Abstract:
:Craniopharyngioma is one of the leading causes of hypothalamic-pituitary dysfunction in childhood, caused either by the tumor itself or the consequences of treatment. Tumor management in terms of recurrence rate, quality of life and complications is still controversial. Sixty-six patients with craniopharyngioma at pediatric age were reviewed for symptoms, signs, types of treatment, recurrence rates, complications, and endocrinological outcome. The majority of symptoms was related to the neurological system. Complaints only affecting the endocrinological system were seen in 6% of patients. The most frequent complaints were headache and vomiting (74.2%). The main endocrinological complaints were polyuria and polydipsia (15%), and lassitude (10.6%). Although short stature was a symptom in 9.1% of patients, it was a finding in 39.7% of patients. Plain skull X-rays raised the suspicion of intracranial tumor in more than 90% of children with craniopharyngioma. Recurrence rates were independent of the extent of tumor removal (total or subtotal). The frequency of endocrine dysfunction increased significantly after treatment. The most frequent hypothalamic-pituitary dysfunction was growth hormone deficiency (100%) and gonadotropin deficiency (80%). Hypothyroidism was diagnosed in 74% of patients. The frequency of hypothalamic-pituitary dysfunction was not affected by the extent of tumor removal. Radiotherapy did not increase the frequency of endocrine dysfunctions further. In conclusion, growth follow-up in childhood seems to be an important indicator of craniopharyngioma in early diagnosis. Radiotherapy and extent of tumor removal - either total or subtotal - did not influence endocrine outcome.
journal_name
Pediatr Neurosurgjournal_title
Pediatric neurosurgeryauthors
Gonc EN,Yordam N,Ozon A,Alikasifoglu A,Kandemir Ndoi
10.1159/000079852keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
112-9issue
3eissn
1016-2291issn
1423-0305pii
79852journal_volume
40pub_type
杂志文章abstract::Tumors of the pineal region in children often belong to 2 categories, namely germ cell tumors and pineal parenchymal tumors. Very rare pathologies have previously been reported in this region. Most of these tumors may be similar radiologically, while their management differs. The present series reports 2 children with...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000369033
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journal_title:Pediatric neurosurgery
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pub_type: 历史文章,杂志文章
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028693
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journal_title:Pediatric neurosurgery
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doi:10.1159/000056052
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doi:10.1159/000050444
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000365763
更新日期:2013-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000050397
更新日期:2001-08-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028828
更新日期:1999-07-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
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更新日期:1999-04-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000336752
更新日期:2011-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000138375
更新日期:2008-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000121191
更新日期:1997-04-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120649
更新日期:1992-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120540
更新日期:1990-01-01 00:00:00
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journal_title:Pediatric neurosurgery
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000069100
更新日期:2003-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000452804
更新日期:2017-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000028630
更新日期:1998-02-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type:
doi:10.1159/000508940
更新日期:2020-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000120147
更新日期:2008-01-01 00:00:00
abstract::Holocord intramedullary low-grade astrocytomas in children and adolescents - involving most or all of the cervical and thoracic spinal cord - are a rare finding. Most of the tumors seem to be pilocytic astrocytomas. Surgical management strategies might not be as clear as in small and circumscribed intramedullary tumor...
journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000345593
更新日期:2012-01-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章
doi:10.1159/000055975
更新日期:2000-12-01 00:00:00
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journal_title:Pediatric neurosurgery
pub_type: 杂志文章,评审
doi:10.1159/000028945
更新日期:2000-05-01 00:00:00