Abstract:
:To compare the functional development of the fourth ventricular outlet in the myeloschisis-Chiari malformation complex with that of a normal brain, the chronological development of the outlet in C57BL/6J non-neural-tube defect mouse embryos was examined as the first step. Then we compared the results with those of homozygotic delayed splotch (Spd) mouse embryos which had neural-tube defects (NTDs). Ferrous chloride (Prussian blue) solution was injected into the lateral or mesencephalic ventricle on gestation days 13-16 in the case of control C57BL/6J mouse embryos and on gestation days 14-16 in the case of homozygotic Spd mouse embryos which had open spinal NTDs and hindbrain anomalies comparable to human Chiari malformation. At 30 min after the injection, acid fixative was infused through the heart to set off the Prussian blue reaction, which makes the dye visible by the precipitation of ferric chloride. According to the present method, more than 75% of C57BL/6J mouse (non-NTD control) embryos showed the evidence of function of the fourth ventricular (4V) outlet from gestation day 15. It was difficult to apply the same method to Spd mouse embryos with NTDs due to the small size of ventricles. Only 4 injections were successful, of which 3 showed the functioning evidence of the 4V outlet. Though the number of mouse embryos with NTDs studied was small, the results suggest that the chronological progress of functional opening of the fourth ventricle in mouse embryos with NTDs is similar to that of control non-NTD embryos.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Wang KC,Higbee R,Knepper PA,McLone DGdoi
10.1159/000121248subject
Has Abstractpub_date
1997-10-01 00:00:00pages
176-81issue
4eissn
1016-2291issn
1423-0305journal_volume
27pub_type
杂志文章abstract::This study was performed to compare the effects of continuous intrathecal baclofen infusion (CIBI) and selective posterior rhizotomy (SPR) on upper extremity (UE) spasticity and range of motion in children with cerebral palsy. Spasticity was assessed with the Ashworth scale of muscle tone and range of motion was evalu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120941
更新日期:1995-01-01 00:00:00
abstract::A rare case of a patient with Laurence-Moon-Biedl syndrome associated with hypothalamic hamartoma is described. The English-language literature contains no cases of patients with this association. The clinical manifestations of this syndrome, those of hypothalamic hamartomas, and the appearance of the tumors on magnet...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000120563
更新日期:1991-01-01 00:00:00
abstract::Tumors located in the region of the foramen of Monro often present with signs and symptoms of obstructive hydrocephalus. Various types of lesions occur in this location. We describe a case of a dysembryoplastic neuroepithelial tumor of the septum pellucidum presenting with obstructive hydrocephalus and its successful ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000090464
更新日期:2006-01-01 00:00:00
abstract::A series of neuroendoscopic third ventriculostomies in children less than 1 year old is reported. Twenty-seven patients underwent the procedure with 21 (77%) failing within a mean of 1.36 months of the procedure. Nineteen were subsequently shunted. The presence or absence of flow through the ventriculostomy and the si...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028693
更新日期:1998-08-01 00:00:00
abstract::Twelve patients underwent endoscopic biopsy of a tumor involving the third ventricle. Nine patients had no significant medical history while 3 had a history of cancer. Unique characteristics of each case dictated the optimal surgical technique. Endoscopic tumor biopsy was combined with additional procedures in 9 cases...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028994
更新日期:2000-09-01 00:00:00
abstract::This is a report of a prenatal sonographic diagnosis of a lateral ventricle choroid plexus papilloma in an in vitro fertilization (IVF)-induced pregnancy of a 40-year-old woman. The baby was delivered at 35 weeks of gestation and surgery was performed 5 days later with a good outcome. Several cases of malignancies ass...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000066210
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:The cavum veli interpositi (CVI) usually is a small CSF-containing abnormality of septum pellucidum, asymptomatic and rare after the age of 3 years. When symptomatic, it is large and can be related to psychiatric disorders, syndromic association of mental retardation and seizures or to hydrocephalus. METHOD...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336881
更新日期:2011-01-01 00:00:00
