Pathogenesis of lumbosacral lipoma: a test of the "premature dysjunction" theory.

Abstract:

:Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or "premature dysjunction" theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.

journal_name

Pediatr Neurosurg

journal_title

Pediatric neurosurgery

authors

Li YC,Shin SH,Cho BK,Lee MS,Lee YJ,Hong SK,Wang KC

doi

10.1159/000056007

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

124-30

issue

3

eissn

1016-2291

issn

1423-0305

pii

56007

journal_volume

34

pub_type

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