Abstract:
BACKGROUND:Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a scavenger of hydroxyl radicals. METHODS:We aimed to measure and compare the effects of both methylprednisolone and edaravone on tissue and on serum concentrations of nitric oxide (NO), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, and tissue total antioxidant capacity (TAC) in rats with SCI. SCI was induced in four groups of Wistar albino rats by a weight-drop method. The neurological function of the rats was periodically tested. At the end of the experiment, blood samples were collected, and SC tissue samples were harvested for biochemical evaluation. RESULTS:The tissue level of NO was decreased in the edaravone-treated group compared with the no-treatment group (p < 0.05). The tissue levels of SOD and GSH-Px were higher in the edaravone-treated group than in the no-treatment group (p < 0.05). The serum levels of NO were lower in the edaravone-treated and methylprednisolone-treated groups than in the no-treatment group (p < 0.05). The serum levels of SOD in the edaravone-treated group did not differ from those of any other group. The serum levels of MDA in the edaravone-treated and no-treatment groups were higher than in the two other groups (p < 0.05). Tissue levels of MDA in the edaravone-treated group were lower than in the no-treatment group (p < 0.05). Tissue levels of TAC in the edaravone-treated group were higher than in the no-treatment and methylprednisolone-treated groups (p < 0.05). The neurological outcome scores of the animals in treatment groups did not depict any statistically significant improvement in motor functions. However, edaravone seemed to prevent further worsening of the immediate post-SCI neurological status. CONCLUSION:Our biochemical analyses indicate that edaravone is capable of blunting the increased oxidative stress that follows SCI. We show, for the first time, that edaravone enhances the TAC in SC tissue. This beneficial effect of edaravone on antioxidant status may act to minimize the secondary neurological damage that occurs during the acute phase after SCI.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Ozgiray E,Serarslan Y,Oztürk OH,Altaş M,Aras M,Söğüt S,Yurtseven T,Oran I,Zileli Mdoi
10.1159/000335400subject
Has Abstractpub_date
2011-01-01 00:00:00pages
254-60issue
4eissn
1016-2291issn
1423-0305pii
000335400journal_volume
47pub_type
杂志文章abstract:BACKGROUND:The cavum veli interpositi (CVI) usually is a small CSF-containing abnormality of septum pellucidum, asymptomatic and rare after the age of 3 years. When symptomatic, it is large and can be related to psychiatric disorders, syndromic association of mental retardation and seizures or to hydrocephalus. METHOD...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336881
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:An 11-month-old boy with autosomal recessive infantile osteopetrosis presented, 7 months after bone marrow transplantation, with normal ventricular size and life-threatening intracranial hypertension due to pansynostosis. METHODS:The cranial vault was expanded by using jackscrew distracters to upwardly adva...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000098381
更新日期:2007-01-01 00:00:00
abstract::The Meckel-Gruber syndrome is a rare, congenital, and lethal malformation characterized by typical manifestations such as encephalocele, polycystic kidneys, and polydactyly. Herein, we present a case of a patient with the typical triad as well as facial, ocular, liver, and genital abnormalities who lived for almost 5 ...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000500766
更新日期:2019-01-01 00:00:00
abstract::There are several treatment modalities for Langerhans' cell histiocytosis (LCH) of bone, formerly usually referred to as eosinophilic granuloma, including surgery, radiotherapy and chemotherapy. In spinal lesions, surgery is not recommended generally, because of the potential for reconstitution of vertebral height. We...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000069100
更新日期:2003-04-01 00:00:00
abstract::Pineal region lesions consist of a wide variety of rare tumor types, including deep midline cysts, intrinsic pineal tumors, germ cell tumors and vascular lesions. Advances in microsurgical, endoscopic and stereotactic techniques have helped to lower morbidity and mortality in the care of patients harboring these lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000070415
更新日期:2003-06-01 00:00:00
abstract::Posterior fossa syndrome (PFS), also known as cerebellar affective syndrome, is characterized by emotional lability and decreased speech production following injury or surgery to the cerebellum. Rarely, oculomotor dysfunction has been described in association with PFS. Here, we report a case of complete ocular paresis...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000339382
更新日期:2012-01-01 00:00:00
