Abstract:
:Radiotherapy has remained the mainstay of treatment for children with intrinsic, diffuse pontine tumors in spite of over 20 years of clinical trials attempting to validate the additional role of chemotherapy. Conventional phase II clinical trials conducted in patients with recurrent or progressive brainstem gliomas using single chemotherapy agents such as cyclophosphamide, carboplatin, cisplatin, etoposide and thiotepa or combinations of chemotherapy agents have produced low response rates in the range of 15-20%. Preradiotherapy chemotherapy phase II trials in newly diagnosed patients have yielded similar results with a therapeutic window as long as 4 months. Preliminary data from protocols employing high-dose chemotherapy with stem cell support have also met with disappointment. The one published phase III trial conducted by the Children's Cancer Study Group comparing radiotherapy with radiotherapy plus chemotherapy (CCNU, vincristine and prednisone) failed to establish a benefit to multimodality therapy. Current studies include the use of radiosensitizing chemotherapy (carboplatin, estramustine and cisplatin) in newly diagnosed patients and more intensive neoadjuvant chemotherapy trials. Major advances in our management await insights into molecular vulnerability of high-grade gliomas.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Allen JC,Siffert Jdoi
10.1159/000121024subject
Has Abstractpub_date
1996-01-01 00:00:00pages
98-102issue
2eissn
1016-2291issn
1423-0305journal_volume
24pub_type
临床试验,杂志文章,多中心研究abstract::Endoscopic third ventriculostomy (ETV) provides a physiological restoration of cerebrospinal fluid and a shunt-free option for hydrocephalus children. Continuous developments in techniques and instruments have improved ETV as the first-line treatment. This paper focuses on the recent advances in surgical techniques, i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000491638
更新日期:2018-01-01 00:00:00
abstract::Schimmelpenning syndrome is a rare, well-defined constellation of clinical phenotypes associated with the presence of nevus sebaceous and multisystem abnormalities most commonly manifested as cerebral, ocular, and skeletal defects [
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000497149
更新日期:2019-01-01 00:00:00
abstract::This is a report of a prenatal sonographic diagnosis of a lateral ventricle choroid plexus papilloma in an in vitro fertilization (IVF)-induced pregnancy of a 40-year-old woman. The baby was delivered at 35 weeks of gestation and surgery was performed 5 days later with a good outcome. Several cases of malignancies ass...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000066210
更新日期:2002-11-01 00:00:00
abstract::In the older infant with a marked skull deformation from sagittal synostosis a midline craniectomy will not produce an optimal cosmetic result as the brain grows at a much reduced rate and cannot provide the impetus for passive correction of the deformity. An operative technique is described whereby the occipital prom...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120772
更新日期:1994-01-01 00:00:00
abstract::Hemifacial spasm (HFS), generally a disease of the elderly, is caused by vascular compression of the seventh nerve. Vascular compression is thought to result from atherosclerotic changes within the vessels of the posterior fossa, and therefore rarely presents in childhood. Here we describe our experience with 12 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121260
更新日期:1997-11-01 00:00:00
abstract::Intracranial metastasis without pulmonary involvement of Wilms' tumor is very rare, and most previously reported metastatic sites have been in the cerebral parenchyma. We experienced a rare case of metastasis of Wilms' tumor in the tectal plate without pulmonary involvement. A 3-month-old boy was admitted to our hospi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028819
更新日期:1999-06-01 00:00:00
abstract::Eight myelodysplastic children developed isolated lateral ventriculomegaly following shunt insertion for progressive hydrocephalus after closure of a myelomeningocele. In all patients a low-pressure distal slit valve (Uni-shunt) system preceded development of an isolated contralateral ventricle. Six of 8 children requ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120547
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Modern neuroimaging and intensive care permit precise delineation and specific treatment of head injury. Children sustaining cranial trauma associated with epidural hematoma (EDH) represent a heterogeneous group with a variety of clinical outcomes. Treatment consists of simple observation or surgical evacuati...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121144
更新日期:1996-12-01 00:00:00
abstract::The aquaporins (AQPs) are a family of water-transporting proteins that are broadly expressed in mammalian cells. Two AQPs in the central nervous system, AQP1 and AQP4, might play a role in hydrocephalus and are thus potential drug targets. AQP1 is expressed in the ventricular-facing membrane of choroid plexus epitheli...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000452168
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The failure rate following endoscopic third ventriculostomy (ETV) in infants younger than 2 years of age has been reported to be higher compared with that of older children, and it is unclear whether ETV might be superior to shunt placement in this age group. METHODS:Between 2003 and 2009, 23 patients young...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000324913
更新日期:2010-01-01 00:00:00
abstract::Wakeboarding is a relatively new and exciting sporting activity which is similar to water-skiing. While there have been several reports of water-skiing-related injuries, there has been nothing reported in the literature so far concerning injuries in wakeboarding. We present the case of a 14-year-old male who sustained...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028957
更新日期:2000-06-01 00:00:00
abstract::Traumatic acute subdural hematoma is associated with high mortality in the pediatric population, yet the pathophysiology remains poorly understood. The objective of this study was to develop a pediatric model of acute subdural hematoma, and to evaluate the resultant histopathological changes in the brain. Ten 3-week-o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121109
更新日期:1996-09-01 00:00:00
abstract::Although some complications have been reported when using endoscopic techniques, epidural hematoma (EDH) has rarely been caused. The authors report a case of EDH complicating a concomitant endoscopic biopsy procedure with ventricular shunt placement in a young, 14-year-old boy harboring a third ventricle tumor with a ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000082301
更新日期:2004-09-01 00:00:00