abstract::It is essential that various factors be considered when determining the differential diagnosis of congenital scalp lesions, including lesion size, appearance, intracranial extension, underlying medical condition and the embryological germ layer involved. We present the case of a newborn diagnosed as having a sebaceous...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000113118
更新日期:2008-01-01 00:00:00
abstract::The purpose of this study was to examine the current patterns of head trauma associated with child abuse. We reviewed the records of all patients admitted to our medical center between 1995 and 1997 with a primary diagnosis of head trauma, and analyzed the clinical presentation, mechanism of injury, socioeconomic stat...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028880
更新日期:1999-12-01 00:00:00
abstract::Hemifacial spasm (HFS), generally a disease of the elderly, is caused by vascular compression of the seventh nerve. Vascular compression is thought to result from atherosclerotic changes within the vessels of the posterior fossa, and therefore rarely presents in childhood. Here we describe our experience with 12 patie...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121260
更新日期:1997-11-01 00:00:00
abstract::Blunt carotid injury (BCI) is an uncommon yet potentially devastating entity which has received little attention in the pediatric literature. In an attempt to better characterize pediatric BCI, a review of the National Pediatric Trauma Registry was performed. Records were obtained from all children diagnosed with inte...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028804
更新日期:1999-05-01 00:00:00
abstract::A 4-year-old child with AIDS developed encephalitis 2 months prior to death. Adenovirus was cultured from the cerebrospinal fluid. At autopsy, sections of the brain revealed complete sloughing of the intracranial ependyma, with marked gliosis and edema of the periventricular white matter. Cells with large, dark, smudg...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120551
更新日期:1990-01-01 00:00:00
abstract::Cavernous malformations (CMs) of the central nervous system are benign, angiographically occult vascular lesions and are diagnosed by magnetic resonance imaging techniques. Giant CMs do not differ from smaller-sized CMs in their clinical, surgical or histopathological presentation but may be radiologically different. ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000447407
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:Over 170 years ago, traumatic spondylolisthesis of the axis or hangman's fracture was described. Most descriptions of this entity have focused on adult presentations. METHODS:We review the literature on pediatric cases of hangman's fracture emphasizing the embryological as well as presentation aspects. RESULT...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000455923
更新日期:2017-01-01 00:00:00
abstract::With an incidence of less than 1-3 per million, pediatric aneurysms are rare clinical entities. A traumatic etiology is implicated in a large proportion of these cases, leading to the formation of both 'false' and 'true' aneurysms. These occur most often in the distal circulation, but have also been described in the s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000339355
更新日期:2011-01-01 00:00:00
abstract::Craniopharyngioma is one of the leading causes of hypothalamic-pituitary dysfunction in childhood, caused either by the tumor itself or the consequences of treatment. Tumor management in terms of recurrence rate, quality of life and complications is still controversial. Sixty-six patients with craniopharyngioma at ped...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000079852
更新日期:2004-05-01 00:00:00
abstract::Prepontine arachnoid cysts are rare developmental anomalies that occur almost exclusively in children. The symptomatic child typically suffers from hydrocephalus, visual impairment, endocrine dysfunction and/or cranial neuropathies. Some cysts, however, are discovered incidentally upon prenatal or postnatal imaging fo...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000064394
更新日期:2002-09-01 00:00:00
abstract::Epidermoid cysts (ECs) are rare developmental lesions occurring anywhere along the central nervous system. Usually affecting adult patients, the occurrence of supratentorial dorsal cistern ECs has been reported in only 1 certain case of pediatric age. An additional pediatric case is presented. An 11-year-old boy had a...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028722
更新日期:1998-10-01 00:00:00
abstract::Meningeal melanocytoma is an infrequent neoplasm of the central nervous system (CNS), especially in childhood and infancy. It was first described as an entity different from pigmented meningiomas and schwannomas in 1972, and few cases have been published so far. In this article, a 5-month-old male patient with meninge...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028945
