Abstract:
:Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or "premature dysjunction" theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburger and Hamilton stage 12 or 13 chick embryos. Among 35 embryos evaluated, 15 showed abnormal findings, and of these one showed findings which suggested lumbosacral lipoma: a back lump, blending of the neuroepithelium and mesenchyme through indistinct basement membrane and vertebral body abnormalities. The other 14 embryos showed abnormalities including blunt tails, open neural tube defects, incomplete closure of the dorsal neuroepithelium with intact skin, skin dimples, disorganized gray matter, scoliosis, ectopic neuroepithelium and an accessory spinal cord. The results revealed that the incision of the unilateral neural fold in the early chick embryo may produce a lesion suggestive of lumbosacral lipoma, a finding which supports the premature dysjunction theory. This method needs further refinement to overcome technical difficulties, high mortality, and a low yield before being adopted as an experimental model for lumbosacral lipoma.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Li YC,Shin SH,Cho BK,Lee MS,Lee YJ,Hong SK,Wang KCdoi
10.1159/000056007keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
124-30issue
3eissn
1016-2291issn
1423-0305pii
56007journal_volume
34pub_type
杂志文章abstract:BACKGROUND/AIMS:The object of this report is to review the management of patients having the composite type of aplasia cutis congenita in the context of the relevant literature on this condition. METHODS:Clinical records, neuroimaging and photographic documentation of identified cases of composite type aplasia cutis c...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000442989
更新日期:2016-01-01 00:00:00
abstract::The optimal treatment for Dandy-Walker malformation is still controversial. Ventriculoperitoneal shunting, cystoperitoneal shunting or combinations are the most common surgical options in the management of this clinical entity. Endoscopic procedures like ventriculocystostomy, 3rd ventriculostomy or endoscopy-assisted ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000353610
更新日期:2012-01-01 00:00:00
abstract::Fetus in fetu (FIF) is an extremely rare congenital anomaly in the pediatric age group. It is defined by the presence of an axial skeleton and well-formed internal organs in a fetiform mass. Only about 15 cases of intracranial FIF have been reported in the literature worldwide. We report a case of temporo-occipitocerv...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000441035
更新日期:2016-01-01 00:00:00
abstract::Molecular genetic analysis of several common cancers has yielded information concerning their etiology and prognosis. Restriction fragment length polymorphism (RFLP) studies showing consistent loss of specific DNA sequences in tumor tissue have identified genes, known as tumor suppressors, associated with the etiology...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120605
更新日期:1991-01-01 00:00:00
abstract::Malignant tumors arising within dysrhaphic malformations are very rare and are mostly teratomas; so far, only one rhabdomyosarcoma has been reported in this context. We report another case of a girl with lipomyelomeningocele who developed a lumbar rhabdomyosarcoma 2 years after birth and primary closure of the neural ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000083742
更新日期:2004-11-01 00:00:00
abstract::Primary spinal primitive neuroectodermal tumor (PSPNET) is extremely rare and only 25 cases have been reported in the world literature so far. Three patients of 8, 9 and 18 years of age, who presented with variable grades of neurological deficit were diagnosed as having a dorsal intramedullary lesion, a holocord lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000097517
更新日期:2007-01-01 00:00:00
abstract::Eighteen children under the age of 1 year underwent surgery for lipomeningocele at our institution between 1983 and 1991. All the patients had neurologic exams and urodynamic studies (UDS) including a cystometrogram and electromyography of the external urethral sphincter pre- and postoperatively. The surgical procedur...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120741
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:Over 170 years ago, traumatic spondylolisthesis of the axis or hangman's fracture was described. Most descriptions of this entity have focused on adult presentations. METHODS:We review the literature on pediatric cases of hangman's fracture emphasizing the embryological as well as presentation aspects. RESULT...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000455923
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Interictal 18F-fluorodeoxyglucose-positron emission topography (FDG-PET) hypometabolism is routinely used in the presurgical workup of children with medically intractable epilepsy (MIE). FDG-PET hypermetabolism, however, is rarely seen, and the significance of this finding in the epilepsy workup is not well ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000487088
更新日期:2018-01-01 00:00:00
abstract::Intracranial hydatidosis is mainly a pediatric disease. Surgical evacuation of the mass in toto is the gold standard of therapy. No concise data related to the requirement of diversion procedures after uncomplicated hydatid cyst removal is encountered in the literature. The aim of this report is to focus on this idea ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000095570
更新日期:2006-01-01 00:00:00
abstract::Attempts at radical excision of craniopharyngioma has been made increasingly possible by the advent of neuroradiological imaging and the use of microscopic technique. Between 1977 and 1993, 62 patients of The National Hospital for Neurology and Neurosurgery, London, have undergone surgical excision of craniopharyngiom...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120864
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Initial therapy for craniopharyngioma remains controversial. Population-based datasets indicate that traditional algorithms [gross total resection (GTR) vs. subtotal resection (STR) +/- radiation therapy (XRT)] are often not employed. We investigated neurosurgical practice patterns. METHODS:A ten-question s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000357783
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:Myxopapillary ependymomas (MPEs) in children are rarely reported low-grade glial tumors; however, MPEs sometimes possess malignant characteristics such as spinal seeding/drop metastasis (SSM). We aimed to present 3 pediatric MPE cases that experienced SSM at 2 neurosurgical centers. MATERIALS AND METHODS:We ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000509061