abstract::Hyponatremia is a common complication of intracranial disease or surgery. An evaluation should be undertaken to determine whether cerebral salt wasting (CSW) or inappropriate secretion of antidiuretic hormone is present as a cause. Since the treatment principles are completely different in the two pathological states,...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050424
更新日期:2001-10-01 00:00:00
abstract::We describe the initiation and development of a comprehensive multidisciplinary and multi-institutional program for the evaluation and management of youth with spasticity. A descriptive step-by-step process of the administrative and organizational sequence of the development of the program is delineated. The Spasticit...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,多中心研究
doi:10.1159/000355125
更新日期:2013-01-01 00:00:00
abstract::Several groups have begun to explore the feasibility and utility of intrauterine closure of myelomeningocele. A subset of these fetuses have defects which fall into the category of myeloschisis, and therefore have inadequate skin to enable primary closure. After considerable discussion, it was decided to utilize biped...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028898
更新日期:2000-01-01 00:00:00
abstract::The unified theory, proposed by Pang et al., explains the embryogenetic mechanisms of all variants of split cord malformations (SCMs). All SCMs originate from one basic error occurring around the time when the primitive neurenteric canal closes. The basic error is the formation of an accessory neurenteric canal betwee...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121033
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Lateral meningocele syndrome (LMS) is an exceedingly rare connective tissue disease with phenotypic anomalies similar to those seen in Marfan syndrome, Ehler-Danlos syndrome, and Loeys-Dietz syndrome. However, this syndrome is invariably associated with the presence of multiple lateral thoracolumbar spinal m...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000504060
更新日期:2020-01-01 00:00:00
abstract::We here describe the case of a boy with an atypical teratoid-rhabdoid tumor (ATRT) of the 4th ventricle at 1 year of age and a local tumor recurrence at 19 months of age. Due to brainstem infiltration, only incomplete tumor resection was possible each time. High-dose chemotherapy, stem cell transplantation and irradia...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000092366
更新日期:2006-01-01 00:00:00
abstract::Cystoperitoneal (CP) shunting is minimally invasive and achieves a high rate of resolution on neuroimaging. However, in the absence of definite symptoms, shunting should be reconsidered, because some patients can experience shunt dependency after CP shunting. In this study, the risk of shunt dependency in patients wit...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000065393
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:Tumours of the choroid plexus are rare tumours of neuro-ectodermal origin, accounting for less than 1% of all intracranial tumours. Most cases present in children less than 2 years of age. While choroid plexus carcinomas (CPC) are reported to have an extremely poor prognosis, choroid plexus papillomas (CPP) a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028933
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Although subdural hematomas (SDH) are common in infants, their long-term outcome is poorly documented in the literature. METHODS:Infants operated for SDH were followed prospectively and evaluated during their sixth year with systematic neurological evaluation and standard neuropsychological testing. RESULTS...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000071648
更新日期:2003-09-01 00:00:00
abstract::The object of the study are 126 children with internal hydrocephalus treated within the period 1978-1990. The children were preoperatively divided into six groups according to the etiology of the hydrocephalus. Disorders of the visual functions accompanying elevated intracranial pressure (setting sun 51, syndrome of t...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120617
更新日期:1991-01-01 00:00:00
abstract::A great majority of growing skull fractures occur in infancy and earlychildhood. Since the growth of brain is necessary as a driving force for these lesions to occur, almost all reported cases have been before the first 3 years of life. Although a number of uncommon locations, such as basiooccipital and skull base are...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028682
更新日期:1998-07-01 00:00:00
abstract:BACKGROUND:Endoscopic third ventriculostomy (ETV) has gained wide popularity as a first-line treatment for obstructive hydrocephalus (OHC). We have been performing ETV since 1998. We report our experience with this technique in the management of OHC. METHODS:Between 1998 and 2007, we performed 49 ETV procedures in 46 ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000257525
更新日期:2009-01-01 00:00:00
abstract::Severe diffuse brain injury in children has a devastating influence on their physical and psychological development. This retrospective study was undertaken to analyse the factors that influence outcome in children with such injuries. The short-term outcomes (Glasgow outcome score) of 74 children (age < or =15 years) ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000056002
更新日期:2001-02-01 00:00:00
abstract::Encephaloceles arise from developmental defects in neural tube formation. These lesions contain brain and meninges which herniate through a defect in the skull. These may present as isolated malformations or rarely be associated with brain tumors. We hereby discuss a case of an unusual association of an occipital ence...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339555
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Animal experiments have suggested that the intrauterine environment causes secondary injury to the congenitally dysplastic spinal cord. This in turn suggests that early closure of the myelomeningocele sac might prevent secondary injury and therefore improve neurologic outcome. This study was designed to exam...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000048358
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVE AND IMPORTANCE:Complications arising from the placement of ventriculoperitoneal (VP) shunts are well documented. A case of infertility is presented that was thought to result from factors related to the distal end of a VP shunt residing within a patient's abdomen. CLINICAL PRESENTATION:A 30-year-old female w...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098391
更新日期:2007-01-01 00:00:00
abstract::Intracranial and intraspinal ependymomas are uncommon tumors of the central nervous system. These tumors have a variety of imaging characteristics, some of which are fairly specific for ependymoma. We discuss the MRI features of ependymomas for each of the typical locations within the neuraxis, and provide MR imaging ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028630
更新日期:1998-02-01 00:00:00