Abstract:
:In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range 1.5-5.6) years after diagnosis from 16 survivors of 51 consecutively diagnosed children with brain stem glioma between 1983 and 1991. Among 11 children with dorsally exophytic tumors, 7 were treated with surgery alone (SRG) and 4 received conventionally fractionated local cranial radiation therapy (CFRT; 54-56 Gy) to the brain stem following surgery, 3 of these because of recurrent disease. Five others with diffusely infiltrative brain stem tumors received hyperfractionated radiation therapy (HFRT; 70.2 Gy) to the brain stem; 4 following biopsy or limited resection and 1 without prior surgery. IQs of children in the CFRT (mean 89, SD 24.4) and HFRT (mean 85, SD 12.7) groups were not significantly different. Children in the SRG group had significantly higher IQs (mean 100, SD 11.0) and fewer neurologic deficits than those who had received CFRT or HFRT. However, after statistically controlling for severity of neurologic deficits, treatment had no effect on IQ. The severity of residual neurologic deficits accounted for 42% of the variance in IQ scores; children with fewer neurologic problems scored higher. Additional studies are required to evaluate the potential neuropsychological benefits of equivalent total doses of HFRT compared to CFRT.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Mulhern RK,Heideman RL,Khatib ZA,Kovnar EH,Sanford RA,Kun LEdoi
10.1159/000120795subject
Has Abstractpub_date
1994-01-01 00:00:00pages
226-32issue
4eissn
1016-2291issn
1423-0305journal_volume
20pub_type
杂志文章abstract::Pineal region lesions consist of a wide variety of rare tumor types, including deep midline cysts, intrinsic pineal tumors, germ cell tumors and vascular lesions. Advances in microsurgical, endoscopic and stereotactic techniques have helped to lower morbidity and mortality in the care of patients harboring these lesio...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000070415
更新日期:2003-06-01 00:00:00
abstract::It is essential that various factors be considered when determining the differential diagnosis of congenital scalp lesions, including lesion size, appearance, intracranial extension, underlying medical condition and the embryological germ layer involved. We present the case of a newborn diagnosed as having a sebaceous...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000113118
更新日期:2008-01-01 00:00:00
abstract::Premature separation of the neuroectoderm from the ipsilateral surface ectoderm allowing mesenchymal tissue to invade into the central canal, or "premature dysjunction" theory, was proposed for the pathogenesis of dorsal type lumbosacral lipoma. To test this theory, the unilateral neural fold was incised using Hamburg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000056007
更新日期:2001-03-01 00:00:00
abstract::A case of an intracerebral juvenile xanthogranuloma (JXG) producing complex-partial seizures in a 13-year-old boy is presented. Although the child had no history of JXGs or a systemic histiocytic proliferative disorder, the histopathological and immunocytochemical studies of this lesion were identical to that of a cut...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000121212
更新日期:1997-06-01 00:00:00
abstract:UNLABELLED:Since 1990, 110 retrograde ventriculo-sinus (RVS) shunts were implanted; 98 patients (89.1%) benefited - 1 of them (0.9%) after shunt revision. The manifestations of high intra cranial pressure (ICP) disappeared, there were no problems related to improper cerebrospinal fluid (CSF) drainage, and the transcran...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000088733
更新日期:2005-11-01 00:00:00
abstract::Fifty consecutive children are described with spastic cerebral palsy treated with selective functional lumbar and sacral rhizotomy and followed for a minimum of 6 months. In all patients, spasticity improved postoperatively, but this was not necessarily accompanied by a functional improvement. Eighteen children who co...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120639
更新日期:1992-01-01 00:00:00
abstract::Although the transsphenoidal approach offers a narrow operative field and poor visual control through a small sellar opening, this approach has the advantage of being associated with minimal surgical trauma, especially in children. We share our experience of good surgical outcome achieved by the transsphenoidal approa...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000071321
更新日期:2003-07-01 00:00:00
abstract::Intracranial schwannomas not arising from a cranial nerve are very rare. Schwannomas of the dura are even rarer; in the literature, we found only two cases: a schwannoma of the falx and one of the torcula. We report a third case of a 9-year-old girl with a schwannoma of the tentorium cerebelli. The different theories ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000048371
更新日期:2002-03-01 00:00:00
abstract::Arteriovenous malformations (AVMs) of the central nervous system are dynamic lesions that can change with time. One of the most clinically important concerns is the development and potential rupture of AVM-associated aneurysms. In this report, we review pediatric cases of de novo development of AVM-associated aneurysm...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000501041
更新日期:2019-01-01 00:00:00
abstract::Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000048342
更新日期:2002-01-01 00:00:00
abstract::Intracranial hydatidosis is mainly a pediatric disease. Surgical evacuation of the mass in toto is the gold standard of therapy. No concise data related to the requirement of diversion procedures after uncomplicated hydatid cyst removal is encountered in the literature. The aim of this report is to focus on this idea ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000095570
更新日期:2006-01-01 00:00:00
abstract:AIM:To evaluate the effectiveness of Novalis radiosurgery (RS) in children with optic gliomas. METHODS:Four pediatric patients (1 male and 3 female) were treated for optic gliomas with Novalis RS in our institution between February 2002 and July 2002. Their mean age was 12 (range 5-16) years at presentation for Novali...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000103305
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Spinal cord injury (SCI) is a leading cause of morbidity and mortality among youth and adults. Secondary injury mechanisms within the spinal cord (SC) are well known to cause deterioration after an acute impact. Free radical scavengers are among the most studied agents in animal models of SCI. Edaravone is a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000335400
更新日期:2011-01-01 00:00:00
abstract::The Meckel-Gruber syndrome is a rare, congenital, and lethal malformation characterized by typical manifestations such as encephalocele, polycystic kidneys, and polydactyly. Herein, we present a case of a patient with the typical triad as well as facial, ocular, liver, and genital abnormalities who lived for almost 5 ...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000500766
更新日期:2019-01-01 00:00:00
abstract::Intracranial metastasis without pulmonary involvement of Wilms' tumor is very rare, and most previously reported metastatic sites have been in the cerebral parenchyma. We experienced a rare case of metastasis of Wilms' tumor in the tectal plate without pulmonary involvement. A 3-month-old boy was admitted to our hospi...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028819
更新日期:1999-06-01 00:00:00
abstract::Dermoids and epidermoids found at reoperation for tethered cord following myelomeningocele repair have been attributed to inadequate excision of cutaneous elements and 'implantation' in the repair site. This study reviews the pathological findings in excised placodes from fresh myelomeningoceles and specimens from tet...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120780
更新日期:1994-01-01 00:00:00
abstract:INTRODUCTION:The cumulative incidence of radiation-induced second malignancy is 1-2% per decade after radiotherapy (RT). Radiation-induced malignant glioma (RIMG) is a rare complication of cranial RT. CASE PRESENTATION:We herein describe a case of left frontal glioblastoma arising 5 years after prophylactic cranial ir...
journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000511996
更新日期:2020-01-01 00:00:00
abstract::A great majority of growing skull fractures occur in infancy and earlychildhood. Since the growth of brain is necessary as a driving force for these lesions to occur, almost all reported cases have been before the first 3 years of life. Although a number of uncommon locations, such as basiooccipital and skull base are...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028682
更新日期:1998-07-01 00:00:00
abstract::We present a case report of a 21-month-old female patient to highlight magnetic resonance (MR) imaging findings associated with papilledema in a pediatric patient with an intracranial tumor. The MR findings included optic disc elevation, dilated perioptic subarachnoid spaces, optic nerve tortuosity and restricted diff...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000270156
更新日期:2009-01-01 00:00:00
abstract::Maternal malignancy metastatic to the fetus is a rare event, with most neoplasms being either melanocytic or hematopoietic in origin. This report is the first known case of a maternal lung adenocarcinoma metastatic to a fetus. At 2 months of age, this male infant developed multiple scalp masses that were locally resec...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050384
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:This study aims to elucidate surgical risk factors in neuromuscular scoliosis (NMS) with respect to wound site infection after spinal fusion. METHODS:A retrospective review was performed of all patients treated surgically for NMS between January 2008 and December 2016 (minimum 6 months' follow-up). A sub-coh...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000496693
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To induce experimental split cord malformations (SCMs) produced through the surgical induction of a dorsal midline fistula. METHODS:In addition, the theory of embryogenesis of SCMs was verified by examining the developmental process of this experimentally induced anomaly. In Cynopus pyrrhogaster (amphibian) ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000058425
更新日期:2002-05-01 00:00:00
abstract::Breath-holding or reflex anoxic seizures predominantly occur in preschool children and usually resolve by late childhood, rarely persisting through adolescence and into adulthood. Investigations are generally unnecessary. Education and reassurance is the mainstay of management. In this report, the author describes a c...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000365763
更新日期:2013-01-01 00:00:00
abstract::Intracranial and intraspinal ependymomas are uncommon tumors of the central nervous system. These tumors have a variety of imaging characteristics, some of which are fairly specific for ependymoma. We discuss the MRI features of ependymomas for each of the typical locations within the neuraxis, and provide MR imaging ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028630
更新日期:1998-02-01 00:00:00
abstract::The existence of air in the spinal canal is referred to as pneumorrhachis. It is classified as extradural (epidural) or intradural (subdural or subarachnoid) according to the location where it is found. Nontraumatic, traumatic, and iatrogenic causes have been attributed to its occurrence. Traumatic pneumorrhachis is v...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000496395
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:We sought to describe pediatric "big data" publications since 2000, their statistical output, and clinical implications. METHODS:We searched 4 major North American neurosurgical journals for articles utilizing non-neurosurgery-specific databases for clinical pediatric neurosurgery research. Articles we...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000495790
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Scoliosis is common in patients with Chiari malformation-I (CM-I). This study examined the change in scoliosis severity after posterior fossa decompression (PFD) for CM-I. METHODS:We conducted a retrospective review at a single tertiary center for children undergoing PFD with untreated scoliosis, and i...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000485254
更新日期:2018-01-01 00:00:00
abstract::The placement of a ventriculoperitoneal (VP) shunt is the most common form of treatment for hydrocephalus.The distal end of the VP shunt is commonly placed in the peritoneal cavity. Various complications of the distal end of the shunt have been described in the literature.We report an unusual case of perforation of th...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000204904
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The failure rate following endoscopic third ventriculostomy (ETV) in infants younger than 2 years of age has been reported to be higher compared with that of older children, and it is unclear whether ETV might be superior to shunt placement in this age group. METHODS:Between 2003 and 2009, 23 patients young...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000324913
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:An international multicenter randomized trial comparing standard pressure differential valves, Orbis Sigma valves and PS Medical Delta valves, for children with newly diagnosed hydrocephalus failed to show a difference in the time to first shunt failure (power 80%). In order to avoid observer bias, the pri...
journal_title:Pediatric neurosurgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000028764
更新日期:1999-02-01 00:00:00