abstract::An intradural, intramedullary lipoma originating within the upper cervical cord with significant extension into the posterior fossa is reported in an infant. Two additional lipomas were found in the lumbar region. This constellation of findings represents the first description of multiple intradural, intramedullary sp...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121008
更新日期:1996-01-01 00:00:00
abstract::Diffuse pontine tumors are highly lethal and conventional therapy with irradiation provides long-term survival to a very small proportion of the patients. We have reported promising results using high-dose chemotherapy with autologous stem cell rescue in patients with recurrent high-grade astrocytomas in other anatomi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121049
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:Cephalocele is a central nervous system (CNS) birth defect. Various CNS and extra-CNS anomalies, as well as prognostic factors have been reported with cephalocele. The aim of this study was to discuss prognostic factors and current possible theories explaining associated anomalies seen in a series of 55 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000277622
更新日期:2009-01-01 00:00:00
abstract::Cavernous malformations (CMs) of the central nervous system are benign, angiographically occult vascular lesions and are diagnosed by magnetic resonance imaging techniques. Giant CMs do not differ from smaller-sized CMs in their clinical, surgical or histopathological presentation but may be radiologically different. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000447407
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Myxopapillary ependymomas (MPEs) in children are rarely reported low-grade glial tumors; however, MPEs sometimes possess malignant characteristics such as spinal seeding/drop metastasis (SSM). We aimed to present 3 pediatric MPE cases that experienced SSM at 2 neurosurgical centers. MATERIALS AND METHODS:We ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000509061
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Our appreciation and understanding of what is now known as the split cord malformation (SCM) have a long history. The oldest known example of SCM is from roughly AD 100. Other isolated examples can be found in the large body of work of the pathologists of the 1800s, where the SCMs were found incidentally d...
journal_title:Pediatric neurosurgery
pub_type: 历史文章,杂志文章
doi:10.1159/000450584
更新日期:2017-01-01 00:00:00
abstract::Three patients with colloid cysts were identified among approximately 1,400 patients with brain tumors seen at the Hospital for Sick Children in Toronto between 1952 and 1992. These and 34 previously published cases of colloid cysts in children were reviewed. Colloid cysts are rare causes of headaches and papilloedema...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120782
更新日期:1994-01-01 00:00:00
abstract::We discuss the surgical approach used for and outcome in 11 infants (< or =3 years) who were treated at our institution for ependymomas arising in the cerebellar-pontine (C-P) angle. The median age of the group was 19 months (range: 6-26 months). Of these 11 patients, the initial surgery for 8 was performed at our cen...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121232
更新日期:1997-08-01 00:00:00
abstract::A rare case involving multiple intracranial aneurysms with intraventricular hemorrhage (IVH) in a child, accompanied by unilateral fibromuscular dysplasia (FMD) of the renal artery, is reported. A 12-year-old girl presented with secondary hypertension and fourth-ventricle IVH. Cerebral angiography showed multiple aneu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000180304
更新日期:2008-01-01 00:00:00
abstract::Eighteen children under the age of 1 year underwent surgery for lipomeningocele at our institution between 1983 and 1991. All the patients had neurologic exams and urodynamic studies (UDS) including a cystometrogram and electromyography of the external urethral sphincter pre- and postoperatively. The surgical procedur...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120741
更新日期:1993-09-01 00:00:00
abstract:INTRODUCTION:Traumatic posterior fossa extradural hematomas (PFEDH) are rare lesions constituting <10% of all extradural hematomas. Reliance on clinical findings alone is not recommended as these are nonspecific; for all suspicious cases, it is advisable to conduct a CT scan. Only a handful of pediatric studies have be...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000438488
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:Over 170 years ago, traumatic spondylolisthesis of the axis or hangman's fracture was described. Most descriptions of this entity have focused on adult presentations. METHODS:We review the literature on pediatric cases of hangman's fracture emphasizing the embryological as well as presentation aspects. RESULT...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000455923