更新日期:2000-05-01 00:00:00
abstract::Today, hemispherectomy is a well-established procedure for the treatment of some sorts of catastrophic epilepsies. This, however, has not always been the case. The technique was developed to deal with brain tumors; however, the initial results were not remarkable. Moreover, when its morbidity became evident, it was al...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000085870
更新日期:2005-05-01 00:00:00
abstract::In the older infant with a marked skull deformation from sagittal synostosis a midline craniectomy will not produce an optimal cosmetic result as the brain grows at a much reduced rate and cannot provide the impetus for passive correction of the deformity. An operative technique is described whereby the occipital prom...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120772
更新日期:1994-01-01 00:00:00
abstract::Although the transsphenoidal approach offers a narrow operative field and poor visual control through a small sellar opening, this approach has the advantage of being associated with minimal surgical trauma, especially in children. We share our experience of good surgical outcome achieved by the transsphenoidal approa...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000071321
更新日期:2003-07-01 00:00:00
abstract::Eighteen children under the age of 1 year underwent surgery for lipomeningocele at our institution between 1983 and 1991. All the patients had neurologic exams and urodynamic studies (UDS) including a cystometrogram and electromyography of the external urethral sphincter pre- and postoperatively. The surgical procedur...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120741
更新日期:1993-09-01 00:00:00
abstract::Sylvian arachnoid cysts pose considerable management dilemmas. Surgical options include cyst fenestration, either endoscopically or microsurgically, and cysto-peritoneal shunt. One of the rare complications after rapid decompression of the arachnoid cysts is haemorrhage in the surrounding brain as well as in remote ar...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000452224
更新日期:2017-01-01 00:00:00
abstract::Focal intracranial infections due to Salmonella are rare. So far, around 80 cases have been reported in the world literature. The authors present their experience of 6 cases of intracranial Salmonella infections, mainly subdural empyema in 5 and effusion in 1. In 1 case, subdural empyema was bilateral, and in another ...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000048342
更新日期:2002-01-01 00:00:00
abstract::We report here the first case of ruptured arteriovenous malformation (AVM) in a patient with Beckwith-Wiedemann syndrome (BWS). The subject was a 9-year-old boy exhibiting various abnormal features characteristic of BWS, who had undergone frequent surgical management for conditions such as umbilical hernia, polydactyl...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028854
更新日期:1999-09-01 00:00:00
abstract::Spinal cord injuries are a well-known cause of neurological bladder and a well-known complication of high-velocity trauma. They can, however, be difficult to diagnose in young children, in whom the absence of initial neurological symptoms and normality of the radiological workup can be falsely reassuring. Management o...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000360402
更新日期:2013-01-01 00:00:00
abstract::A case is presented illustrating the usefulness of computerized tomography (CT) with 3-dimensional (3-D) reconstruction for evaluation of a subdental synchondrosis fracture in a child. Odontoid fractures in children less than 7 years of age occur at the subdental synchondrosis and are typically diagnosed with plain x-...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121135
更新日期:1996-11-01 00:00:00
abstract::A rare case involving multiple intracranial aneurysms with intraventricular hemorrhage (IVH) in a child, accompanied by unilateral fibromuscular dysplasia (FMD) of the renal artery, is reported. A 12-year-old girl presented with secondary hypertension and fourth-ventricle IVH. Cerebral angiography showed multiple aneu...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000180304
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Initial therapy for craniopharyngioma remains controversial. Population-based datasets indicate that traditional algorithms [gross total resection (GTR) vs. subtotal resection (STR) +/- radiation therapy (XRT)] are often not employed. We investigated neurosurgical practice patterns. METHODS:A ten-question s...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000357783
更新日期:2013-01-01 00:00:00