly when corrected too rapidly. It is a concentrated, frequently symmetric, noninflammatory demyelination within the central basis pontis. We describe a head injury patient who suffered this clinical ent...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000315003
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Complications arising from the placement of ventriculoperitoneal (VP) shunts are well documented. A case of infertility is presented that was thought to result from factors related to the distal end of a VP shunt residing within a patient's abdomen. CLINICAL PRESENTATION:A 30-year-old female w...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098391
更新日期:2007-01-01 00:00:00