更新日期:2017-01-01 00:00:00
abstract::The epidemiology of cerebrospinal fluid (CSF) shunting in the United States is not well known; however, with recent national surveys, the prevalence, incidence, and cost of these procedures can be estimated. The prevalence of CSF shunts in the United States appears to be greater than 125,000, though this is likely an ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120968
更新日期:1995-01-01 00:00:00
abstract:AIM:To evaluate the effectiveness of Novalis radiosurgery (RS) in children with optic gliomas. METHODS:Four pediatric patients (1 male and 3 female) were treated for optic gliomas with Novalis RS in our institution between February 2002 and July 2002. Their mean age was 12 (range 5-16) years at presentation for Novali...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000103305
更新日期:2007-01-01 00:00:00
abstract::A case of a 16-year-old male with both a nasal dermoid sinus cyst (NDSC) and a third ventricle colloid cyst is presented. The NDSC was excised via a single-stage combined intracranial-extracranial approach and the third ventricle colloid cyst was resected endoscopically. The pathogenetic theories of NDSC and third ven...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028862
更新日期:1999-10-01 00:00:00
abstract::It is essential that various factors be considered when determining the differential diagnosis of congenital scalp lesions, including lesion size, appearance, intracranial extension, underlying medical condition and the embryological germ layer involved. We present the case of a newborn diagnosed as having a sebaceous...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000113118
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Animal experiments have suggested that the intrauterine environment causes secondary injury to the congenitally dysplastic spinal cord. This in turn suggests that early closure of the myelomeningocele sac might prevent secondary injury and therefore improve neurologic outcome. This study was designed to exam...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000048358
更新日期:2002-02-01 00:00:00
abstract::The computed tomographic (CT) scanning characteristics of a case of intra-fourth-ventricle mature teratoma in a 15-month-old child are described and correlated with intraoperative findings. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028795
更新日期:1999-04-01 00:00:00
abstract::Tumors of the pineal region in children often belong to 2 categories, namely germ cell tumors and pineal parenchymal tumors. Very rare pathologies have previously been reported in this region. Most of these tumors may be similar radiologically, while their management differs. The present series reports 2 children with...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000369033
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the head injury in children caused by an unusual projectile, a tear gas cartridge. The study is the only one on this subject which has been done in a teenage population. METHOD:This was a prospective study conducted over a period of 4 years in which all the patients aged ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000314054
更新日期:2010-01-01 00:00:00
abstract::This report describes a neonatal case in whom a large interhemispheric cyst associated with agenesis of the corpus callosum was revealed by fetal ultrasonography and demonstrated by MRI to be multilobulated. Endoscopic fenestration of cysts was initially designed in view of the development of the patient's brain and s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028972
更新日期:2000-07-01 00:00:00
abstract::A 1-month-old boy was evaluated after a fall from a height of 3 feet and found to have right parietal skull fracture as well as right and left frontal traumatic hemorrhage. Ten days after the injury, he represented with a persistent left gaze preference. Further workup including MRI and EEG determined that this findin...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000441680
更新日期:2016-01-01 00:00:00
abstract::Fetus in fetu (FIF) is an extremely rare congenital anomaly in the pediatric age group. It is defined by the presence of an axial skeleton and well-formed internal organs in a fetiform mass. Only about 15 cases of intracranial FIF have been reported in the literature worldwide. We report a case of temporo-occipitocerv...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000441035
更新日期:2016-01-01 00:00:00
abstract::Associated cranial abnormalities with spinal dysraphism are not uncommon. We came across an unusual case of a 1-year-old male child with spinal dysraphism having lumbar meningomyelocele, who also had split cord malformation (hemicord with intervening bony spur) with lipoma of one of the hemicord and filum terminale. T...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000091862
更新日期:2006-01-01 00:00:00