更新日期:2020-01-01 00:00:00
abstract:OBJECT:The evolution and severity of hydrocephalus in animal models varies in the species and mode of induction. This makes comparisons of the physiological system under investigation difficult between models. We noted that injection of kaolin into neonatal rats results in a dichotomous outcome into either an acute or ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000055975
更新日期:2000-12-01 00:00:00
abstract::Today, hemispherectomy is a well-established procedure for the treatment of some sorts of catastrophic epilepsies. This, however, has not always been the case. The technique was developed to deal with brain tumors; however, the initial results were not remarkable. Moreover, when its morbidity became evident, it was al...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000085870
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The cavum veli interpositi (CVI) usually is a small CSF-containing abnormality of septum pellucidum, asymptomatic and rare after the age of 3 years. When symptomatic, it is large and can be related to psychiatric disorders, syndromic association of mental retardation and seizures or to hydrocephalus. METHOD...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336881
更新日期:2011-01-01 00:00:00
abstract::Radiotherapy has remained the mainstay of treatment for children with intrinsic, diffuse pontine tumors in spite of over 20 years of clinical trials attempting to validate the additional role of chemotherapy. Conventional phase II clinical trials conducted in patients with recurrent or progressive brainstem gliomas us...
journal_title:Pediatric neurosurgery
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000121024
更新日期:1996-01-01 00:00:00
abstract::Arteriovenous malformations (AVMs) of the central nervous system are dynamic lesions that can change with time. One of the most clinically important concerns is the development and potential rupture of AVM-associated aneurysms. In this report, we review pediatric cases of de novo development of AVM-associated aneurysm...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000501041
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:Craniosynostosis patients treated with one-stage cranioplasty often have bleeding from the dura mater, fluid collection in the extradural space, and poor wound healing due to skin overstretching. To avoid these complications, we began using distraction osteogenesis. To determine the advantages and disadvantages...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000094064
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Complications arising from the placement of ventriculoperitoneal (VP) shunts are well documented. A case of infertility is presented that was thought to result from factors related to the distal end of a VP shunt residing within a patient's abdomen. CLINICAL PRESENTATION:A 30-year-old female w...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098391
更新日期:2007-01-01 00:00:00
abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000491638
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000495790
更新日期:2019-01-01 00:00:00
abstract::Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are dire neurological disorders, characterized by severe damage to the myelin sheath of neurons, which typically result from rapid correction or overcorrection of systemic hyponatremia. For many years, both conditions have been considered universal...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000320146
更新日期:2010-01-01 00:00:00
abstract::We report a 16-year-old healthy boy who presented with sudden loss of vision in both eyes, accompanied by a mild headache. Magnetic resonance imaging showed a chiasmal apoplexy. An urgent craniotomy revealed a cavernous malformation of the chiasm, which was evacuated. There was a subsequent dramatic improvement in bil...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000149911
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:As prior studies analysed predictive factors for various post-laminectomy spinal deformities in mixed spinal regions, age groups or pathologies, their validity and conclusions were unclear. The objective of this study was to determine predictive factors for worsened cervical or thoracic spinal sagi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050444
更新日期:2001-12-01 00:00:00
abstract::A 3-month-old female patient presented with a meningomyelocele at the lumber region associated with congenital hydrocephalus. She underwent ventriculoperitoneal (V-P) shunt surgery using the Sophy system. The shunt system was replaced due to a malformation. Following replacement, the patient presented with cerebrospin...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028752
更新日期:1999-01-01 00:00:00
abstract::Extraventricular neurocytomas mimic central neurocytomas histologically but are located outside the lateral and/or third ventricles. Pontine neurocytomas represent an extremely rare subset of extraventricular neurocytomas, and reports are limited to 2 adults followed under 28 months. The authors present the case of a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000351576
更新日期:2012-01-01 00:00:00
abstract::The unified theory, proposed by Pang et al., explains the embryogenetic mechanisms of all variants of split cord malformations (SCMs). All SCMs originate from one basic error occurring around the time when the primitive neurenteric canal closes. The basic error is the formation of an accessory neurenteric canal betwee...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121033
更新日期:1996-01-01 00:00:00
abstract::Although unilateral epidural hematomas are well known, bilateral presentation, especially at the confluens sinuum, is uncommon, and its diagnosis may be delayed, thus causing morbidity. We report a case of acute posttraumatic cortical blindness due to epidural hematoma at the confluens sinuum caused by venous sinus te...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000068813
更新日期:2003-03-01 00:00:00
abstract::Dermoids and epidermoids found at reoperation for tethered cord following myelomeningocele repair have been attributed to inadequate excision of cutaneous elements and 'implantation' in the repair site. This study reviews the pathological findings in excised placodes from fresh myelomeningoceles and specimens from tet...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120780
更新日期:1994-01-01 00:00:00